全文获取类型
收费全文 | 493篇 |
免费 | 26篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 30篇 |
妇产科学 | 5篇 |
基础医学 | 56篇 |
口腔科学 | 4篇 |
临床医学 | 64篇 |
内科学 | 77篇 |
皮肤病学 | 11篇 |
神经病学 | 133篇 |
特种医学 | 61篇 |
外科学 | 34篇 |
综合类 | 17篇 |
预防医学 | 12篇 |
眼科学 | 6篇 |
药学 | 15篇 |
肿瘤学 | 11篇 |
出版年
2022年 | 2篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 9篇 |
2016年 | 11篇 |
2015年 | 11篇 |
2014年 | 9篇 |
2013年 | 23篇 |
2012年 | 28篇 |
2011年 | 11篇 |
2010年 | 20篇 |
2009年 | 32篇 |
2008年 | 18篇 |
2007年 | 32篇 |
2006年 | 18篇 |
2005年 | 13篇 |
2004年 | 9篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 18篇 |
2000年 | 10篇 |
1999年 | 14篇 |
1998年 | 12篇 |
1997年 | 15篇 |
1996年 | 20篇 |
1995年 | 8篇 |
1994年 | 18篇 |
1993年 | 12篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 13篇 |
1988年 | 5篇 |
1987年 | 10篇 |
1986年 | 14篇 |
1985年 | 10篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1977年 | 6篇 |
1975年 | 3篇 |
1942年 | 2篇 |
1933年 | 3篇 |
1932年 | 2篇 |
1929年 | 2篇 |
1927年 | 1篇 |
排序方式: 共有537条查询结果,搜索用时 187 毫秒
81.
82.
Kasten M Kertelge L Tadic V Brüggemann N Schmidt A van der Vegt J Siebner H Buhmann C Lencer R Kumar KR Lohmann K Hagenah J Klein C 《Movement disorders : official journal of the Movement Disorder Society》2012,27(6):754-759
Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P < 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized. 相似文献
83.
Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities 下载免费PDF全文
84.
85.
86.
N. Jung B. Gleich N. Gattinger C. Höss C. Haug H. Siebner V. Mall 《Clinical neurophysiology》2017,128(10):e308-e309
87.
Eruptive syringoma is a very rare variant of syringoma. It is a benign adnexal tumor of the intraepidermal portion of eccrine sweat ducts. Here we report a 32-year-old female presented with classical asymptomatic eruptive syringomas involving her face and extremities. 相似文献
88.
89.
S. KlÖHR R. ROTH T. HOFMANN R. ROSSAINT M. HEESEN 《Acta anaesthesiologica Scandinavica》2010,54(8):909-921
Background: Spinal anaesthesia for caesarean section may cause hypotension, jeopardizing the foetus and its mother. We aimed to identify the spectrum of definitions of hypotension used in the scientific literature. In a second part, we applied these definitions to a prospective cohort in order to evaluate the effect of different definitions on the incidence of hypotension. Methods: A systematic literature search in PubMed was performed from 1999 to 2009 with the search terms ‘hypotension’ and ‘caesarean section’. Consecutive parturients undergoing caesarean section under spinal anaesthesia were included in a prospective study. Results: Sixty‐three eligible publications (7120 patients) were retrieved, revealing 15 different definitions of hypotension. A decrease below 80% baseline and the combined definition of a blood pressure below 100 mmHg or a decrease below 80% baseline were the two most frequent definitions, found in 25.4% and 20.6% of the papers, respectively. When applying the spectrum of definitions to a prospective cohort, the incidences of hypotension varied between 7.4% and 74.1%. The incidence increased from 26.7% to 38.5% when using a value below 75% of baseline instead of below 70% of baseline. Conclusion: There is not one accepted definition of hypotension in the scientific literature. The incidence of hypotension varies depending on the chosen definition. Even minor changes of the definition cause major differences in the frequency of hypotension. This makes it difficult to compare studies on interventions to treat/prevent hypotension and probably hampers progress in this area of research. 相似文献
90.
The role of high‐field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward 下载免费PDF全文
Stéphane Lehericy MD PhD David E. Vaillancourt PhD Klaus Seppi MD Oury Monchi PhD Irena Rektorova MD PhD Angelo Antonini MD PhD Martin J. McKeown MD Mario Masellis MD PhD Daniela Berg MD James B. Rowe MD PhD Simon J. G. Lewis MD Caroline H. Williams‐Gray MRCP PhD Alessandro Tessitore MD PhD Hartwig R. Siebner MD 《Movement disorders》2017,32(4):510-525
Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several complementary markers that are useful for research and clinical applications. Iron‐ and neuromelanin‐sensitive MRI detect qualitative changes in the substantia nigra. Quantitative MRI markers can be derived from diffusion weighted and iron‐sensitive imaging or volumetry. Functional brain alterations at rest or during task performance have been captured with functional and arterial spin labeling perfusion MRI. These markers are useful for the diagnosis of PD and atypical parkinsonism, to track disease progression from the premotor stages of these diseases and to better understand the neurobiological basis of clinical deficits. A current research goal using MRI is to generate time‐dependent models of the evolution of PD biomarkers that can help understand neurodegeneration and provide reliable markers for therapeutic trials. This article reviews recent advances in MRI biomarker research at high‐field (3T) and ultra high field‐imaging (7T) in PD and atypical parkinsonism. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. 相似文献