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991.
992.
目的介绍同水平析因设计矩阵的分解方法、分解结果及其特点,为多因素试验设计提供一种有效方法.方法以n水平(n≥3)的同水平多因素析因设计矩阵为基本的设计矩阵,不增加任何限定条件,仅考察各试验点对其余试验点的影响,采用"主成分分析、聚类分析和规则归纳"等数据挖掘技术相结合的方法,可将此矩阵分解成一系列彼此互不重叠的独立设计矩阵.结果独立设计矩阵具有一些很好的特点,有些本身就是正交设计,有些本身就是均匀设计,还有些是它们所不包含的特殊设计,这些设计一般都是比较理想的多因素试验设计.结论独立设计不仅涵盖了多因素析因设计、分式析因设计、正交设计、均匀设计,还有一些是具有实用性的特殊设计,它是一类具有很高理论研究价值和实际应用前景的综合性极强的多因素试验设计方法. 相似文献
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996.
痉、痿证方对大鼠脊髓持续性压迫损伤局部NGF、BDNF的调节作用 总被引:1,自引:0,他引:1
目的:研究大鼠脊髓持续性压迫后NGF、BDNF含量及NGF、BDNF原位基因表达变化,探讨痉、痿证方对大鼠脊髓持续性慢性损伤NGF、BDNF的影响.方法:采用大鼠颈椎前路螺钉压迫颈脊髓,螺钉持续留置压迫30天以产生慢性损伤,蛋白含量用免疫组化EnVision法,基因表达用原位杂交法.结果:(1)免疫组化:统计结果NGF、BDNF结果相近:轻压模型组与假手术组比较,具有显著性差异,P<0.05;析因设计:①试验压迫与药物2因素间无交互作用; 药物因素有统计意义;②不同药物因素之间(含模型组)有非常显著性差异,P<0.01.(2)原位杂交:假手术组少见阳性染色的细胞,而模型组和用药组可见明显阳性染色的细胞,NGF和BDNF的阳性细胞特征大致相近.结论:药物干预能促进神经营养因子的分泌,脊髓神经细胞和胶质细胞参与了NGF和BDNF的分泌. 相似文献
997.
The expression of thrombomodulin and neural cell adhesion molecule (NCAM) was studied immunocytochemically in biopsied muscle specimens from 10 patients with rhabdomyolysis with different etiologic factors, including 5 with malignant hyperthermia. We have already reported that thrombomodulin was expressed on regenerating muscle cell membranes as well as on vessel walls in patients with various neuromuscular diseases, including Duchenne muscular dystrophy, Becker muscular dystrophy and inflammatory myopathy. We found increased expression of thrombomodulin not only on the sarcolemma, but also in the sarcoplasm of a fair number of muscle fibers in the acute phase of rhabdomyolysis. The granular pattern of thrombomodulin expression in the sarcoplasm seems to be a characteristic finding in the acute phase of rhabdomyolysis. Most muscle fibers which expressed NCAM on the sarcolemma also expressed thrombomodulin. However, the muscle fibers which expressed thrombomodulin in the sarcoplasm did not express NCAM, and showed a degenerative appearance on electron microscopic examination. These results suggest that thrombomodulin is expressed in the sarcoplasm during the acute degeneration phase of rhabdomyolysis in addition to the expression on the sarcolemma during the muscle fiber regeneration as shown in our previous study, and the former process, which is characterized by the granular expression of thrombomodulin in the sarcoplasm, may be a characteristic finding in rhabdomyolysis. 相似文献
998.
