Chlamydia pneumonia seropositivity correlates with serum fibrinogen and lipoprotein a levels: any role in atherosclerosis?

The aim of the study is to determine the impact of Chlamydial seropositivity on atherosclerosis in a group of patient requiring coronary and/or carotid revascularization. A population of 30 diabetic patients (group 3) and 26 nondiabetic patients (group 2) with angiographically documented coronary and/or carotid artery disease were enrolled for the study. Volunteers from the relatives of hospital staff with no known disease (n=29; group 1) were included as the control group. Serum samples from the participants were assayed for cardiovascular risk factors including total serum cholesterol, triglyceride and lipoprotein levels, fibrinogen, Hb A1c levels and IgG titers for Chlamydia pneumonia (C. pneumonia). Chlamydial seropositivity was analysed further to determine a possible impact on atherogenesis. Serum LDL cholesterol levels revealed statistically significant difference between groups 1 and 2 (p=0.001). There was no difference between groups 2 and 3 regarding LDL cholesterol levels. There was no significant difference among the groups with respect to C. pneumonia seropositivity and the other atherosclerotic risk factors. Chlamydial seropositivity was found to be more frequent in males than in females (p=0.008). In the C. pneumonia seropositive group, serum fibrinogen and lipoprotein a levels were found to be significantly higher than the seronegative group (p=0.0001 and p=0.001, respectively). Other atherogenic risk factors were similar in the seropositive and negative groups. The causal role of Chlamydial infections in atherosclerotic plaque formation might be due to their influence on the serum fibrinogen and lipoprotein a levels.     

3种光敏剂对5株人鼻咽癌细胞PDT量效关系的研究

用ＭＴＴ法比较了不同能量的脉冲铜蒸气激光、不同浓度的３种光敏剂（ＰＳＤ－００７、ＢＨｐＤ和ＹＨ－ｐＤ）对５株人鼻咽癌细胞（ＣＮＥ２、ＨＮＥ１、ＨＮＥ２、ＨＮＥ３，和ＨｏＮＥ１的体外杀伤效应。结果表明：（１）激光合并光敏剂即令能量较低、剂量较小，也能显示明显的杀伤效应，而单用激光或单用光敏药物则只在较高能量和较大剂量时才显示轻微杀伤效应。（２）５株鼻咽癌细胞对３种光敏剂的ＰＤＴ敏感性彼此存在着差异。（３）在一定激光能量和光敏剂浓度时，ＰＳＰ－００７的杀伤效应优于ＢＨｐＤ和ＹＨｐＤ，而ＹＨｐＤ又稍优于ＢＨｐＤ。     

不同辅料炮制对淡豆豉中大豆异黄酮含量的影响

目的考察用不同辅料炮制淡豆豉对其大豆异黄酮含量的影响。方法采用发酵法制取淡豆豉样品,用HPLC色谱法测定样品中大豆异黄酮的含量。色谱柱为Hanbo（250 mm×4.6 mm,5μm）;流动相为甲醇∶水∶冰醋酸（40∶60∶0.5）;流速：1 m L/min;检测波长：260 nm。结果以大豆苷为考察指标时三者的差别不大,与青蒿、桑叶比较,淫羊藿和人参为辅料发酵的淡豆豉含量略低;以染料木苷为考察指标时,与青蒿、桑叶比较,淫羊藿为辅料发酵的淡豆豉含量略有升高,人参为辅料发酵的淡豆豉含量升高明显。结论炮制辅料不同,对淡豆豉中大豆异黄酮含量有一定影响,且人参为炮制辅料时影响较大。     

Artglass玻璃瓷在牙齿美容修复中的应用

目的探讨Artglass玻璃瓷在牙齿美容修复中的应用，从临床、技工操作和使用等方面分析合理使用该材料的方法以及注意事项。方法对335例2196单位使用Artglass玻璃瓷完成美容修复的病例进行总结，检查修复效果，分析失败原因。结果绝大多数修复都达到了改善美观的效果，其中21例44个修复单位失败，占2％。修复失败者主要是修复体的部分崩裂和修复体脱落，重新修复后得到解决。结论Artglass玻璃瓷是一种较为理想的牙齿美容修复材料，色泽、强度和可操作性比以往的修复材料有了明显的提高，应用时要特别注意黏结过程和咬合调整。     

Congenital mesenteric aneurysm and mesenteric arterioportal fistula

A unique case with superior mesenteric artery aneurysm and arterioportal fistula resulting from mesenteric arteriovenous malformation is presented, and the relevant literature is reviewed. Received: 16 December 1994/Accepted after revision: 31 March 1995     

An experimental evaluation of response to contrast media: Pantopaque, iopamidol, and iohexol in the subarachnoid space

Myelography in dogs was performed with Pantopaque, iopamidol and iohexol. The effects of these agents were evaluated by histologic study of the brain, spinal cord, and meninges four months after the procedure. Retained Pantopaque was always accompanied by some degree of arachnoidal reaction, mild in the cervical cord segment and severe in the most caudal part of the cul-de-sac. No apparent protection against Pantopaque arachnoiditis was provided by either intrathecal or intramuscular methylprednisolone. We found no histologic evidence of arachnoiditis in animals examined with iopamidol and iohexol.     

Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation

OBJECTIVE: The purpose of this study is to report a case of acquired angioedema and Factor V Leiden mutation in a woman who had started taking an oral contraceptive (OC), and to review the literature. RESULTS: A 44-year-old nonobese and nonsmoking woman was admitted to our hospital because of pain and progressive erythematous lesion on her left groin. The patient had had a 6-week history of combined OC use. There was no family history of angioedema. With a diagnosis of necrotizing fasciitis, surgical debridement of all necrotic tissue was considered with fasciocutaneous flap. Histopathological analysis showed diffusely fresh bleeding areas with diffused subcutaneous necrosis. The culture of the necrotic tissue was negative. Postoperatively, she restarted combined OC, and then the painful petechial and rapidly disseminated ecchymotic lesions were seen. Oral contraceptive was stopped immediately. A venous Doppler ultrasonography of the lower extremities showed subacute thrombosis in the left popliteal vein. Complement C3 level was normal, but amounts of C4, C1 esterase inhibitor level and activity were low. Factor V Leiden was positive for the heterozygous presence of Factor V gene. CONCLUSIONS: Women with angioedema and Factor V Leiden should be counseled against using hormonal contraceptives containing estrogen, and because they may interact in a synergistic manner in the pathogenesis of cutaneous lesions and/or venous thrombosis, appropriate individualized therapy should be defined. Further studies are needed.