Type IIB Human Skeletal Muscle Fibers Positively Correlates with Bone Mineral Density Irrespective to Age

Background Age-associated decrease in type IIA/B human skeletal muscle fibers was detected in human biopsies in our previous study. The relationship between change in muscle fiber typing and bone mineral density (BMD) is, however, unknown neither cross-sectional nor longitudinal. We therefore conducted a cross-sectional study to investigate their correlation using human muscle biopsies. Methods 40 human subjects aged 53.4 ± 20.2 years were recruited. Histomorphometric parameters of their muscle biopsies were measured by ATPase staining and image analysis, including average area percentage, fiber number percentage, mean fiber area, and area percentage of connective tissues. Hip and spine BMD were measured by dual-energy X-ray absorptiometry. Partial correlation with adjusting age was performed. Results Type IIB muscle fiber was found positively correlated with hip BMD irrespective to age and demonstrated significantly stronger relationship with BMD among all fiber types, in terms of its cross-sectional area (r=0.380; p=0.029) and size (r=0.389; p=0.025). Type IIA muscle fibers associated with hip BMD in mean fiber area only (r=0.420; p=0.015). Conclusions Type IIB muscle fiber may play an important role in maintaining bone quality. This may also be a relatively more sensitive fiber type of sarcopenia and osteoporosis. These findings further consolidate the muscle-bone relationship.     

新型高效皮肤渗透促进剂——氮酮

近年来,从一系列N-烃代氮杂环酮的化合物中已开发出新型、高效的皮肤渗透促进剂——氮酮(Azone),其化学名称为,1-正十二烷基氮杂环庚烷酮-2,结构式如下:     

修理血压计的一些经验介绍

血压计是帮助物理诊断的器械,是医疗单位常备器械之一,有表式和水银柱式两种,这里仅将水银柱式血压计故障的修理作一个简单的介绍。血压计应用很普遍,如因使用不慎或使用过久发生故障者很多,若有故障不加修理而致报发更是可惜。我们曾将过去发生故障而积压在仓库的血压计加以修理,并从中得到一些经验,茲介绍如下,供有关同志们参考。     

无錫已故名医鄧星伯軼事

邓师星伯,无锡南门外江溪桥人,自幼好学,长承父业习医,复从常州孟河马氏游,擅长内外科,识见广博,登门求治者,日以数百计,然邓师并不以业务之繁重而简略,孜孜屹屹,日以继夜,面无倦容,尤其对于劳动人民之贫而病者,送诊送药不遗余力。至于待人接物,谦恭和藹,而对已则勤俭朴实,为时人所称颂。我追随邓师十余年,印象弥深;忆及邓师生平秩事,追记三则于后。     

肥胖患者情绪异常与减重手术效果的相关性

背景 减重手术是治疗肥胖的重要手段之一,部分拟行减重手术的患者存在异常的情绪及较高的外周血炎症因子水平,可能会影响减重手术效果。目前国内对于该群体术前情绪状态和外周血炎症因子水平与减重手术效果相关性的研究有限。目的 探讨术前情绪异常与肥胖患者减重手术效果的相关性,以期为提高患者减重手术的效果提供参考。方法 纳入2022年12月30日—2023年6月30日,于四川大学华西医院胃肠外科住院的、拟行减重手术的肥胖患者81例,采用汉密尔顿抑郁量表17项版（HAMD-17）和汉密尔顿焦虑量表（HAMA）评定患者的情绪状态,将HAMD-17或HAMA评分≥7分或有抑郁或焦虑障碍史的患者纳入情绪异常组（n=34）,将HAMD-17与HAMA评分均<7分且无上述既往史的患者纳入不伴情绪异常组（n=47）。采用自制问卷收集一般资料,采用贝克自杀意念量表中文版（BSI-CV）、进食障碍调查问卷（EDI）以及匹兹堡睡眠质量指数量表（PSQI）分别评定自杀意念、进食及睡眠情况;检测两组患者外周血C反应蛋白（CRP）和白细胞介素-6(IL-6)水平。术后1个月和术后6个月通过门诊或电话随访收集患者当日清...