六味能消胶囊联合脂必泰胶囊治疗高脂血症的临床研究

目的探讨六味能消胶囊联合脂必泰胶囊治疗高脂血症的临床效果。方法选取2017年5月—2018年10月东营市东营区人民医院收治的64例高脂血症患者,随机分为对照组和治疗组,每组各32例。对照组口服脂必泰胶囊,1粒/次,2次/d。治疗组在对照组治疗基础上口服六味能消胶囊,1粒/次,3次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组治疗前后血脂指标、血流变学指标、血小板参数及血清学指标的变化情况。结果治疗后,对照组和治疗组的总有效率分别是75.0%、96.9%,两组比较差异具有统计学意义(P0.05)。治疗后,两组总胆固醇(TC)、非-HDL-C、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前显著降低,而高密度脂蛋白胆固醇(HDL-C)显著升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组TC、非-HDL-C、TG、LDL-C水平低于对照组,而HDL-C高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血浆黏度(PV)、红细胞比容(HCT)、聚集指数(RCAI)、平均血小板体积(MPV)、血小板最大聚集率(MAR)均显著降低,而变形指数(RDI)值均显著升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,PV、HCT、RCAI、MPV、MAR值均显著低于对照组,而RDI值高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血清C反应蛋白(CRP)、内皮素(ET)水平较治疗前均显著降低,而一氧化氮(NO)水平显著增高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组CRP、ET水平低于对照组,而NO水平高于对照组,两组比较差异有统计学意义(P0.05)。结论六味能消胶囊联合脂必泰胶囊治疗高脂血症具有较好的临床疗效,综合调脂作用显著,可明显纠正患者体内血流变学异常,改善血小板功能及微炎症状态,保护血管内皮功能,具有一定的临床推广应用价值。     

Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits

Epidemiological studies have shown dietary magnesium (Mg) intake and serum Mg levels to be inversely correlated with the development of atherosclerosis. We hypothesized that low levels of Mg would promote atherosclerotic plaque development in rabbits. New Zealand white rabbits (4 months old, n = 22) were fed an atherogenic diet containing 0.12% (−Mg), 0.27% (control), or 0.43% (+Mg) Mg for 8 weeks. Blood samples were obtained at baseline, 2, 4, 6, and 8 weeks and were assayed for total cholesterol, high-density lipoprotein (HDL), non-HDL, triglycerides (TG), C-reactive protein, serum Mg, and erythrocyte Mg. Aortas from −Mg had significantly more plaque, with an intima thickness 42% greater than control and 36% greater than +Mg. Serum cholesterol levels rose over time, and at 8 weeks, −Mg had the highest and +Mg the lowest total and non-HDL cholesterol and TG levels, although these results did not reach significance. Over time, serum Mg levels increased, and erythrocyte Mg levels decreased. C-reactive protein significantly increased in all groups at 4 and 6 weeks but returned to baseline levels by 8 weeks. This study supports the hypothesis that inadequate intake of Mg results in an increase in atherosclerotic plaque development in rabbits.     

胃癌10和11组淋巴结转移及其清扫

目的：研究胃癌脾门淋巴结(No．10)和脾动脉周围淋巴结(No．11)转移规律，进一步探讨No．10和11清扫的必要性和方法。方法：1991年-2000年132例行全胃切除，D2以上淋巴结清扫的胃癌患者，回顾性研究临床病理资料，包括性别、年龄、肿瘤部位、大小、浸润深度、病理类型、其他淋巴结转移等对No．10和11转移的影响，比较全胃切除和全胃联合脏器切除的并发症发生率。结果：胃癌具有较高的No．10或11淋巴结转移率(18．9％)，Logistic回归分析表明，胃癌部位、病理类型、浸润深度和大小弯淋巴结转移五项临床病理指标影响No．10和U转移率。联合脏器切除的并发症发生率(32％)明显高于单纯全胃切除(11．2％)，联合肢体尾切除增加肠下脓肿发生率，而脾切除并不增加全胃切除的危险性。结论：No．10和11在胃癌有较高的转移率和特定的转移规律，预防性和治疗性的清扫实属必要，联合左侧肢体尾加脾切除增加手术危险性，应严格掌握的适应证。而保留胰腺，切除脾血管和脾清扫No．10．和ll淋巴结合理可靠。     

