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Farhad Ahmadi Batool Jafari Mehdi Rahimi-Nasrabadi Sahar Ghasemi Kumars Ghanbari 《Toxicology in vitro》2013,27(2):641-650
In this work we proposed a model for in vitro interaction of fenitrothion (FEN) with calf thymus-DNA by combination of multispectroscopic and two dimensional molecular modeling (ONIOM) methods. The circular dichroism results showed that FEN changes the conformation of B-DNA and caused some changes to C-DNA form. The FT-IR results confirmed a partial intercalation between FEN and edges of all base pairs. The competitive fluorescence, using methylene blue as fluorescence probe, in the presence of increasing amounts of FEN, revealed that FEN is able to release the non-intercalated methylene blue from the DNA. The weak chemical shift and peak broadening of 1H NMR spectrum of FEN in the presence of DNA confirmed a non-intercalation mode. The 31P NMR showed that FEN interacts more with DNA via its –NO2 moiety. The ONIOM, based on the hybridization of QM/MM (DFT, 6.31++G (d,p)/UFF) methodology, was also performed by Gaussian 2003 package. The results revealed that the interaction is base sequence dependent, and FEN interacts more with AT base sequences. 相似文献
3.
A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia 总被引:2,自引:0,他引:2
Jiang ZG Lu XC Nelson V Yang X Pan W Chen RW Lebowitz MS Almassian B Tortella FC Brady RO Ghanbari HA 《Proceedings of the National Academy of Sciences of the United States of America》2006,103(5):1581-1586
Cellular and molecular pathways underlying ischemic neurotoxicity are multifaceted and complex. Although many potentially neuroprotective agents have been investigated, the simplicity of their protective mechanisms has often resulted in insufficient clinical utility. We describe a previously uncharacterized class of potent neuroprotective compounds, represented by PAN-811, that effectively block both ischemic and hypoxic neurotoxicity. PAN-811 disrupts neurotoxic pathways by at least two modes of action. It causes a reduction of intracellular-free calcium as well as free radical scavenging resulting in a significant decrease in necrotic and apoptotic cell death. In a rat model of ischemic stroke, administration of PAN-811 i.c.v. 1 h after middle cerebral artery occlusion resulted in a 59% reduction in the volume of infarction. Human trials of PAN-811 for an unrelated indication have established a favorable safety and pharmacodynamic profile within the dose range required for neuroprotection warranting its clinical trial as a neuroprotective drug. 相似文献
4.
Ashraf Mohamadkhani Faegh Bastani Samaneh Khorrami Reza Ghanbari Sareh Eghtesad Maryam Sharafkhah Ghodratollah Montazeri Hossein Poustchi 《Hepatitis monthly》2015,15(6)
Background:
Chronic Hepatitis B (CHB) is accompanied by inflammation of liver because of infection with Hepatitis B Virus (HBV). Previous studies revealed an inverse association between vitamin D and HBV DNA levels.Objectives:
The current study aimed to investigate the levels of 25 (OH) D3 (the steady form of vitamin D), miR-378 and HBV DNA in the patients with CHB.Patients and Methods:
One hundred and seventy three patients with HBeAg negative CHB were recruited for the study. Plasma levels of HBVDNA and 25 (OH) D3 were quantified. The expression level of miR-378 in plasma was measured by a relative quantitative Real Time Polymerase Chain Reaction (qRT-PCR) assay.Results:
In the pathway regression analysis, the plasma level of 25 (OH) D3 showed a significant inverse correlation with plasma levels of HBV DNA (-0.198, P = 0.008) and direct correlation with miR-378 (0.188, P = 0.013). Similarly plasma level of miR-378 had inverse association with HBV DNA level (-0.177, P = 0.020).Conclusions:
These results suggest that vitamin D could involve in a miRNA- mediated regulatory pathway in control of HBV replication. Further studies are recommended to understand the effects of miR-378 and anti-infective action of vitamin D on Hepatitis B Virus. 相似文献5.
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Akash Makkar Joann Prisciandaro Sunil Agarwal Morgan Lusk Laura Horwood Jean Moran Colleen Fox James A. Hayman Hamid Ghanbari Brett Roberts Diego Belardi Rakesh Latchamsetty Thomas Crawford Eric Good Krit Jongnarangsin Frank Bogun Aman Chugh Hakan Oral Fred Morady Frank Pelosi 《Heart rhythm》2012,9(12):1964-1968
8.
Amrish Deshmukh MD John Larson MD Michael Ghannam MD Mohammed Saeed MD Ryan Cunnane MD Hamid Ghanbari MD Rakesh Latchamsetty MD Thomas Crawford MD Krit Jongnarangsin MD Frank Pelosi Jr. MD Aman Chugh MD Hakan Oral MD Fred Morady MD Frank Bogun MD Jackson J. Liang DO 《Journal of cardiovascular electrophysiology》2021,32(12):3173-3178
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10.
Fatemeh Rajati Masoud Ghanbari Tolou Hasandokht Rasool Akbarzadeh Hossein Ashtarian 《Disability and rehabilitation》2017,39(23):2436-2445
Purpose: Self-efficacy plays a key role in varying areas of human conditions which can be measured by different scales. The present study was aimed to evaluate the psychometric properties of Moorong Self-Efficacy Scale (MSES) in Iranian Subjects with Physical Disability (SWPD).Method: Data were collected by face-to-face interviews and self-report surveys from 214 subjects. The face and content validity, and reliability were evaluated. Discriminates were evaluated between the sub-groups of disability levels, physical activity, and health condition levels. The concurrent, convergent, divergent, and construct validity were assessed by short form health survey scale (SF-36), general self-efficacy scale (GSES), hospital anxiety and depression scale (HADS), respectively. Replaceable exploratory factor analysis was evaluated. SPSS software was used for statistical analysis.Results: There were acceptable face and content validity, and reliability. Furthermore, significant correlation was found between PSES and SF-36 (p?0.001). Self-efficacy was statistically different among the disability levels (p?=?0.02), physical activity levels (p?0.001), and health status (p?=?0.001). The correlation of Persian Self-Efficacy Scale (PSES) scores with GSES (r?=?0.61, p?0.001), and HADS (R?=??0.53, p?0.001) was significant. This scale yielded a two-dimensional structure, with a good internal replicability. The external replicability was satisfactory when we compared factor loadings with the original study.Conclusions: The PSES is a valid, reliable and sensitive tool to measure the self-efficacy among SWPD for planning and managing of disability problems.
- Implications for rehabilitation
Psychometric properties of the Persian version of self-Efficacy scale (PSES) appear to be similar to original, English version.
The PSES has been shown to have validity and reliability in Persian physical disables and can be used for patients with more different types of physical disability than individuals suffering from only Spinal Cord Injury (SCI).
The PSES can be used in clinical practice and research work to evaluate the patients’ confidence in performing daily activities.