不同有机氮源对肌苷合成的影响

通过研究不同有机氮源对肌苷合成的影响,结合蛋白、核酸及菌体生长的分析测定,结果显示:国产酵母膏A是肌苷发酵的理想氮源。此外,由于国产酵母膏A部分可溶,其水解出的氨基酸的碳骨架可能作为前体物质直接进入糖酵解和三羧酸途径,使得以国产酵母膏A为氮源时肌苷生产期的呼吸熵(RQ)由1.0降至0.6左右,从而促进了肌苷的合成,糖苷转化率由原来的15%提高至29%。     

6-甲氧基-4-二烃氨基乙氨基喹啉衍生物的合成

合成了四种新的6-甲氧基-4-二烴氨基乙氨基喹啉衍生物,以供对感染日本血吸虫病实驗动物疗效試驗之用。     

In-situ T lymphocyte identification in cutaneous tissue sections of benign and malignant dermatoses

An indirect immunoperoxidase technique employing a specific anti-human T lymphocyte antiserum has been used to identify T lymphocytes in cutaneous tissue sections of various benign and malignant dermatoses. Skin biopsies from patients with histologically confirmed lichen planus, discoid lupus erythematosus, psoriasis, actinic keratosis, squamous cell carcinoma, Bowen's disease, keratoacanthoma, malignant melanoma, inflamed serborrhoeic warts, sarcoidosis, follicular lymphoma and multicentric reticulohistiocytosis were examined. T lymphocytes were found to be the predominant cell type in the cutaneous infiltrates of the majority of these dermatoses. However, only few T lymphocytes were identified in sarcoidosis where they tended to be restricted to the periphery of the epithelioid cell granulomas. Similarly, in the cutaneous infiltrates of follicular lymphoma and in a patient with multicentric reticulohistiocytosis, few T lymphocytes were identified.     

Mechanism of the Anemia of Pyridoxine Deficiency in the Rat

Rats were fed a diet deficient in pyridoxine until they developed a microcytic, hypochromic, pyridoxine-responsive anemia. Studies of red cell survivaltime demonstrated that there was a hemolytic factor involved in this anemia;and the more severe the anemia, the more rapid the destruction of red cells.It also demonstrated that the defect was intracorpuscular. Blood regenerationstudies confirmed findings by others that erythropoiesis was impaired in pyridoxine deficiency, particularly when the accompanying anemia was severe.These studies indicate that a dual mechanism may be operating in theseanemic rats.

Submitted on February 15, 1967 Accepted on April 17, 1967