To date, the delineation of the human visual “motion area” still relies on functional paradigms originally devised to identify
monkey area
MT. Using fMRI, we have identified putative human area
V5/MT+ in normals by modelling the BOLD responses to alternating radially moving and stationary dot patterns. Functional activations
were compared with cytoarchitectonic probability maps of its putative correlate area
hOc5, which was calculated based upon data from histological sections of ten human post-mortem brains. Bilateral visual cortex
activations were seen in the single subject
dynamic versus stationary contrasts and in the group random-effects analysis. Comparison of group data with area
hOc5 revealed that 19.0%/39.5% of the right/left functional activation was assigned to the right/left
hOc5. Conversely, 83.2%/53.5% of the right/left
hOc5 was functionally activated. Comparison of functional probability maps (fPM) with area
hOc5 showed that 28.6%/18.1% of the fPM was assigned to
hOc5. In turn, 84.9%/41.5% of the area
hOc5 was covered by the respective fPM. Thus, random-effects data and fPMs yielded similar results. The present study shows for
the first time the correspondence between the functionally defined human
V5/MT+ and the post-mortem cytoarchitectonic area
hOc5.
相似文献