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排序方式: 共有70条查询结果,搜索用时 15 毫秒
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Jensen Jakob Schmidt Christensen Julie Thor Hkansson Katrin Zamani Martin Vogelius Ivan R. Lfgren Johan Fischer Babara Malene Friborg Jeppe von Buchwald Christian Rasmussen Jacob Hygaard 《European journal of nuclear medicine and molecular imaging》2020,47(5):1039-1045
European Journal of Nuclear Medicine and Molecular Imaging - The purpose of this study was to investigate if FDG uptake metrics in primary tumor and lymph node metastases in patients with... 相似文献
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Friborg O Hjemdal O Rosenvinge JH Martinussen M 《International journal of methods in psychiatric research》2003,12(2):65-76
Resources that protect against the development of psychiatric disturbances are reported to be a significant force behind healthy adjustment to life stresses, rather than the absence of risk factors. In this paper a new scale for measuring the presence of protective resources that promote adult resilience is validated. The preliminary version of the scale consisted of 45 items covering five dimensions: personal competence, social competence, family coherence, social support and personal structure. The Resilience Scale for Adults (RSA), the Sense of Coherence scale (SOC) and the Hopkins Symptom Checklist (HSCL) were given to 59 patients once, and to 276 normal controls twice, separated by four months. The factor structure was replicated. The respective dimensions had Cronbach's alphas of 0.90, 0.83, 0.87, 0.83 and 0.67, and four-month test-retest correlations of 0.79, 0.84, 0.77, 0.69 and 0.74. Construct validity was supported by positive correlations with SOC and negative correlations with HSCL. The RSA differentiated between patients and healthy control subjects. Discriminant validity was indicated by differential positive correlations between RSA subscales and SOC. The RSA-scale might be used as a valid and reliable measurement in health and clinical psychology to assess the presence of protective factors important to regain and maintain mental health. 相似文献
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Hjemdal O Aune T Reinfjell T Stiles TC Friborg O 《Clinical child psychology and psychiatry》2007,12(1):91-104
This correlational study explored the Resilience Scale for Adolescents (READ) as a predictor for developing depressive symptoms controlling for known risk factors. A young adolescent sample (N = 387) completed the READ, the Short Mood and Feeling Questionnaire (SMFQ), Social Phobia Anxiety Index for Children (SPAI-C), and the occurrence of Stressful Life Events (SLE). In addition, a subsample of their parents (N = 240) completed a parental version of READ (READ-P). The results indicated that the READ assesses important protective factors that are associated with fewer depressive symptoms among young adolescents even when controlling for known risk factors. All five READ-factors were predictors of depressive symptoms, while the READ-P showed no predictive value. There were no significant interaction effects between READ and SLE. There were, however, significant main-effects supporting a compensatory model of protective factors. The findings suggest that the READ is a significant predictor of mental health and a useful tool for further research examining differences in stress tolerance among young adolescents. 相似文献
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BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare disease in most populations; however, in areas of Southeast Asia and North Africa and in the Arctic, undifferentiated NPC is the most frequent pharyngeal malignancy. Although smoking and alcohol have been established firmly as synergistic risk factors for other pharyngeal carcinomas, previous studies on the association between these risk factors and NPC have not been consistent. Therefore, the authors analyzed this relation in a cohort of Singapore Chinese, which is a population with a high incidence of NPC. METHODS: From 1993 to 1998, a population-based cohort of 61,320 Singapore Chinese ages 45 years to 74 years who were free of cancer completed a comprehensive interview on living conditions and dietary and lifestyle factors. By linkage to Singapore population-based registries, the cohort was followed through 2005, and cancer occurrence was determined. The relative risk of NPC and other oropharyngeal carcinomas in the cohort was investigated by using a Cox proportional hazards model. RESULTS: In total, 173 NPCs and 75 other oropharyngeal carcinomas were observed during 601,879 person-years of follow-up. Smoking for >40 years was associated with a doubled risk of NPC (relative risk, 2.0; 95% confidence interval, 1.2-3.3), whereas smoking intensity, age at smoking initiation, and alcohol consumption were not associated with NPC risk. In contrast, smoking duration, smoking intensity, age at smoking initiation, and alcohol consumption all were associated with an increased risk of other oropharyngeal carcinoma (P for trend, <.0001). CONCLUSIONS: Smoking and alcohol influenced the risk of NPC and other oropharyngeal carcinomas differently in a high-incidence NPC population. Long-term smoking was a risk factor for NPC, but alcohol consumption was not. 相似文献
