补骨胶囊薄层色谱鉴别法研究

采用薄层色谱法对补骨胶囊中的人参、黄芪、血竭进行了定性鉴别。方法简便,具重现性和专属性,且无阴性干扰,对样品的质量控制有重要意义。     

Participatory design in the development of the wheelchair convoy system

Background  

In long-term care environments, residents who have severe mobility deficits are typically transported by having another person push the individual in a manual wheelchair. This practice is inefficient and encourages staff to hurry to complete the process, thereby setting the stage for unsafe practices. Furthermore, the time involved in assembling multiple individuals with disabilities often deters their participation in group activities.     

肝移植术后严重精神神经并发症2例分析

1临床资料 1997-06／2004—10共连续施行肝移植52例,发生神经精神并发症12例,其中严重2例,均为男性,年龄为56岁和38岁,原发病均为乙型肝硬化,均经背驮式肝移植．术前6h服用3mgFKS06,术后拔管后给予FK506口服,0．07mg／kg,同时常规应用强的松及骁悉口服,应用ELISA法动态监测患者全血FK506浓度,使其保持在10～12μg／L．分别在术后2d和4d出现神经精神并发症,并逐渐加重,开始以谵妄样精神障碍为主要症状,发展为癫痫发作和深昏迷,随时间的延长,出现排痰不畅、高热、大量胸水等症状．     

四肢深部血管畸形介入治疗21例

1临床资料四肢深部血管畸形21(男12,女9)例,年龄11~54岁.患肢及病灶部位疼痛14例;病变皮肤颜色正常18例,灰紫色3例;全部病例局部可扪及软组织肿块,肿块大小为3cm×5cm至15cm×25cm不等,其中直径≤10cm7例,>10cm14例.病变位于上臂和肩部5例,大腿14例和小腿2例.2例有外科手术史.11例经MRI,10例经多普勒超声检查提示肢体血管畸形.全部病例介入治疗前行DSA血管造影进一步确诊,伴有动静脉瘘4例.4例栓塞治疗后3~10mo病灶缩小后行外科手术切除,组织送病理检查.血管栓塞材料为聚乙烯醇(PVA),颗粒直径500~710μm;明胶海绵条或顆粒(大小分别为1mm…     

Arm circumference in adults in Poland as an important factor influencing the accuracy of blood pressure readings

AIMS: The aim of this study was to assess the distribution of right arm circumference (RAC) in adults in Poland and to establish how often other than standard cuffs should be used in everyday practice. We also wanted to examine whether large cuffs are available in the market in Poland and whether the cuffs comply with WHO and JNC VII recommendations. MATERIAL AND METHODS: In 2002, we conducted a cross-sectional representative survey NATPOL PLUS to examine prevalence and control of cardiovascular risk factors in Poland. The survey included a questionnaire interview, blood pressure (BP) and anthropometric measurements, as well as laboratory tests. The examined representative sample of adults in Poland consisted of 3051 men and women aged 18-94 years. The measurements of RAC were performed in all respondents. Arterial hypertension (AH) diagnosis was based on three separate visits (BP > or =140/90 mmHg or treatment). Subjects with body mass index (BMI) > or =25 kg/m were included to overweight/obese group. RESULTS: The prevalence of AH was 29% and of overweight or obesity, 52%. In 24% of all adults RAC was > or = 32 cm, and in 6% was < 24 cm. In hypertensives, the respective figures were 36 and 3%; and in overweight/obese subjects 40 and 0.6%. Mean RAC was 29.2+/-3.8 cm (males 30.2+/-3.5 cm; females 28.3+/-3.9 cm, P<0.001). Mean RAC was significantly greater (P<0.01) in patients with AH (30.4+/-3.9 cm; males 30.7+/-3.5 cm; females 30.2+/-3.8 cm) than in normotensive subjects (28.4+/-3.7 cm; males 29.9+/-3.4 cm; females 27.3+/-3.5 cm). However, these differences were not statistically significant when the results were adjusted for age and BMI. Additional analysis of sphygmomanometers available in Poland showed that parameters of standard cuffs fulfilled recommendations of JNC VII and WHO/ISH guidelines. However, the sets with large cuffs were usually much more expensive and only one manufacturer made them available as a special order. CONCLUSIONS: One-third of adults in Poland have an arm circumference, which requires use of a 'non-standard' sized cuff. Moreover, in patients with AH or overweight/obese subjects, wider or narrower cuffs should be used in approximately 40% of subjects.     

Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?

Contemporary mechanistic models of several psychiatric disorders propose abnormalities in the structure and function of distinct neural networks. The cerebellum has both anatomic and functional connections to the prefrontal cortex, the subcortical limbic structures and monoamine-producing brainstem nuclei. Conspicuously, however, the cerebellum has been underemphasized in neuropsychiatric research. A growing confluence of scientific data indicate that the cerebellum may not be irrelevant, which suggests that an integrated model of neuropsychiatric disorders should include a role for the cerebellum and its relevant neural connections. This review summarizes the published data describing and characterizing the putative role of the cerebellum in normal and abnormal mood regulation, with specific attention to states of psychosis, depression and mania. The available evidence suggests that a functional role for the cerebellum should be considered in future neuropsychiatric studies.     

Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines

While the cellular sources for granulocyte-macrophage colony- stimulating factor (GM-CSF) are known to be widely distributed among several cell types, interleukin-3 (IL-3) gene expression has been demonstrated in only certain T-cell clones and in blood mononuclear cells stimulated with phytohemagglutinin (PHA) and phorbol-myristate- acetate (PMA). To determine which blood cells were responsible for this expression, we fractionated PHA/PMA-stimulated mononuclear cells and identified T lymphocytes as the source of IL-3 mRNA. Low-level IL-3 expression was detected as well in several stimulated human T-cell lines. Hematopoietic stromal cells such as fibroblasts and endothelial cells could not be induced to express IL-3 mRNA. The kinetics of IL-3 mRNA induction in mononuclear cells and lymphocytes stimulated with PHA/PMA or anti-CD3 monoclonal antibody (MoAb) and interleukin-1 (IL-1) were similar to those observed for GM-CSF expression.     

青蒿琥酯在奶牛体内的药代动力学与代谢

青蒿琥酯(artesunate,AS)是抗疟新药青蒿素的一个活性衍生物。近年来我国兽医工作者将其用于治疗牛羊泰勒氏焦虫病及双芽、巴贝斯焦虫病、鸡球虫病和耕牛血吸虫病,也收到了满意的效果。AS在大白鼠、兔、狗及人体内的药代动力学研究已见报道。本