成人高尿酸血症相关危险因素的研究进展

<正>随着社会经济的不断发展,人民生活水平日益提高,生活方式及饮食结构发生改变,人群疾病流行规律、疾病谱和死因谱都发生了巨大变化,慢性非传染性疾病正严重威胁着人们的健康和生命,已成为社会越来越突出的公共卫生问题。与高血压、糖尿病、高脂血症等慢性病相似,近几十年来,中国人群高尿酸血症的患病率也在不断升高。20世纪80年代初期,调查显示[1],中国男性高尿酸血症患病率为1.4%,女性为1.3%。2011年,有学者[2]对大     

脑卒中后愤怒倾向危险因素研究进展

脑卒中后愤怒倾向是脑卒中后病人常见的情感障碍,但相关研究较少,早期不易被发现。对脑卒中后愤怒倾向及其危险因素的研究进展进行综述,以期加深护理人员对脑卒中后愤怒倾向的了解,提高护理服务质量。     

普米克令舒联合可必特雾化吸入治疗小儿支气管哮喘急性发作的临床探讨

目的:探讨普米克令舒混悬液联合可必特溶液雾化吸入,治疗小儿支气管哮喘急性发作的临床疗效。方法:对82例支气管哮喘急性发作的患者随机分成两组,治疗组给予普米克令舒联合可必特雾化吸入;对照组给予可必特溶液联合注射用盐酸氨溴索雾化吸入。结果:治疗组总有效率95.23%,对照组总有效率80%,经统计学处理,P<0.05,两者差异有显著性。结论:普米克令舒联合可必特雾化吸入,治疗小儿支气管哮喘急性发作取得满意临床效果,值得临床推广应用。     

米力农联合参麦注射液对缺血性心肌病患者心功能指标的影响

目的观察米力农联合参麦注射液对缺血性心肌病患者心功能指标的影响。方法选取缺血性心肌病患者160例,随机分为常规组和观察组,每组各80例,常规组常规给予血管扩张剂、利尿剂、血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂、β受体阻滞剂、洋地黄等药物,观察组在常规组治疗基础上加用米力农和参麦注射液,分别治疗7 d和14 d,观察两组治疗前及治疗后2周的临床疗效、血浆N端脑钠肽前体(NT-proBNP)水平、左室射血分数(LVEF)和6 min步行距离变化。结果治疗2周后,观察组总有效率明显优于常规组,观察组血浆NT-proBNP水平较常规组下降更为明显,观察组心脏超声LVEF值及6 min步行距离较常规组增加更为显著,两组比较差异有统计学意义(P<0.05)。结论米力农联合参麦注射液可明显改善缺血性心肌病患者各项心功能指标,短期疗效显著,且无明显不良反应。     

铁代谢异常与人体疾病研究进展

微量元素是人体必不可少的营养要素之一,铁作为人体必需微量元素中含量最高的一种,与人体的健康和疾病的发生发展息息相关。当机体铁代谢异常时会引起很多生理上的变化,同时也会引发某些疾病,如机体铁负荷会引起肝脏疾病、糖尿病、心脑血管疾病等慢性疾病,     

TP化疗方案联合康莱特治疗宫颈癌的效果及对血清CYFRA21-1、CK19水平的影响

Objective: To study the effect of TP chemotherapy regimen combined with Kanglaite in the treatment of cervical carcinoma and its effect on the serum level of CYFRA21-1 and CK19. Methods: 74 patients with cervical carcinoma were admitted in our hospital from October 2015 to May 2017 and were randomly divided into observation group and control group according to random digital table method, 60 cases in each group. The control group was treated with TP chemotherapy and the observation group was treated with TP chemotherapy regimen combined with Kanglaite. The clinical efficacy, the quality of life, serum CYFRA21-1 and CK19 levels and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the clinical effective rate(83.78%) in the observation group was significantly higher than that of control group (62.16%), u=4.390,P=0.036, with statistical significance(P<0.05). The KPS scores of the two groups were significantly decreased, and the KPS scores in the observation group were significantly higher than those in the control group(u=6.538,P=0.000). After treatment, the serum levels of CYFRA21-1 and CK19 were significantly decreased in both groups, and the levels in the observation group were significantly lower than those in the control group (u = 6.659, 8.647, P=0.000). The adverse reactions were mainly myelosuppression, gastrointestinal reaction and phlebitis. The incidences of myelosuppression and gastrointestinal reaction of grade III-IV in the observation group were significantly lower than that in the control group, while the incidence of phlebitis was significantly higher in the observation group than in the control group ((u = 2.160, 2.000, 4.16, P = 0.030, 0.045, 0.041, respectively). Conclusion: The effect of TP chemotherapy regimen combined with Kanglaite on cervical carcinoma is significantly. It can effectively reduce serum CYFRA21-1 and CK19 levels, improve the quality of life and safety, which is worth popularizing in clinical application.     

