辽宁省碘缺乏病轻病区不同时期出生儿童智力水平分析

目的了解和比较辽宁省碘缺乏病轻病区不同时期出生儿童智力水平。方法在3个县(市)4个乡6所学校,以病区未防治时期、供应碘盐初期、全民食盐加碘后出生7～14岁儿童为调查对象,用中国联合型瑞文测验图册(CRT-C)和第二版农村儿童智商常模(CRT-RC2)测验判定儿童智商(IQ)。结果碘缺乏病轻病区未防治时期、供应碘盐初期、全民食盐加碘后出生儿童智商分别为94.7±14.6、99.2±14.7、104.9±15.2,全民食盐加碘后儿童智商明显高于未防治时期儿童和供应碘盐初期儿童(P<0.01);IQ≤69者分别占5.6%、3%、2.4%,全民食盐加碘后智力落后儿童比例明显低于未防治时期儿童(P<0.005)。结论全民食盐加碘后碘缺乏病轻病区出生儿童智力水平有明显提高。     

碘缺乏病区儿童精神运动成套测验的T分值分析

津医精神运动成套测验 (JPB)是检测由各种因素所致脑功能受损 ,而引发中枢神经功能的速度和准确性改变的方法〔1〕。JPB对筛选因轻度缺碘和补碘不足引起的轻度神经系统损伤有较高的灵敏性和特异性 ,为诊断亚临床克汀病提供了有效、可信的测验方法。为进一步明确精神运动功能与智商水平的关系 ,我们将碘缺乏病区 7～ 14岁不同智商水平儿童的JPB检测T分值进行分析。1　对象和方法1 1　对象 :在辽宁省地处丘陵地区 ,已经供应碘盐30多年的开原、凤城两市农村碘缺乏中、重病区 ,选择出生并居住当地的 7～ 14岁儿童为调查对象。1 2　方法1 2 …     

供应碘盐碘缺乏病轻病区与非缺碘地区同期出生儿童亚临床损伤状况

目的 比较供应碘盐IDD轻病区、非缺碘地区同期出生儿童亚临床损伤状况。方法 用CRT－C2测验判定儿童智商,用JPB、测听仪、拍X线片、标准度衡器具检测IQ50－69儿童精神运动、听力、骨龄、身高和体重。结果 供应碘盐IDD轻病区、非缺碘地区儿童人群智商均值分别为100．9、102．6,轻度智力落后率分别为3．5％、2．3％。IQ50－69儿童伴有精神运动、听力障碍和骨龄、体格发育落后分别占40．2％、37．5％。IDD轻病区儿童人群智商均值显低于非缺碘地区,轻度智力落后率显高于非缺碘地区（P＜0．05）。IQ50－69儿童亚临床损伤率较非缺碘地区有增高趋势。结论 碘盐预防提高了IDD轻病区儿童智力水平,但亚临床损伤程度较非缺碘地区重。     

辽宁省农村碘缺乏病病区和非病区儿童的亚临床损伤状况

目的了解辽宁省农村碘缺乏病病区和非病区7～14岁儿童的亚临床损伤状况.方法先用CRT-C2测定儿童智商(IQ),然后用JPB、测听仪、拍X线片、标准度衡器具检出IQ 50～69儿童的精神运动、听力障碍和骨龄、体格发育落后者.结果碘盐防治重、中、轻病区和碘盐碘油防治重病区、未补碘轻病区、非病区儿童人群轻度智力落后率分别为6.8%、5.0%、3.5%、2.3%、7.5%、2.3%;轻度智力落后儿童具有神经系统障碍和甲状腺功能障碍的亚临床损伤率分别为79.5%、77.0%、40.2%、50.0%、66.7%、37.5%.碘盐防治重、中、轻病区儿童亚克汀病患病率分别为5.4%、3.9%、1.4%,碘盐碘油防治重病区、未补碘轻病区儿重亚克汀病患病率分别为1.2%、5.0%.结论病区儿童亚临床损伤率和亚克汀病患病率以碘盐防治重病区和未补碘轻病区最高,次之为碘盐防治中度病区,碘盐碘油防治重病区和碘盐防治轻病区最低.碘盐碘油防治重病区和碘盐防治轻病区儿童与非病区儿童的亚临床损伤率无明显差异.     

辽宁省6—14岁儿童超声波水平甲状腺肿大率

碘是甲状腺合成甲状腺激素的重要原料。当人体碘摄入不足时,甲状腺细胞出现代偿性肿大。辽宁省100个县(市、区),原有63个IDD病区县(市、区),现确认99个县(市、区)是缺碘地区。原划定的IDD病区长期供应碘盐或用碘油防治,而原“非病区”未采取防治措施。为了解补碘和未补碘防治的不同程度缺碘地区儿童甲状腺肿大情况,以便为实行全民供应碘盐和对特需人群采用碘油等措施提供科学依据,作者于1993～1994年对辽宁省13个县(市、区)的36所学校6～14岁儿童甲状腺进行了B超检查。现将儿童甲状腺肿大报告如下。     

