Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway

Cardiovascular Drugs and Therapy - The purpose of this study was to determine whether the epidermal growth factor receptor (EGFR), which is a classical receptor tyrosine kinase, is involved in the...     

小剂量白细胞介素2联合肝动脉化疗栓塞术和CT引导下射频消融术治疗大于5 cm原发性肝癌的疗效和安全性

目的 探讨小剂量白细胞介素2(IL-2)联合肝动脉化疗栓塞术(TACE)在CT引导下行射频消融术(RFA)对大于5 cm的原发性肝癌的疗效和安全性.方法 将2011年1月至2013年12月初治的50例原发性肝癌患者,按照随机数字表法分入小剂量IL-2联合RFA +TACE组(A组)或单纯RFA+ TACE组(B组),各25例.患者至少有1个肿瘤最大直径≥5 cm.第1天行TACE.第(5±2)天行RFA.A组患者白第10天连续皮下注射重组人IL-2 250万单位,隔日皮下注射,共8周.主要观察终点为随机化开始至疾病进展时间(TTP);次要观察终点为客观有效率(ORR)、总生存期和安全性.结果 患者中位年龄为55岁.中位随访期为518 d(91 ～1 227 d).IL-2相关的不良事件主要为注射部位硬结[64.0％ (16/25)]、低热[48.0％ (12/25)]和乏力[36.0％ (9/25)].TACE联合RFA治疗相关的不良事件包括发热[88.0％(44/50)]、丙氨酸转氨酶(ALT)及天冬氨酸转氨酶(AST)升高[均为80.0％ (40/50)]、疼痛[76.0％(38/50)]和胆红素升高[66.0％ (33/50)].其中Ⅲ度疼痛10例,Ⅲ度ALT和AST升高各5例.2组之间在微创治疗的安全性方面差异无统计学意义(P=0.062).总ORR均为74.0％ (37/50),其中完全缓解11例,部分缓解26例.A组TTP较B组明显延长,差异有统计学意义.1年和2年生存率分别为67.8％(34例)和52.9％(26例).结论 小剂量IL-2可能会进一步提高RFA+ TACE治疗大于5 cm的原发性肝癌的临床效果,且耐受性良好.     

Toll样受体2亚家族基因单核苷酸多态性与哮喘的关系研究

目的:探讨Toll样受体(Toll-like receptor,TLR)2亚家族基因单核苷酸多态性(single nucleotide polymorphisms,SNP)与中国东南方成人哮喘以及其临床表型之间的关系。方法:共招募哮喘患者318例,正常对照352例,TLR2亚家族中共8个SNP使用SNPstream方法进行了基因分型。对各SNP和单倍型与哮喘及其表型进行了分析。结果:运用Logistic回归分析后,发现rs7656411/TLR2突变基因型TT与野生型rs7656411 GG比较能明显降低37%哮喘的发生(校正OR=0.63,95%CI:0.41~0.98,P=0.41),rs7656411 TT+GT与哮喘无明显关系(校正OR=0.77,95%CI:0.54~1.09,P>0.05)。携有rs2381289/TLR6 T等位基因的哮喘患者患过敏性鼻炎的危险度为不携带此等位基因哮喘患者的1.79倍(95%CI:1.10~2.91,P=0.025),然而携有rs11466651/TLR10 A等位基因的哮喘患者患过敏性鼻炎的危险度较不携带此等位基因的哮喘患者下降了51%(95%CI:0.26~0.95,P=0.046)。结论 :TLR2亚家族基因的突变可能在哮喘易感性中起着重要作用。     

Acupoint injection therapy for diabetic retinopathy: A protocol for systematic review and meta-analysis