Changes in sodium, potassium, and water content in brain tissue are important in the progression of pathology that follows ischemic stroke. Determining these parameters regionally in rodent models of experimental ischemia has been limited because typical tissue weights of more than 35 mg are too large. Identifying ischemic tissue to direct tissue sampling towards ischemic cortex is also represents a difficult generally unresolved area. We suggest that larger differences between normal and ischemic cortex of sodium, potassium, and water content than previously observed can be obtained from directed sampling of 2-mg brain tissue in a model of focal cerebral ischemia. In five rats, the middle cerebral artery and both common carotid arteries were occluded for 4.9+/-0.13 h (mean+/-SEM). Punch-sampling of 1-mm diameter tissue cores for water content (H(2)O%) by the wet-dry method, and [Na(+)] and [K(+)] by flame photometry, was guided by the observation of a subtle change in the surface reflectivity of ischemic cortex of quickly dried, 20-microm frozen brain sections, that was confirmed by MAP2 immunohistochemistry. The ratio of the lesion areas as determined by the reflective change and MAP2 immunoreactivity was 0.96+/-0.03 (n=5). In ischemic cortex H(2)O% was 79.9%+/-0.8%, [Na(+)] was 550+/-25 mEq/kg dry-weight, and [K(+)] 94.2+/-19.2 mEq/kg dry-weight (n=5), all significantly different from the values in border zone cortex, and in cortex contralateral to ischemic cortex and border zone (for all samples n=60, mean wet weight 2.037+/-0.046 mg). Differences between ischemic and normal cortex were 5.4+/-1.1%, 317+/-21 mEq/kg dry-weight, -304+/-27 mEq/kg dry-weight (n=5) for H(2)O%, [Na(+)], and [K(+)]. These differences between ischemic and normal cortex are 1.4-2.5, 1-3.11, and 1.4-3.5 times greater, respectively, than previous results obtained using samples weighing 35 mg or more. These results extend the association of sodium and potassium with ischemic brain edema in the rodent model, and show that these classical measurements can keep pace with the regionality of histochemical and morphological methods. 相似文献
999.
Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome 下载免费PDF全文
Reuter I Hu MT Andrews TC Brooks DJ Clough C Chaudhuri KR 《Journal of neurology, neurosurgery, and psychiatry》2000,68(2):238-241
Huntington's disease is characterised by hyperkinetic movements, mainly chorea, cognitive dysfunction, and psychiatric abnormalities. Non-dopa responsive parkinsonism occurs in the later stages of choreic disease or as the predominant feature of juvenile patients (Westphal variant). Late onset Huntington's disease presenting as levodopa responsive parkinsonism is rare. A series of four patients with late onset Huntington's disease presenting as levodopa responsive parkinsonism and cardiovascular dysautonomia, initially misdiagnosed as multiple system atrophy (MSA) in three patients, is reported. Levodopa treatment did not unmask significant chorea. These cases suggest the presence of a distinct phenotypic variant of Huntington's disease to be added to the differential diagnosis of other akinetic rigid syndromes. 相似文献
1000.
大鼠脑铅和血铅含量对学习记忆的影响与硒锌的保护作用 总被引:8,自引:1,他引:8
目的 探讨食物铅进入机体后对记忆功能的影响以及补充锌和硒对铅致损伤的保护作用。方法 将Wistar大鼠按体重随机分为 10组 ,在基础饲料里分别添加不同剂量的亚硒酸钠、乳酸锌及醋酸铅 ,实验期为 12周。结果 染铅各组大鼠的脑和全血中铅含量均显著高于对照组。在染铅各组中 ,从低硒缺锌到高硒高锌组大鼠的脑铅含量呈下降趋势 ,对照组大鼠的脑铅含量未检出。染铅各组大鼠血铅含量也不同程度地受饲料中硒和锌水平的影响 ,硒和锌对降低脑铅含量有协同作用 (P <0 0 0 1)。各组大鼠发生错误次数和到达终点所需时间明显不同 ,缺锌低硒染铅组发生的错误次数和所需时间显著高于其他染铅各组和对照组(P <0 0 5 ) ;补硒可显著改善染铅大鼠水迷宫实验所需时间和降低错误次数 (P =0 0 0 2和P =0 0 0 7)。大鼠水迷宫试验中随着脑铅和血铅含量的增加 ,到达终点所需时间延长和发生的错误次数增加。结论 良好的锌和硒营养状况有助于降低组织中铅的水平 ,提示可能具有拮抗铅毒性的作用 相似文献