微创挂线术治疗直肠肛周脓肿的效果

〔摘 要〕 目的：评价直肠肛周脓肿患者运用微创挂线术治疗的效果。方法：选取 2019 年 1 月至 2020 年 1 月期间 安阳市中医院接收治疗的直肠肛周脓肿患者 50 例为研究对象，根据不同治疗方式分为对照组和观察组，各 25 例。对 照组接受一期根治术治疗，观察组展开微创挂线术治疗，术后比较两组患者手术指标、临床疗效、疼痛程度数字评估 量表（NRS）评分及日常生活能力评定量表（ADL）评分等。结果：观察组患者的手术时长、住院天数、手术出血量、 创面愈合时间等指标均优于对照组，差异具有统计学意义（P ＜ 0.05）。在临床疗效方面，观察组患者的总有效率明 显更高于对照组，差异具有统计学意义（P ＜ 0.05）。术后，两组患者的 NRS 评分均下降，ADL 评分均上升，且观 察组 NRS 评分低于对照组，ADL 评分高于对照组，差异均具有统计学意义（P ＜ 0.05）。结论：直肠肛周脓肿患者 运用微创挂线术治疗，相对于一期根治术可以缩短治疗时间和患者康复时间，且能更有效地提高患者的日常生活能力， 降低术后疼痛。     

陈氏绕肝双悬吊法联合右半肝血流阻断行右后叶肝肿瘤切除术

目的 评价右半肝阻断技术结合陈氏绕肝双悬吊法在右后叶肝肿瘤切除术中的应用价值.方法 2011年1月至2015年1月,在37例解剖性肝脏右后叶切除术中应用持续右半肝及陈氏绕肝双悬吊法辅助肝切除.右后叶肝肿瘤行右后叶切除时,采取持续右半肝阻断技术并结合陈氏绕肝双悬吊法经下腔静脉右侧放置2根提肝带,离断肝实质的过程中通过牵拉提肝带辅助肝切除.结果 全组共37例肝右后叶肿瘤病人行肝右后叶肿瘤切除术.术中均成功分离出右半肝肝蒂和右后叶肝蒂,游离右肝后均成功放置绕肝提拉带,断肝时行右半肝持续肝门阻断,术中无胆管损伤、肝短静脉、肝右静脉撕裂和大出血等相关操作并发症.肝实质离断时间17～28 min,阻断时间约20～30min,术中出血量60～330 ml.术后第1天丙氨酸转氨酶(ALT) 183～352 U/L,生化指标均在1周内恢复正常,无围手术期死亡.结论 右半肝持续阻断结合陈氏绕肝双悬吊法有助于减少右后叶肝切除术中出血量以及改善手术野,缩短肝实质离断时间,减轻肝脏缺血再灌注损伤,其操作简单、使用安全、适用范围广泛.     

正中悬头位Dix-Hallpike法诊断良性阵发性位置性眩晕

目的评价正中悬头位Dix-Hallpike诱发检查法在诊断后半规管良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)中的意义。方法回顾性总结广东省人民医院耳鼻咽喉科眩晕门诊2008年4月1日到5月29日根据经典或者正中悬头位Dix-Hallpike法诊断为后半规管BPPV患者28例的临床资料,均首先进行正中悬头位Dix-Hallpike诱发试验,如结果为阴性后继续行经典Dix-Hallpike检测证实为后半规管性BPPV。比较正中悬头位Dix-Hallpike相对于经典Dix-Hallpike的阳性率。结果28例后半规管BPPV患者中,正中悬头位Dix-Hallpike诱发试验相对于经典Dix-Hallpike诱发实验的阳性率为78.57%(22/28)。结论正中悬头位Dix-Hallpike法诊断BPPV可以有效地简化诊治程序,并减轻部分患者诱发的眩晕及眼震强度,具有一定的临床意义。但由于其阳性率低于经典方法,故在临床上不能完全代替经典方法。     

绕肝提拉法前入路肝切除术(附6例临床报告)

目的　绕肝提拉法 (liverhangingmaneuver)进一步提高前入路肝切除术 (anteriorapproach)的安全性。方法　钝性分离肝后下腔静脉前间隙而形成肝后隧道。通过该隧道安放绕肝带 ,前入路肝切除时拉紧绕肝带 ,配合自行设计的止血板 ,完成 6例复杂肝切除术。结果　 6例成功安放绕肝带 ,未发生与该操作有关的并发症 ,前入路肝切除时肝正中裂界面内管道显露清楚 ,绕肝带具有指示作用。结论　复杂肝切除时使用绕肝带和止血板 ,有助于提高前入路肝切除的安全性。保证断肝能在最短的界面上进行。     

Designing Better Radiology Workstations: Impact of Two User Interfaces on Interpretation Errors and User Satisfaction

This paper presents our solution for supporting radiologists interpretation of digital images by automating image presentation during sequential interpretation steps. We extended current hanging protocols with support for stages which reflect the presentation of digital information required to complete a single step within a complex task. We demonstrated the benefits of staging in a user experiment with 20 lay subjects involved in a comparative visual search for targets, similar to a radiology task of identifying anatomical abnormalities. We designed a task and a set of stimuli that allowed us to simulate the interpretation workflow from a typical radiology scenario—reading a chest radiography exam when a prior study is also available. The simulation was enabled by abstracting both the radiologists task and the basic workstation navigation functionality. The staged interface was significantly faster than the traditional user interface, provided a 37% reduction in the interpretation errors, and improved user satisfaction.     

Spheroid Preparation from Hanging Drops: Characterization of a Model of Brain Tumor Invasion

BACKGROUND: The use of three-dimensional in vitro models of brain tumor invasion has provided a system for reconstructing some of the cellular microenvironments present in the tumor mass. While spheroids of murine and human astrocytoma cells can be prepared using spinning cultures, spheroid preparation using many cell lines is not amenable to this method. We have developed a reproducible system of creating implantable spheroids that is applicable to different cell lines, and is independent of cell line characteristics. METHODS: For murine and human brain tumor cell lines, 20 microl drops containing predetermined cell concentrations were suspended from the lids of culture dishes and the resulting aggregates were transferred to culture dishes base-coated with agar. The two-dimensional aggregates formed three-dimensional spheroids on the non-permissive agar substrate, and were then implanted into three-dimensional collagen I gels and the invasive activity assessed. The invasive activity of C6 and U251 spheroids prepared by hanging drops was compared to spheroids of similar size prepared by spinner culture. RESULTS: The hanging drop method produced implantable spheroids capable of sustained invasion using all cell lines tested. Most cell lines required initial hanging drop cell concentrations of 45,000 cells/drop, suspension times of 48, and 72 h on agar. C6 spheroids had the same invasive capacity regardless of the model utilized, however U251 spheroids produced by hanging drops had significantly increased invasion compared to those prepared by spinner culture. Only spheroids prepared by spinner culture showed histological evidence of central necrosis. CONCLUSIONS: This model represents a reproducible approach to the preparation of implantable spheroids with invasive potential that compares with those produced using spinner culture. The use of hanging drops broadens the applicability of three-dimensional in vitro assays examining brain tumor invasiveness.     

Estimation of Tegaserod Maleate by Differential Pulse Polarography

A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation.     

模拟失重条件下高浓度氧对大鼠肺脏的影响

本实验目的是观察模拟失重与高浓度氧暴露１２－３６ｈ对大鼠肺脏的影响。研究两者的复合效应。实验共用Ｗｉｓｔａｒ大鼠６０只，分为５个组。尾悬吊作为模拟失重的动物模型。