全文获取类型
收费全文 | 1009篇 |
免费 | 84篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 49篇 |
妇产科学 | 32篇 |
基础医学 | 125篇 |
口腔科学 | 42篇 |
临床医学 | 117篇 |
内科学 | 179篇 |
皮肤病学 | 23篇 |
神经病学 | 48篇 |
特种医学 | 28篇 |
外科学 | 86篇 |
综合类 | 22篇 |
预防医学 | 61篇 |
眼科学 | 69篇 |
药学 | 116篇 |
中国医学 | 9篇 |
肿瘤学 | 84篇 |
出版年
2024年 | 6篇 |
2023年 | 25篇 |
2022年 | 74篇 |
2021年 | 109篇 |
2020年 | 43篇 |
2019年 | 68篇 |
2018年 | 67篇 |
2017年 | 64篇 |
2016年 | 67篇 |
2015年 | 67篇 |
2014年 | 92篇 |
2013年 | 75篇 |
2012年 | 93篇 |
2011年 | 74篇 |
2010年 | 42篇 |
2009年 | 21篇 |
2008年 | 29篇 |
2007年 | 26篇 |
2006年 | 17篇 |
2005年 | 15篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
排序方式: 共有1098条查询结果,搜索用时 0 毫秒
1.
Priyanka Sharma Guojun Wu Deeptha Kumaraswamy Natalie Burchat Hong Ye Yongjia Gong Liping Zhao Yan Y. Lam Harini Sampath 《Nutrients》2021,13(2)
7,8-Dihydroxyflavone (DHF) is a naturally occurring flavonoid that has been reported to protect against a variety of pathologies. Chronic administration of DHF prevents high-fat diet (HFD)-induced obesity in female, but not male, mice. However, the mechanisms underlying this sexual dimorphism have not been elucidated. We have discovered that oral DHF supplementation significantly attenuates fat mass, hepatic lipid accumulation, and adipose tissue inflammation in female mice. In contrast, male mice were not protected from adiposity, and had a paradoxical worsening of hepatic lipid accumulation and adipose tissue inflammation upon DHF supplementation. Consistent with these sexually dimorphic effects on body weight and metabolic health, 7,8-DHF induced early and stable remodeling of the female intestinal microbiome. DHF supplementation significantly increased gut microbial diversity, and suppressed potentially detrimental bacteria, particularly Desulfovibrionaceae, which are pro-inflammatory and positively associated with obesity and inflammation. Changes in the female gut microbiome preceded alterations in body weights, and in silico analyses indicated that these early microbial changes were highly predictive of subsequent weight gain in female mice. While some alterations in the intestinal microbiome were also observed in male DHF-supplemented mice, these changes were distinct from those in females and, importantly, were not predictive of subsequent body weight changes in male animals. The temporality of microbial changes preceding alterations in body weight in female mice suggests a role for the gut microbiome in mediating the sexually dimorphic effects of DHF on body weight. Given the significant clinical interest in this flavonoid across a wide range of pathologies, further elucidation of these sexually dimorphic effects will aid the development of effective clinical therapies. 相似文献
2.
3.
Ibadur Rahman Priyanka Singh Nirendra Dev Mohammed Arif Faiz Noor Khan Yusufi Ameer Azam M. Masroor Alam Sandeep Singh Jasgurpreet Singh Chohan Raman Kumar Lovneesh Sharma Elsayed Tag-Eldin Shubham Sharma Muhammad Rizal Muhammad Asyraf 《Materials》2022,15(22)
The findings of an extensive experimental research study on the usage of nano-sized cement powder and other additives combined to form cement–fine-aggregate matrices are discussed in this work. In the laboratory, dry and wet methods were used to create nano-sized cements. The influence of these nano-sized cements, nano-silica fumes, and nano-fly ash in different proportions was studied to the evaluate the engineering properties of the cement–fine-aggregate matrices concerning normal-sized, commercially available cement. The composites produced with modified cement–fine-aggregate matrices were subjected to microscopic-scale analyses using a petrographic microscope, a Scanning Electron Microscope (SEM), and a Transmission Electron Microscope (TEM). These studies unravelled the placement and behaviour of additives in controlling the engineering properties of the mix. The test results indicated that nano-cement and nano-sized particles improved the engineering properties of the hardened cement matrix. The wet-ground nano-cement showed the best result, 40 MPa 28th-day compressive strength, without mixing any additive compared with ordinary and dry-ground cements. The mix containing 50:50 normal and wet-ground cement exhibited 37.20 MPa 28th-day compressive strength. All other mixes with nano-sized dry cement, silica fume, and fly ash with different permutations and combinations gave better results than the normal-cement–fine-aggregate mix. The petrographic studies and the Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) analyses further validated the above findings. Statistical analyses and techniques such as correlation and stepwise multiple regression analysis were conducted to compose a predictive equation to calculate the 28th-day compressive strength. In addition to these methods, a repeated measures Analysis of Variance (ANOVA) was also implemented to analyse the statistically significant differences among three differently timed strength readings. 相似文献
4.
5.
Mrigesh Bhatia Priyanka Dixit Manish Kumar Laxmi Kant Dwivedi 《Journal of clinical hypertension (Greenwich, Conn.)》2022,24(11):1506
Self‐reported measures of health, in the context of developed countries, are well‐researched and commonly regarded as reliable predictors of the underlying health of the population. However, the validity of these measures is under‐researched and questionable in the context of low‐ and middle‐income countries. The authors used Longitudinal Ageing Study in India (LASI) survey data from India to compare self‐reported hypertension with biometrically‐measured hypertension. The results are reported in terms of sensitivity, specificity, and kappa as a measure of agreement. Logistic regression was undertaken to examine the characteristics of those who were unaware of their hypertensive status. Our analysis showed a low sensitivity of 56% and a high specificity of 90.5%. Agreement between self‐reported data and biometric measurement of hypertension was observed to be moderate (κ = 0.48). Large variations were observed among states and sub‐groups. The odds of false negative reporting of hypertension were lower in the individuals with higher age, high education, and greater wealth status. The authors conclude that self‐reported hypertension has important limitations and may be a source of systematic bias. It is recommended that planning and policy‐making in India be based more on an objective assessment of hypertension. 相似文献
6.
7.
8.
Shashi Bhushan Kumar Shanvanth R. Arnipalli Priyanka Mehta Silvia Carrau Ouliana Ziouzenkova 《Nutrients》2022,14(14)
Iron deficiency anemia (IDA) has reached epidemic proportions in developing countries and has become a major global public health problem, affecting mainly 0–5-year-old children and young women of childbearing age, especially during pregnancy. Iron deficiency can lead to life-threatening loss of red blood cells, muscle function, and energy production. Therefore, the pathogenic features associated with IDA are weakness and impaired growth, motor, and cognitive performance. IDA affects the well-being of the young generation and the economic advancement of developing countries, such as India. The imbalance between iron intake/absorption/storage and iron utilization/loss culminates into IDA. However, numerous strategic programs aimed to increase iron intake have shown that improvement of iron intake alone has not been sufficient to mitigate IDA. Emerging critical risk factors for IDA include a composition of cultural diets, infections, genetics, inflammatory conditions, metabolic diseases, dysbiosis, and socioeconomic parameters. In this review, we discuss numerous IDA mitigation programs in India and their limitations. The new multifactorial mechanism of IDA pathogenesis opens perspectives for the improvement of mitigation programs and relief of IDA in India and worldwide. 相似文献
9.
10.