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Friborg J Jarrett RF Liu MY Falk KI Koch A Olsen OR Duncan P Wohlfarht J Chen JY Melbye M 《Journal of medical virology》2007,79(12):1877-1881
Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N = 20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P < 0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits. 相似文献
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Rik A. de Groen Arjan Boltjes Jun Hou Bi‐Sheng Liu Fiona McPhee Jacques Friborg Harry L. A. Janssen André Boonstra 《European journal of immunology》2015,45(1):250-259
With increasing interest in alternative options to interferon‐alpha‐based treatments, IFN‐λ has shown therapeutic promise in a variety of diseases. Although the antiviral activity of IFN‐λ has been extensively studied, there is limited knowledge regarding the immunological functions of IFN‐λ and how these differ from those of other classes of IFNs. In this study, we investigated the effects of IFN‐λ on primary human NK cells, both in a direct and indirect capacity. We demonstrate that in contrast to interferon‐alpha, IFN‐λ is unable to directly stimulate NK cells, due to the absence of IFN‐λ receptor chain 1 (IFN‐λR1) on NK cells. However, IFN‐λ, in combination with TLR4 challenge, is able to induce the production of select members of the IL‐12 family of cytokines in monocyte‐derived macrophages. We further show that through macrophage‐mediated IL‐12 production, IFN‐λ is able to indirectly affect NK cells and ultimately induce IFN‐γ production. 相似文献
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Jeppe Friborg Marianne Hamilton-Therkildsen Preben Homoe Claus Kristensen Angela Hui Fei-Fei Liu Ilan Weinreb 《Head and neck pathology》2012,6(4):445-450
Nasopharyngeal carcinomas of the undifferentiated or lymphoepithelial type are most commonly seen in South East Asians. Identical tumors have also been described at a variety of other sites including lung, skin and salivary gland and have been referred to by a number of names including lymphoepithelial carcinoma (LEC). LECs of major salivary gland are extremely rare. They are particularly common amongst the Inuit populations of the arctic region including Greenland (Denmark), Canada and Alaska, as well as South East Asians. Within the Inuit group, this tumor represents the majority of all salivary gland carcinomas. Amongst primary LEC of major salivary gland, most cases reported in the literature have represented typical nasopharynx-like tumors. Variants of Epstein–Barr Virus (EBV) associated LEC have not been described previously, to the best of our knowledge. In this report, we describe 4 EBV-associated major salivary gland LECs with prominent basaloid morphology, which represent 22 % of a cohort of 18 salivary LECs from an Inuit population in Greenland. The features described in these cases raise a differential diagnosis of other basaloid tumors, particularly in light of the salivary gland location. A basaloid variant of LEC in major salivary gland should be recognized, especially in highly prone populations, to avoid misdiagnosis of other more common salivary tumors. 相似文献
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Nine different serum proteins from 50 patients suffering from ulcerative colitis were quantitated by means of Laurell's rocket-electrophoresis. The periods of study extended for up to five years. Twenty-six patients were seen at brief intervals from days up to two months; 18 patients were seen at intervals from two to six months. As surgical intervention was urgently required in six cases, few determinations were made in these patients. The disease was classified into five phases according to its clinical activity (as assessed by temperature, blood via the rectum, and number of episodes of diarrhoea). The phases are designated: active febrile; active afebrile; unstable; remission; and restitution. The concentrations of orosomucoid and haptoglobin were found to rise in parallel with intensified clinical activity, while the concentration of pre-albumin falls, thus making these proteins particularly useful for determining changes in the clinical status of the patients. The concentration of pre-albumin during the active phase was especially useful in cases where it was to be decided whether or not surgery was indicated. Concentrations of orosomucoid and IgG were not as useful as pre-albumin in these cases. In patients who escaped operation, the concentration of pre-albumin was seen to rise from low values up to normal before clinical improvement set in. 相似文献