止痒舒肤酊在皮肤病中的临床应用

止痒舒肤酊是笔者自制的一种中药酊剂，在皮肤病中应用取得了较满意的疗效，现报道如下     

血管性痴呆诊断与治疗

血管性痴呆(VD)是指因脑血管疾病所致的智能及认知功能障碍的临床综合征,是老年性痴呆最常见的类型之一,是仅次于阿尔茨海默病(AD)造成老年性痴呆的第2位原因.VD是由血管因素和脑血管病相关因素共同作用的结果[1],它与脑血管病的发生密切相关,脑血管病患者中痴呆发生率是26%,是无脑血管病者的5.8倍.VD预后相对较好,治疗途径广泛,且在一定程度上可以进行预防.     

以气胸为首发表现的原发性支气管癌X线漏诊分析

随着CT、MRI等影像技术的发展，以及支气管镜检查的普及，原发性支气管癌(肺癌)的诊断多不难。胸部X线平片作为方便的检查方法，对肺癌的诊断仍有不可忽视的作用。但因X线分辨率较低，特别当心影、肋骨、膈肌重叠时，X线检查易出现失误。我院1990～2001年收治的肺癌合并气胸的患者中，有3例首次胸部X线片仅诊断为气胸，遗漏了肺野内异常病变征象。现报告如下。     

加速多巴酚丁胺负荷超声心动图诊断冠心病的临床观察

目的 探讨加速多巴酚丁胺负荷超声心动图(ADSE)对于冠心病的诊断价值及其安全性.方法 对144例已诊断为冠心病或疑似心绞痛的患者随机分组并分别进行ADSE(观察组86例)及传统多巴酚丁胺负荷超声心动图(DSE)检查(对照组58例),动态观察其阳性指标终止率、有效负荷剂量、终止时间及主要不良反应等相关指标.结果 观察组患者总体阳性指标终止率达到93.0%,多巴酚丁胺灌注剂量为(298.56±102.13)μg/kg,灌注时间为(6.2±2.7)min,均显著优于对照组的相关指标[分别为81.0%、(359.46±85.70)μg /kg、(8.1 4-2.4)min].且两组出现的不良反应比较差异无统计学意义.结论 ADSE对于诊断冠心病具有重要的临床实用价值,并具有不良反应少、易处置等优点.     

Pathogenesis of congenital pyrimidine 5′ -nucleotidase | deficiency: A study on relationship among erythrocyte morphology, enzyme protein content and activity

Objective: To further explore the mechanism of congenital pyrimidine 5'-nucleotidase I deficiency. Methods; The samples were collected from the family members of a patient with P5'N- I deficiency. The enzyme activities were measured by UMP method and the enzyme proteins were quantified by ELISA while the morphology of peripheral blood cells was observed. Results: The enzyme contents reduced as their enzyme activities decreased in the family especially in four members. There was a significant positive correlation(r =0. 955) between the activity and the content of P 5'N- I . The count of the stippling cell was varied in the family. Conclusion.- One of the reasons for congenital P5' N- I deficiency might be the deficiency in the enzyme content. The morphology of peripheral blood erythrocyte may be an assistant diagnotic index. The P5'N- I activities and contents were measured simultaneously may be a effective method in clinic diagnosis.     

甲氰咪胍在儿科的临床应用

近年来甲氰咪胍被广泛应用于儿科临床，现总结报道如下。     

Therapeutic effect of 5-FC on YCD modified murine P388 leukemia in vivo

Cytosine deaminases (CDs) in bacteria andfungi are found to deaminate prodrug 5 - FC intocytotoxic agent 5 - FU .Yeast CD (YCD) is clonedfrom Saccharomyces cerevisiae.It has been shownpreviously that YCD was more efficient inconversing5 - FC than bacterial CD(b CD) [1-3 ] .As anovel suicide gene therapy system,YCD/ 5 - Fcsystem may be promising in cancer therapy andprevention of graft versus host disease.In thepresent study,we established a P388/ DBA murineleukemia model by infusin…     

上海市长宁区社区居民健康行为咨询点状况评估

目的了解社区居民健康行为咨询点现况,以进一步规范咨询点工作,为居民提供一流健康服务。方法采用资料法、现场观察法及问卷调查方法,对全区所有咨询点的硬件、软件配备情况、工作开展情况和规范程度以及咨询点服务对象对咨询点知晓情况、满意度进行综合评估。结果60.5%的咨询点工作完全达标;99.2%的居民知晓服务信息;97.8%的居民接受过咨询服务,居民对咨询点服务满意率达97.2%;分别有25.7%的咨询员、50.4%的居委干部、23.2%的居民提出增加服务时间、内容,改善服务条件等建议。结论调查对象对健康行为咨询点服务满意度逐年上升,但咨询点的整体服务水平还有待提高,特别在服务时间、服务内容以及服务条件等方面,还有待完善。     

壶腹部腺癌伴胃小弯原位癌一例

患者男,52岁。因进行性黄疸,餐后上腹饱胀2个月而入院。检查:消瘦,全身皮肤及巩膜重度黄染,右额一蜘蛛痣,面部毛细血管扩张。颈、锁骨上及腋窝处未触及肿大淋巴结。肝肋下3.5cm,剑突下5cm,右肋缘下可触及约8×8×12cm 肿大的胆囊。心肺无异常。实验室检查:,WBC7.7×10~9/L(7740/mm~3),N85%,L12%,E3%,Hb112g/L(11.2g),尿胆红质(++),大便隐血(+++),血氨130μg%,黄疸指数94u,凡登伯试验双向,胆红素51.3umol/L(3.8mg%),血沉90mm/h,γ—GT380u,GPT204u,AFP 阴性,HBsAg 阴性,CEA2.6mg%,IgG1.340mg%,IgA 372mg%,IgM264mg%。     

门诊冠心病患者二级预防用药依从性观察

冠心病二级预防用药的突出作用已经大量循证医学所证实,提高门诊冠心患者二级预防用药的依从性具有重大意义.本文观察了186例门诊冠心病患者二级预防用药情况,并与随机抽取的同期住院186例患者进行了对比观察,报告如下.