Background:Diabetic retinopathy (DR) is a common diabetic microvascular complication, and it is also the main cause of blindness in adults. At present, some studies have reported acupoint injection for the treatment of DR. However, the effectiveness and safety are still uncertain. This study aims to evaluate the efficacy and safety of acupoint injection for the treatment of patients with DR.Methods:The databases of English databases (PubMed, Embase, Cochrane Library, Web of Science) and Chinese databases (China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, and Chinese Biomedical Literatures Database) will be retrieved. Published randomized controlled trials and quasi-randomized controlled trials on the topic will be retrieved by 2 investigators independently. We will apply a fixed-effect model or random effect model basis on the heterogeneity test and employ with RevMan 5.3 software for data synthesis. The total effective rate will be selected as the primary outcome, visual acuity, hemorrhage areas, exudates, capillary nonperfusion areas, hemorheological indicators, mean defect of visual field, glycated hemoglobin, and adverse events as secondary outcomes.Results:This study will comprehensively summarize the high-quality trials to determine the effectiveness and safety of acupoint injection treatment for patients with DR.Conclusion:The systematic review of this study will summarize the currently published evidence of acupoint injection treatment for DR to further guide its promotion and application.Protocol registration number:INPLASY2020110026     

Acupuncture therapy strategy options in postoperative management after laparoscopic cholecystectomy: A protocol for systematic review and Bayesian meta-analysis

Background:Laparoscopic cholecystectomy (LC) is a common surgery accompanied by some unpleasant adverse effects. Clinical trials indicated that acupuncture therapy may help reduce complications in LC. However, no systematic reviews have been conducted on the topic. Therefore, we will evaluate the current evidence and provide a rank for the efficacy of acupuncture therapy in LC by performing Bayesian network meta-analysis.Methods:A total of 9 databases will be searched from inception to 10 December 2020. Randomized control trails met the criterion will be included. Quality evaluation of included studies will be performed using Cochrane risk-of-bias tool. STATA 14.0, Addis 1.16.8, R 3.6.3, and OpenBUGS 3.2.3 will be used to conduct pairwise meta-analysis and network meta-analysis. The evidence will be assessed by the Grades of Recommendations Assessment Development and Evaluation.Results:This review will be based on clinical evidence to choose the best choice of acupuncture treatment for LC. And the results will be submitted to a peer-reviewed journal for publication.Conclusion:Through this systematic review, we will summarize the best available evidence of acupuncture therapy in LC and help to improve the clinical decision-making ability in LC domain.Systematic review registration:The protocol has been registered on INPLASY2020120056.     

TuYou-County Pediatric Eye (TYPE) study,design issues,baseline demographic characteristics,and implications: Report number 1

To report the rationale, design, and baseline demographic characteristics of TuYou-County Pediatric Eye study, which mainly aimed to determine the retinal microvascular changes with optical coherence tomography angiography (OCTA) and its association with eye abnormalities in school aged children and adolescents at suburban location in Northern China.TuYou-County Pediatric Eye study was a school-based survey conducted in TuYou-County. Multi-ethnic (Mongol, Han, and Hui) participants will be followed up for 5 years. Standardized ophthalmological examinations include visual acuity, ocular biometry, retinal photography, and OCTA. A questionnaire survey was conducted to collect variables regarding to eye disease such as parental history of eye diseases, near work, outdoor activities, living and eating habits, etc.After sampling, 687 participants were eligible for investigation, and 20 students did not attend the investigation, living 667 (response rate, 97.1%) students completed questionnaires and all ocular examinations. The average age of all participants was 14.9 ± 5.11.TYPE study is the first large-scale school-based multi-ethnic survey in suburban site of Northern China. Continuous identification of retinal microvascular changes with eye diseases will provide new insights into the control related diseases in school-age children and adolescents.     

