蛹虫草水提物体外促进小鼠骨髓诱导的树突状细胞的成熟作用

蛹虫草Cordycepsmilitaris长期用于肿瘤病人,已证明具有免疫调节作用和抗肿瘤活性,但其作用机制尚不清楚,作者研究了蛹虫草水提物(WE)体外促进小鼠骨髓(BM)诱导的树突状细胞(DC)成熟作用。小鼠BM细胞在添加GM-CSF和IL-4各20ng/mL的RPMI培养基中培养7d,在不同浓度的WE中保存24h,     

北京市助产单位2005年剖宫产情况分析

目的:了解北京市剖宫产率升高的原因,寻找有效降低剖宫产率的措施。方法:助产单位自查和北京市妇幼保健院及产科专家抽查。结果:计划剖宫产手术占51%,急诊手术占49%;剖宫产手术有医学指征的占74%,社会因素占26%。结论:计划剖宫产手术较多,其产生原因是多方面的,也是今后要降低剖宫产率的主要努力方向。     

总状升麻能诱导肌损伤

已知总状升麻Cimicifuga racemosa有雌激素样作用,能减轻与绝经相关的某些更年期失调症状,如血管舒张症和精神病等。其副作用较少、轻微和可恢复,严重副作用包括肝损伤和循环状态的改变,但因果关系尚不清楚。作者报告了1例妇女服用总状升麻后,出现严重无力、血中肌酸磷酸激酶(C     

蒙药灰剂简介

蒙药有十大剂型,灰药为其中之一。灰剂是将药物置于瓦罐内,密闭封严、用无烟火加热烧成灰、研成细粉制成散剂或制丸,使内服或外用的一种传统剂型。一、蒙药灰剂的简况灰剂作为蒙药独有的剂型,最早始载于《四部医典》,据今已有一千多年的历史。医典第八章中提出:寒性病症灰剂数第一。可见一千多年前不但创造了灰剂,而且阐述了灰剂的功用。以后在十七世纪编著的《蒙医金匮》医书中记载了有关灰剂的制法及应用。解放后,蒙医蒙药事业得到了发展。近四十年出版的蒙医蒙药专著均有关于灰剂的记载。如:《临床医药鉴》记有盐的灰剂,用于消化不良、痞症及血瘀症等。又如《蒙医成方选》中选入了寒水石灰剂两方。还如《中国医学百科全书》。《蒙医学》较详     

聚氯乙烯尘肺一例报告

有关聚氯乙烯粉尘对肺脏危害程度的报道,各家评价意见不一。1970年由法国报道了确诊的第一倒[1];1978年Arnaud报道了第二例[2]。我所1986年经现场调查和临床检查确诊一例,报道如下: 卫××,男,55岁,上海籍。因咳嗽4年进行     

Propofol and Sevoflurane in Subanesthetic Concentrations Act Preferentially on the Spinal Cord: Evidence from Multimodal Electrophysiological Assessment

Background: Animal experiments in recent years have shown that attenuation of motor responses by general anesthetics is mediated at least partly by spinal mechanisms. Less is known about the relative potency of anesthetic drugs in suppressing cortical and spinal electrophysiological responses in vivo in humans, particularly those, but not only those, connected with motor responses. Therefore, we studied the effects of sevoflurane and propofol in humans using multimodal electrophysiological assessment.

Methods: We studied nine healthy volunteers in two sessions during steady state sedation with 0.5, 1.0, and 1.5 [mu]g/l (targeted plasma concentration) propofol or 0.2 and 0.4 vol% (end-tidal) sevoflurane. Following a 15-min equilibration period, motor responses to transcranial magnetic stimulation and peripheral (H-reflex, F-wave) stimulation were recorded, while electroencephalography and auditory evoked responses were recorded in parallel.

Results: At concentrations corresponding to two thirds of C50 awake, motor responses to transcranial magnetic stimulation were reduced by approximately 50%, H-reflex amplitude was reduced by 22%, F-wave amplitude was reduced by 40%, and F-wave persistence was reduced by 25%. No significant differences between sevoflurane and propofol were found. At this concentration, the Bispectral Index was reduced by 7%, and the middle-latency auditory evoked responses were attenuated only mildly (Nb latency increased by 11%, amplitude PaNb did not change). In contrast, the postauricular reflex was suppressed by 77%.     

澳／中FTA能否增强通用名药

据澳大利亚国立大学的Thomas Faunce说，澳大利亚与中国建立两国自由贸易协定（FTA）的商谈时，应认识到该协定为澳大利亚通用名药工业提供了机会。他还建议FTA中应包括一个医药工作委员会。     

Increasing Maternal Blood Pressure with Ephedrine Increases Uterine Artery Blood Flow Velocity during Uterine Contraction

Background: During labor, ephedrine is widely used to prevent or to treat maternal arterial hypotension and restore uterine perfusion pressure to avoid intrapartum fetal asphyxia. However, the effects of ephedrine on uterine blood flow have not been studied during uterine contractions. The purpose of the study was to assess the effects of ephedrine on uterine artery velocities and resistance index using the Doppler technique during the active phase of labor.

Methods: Ten normotensive, healthy parturients with uncomplicated pregnancies at term received intravenous ephedrine during labor to increase mean arterial pressure up to a maximum of 20% above their baseline pressure. Peak systolic and end-diastolic Doppler flow velocities and resistance indices were measured in the uterine artery before and immediately after administration of bolus intravenous ephedrine and after ephedrine washout. Umbilical and fetal middle cerebral arterial resistance indices and fetal heart rate were also calculated.

Results: After ephedrine administration, mean arterial pressure increased by 17 +/- 4%. End-diastolic flow velocity in the uterine artery at peak amplitude of uterine contraction was restored to 74% of the value observed in the absence of contraction. The systolic velocity was totally restored, and the uterine resistance index was significantly decreased, compared with the values in the absence of contraction. Between uterine contractions, ephedrine induced similar but less marked effects. Fetal hemodynamic parameters were not altered by ephedrine administration.     

Pfizer收购Idun医药公司

世界上最大的制药商Pfizer公司称已就收购Idun医药公司达成协议。后者是一家美国私营企业，致力于发现与开发控制细胞凋亡（一种涉及许多疾病过程的程序性细胞死亡）的药物。     

“不批准”函打击Calmactin

Solvay制药公司的治疗以腹泻为主肠易激综合征的研究性药物Calmactin（cilansetron，西兰司琼）（Ⅰ）在接到美国FDA不批准函后，在美国上市的时间将会考虑推迟。