PLGA纳米粒抗肿瘤药物载体的研究进展

目的：阐述近年来PLGA 纳米粒作为抗肿瘤药物载体的研究进展。方法归纳国内外最新的文献报道,对PLGA纳米粒作为抗肿瘤药物载体在主动与被动靶向方面的应用研究进展进行综述。结果由于纳米材料可以增强抗肿瘤药物的靶向作用,而PLGA是经FDA认证的具有生物降解性及生物相容性的功能高分子有机聚合物,已经被广泛地应用于抗肿瘤药物的载体研究。结论 PLGA纳米粒作为抗肿瘤药物载体具有广阔的应用前景。     

近视屈光手术人群角膜非球面特性及其相关因素分析

目的 研究近视屈光手术人群眼角膜非球面特性(Q值)的分布特征以及相关因素对Q值的影响.方法 随机收集近视屈光手术患者300例(600眼),使用Orbscan Ⅱz眼前节分析系统K&Q计算软件获得眼角膜6 mm分析区域的Q值,并针对Q值的分布特征及其与相关的屈光度、角膜曲率和角膜直径等因素进行相关分析.结果 300例600眼角膜Q值分布范围-0.51～1.03,平均(-0.16±0.15).Q值与角膜曲率、模拟角膜镜读数、5 mm区不规则指数和角膜前表面Diff值之间呈负相关,与前房深度和角膜直径呈正相关,而与球镜度数、等效球镜度、柱镜度数、3 mm区不规则指数、角膜后表面Diff值、年龄、眼压和角膜厚度之间不相关.同一个体双眼的Q值差异无统计学意义,但是男女之间的Q值差异有统计学意义.结论 近视屈光手术人群眼角膜Q值呈近似正态分布,角膜Q值不是一个独立的参数,与眼部多个因素相关. Abstract： Objective To study the distribution characters of corneal asphericity (Q-value) in myopia population for corneal laser refractive surgery and the related influencing factors.Methods Six hundred eyes of 300 patients with myopia for corneal laser refractive surgery were enrolled in this study with each patient selected randomly. The K&Q calculator of Orbscan Ⅱz anterior segment system was used to obtain the Q-value of 6 mm optical zone in 300 cases (600 eyes),and statistical analysis was used to comprehend the distribution characters of Q-value and its relations with diopter,cornea curvature and cornea diameter and so on. Results The Q-value of 600 eyes ranged from -0.51-1.03 with the mean value -0.16±0.15.The Q-value showed a negative correlation with cornea curvature, simulated keratometry, irregular index of 5 mm zone, diff value of anterior surface and a positive correlation with anterior chamber depth and cornea diameter, but no relate with spherical diopter,spherical equivalent,astigmatism diopter, irregular index of 3 mm zone, diff value of posterior surface,age, intraocular pressure, cornea thickness. There was no significant difference between right and left eyes individually,but significant differences between men and women.Conclusions The Q-value of 600 eyes of 300 cases are approximately normal distribution.The Q value is not an absolute parameter,it is related with many factors.     

Study on the RFLPs and amplication and rearrangement of the transforming genes in primary hepatic carcinoma,gastric carcinoma and brain tumor with six human oncogene probes

By using c-Ha-ras-1, N-ras Wigler (left sequence) and P52C.(right sequence), c-sis, v-erbB, c-myc and v-fos oncogenes as probes, restriction fragment length polymorphisms (RFLPs) of tumor tissue DNAs of 95 patients with gastric carcinoma, primary hepatic carcinoma and brain tumor, and those of 90 normal individuals were studied with the techniques of Southern blot and dot blot. Gene amplification and recombination were also examined in some tumors simultaneously. Some alleles of oncogene are reported in Chinese population for the first time. Moreover, the characteristic frequency of some "rare" alleles and genotypes occurred in some tumor samples is significantly higher than that occured in normal individuals. Pedigree analysis for 2 patients showed that some "rare" alleles are also abandant. Besides, gene amplification and recombination were found in some tumors.     

Rac1通过调控JAK2/STAT1信号通路参与神经炎症

目的 研究BV2小胶质细胞上Ras相关C3肉毒菌素物底物1(ras-related C3 botulinum toxin,Rac1)参与神经炎症的作用.方法 采用脂多糖(lipopcly saccharide,LPS)诱导BV2小胶质细胞,加入Rac1抑制剂EHT1864,用MTT法检测细胞活力;G-LISA和免疫荧光...     

穴位敷贴与大蠊萃取液治疗男性艾滋病口腔黏膜受损的疗效

目的 评价吴茱萸双足底涌泉穴敷贴联合控温美国大蠊萃取液涂敷口腔黏膜受损处治疗男男性行为艾滋病患者口腔黏膜受损的疗效，探讨有效的治疗方法。方法 选取2019年1月至2021年1月某院进行治疗的男男性行为艾滋病患者且合并口腔黏膜损伤的92例作为研究对象。按照随机数字表法分为研究组46例和对照组46例。研究组给予穴位敷贴联合美国大蠊萃取液进行治疗，对照组给予常规方法进行治疗。观察2组患者的唾液炎症因子水平、生活质量、疼痛指数、焦虑和抑郁评分。结果 治疗后，研究组患者唾液内γ-干扰素(interferon-γ,IFN-γ)、白细胞介素-6(interleukin-6,IL-6)、和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平低于对照组(t=5.302、9.961、7.792,P<0.05),白细胞介素-10(interleukin-10,IL-10)含量高于对照组(t=4.728,P<0.05);治疗后，2组患者的人β防御素(human beta defensin, HBD)-2和HBD-3水平均显著下降(研究组t=16.841、29.970,...