农村非IDD病区智力正常儿童精神运动成套测验的检测结？…

目的：掌握非ＩＤＤ病区智力正常儿童精神运动成套测验的正常值，为制定全国儿童精神运动测验量表提供依据。方法：按“九五”国家医学科技攻关项目的设计，在沿海和内陆平原家村非ＩＤＤ病区对ＩＱ８０￣１１９的无甲肿７￣１４岁儿童进行１０项精神运动测验。结果：选择反应时测验的反应时间（ｍｓ）间隔均值是由于小年龄组向大年龄组逐渐递降，相临两个年龄组差异显（Ｐ〈０．０１或Ｐ〈０．０５）；连续作业、划消数字、目标追     

辽宁省碘缺乏病病区不同补碘时期出生儿童智力水平调查

目的 了解和比较辽宁省碘缺乏病病区不同补碘时期出生儿童智力水平.方法 1900-2007年,在辽宁省的6个碘缺乏病病区县(市、区)各选出1个乡,其中轻中重病区乡各2个.在6个乡的10所学校中,以病区供应碘盐初期(1978-1980年)、非碘盐充销期(1981-1990年)、恢复普及碘盐期(1991-1995年)、全民食盐加碘期(1996-2000年)出生的7～14岁儿童为凋查对象,用中国联合型瑞文测验(CRT-C)和第二版农村儿童智商(intelligence quotient,IQ)常模测试(CRT-RC2)检查儿童IQ.结果 病区儿童IQ在非碘盐充销期(91.9±14.3)明显低于供应碘盐初期(95.8±14.6,q=8.60,P<0.01),恢复普及碘盐期(99.7 ±14.7)明显高于供应碘盐初期、非碘盐充销期(q值分别为9.53、18.13,P均<0.01),全民食盐加碘期(104.3±14.9)明显高于供应碘盐初期、非碘盐充销期、恢复普及碘盐期(q值分别为20.00、28.00、10.46,P均<0.01).儿童智力落后率(IQ≤69)在非碘盐充销期(6.7%,88/1314)高于供应碘盐初期(4.4%,21/471,χ2=3.85,P<0.05),恢复普及碘盐期(3.3%,48/1470)明显低于非碘盐充销期(χ2=15.37,P<0.01),全民食盐加碘期(2.7%,36/1344)低于供应碘盐初期(χ2=4.41,P<0.05)和非碘盐充销期(χ2=26.34,P<0.01).供应碘盐初期各年度出生儿童IQ及智力落后率未有明显变化;非碘盐充销期的10年间,出生儿童IQ呈"∪"形降升,智力落后率则呈"∩"形升降;恢复普及碘盐时期出生儿童IQ逐年提高,智力落后率逐年降低;全民食盐加碘期各年度儿童IQ继续上升,智力落后率降到历史最低程度.结论 碘缺乏病病区非碘盐充销时期出生儿童智力水平明显低于供应碘盐初期儿童,全民食盐加碘期病区出生儿童智力水平较供应碘盐初期和恢复普及碘盐时期出生儿童有明显提高.     

辽宁省碘缺乏病病区不同补碘时期出生儿童智力水平调查

objecfive To know and compare the intelligence level of children born in different time periods in regions with iodine deficiency disorders(IDD)in Liaoning province.Methods All 7-14 year-old children from ten schools were chosen as the subjects respectively from six villages in each of the six counties and in regions with iodine deficiency,who were respectively born at the initialization of iodinated salt supplying period(1978-1980);non-iodinated salt supplying period(1981-1990);recovery of supplied iodized salt period(1991-1995);universal iodized salt period(1996-2000),respectively.Intelligence quotient(IQ)was measured by Combined Ravens Test in China(CRT-C)and Combined Ravens Test-the Rural,in China,2nd edition(CRT-RC2).Results IQ of children during the non-iodized salt period(91.9±14.3)was significantly lower than the initial supply of iodized salt period(95.8±14.6,q=8.60,P<0.01),recovery of supplied iodized salt period(99.7±14.7)was significantly higher than the initial supply of iodized salt period, non-iodized salt sales period(q = 9.53, 18.13, all P < 0.01 ),universal salt iodization( 104.3 ± 14.9) was significantly higher than the initial supply of iodized salt period, non-iodized salt sales period, recovery of supplied salt iodization(q = 20.00,28.00,10.46, all P < 0.01). Children's rate of mental retardation (IQ≤69) was higher in non-iodinated salt supplying period (6.7%, 88/1314 ) than the initial supply of iodized salt (4.4%, 21/471, χ2 = 3.85, P < 0.05), recovery of supplied iodized salt period(3.3%,48/1470) was significantly lower than non-iodinzed salt supplying period (χ2 = 15.37, P < 0.01), universal salt iodization period(2.7%, 36/1344) was lower than the initial supply of iodized salt period(χ2 = 4.41, P < 0.05) and non-iodinzed salt supplying period(χ2 = 26.34, P < 0.01 ). The IQ and intelligent retarded rates in children born during the initial years of iodinated salt supplying period were not different. The IQ of the children during ten years of non-iodized salt supplying period fluctuated in a "∪" curve, while the intelligent retardation rates in a "∩" curve.The children born during the period of recovery supplied iodized salt increased their IQ and lowered the retardation rates year after year. The IQ of the children in universal iodized salt period kept on increasing while intelligent retarded rates reduced to the lowest level. Conclusions The intelligence level of children born in regions with IDD during non-iodized salt supplying period is remarkably lower than that of the beginning years of iodinated salt supplying period. The intelligence level of children born after universal iodized salt period is remarkably higher than that of the initial iodinated salt supplying period and recovery of supplied iodized salt period, respectively.