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

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Remote patient monitoring sustains reductions of hemoglobin A1c in underserved patients to 12 months

AimsWe sought to determine whether underserved patients enrolled in a statewide remote patient monitoring (RPM) program for diabetes achieve sustained improvements in hemoglobin A_1c at 6 and 12 months and whether those improvements are affected by demographic and clinical variables.MethodsDemographic and clinical variables were obtained at baseline, 6 months and 12 months. Baseline HbA1c values were compared with those obtained at 6 and 12 months via paired t-tests. A multivariable regression model was developed to identify patient-level variables associated with HbA_1c change at 12 months.ResultsHbA_1c values were obtained for 302 participants at 6 months and 125 participants at 12 months. Compared to baseline, HbA_1c values were 1.8% (19 mmol/mol) lower at 6 months (p < 0.01) and 1.3% (14 mmol/mol) lower at 12 months (p < 0.01). Reductions at 12 months were consistent across clinical settings. A regression model for change in HbA_1c showed no statistically significant difference for patient age, sex, race, household income, insurance, or clinic type.ConclusionsPatients enrolled in RPM had improved diabetes control at 6 and 12 months. Neither clinic type nor sociodemographic variables significantly altered the likelihood that patients would benefit from this type of technology. These results suggest the promise of RPM for delivering care to underserved populations.     

Comparative study on risk for birth defects among infants after in vitro fertilization and intracytoplasmic sperm injection

This large retrospective study was conducted to compare the risk for birth defects among infants conceived by in vitro fertilization (IVF) with that among infants conceived by intracytoplasmic sperm injection (ICSI) and to explore the effect of frozen embryo transfer (FET) on the risk for birth defects among infants born by IVF and ICSI. All patients who received assisted reproductive technology (ART) treatment and who underwent childbirth during the period January 2005–August 2017 were included in this study. There were 18,221 births after ART included in the analysis; of these births, 12,649 were conceived by IVF, and 5,572 were conceived by ICSI. In the study, the prevalence of any birth defect in singleton infants was 1.15% with the use of IVF and 1.38% with the use of ICSI, and that in twin infants increased to 2.74% by IVF and 2.58% by ICSI. However, no significant difference between IVF and ICSI was found among all infants, singleton births or twin births. Additionally, in assessing ART infants born after FET, we did not detect a difference in the risk for birth defects between infants born by IVF and those born by ICSI. These results indicate that among the entire cohort of children conceived from ART and among the children conceived from FET, the risk for birth defects after ICSI is similar to that after IVF.Abbreviations: IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; FET: frozen embryo transfer; ART: assisted reproductive technology; ET: embryo transfer; BMI: body mass index; OHSS: ovarian hyperstimulation syndrome; CMOH: Chinese Ministry of Health; ICD-10: International Classification of Diseases, 10^th edition; PTB: preterm birth; OR: odds ratio; aOR: adjusted odds ratio; CI: confidence interval     

中国成年人代谢异常相关的体质指数和腰围切点研究

目的 研究中国成年人BMI和腰围与各项代谢危险因素之间的相关性,确定超重肥胖的适宜BMI和腰围切点。方法 中国慢性病前瞻性研究于2004-2008年进行基线调查,并于2013-2014年随机抽取了5%的研究对象进行第2次重复调查。本研究剔除体格指标或代谢危险因素变量缺失或极端值、自报患有恶性肿瘤者,基线纳入501 201人,第2次重复调查纳入19 201人。比较不同BMI和腰围下代谢危险因素异常率,通过受试者工作特征（ROC）曲线分析,确定预测高血压、糖尿病、血脂异常和危险因素聚集的适宜BMI和腰围切点。结果 随BMI或腰围的增加,高血压、糖尿病、血脂异常和危险因素聚集患病率均呈现上升的趋势。依据正确指数最大的原则选取BMI超重切点和腰围切点,男性和女性BMI超重切点均接近24.0 kg/m²,男性腰围切点接近85 cm,女性腰围切点约为80~85 cm。男性和女性中,检出各项代谢危险因素特异度达到90%的BMI切点范围为27.0~28.9 kg/m²,多数接近28.0 kg/m²,以28.0 kg/m²作为肥胖切点。结论 本研究在更新开展的大样本调查中进一步验证了中国肥胖问题工作组2002年推荐的超重和肥胖标准,超重和肥胖的BMI切点分别为24.0和28.0 kg/m²;中心性肥胖的腰围适宜切点男性为85 cm,女性为80~85 cm。