全文获取类型
收费全文 | 34420篇 |
免费 | 3227篇 |
国内免费 | 2528篇 |
专业分类
耳鼻咽喉 | 391篇 |
儿科学 | 409篇 |
妇产科学 | 381篇 |
基础医学 | 4094篇 |
口腔科学 | 643篇 |
临床医学 | 4687篇 |
内科学 | 4794篇 |
皮肤病学 | 378篇 |
神经病学 | 1964篇 |
特种医学 | 1280篇 |
外国民族医学 | 24篇 |
外科学 | 3172篇 |
综合类 | 6592篇 |
现状与发展 | 11篇 |
预防医学 | 2096篇 |
眼科学 | 1100篇 |
药学 | 3558篇 |
30篇 | |
中国医学 | 1934篇 |
肿瘤学 | 2637篇 |
出版年
2024年 | 82篇 |
2023年 | 623篇 |
2022年 | 943篇 |
2021年 | 1806篇 |
2020年 | 1465篇 |
2019年 | 1244篇 |
2018年 | 1270篇 |
2017年 | 1233篇 |
2016年 | 1049篇 |
2015年 | 1626篇 |
2014年 | 2008篇 |
2013年 | 1725篇 |
2012年 | 2697篇 |
2011年 | 2804篇 |
2010年 | 1672篇 |
2009年 | 1339篇 |
2008年 | 1622篇 |
2007年 | 1691篇 |
2006年 | 1717篇 |
2005年 | 1717篇 |
2004年 | 1083篇 |
2003年 | 1031篇 |
2002年 | 899篇 |
2001年 | 800篇 |
2000年 | 828篇 |
1999年 | 950篇 |
1998年 | 603篇 |
1997年 | 667篇 |
1996年 | 502篇 |
1995年 | 421篇 |
1994年 | 359篇 |
1993年 | 207篇 |
1992年 | 271篇 |
1991年 | 240篇 |
1990年 | 202篇 |
1989年 | 179篇 |
1988年 | 168篇 |
1987年 | 129篇 |
1986年 | 100篇 |
1985年 | 77篇 |
1984年 | 34篇 |
1983年 | 20篇 |
1982年 | 27篇 |
1981年 | 15篇 |
1980年 | 8篇 |
1979年 | 9篇 |
1965年 | 2篇 |
1940年 | 3篇 |
1935年 | 2篇 |
1934年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
71.
原发性乳腺恶性淋巴瘤的诊断及外科治疗探讨 总被引:2,自引:0,他引:2
目的探讨原发性乳腺恶性淋巴瘤的诊断与治疗. 方法回顾性分析我院1992~2004年5例原发性乳腺恶性淋巴瘤的临床资料.5例均为术后组织学病理诊断.4例行乳腺癌改良根治术,1例行乳房单纯切除术.5例均行化疗及放疗. 结果乳腺癌改良根治术手术时间60~120 min,平均80 min;乳房单纯切除术加乳腔镜腋窝淋巴结清扫术手术时间75 min.术中出血量150~250 ml,平均200 ml.术后病理组织诊断均为弥漫性非霍奇金氏淋巴瘤,为B细胞来源.且均有腋窝淋巴结转移.全组病例随访6个月~12年,平均4.5年.2例II期,均死于肿瘤多器官转移;3例I期,肿瘤无复发. 结论原发性乳腺恶性淋巴瘤无明显特异性表现,术前诊断困难.钼靶X线照相,对诊断有帮助. 治疗可选择手术、放疗、化疗或单纯给予化疗和放疗. 相似文献
72.
73.
Xingguang Luo Henry R Kranzler Lingjun Zuo Shuang Wang Joel Gelernter 《Neuropsychopharmacology》2007,61(5):599-608
BACKGROUND: Personality traits are associated with substance dependence (SD); genetic factors may influence both. Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study. METHODS: We assessed dimensions of the five-factor model of personality in 243 subjects with SD (175 European Americans [EAs] and 68 African Americans [AAs]) and 296 healthy control subjects (256 EAs and 40 AAs). We also genotyped 7 ADH4 markers (spanning the locus) and 38 unlinked ancestry-informative markers in these subjects. The relationships between the diplotypes, alleles, and genotypes at ADH4 and personality traits were examined using multivariate analysis of covariance (MANCOVA), controlling for potential confounders. RESULTS: Generally, SD patients, older individuals, and male subjects scored higher on neuroticism and lower on other personality factors. Personality factors were associated with the diplotypes. The allele A or genotype A/A of single nucleotide polymorphism (SNP)6 (rs1800759 at the gene promoter) was significantly associated with agreeableness scores. There were associations between extraversion and SNP1 (hcv2033010 at the 3' end) and SNP2 (rs1042364 in exon 9) in subjects with higher conscientiousness scores. CONCLUSIONS: The personality traits of agreeableness and extraversion are related to ADH4 polymorphism. Among the ADH4 markers that appear to predispose to certain personality traits, the functional variant rs1800759 (SNP6) in the promoter region is most important. We conclude that personality traits and SD have a partially overlapping genetic basis. 相似文献
74.
