全文获取类型
收费全文 | 77142篇 |
免费 | 5493篇 |
国内免费 | 2092篇 |
专业分类
耳鼻咽喉 | 661篇 |
儿科学 | 1509篇 |
妇产科学 | 1067篇 |
基础医学 | 5863篇 |
口腔科学 | 1249篇 |
临床医学 | 7566篇 |
内科学 | 9992篇 |
皮肤病学 | 730篇 |
神经病学 | 4648篇 |
特种医学 | 1741篇 |
外国民族医学 | 8篇 |
外科学 | 9957篇 |
综合类 | 13748篇 |
现状与发展 | 1篇 |
一般理论 | 4篇 |
预防医学 | 5985篇 |
眼科学 | 1285篇 |
药学 | 6298篇 |
127篇 | |
中国医学 | 10223篇 |
肿瘤学 | 2065篇 |
出版年
2024年 | 257篇 |
2023年 | 1390篇 |
2022年 | 2611篇 |
2021年 | 3644篇 |
2020年 | 3254篇 |
2019年 | 3208篇 |
2018年 | 2872篇 |
2017年 | 2818篇 |
2016年 | 2666篇 |
2015年 | 2386篇 |
2014年 | 5143篇 |
2013年 | 4756篇 |
2012年 | 4268篇 |
2011年 | 5166篇 |
2010年 | 4552篇 |
2009年 | 3622篇 |
2008年 | 3373篇 |
2007年 | 3482篇 |
2006年 | 3344篇 |
2005年 | 2777篇 |
2004年 | 2240篇 |
2003年 | 2079篇 |
2002年 | 1481篇 |
2001年 | 1338篇 |
2000年 | 1074篇 |
1999年 | 966篇 |
1998年 | 708篇 |
1997年 | 696篇 |
1996年 | 575篇 |
1995年 | 595篇 |
1994年 | 569篇 |
1993年 | 421篇 |
1992年 | 423篇 |
1991年 | 371篇 |
1990年 | 339篇 |
1989年 | 320篇 |
1988年 | 323篇 |
1987年 | 268篇 |
1986年 | 264篇 |
1985年 | 482篇 |
1984年 | 482篇 |
1983年 | 381篇 |
1982年 | 419篇 |
1981年 | 407篇 |
1980年 | 384篇 |
1979年 | 336篇 |
1978年 | 301篇 |
1977年 | 265篇 |
1976年 | 202篇 |
1975年 | 118篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
认知功能障碍在肌萎缩侧索硬化(ALS)患者中是普遍存在的,ALS伴认知功能障碍常提示预后不良。近年来对ALS患者认知功能障碍的研究取得了一定的进展,本文对ALS伴认知功能障碍的临床特点、生物标志物、遗传学特征和最新治疗进展进行综述,以期为ALS伴认知功能障碍的临床诊疗提供新思路。 相似文献
2.
3.
《Transfusion and apheresis science》2022,61(1):103368
The endothelium is a single-layered structure that responds to physical and chemical signals with various factors it synthesizes. In the early days of its discovery, as the inner wall of the vessels, the endothelium was thought to be a simple barrier that lays on the surface. Over time it is discovered that endothelium maintains body homeostasis with the molecules it synthesizes, despite its simple single-layer structure. It has been accepted as an important organ that contributes to the maintenance of vascular tone, cell adhesion, inflammation, vascular permeability and coagulation. Any imbalance in these physiological and pathological events causes endothelial dysfunction. This can cause many diseases such as atherosclerosis, hypertension, diabetes, or it can occur because of these. Endothelial related disorders may also complicate hematopoietic stem cell transplantation (HSCT), which is used to treat various hematologic and neoplastic diseases. These life-threatening complications include graft-versus-host disease, hepatic veno-occlussive disease, transplant-associated thrombotic microangiopathy and diffuse alveolar hemorrhage. They share a similar pathophysiology involving endothelial cells with different clinical presentations. Therefore, current researche on the issue is putting the endothelium under the spotlight for novel markers and treatment options that should be used to monitor or treat at least some of these complications following HSCT. 相似文献
4.
5.
6.
7.
8.
9.
《Journal of vascular and interventional radiology : JVIR》2022,33(4):359-367.e8
PurposeTo review and to compare indirectly the outcomes of minimally invasive therapies for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.Materials and MethodsA literature search via Medline and Cochrane Central databases was completed for randomized control studies published between January 2000 to April 2020 for the following therapies: Rezum, Urolift, Aquablation, and prostatic artery embolization (PAE). Data on the following variables were included: International prostate symptom score (IPSS), maximum urinary flow rate, quality of life, and postvoid residual (PVR). Standard mean differences between treatments were compared through a meta-analysis using transurethral resection of the prostate (TURP) to assess differences in treatment effect.ResultsThere was no significant difference in outcomes between therapies for IPSS at the 3, 6, and 12-month follow ups. Although outcomes for Rezum were only available out to 3 months, there were no consistently significant differences in outcomes when comparing Aquablation versus PAE versus Rezum. TURP PVR was significantly better than Urolift at 3, 6, and 12 months. No significant differences in minor or major adverse events were noted.ConclusionAlthough significant differences in outcomes were limited, Aquablation and PAE were the most durable at 12 months. PAE has been well studied on multiple randomized control trials with minimal adverse events while Aquablation has limited high quality data and has been associated with bleeding-related complications. 相似文献
10.
Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface. 相似文献