噪声和咖啡因联合作用对血液中TG、Ch、LDL和HDL含量的影响

用自动生化分析仪对接触强噪声的纺织女工饮用咖啡前后和不接触强噪声的女大学生进行了血液TG、Ch、LDL和HDL含量测定。结果发现:噪声可使血液TG、Ch及LDL含量显著升高,而噪声和咖啡(含咖啡因)联合作用后其血液TG、Ch及LDL含量明显降低,HDL含量升高,提示咖啡因可拮抗噪声所致的脂代谢异常。     

171例高血压患者血脂,脂蛋白及载脂蛋白水平的分析

本文就171例HBP患者血脂、脂蛋白及载脂蛋白水平与155例正常人进行比较分析发现:HBP患者WI、TG及apoB较对照组显著升高,TC无明显差别,HDL-C、HDL_2-C及apoAI显著降低、正常男性TC、TG和apoB随年龄增长呈升高趋势,女性TC、TG和LDL-C则在50岁以后开始升高。而HBP患者除男性apoB随年龄增加而升高外,其余各项,不分男女,均无随年龄增减而变化的趋势。     

抗人甲状腺球蛋白单克隆抗体的制备及其对抗原决定簇特异性的研究

用杂交瘤技术建立三株分泌抗甲状腺球蛋白(TG)单克隆抗体的杂交瘤细胞株。所获三种单克隆抗体经兔抗小鼠IgG亚类、IgM及IgA血清鉴定表明,两种为IgG_1,一种为IgA;三种含单克隆抗体小鼠腹水的滴度(ELISA法)均为51200以上;以竞争性固相抗体结合试验测定它们对抗原决定簇的特异性差异,结果发现三种单克隆抗体的抗原结合部位是不同的,但对抗原的结合有一定的相互竞争抑制现象。     

Insolubilized anithyroglobulin antibodies: properties and interest in the study of thyroglobulin

Antithyroglobulin antibodies have been insolubilized, either through polymerization of the immune serum by ethyl chloroformate or through covalent binding to cyanogen bromide activated Sepharose 2B. These immunosorbents are able to bind thyroglobulin specifically, however, they have lost a part of the immune serum antibody activity. Thyroglobulin immunosorption is reversible. The degree of reversibility increases respectively with a pH 2 buffer, 3 M NaSCN and 0.1% sodium dodecylsulfate. After desorption by the first two procedures, thyroglobulin remains entirely precipitable by homologous antibodies, however, it undergoes conformational changes, some of them being partially reversible (unfolding of the 19S species, dissociation into 12S subunits). These immunosorbents may be used, under the conditions described, in the quantitative estimation and purification of thyroglobulin.     

Graves’病患者血清leptin与血脂水平变化的观察

目的：探讨Graves’病患者血清瘦素（leptin）与血脂水平变化的临床意义。方法：对29例初诊的Graves’病患者治疗前后及30例健康体检者血清leptin与血脂含量进行测定。结果：29例Graves’病患者治疗前血清leptin、三酰甘油及总胆固醇含量均较对照组明显降低;经治疗T3、T4水平恢复正常后,血清leptin、三酰甘油及总胆固醇含量较治疗前明显升高;与对照组比较差异无显著性。结论：血清leptin与血脂含量的变化可作为判断Graves’病的病情和疗效的指标之一。     

山葡萄籽油(EPC)调节血脂作用的研究

对长白山地区山葡萄籽油调节血脂作用进行了研究.建立Wistar大鼠高脂血症模型后,观察葡萄籽油调节血脂功能.结果15天后高剂量组具有很好的降脂作用,TC下降达17.5%.30天后小剂量和大剂量组均具有调节血脂的作用,TC、TG两项指标均下降15%以上,特别是大剂量组TC下降24.6%(P＜0.001),TG下降23%(P＜0.01).通过对大鼠的试验研究证实,EPC油具有调节血脂作用,且给药时间越长,效果越明显.