Guo-Lin Wei Juri Melnik Jing-Li Luo Alan R. Sanger Karl T. Chuang 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2005,575(2):183-193
The performances of three widely different cathode materials (Pt, strontium-doped lanthanum manganite (LSM), and NiO) have been compared for use with proton conducting Li2SO4–Al2O3 composite electrolyte, using H2S–air and H2–air fuel cells operating at 600 °C. Surface analysis and electrochemical techniques were used to characterize fresh and used electrode materials. Pt or LSM cathodes each became covered with Li2SO4 and Al2O3 and, as a consequence, the fuel cells showed poor performance. In contrast, the NiO cathode catalyst did not become covered with Li2SO4 and good fuel cell performance was achieved. Exceptionally good current densities of over 100 mA/cm2 and power densities of over 30 mW/cm2 were obtained for H2S–air fuel cells having Mo–Ni–S anode catalysts. Slight agglomeration of NiO particles during fuel cell operation had only a minor effect on performance. 相似文献
75.
目的 腭裂手术创口是一类不易愈合的创口,为促进腭裂术后创口愈合速度与质量,减少术后复裂率,在腭裂动物模型上对脱已酰壳聚糖的作用进行药效学研究。方法 选20只Wistar大鼠随机分4组,以两种不同术式的实验组与相应的对照组进行实验。术后1、3、5、7、10天分别进行,)盏床观察和组织病理学观察。结果 实验组1,术后1天创面有缺血,3和5天粘膜颜色基本正常,7和10天拆线后的创口均为一期愈合。对照组1,术后1天创面有缺血,3和5天创缘糜烂,7天减轻,10天拆线创口二期愈合。实验组2与其对照组均有显著差异。组织病理,实验组1和组2重建覆盖上皮较对照组出现的早,实验组2缺损断端有新形成的骨组织连接,新骨周边可见成骨细胞,对照组1,有成纤维连接和炎细胞浸润。对照组2,缺损断处有新形成的软骨细胞,有炎细胞浸润。结论 脱已酰壳聚糖对腭裂术后的愈合有较明显的作用,有深入研究和临床应用的价值。 相似文献
76.
Activity of succinic dehydrogenase(SDH)and acid phosphatase(AcPase)of effector-target cells during the process of LAK cells killing HR8348 cells was estimated by enzyme cyto-chemistry technique.SHD positive granules and AePase gray level were assayed with MIAS-300image analyser.The results showed:(1)After cocultivation of effector and target cells for vari-ous times,the activity of AcPase of HR8348 cells was apparently higher than that of the controlgroup,and it increased following prolonged coincubation.SDH activity of target cells increasedmarkedly within 30 and 60 rain cocultivation,but became low after 90 min treatment.(2)Ac-Pase content within LAK cells at 60,90,120,180 and 240 rain cocultivation was significantlyhigher than that of control group(P<0.01).The phenomenon of high AcPase and SDH activitywithin effector-target cells indicates that the function of the two types of cells was in an activestate.At the early stage of effector-target combining,the increase of SDH with HR8348 cellsmay be related to defensive function of the target cells.Higher AcPase activity of target cells in-dicates the activation of lysosomal enzyme which serves as the material basis for autolysis of thecells. 相似文献
77.
反相高效液相色谱法测定洛氟沙星的血药浓度 总被引:7,自引:1,他引:6
采用反相HPLC法测定洛氟沙星的血药浓度,血浆样品用二氯甲烷在pH7.0条件下提取后进样,流动相为10m mol/L磷酸二氢钾-10m mol/L溴化四丁铵-乙腈-三乙胺(45:44:10:1,磷酸调节pH2.8),紫外检测器λ=295nm,最低检测浓度10μg/L,线性范围:0.1 ̄6.0mg/L,r=0.9999,日内RSD为1.38% ̄3.42%,日间RSD为1.11% ̄2.89%。 相似文献
78.
法半夏罗汉果川贝枇杷膏与强力枇杷露药理作用的比较研究 总被引:3,自引:0,他引:3
法半夏罗汉果川贝枇把膏与强力批他露均有镇咳祛痰作用,罗汉果川贝枇把膏尚能平喘抗炎。 相似文献
79.
Clinical observations on 278 cases of cervical spondylopathy treated with electroacupuncture and massotherapy. 总被引:1,自引:0,他引:1
From Dec. 1990 to Dec. 1993, 278 cases of cervical spondylopathy were treated with electroacupuncture and massotherapy. The cure rate was 82.7%; but in the control group, it was only 61%, indicating that electroacupuncture may enhance the cure rate (P < 0.05). Of the 278 cases treated by three to five sessions, the pain and numbness disappeared in about 96% of the patients. 相似文献
80.
Dr W. Q. Ge Z. C. Luo J. Jin Y. C. Huang S. Wang S. J. Lui 《Medical & biological engineering & computing》1998,36(1):22-26
A novel cardiokymograph system is introduced. The new system features a capacitance transducer with increased sensitivity
and can be used in multichannel measurements. The novelty of this technique is the injection of a current into the patient
coupled with the use of a capacitive displacement transducer and the possibility of multichannel monitoring. It provides for
the possibility of removing breath noise when some signal processing technique, such as adaptive filtering, is used. Further
investigation is needed to demonstrate clinical significance and pathologies. 相似文献