血清肿瘤标记物在卵巢癌诊断和监控治疗中的应用价值

目的 探讨血清肿瘤标记物在卵巢癌诊断及监控中的应用价值.方法 选取收治的60例卵巢癌患者、60例卵巢良性肿瘤患者分别设置为卵巢癌组、卵巢良性肿瘤组,另选取同期在我院接受健康体检的体检正常妇女60例作为对照组,对其血清肿瘤标记物的表达水平进行测定和比较,并计算各单项血清肿瘤标记物检测对卵巢癌的辅助诊断结果.结果 3组受检者的血清癌胚抗原(CEA)、3种糖类抗原(CA125、CA153、CA199)、人附睾蛋白4(HE4)等肿瘤标记物的表达水平进行比较,差异均有统计学意义(P<0.05);5种血清肿瘤标记物单项检测对卵巢癌的辅助诊断灵敏度、特异度、准确性进行比较,差异均无统计学意义(P>0.05).结论 血清肿瘤标记物的表达水平可反映卵巢癌病变,对其实施联合检测有利于提高卵巢癌的检出率,可作为卵巢癌早期诊断的参考依据.     

消纤汤联合穴位贴敷治疗结缔组织病合并肺间质纤维化临床研究

目的:观察消纤汤联合穴位贴敷治疗结缔组织病合并肺间质纤维化的临床疗效观察。方法:选择医院诊治结缔组织病合并肺间质纤维化患者112例,随机分为中医组和西医组各56例,其中西医组采取常规西药+消纤汤,中医组常规西药+消纤汤+穴位贴敷,两组均以30天为1个疗程,治疗3个疗程。观察两组治疗前后血清中半乳糖凝集素-9(Gal-9)、涎液化糖链抗原(KL-6)含量、一氧化碳弥散功能(Dlco)、肺总量(TLC)、用力肺活量(FVC),及生活质量评分,并对比两组治疗后治疗有效率。结果:治疗后,中医组血清中半乳糖凝集素-9(Gal-9)、涎液化糖链抗原(KL-6)含量明显低于西医组,差异有统计学意义(P0.05);治疗后,中医组一氧化碳弥散功能(Dlco)、肺总量(TLC)、及用力肺活量(FVC)明显高于西医组,差异有统计学意义(P0.05);治疗后,中医组生活质量评分(症状评分、活动评分、影响评分)明显低于西医组,差异有统计学意义(P0.05);治疗后,中医组有效率为87.50%,高于西医组71.43%,差异有统计学意义(P0.05)。结论:结缔组织病合并肺间质纤维化患者使用消纤汤联合穴位贴敷进行治疗,能明显提高治疗有效率,改善患者生活质量。     

适形调强放疗治疗非小细胞肺癌临床疗效观察

目的：研究三维适形调强放疗联合化疗治疗非小细胞肺癌的临床疗效。方法：将48例中、晚期非小细胞肺癌患者随机分为观察组和对照组两组进行治疗。两组患者都采用铂类联合诺维本化疗1个周期后进行放疗,放疗结束后再进行化疗3～5个周期。观察组采用三维适形调强放疗和化疗,放疗量为70～76Gy;对照组采用常规放疗和化疗,放疗量为60～66Gy。结果：观察组的有效率高于对照组;观察组患者的1年存活率和3年存活率均高于对照组;观察组的放射性食管炎和放射性肺炎的发生率小于对照组。结论：三维适形调强放疗治疗组的有效率明显高于常规放疗组患者,适形调强放疗组的1年和3年生存率也比常规放疗组高,三维适形调强组的放射性食管炎和急性放射性肺炎发生率也有所下降,适形调强放疗治疗非小细胞肺癌效果较好,值得推广。     

脑卒中伴吞咽障碍患者营养支持及护理

吞咽障碍是脑卒中的常见并发症,随着脑卒中发病率逐年升高而日益增多。脑卒中后吞咽障碍发生率在22%～65%,甚至更高[1]。程度轻者出现吞咽不畅感、误咽;重者易发生营养障碍、多脏器功能衰竭,严重影响患者生活质量,增加了致残率及病死率。积极进行营养支持护理,有利于改善患者预后,促进患者早期康复。