全文获取类型
收费全文 | 268981篇 |
免费 | 23180篇 |
国内免费 | 16104篇 |
专业分类
耳鼻咽喉 | 2419篇 |
儿科学 | 3356篇 |
妇产科学 | 5184篇 |
基础医学 | 31329篇 |
口腔科学 | 4718篇 |
临床医学 | 34813篇 |
内科学 | 41958篇 |
皮肤病学 | 3197篇 |
神经病学 | 14589篇 |
特种医学 | 9399篇 |
外国民族医学 | 112篇 |
外科学 | 28677篇 |
综合类 | 40777篇 |
现状与发展 | 51篇 |
一般理论 | 49篇 |
预防医学 | 17194篇 |
眼科学 | 7367篇 |
药学 | 27570篇 |
196篇 | |
中国医学 | 12826篇 |
肿瘤学 | 22484篇 |
出版年
2024年 | 510篇 |
2023年 | 3386篇 |
2022年 | 5940篇 |
2021年 | 12639篇 |
2020年 | 9426篇 |
2019年 | 8379篇 |
2018年 | 8874篇 |
2017年 | 7896篇 |
2016年 | 7461篇 |
2015年 | 11467篇 |
2014年 | 14593篇 |
2013年 | 13770篇 |
2012年 | 20170篇 |
2011年 | 22069篇 |
2010年 | 13888篇 |
2009年 | 11208篇 |
2008年 | 14797篇 |
2007年 | 14809篇 |
2006年 | 14265篇 |
2005年 | 14022篇 |
2004年 | 9595篇 |
2003年 | 8571篇 |
2002年 | 7372篇 |
2001年 | 6580篇 |
2000年 | 6702篇 |
1999年 | 6975篇 |
1998年 | 3958篇 |
1997年 | 4010篇 |
1996年 | 3026篇 |
1995年 | 2819篇 |
1994年 | 2439篇 |
1993年 | 1607篇 |
1992年 | 2418篇 |
1991年 | 2112篇 |
1990年 | 1771篇 |
1989年 | 1516篇 |
1988年 | 1341篇 |
1987年 | 1222篇 |
1986年 | 983篇 |
1985年 | 792篇 |
1984年 | 521篇 |
1983年 | 398篇 |
1982年 | 236篇 |
1981年 | 215篇 |
1980年 | 196篇 |
1979年 | 251篇 |
1978年 | 141篇 |
1977年 | 112篇 |
1976年 | 97篇 |
1974年 | 116篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
32.
33.
34.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study 下载免费PDF全文
35.
36.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
37.
Yang Liu Yanyan Gao Hengliang Liu Qi Chen Jinrui Ji Kailong Jia 《Arquivos brasileiros de cardiologia》2021,116(2):229
BackgroundDual antiplatelet therapy (DAPT) is the cornerstone treatment of acute myocardial infarction (AMI).ObjectiveThe present study aimed to investigate the efficacy and safety of triple antiplatelet therapy (TAPT) in elderly female patients with diabetes and ST segment elevation myocardial infarction (STEMI), who had undergone percutaneous coronary intervention (PCI).MethodsWe designed a randomized, single-blind study. Control group A (97 elderly male patients with diabetes and STEMI, whose CRUSADE scores were < 30) received aspirin, ticagrelor, and tirofiban. A total of 162 elderly female patients with diabetes and STEMI were randomly divided into two groups according to CRUSADE score. Group B (69 patients with CRUSADE score > 31) received aspirin and ticagrelor. Group C (93 patients with CRUSADE score < 30) received aspirin, ticagrelor and tirofiban. P values < 0.05 were considered statistically significant.ResultsCompared to the findings in group A, post-PCI Thrombolysis in Myocardial Infarction (TIMI) grade 3 blood flow and TIMI myocardial perfusion grade 3 were significantly less prevalent in group B (p < 0.05). When compared to groups A and C, the incidence of major adverse complications was significantly higher in group B (p < 0.05).ConclusionTAPT could effectively reduce the incidence of major complications in elderly female patients with diabetes and STEMI. However, close attention should be paid to hemorrhage in patients receiving TAPT. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0) 相似文献
38.
39.
目的以基因表达数据集资料为研究对象,分析BCAN基因在肾透明细胞癌中的表达情况以及对患者预后的影响。方法在Oncomine数据库中挖掘BCAN在肾透明细胞癌(ccRCC)中的表达情况。从TCGA数据库中获取ccRCC患者临床资料和目的基因的表达信息并进行统计分析。利用GEO数据库中GSE73731数据集的ccRCC样本进行基因富集分析。利用String数据库分析与BCAN相关的蛋白。结果BCAN低表达组的ccRCC患者在病理分期及T分期方面低于高表达组(P<0.001;P=0.001);N分期及M分期差异无统计学意义(P>0.05)。BCAN低表达组患者的总生存期优于高表达组(P=0.033)。BCAN基因高表达组的样本主要富集在KRAS信号通路。结论BCAN可以通过多种途径来促进肿瘤细胞的侵袭能力,有望成为ccRCC不良预后的重要生物标志物之一。 相似文献
40.
目的探讨分诊安全管理结合风险管理提高急诊科护理质量评分的作用。方法该院于2018年6月起加强对急诊科的分诊安全管理结合风险管理,以于2017年6月—2019年6月在该院急诊科就诊的患者为研究对象,评价管理策略实施前后护理风险发生率、护理质量评分以及患者满意度等评价指标变化情况。结果实施后基础护理、实践操作、消毒隔离、急救药品、护理文件方面的护理质量评分均较实施前显著提高(P<0.05);实施后护理差错、护理缺陷、护理投诉的发生率分别为0.26%、0.58%、0.19%,均较实施前显著降低(P<0.05);实施后护理总满意率为94.92%,较实施前显著提高(P<0.05)。结论分诊安全管理结合风险管理有效提高了急诊科护理质量,提升了患者满意度,减少了护理风险事件的发生。 相似文献