全文获取类型
收费全文 | 5505篇 |
免费 | 211篇 |
国内免费 | 71篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 4篇 |
妇产科学 | 8篇 |
基础医学 | 462篇 |
口腔科学 | 64篇 |
临床医学 | 576篇 |
内科学 | 626篇 |
皮肤病学 | 2篇 |
神经病学 | 31篇 |
特种医学 | 320篇 |
外科学 | 2146篇 |
综合类 | 555篇 |
预防医学 | 116篇 |
眼科学 | 1篇 |
药学 | 328篇 |
中国医学 | 516篇 |
肿瘤学 | 31篇 |
出版年
2024年 | 10篇 |
2023年 | 149篇 |
2022年 | 314篇 |
2021年 | 310篇 |
2020年 | 256篇 |
2019年 | 301篇 |
2018年 | 292篇 |
2017年 | 189篇 |
2016年 | 174篇 |
2015年 | 184篇 |
2014年 | 511篇 |
2013年 | 445篇 |
2012年 | 291篇 |
2011年 | 325篇 |
2010年 | 244篇 |
2009年 | 279篇 |
2008年 | 223篇 |
2007年 | 207篇 |
2006年 | 164篇 |
2005年 | 141篇 |
2004年 | 141篇 |
2003年 | 107篇 |
2002年 | 75篇 |
2001年 | 61篇 |
2000年 | 52篇 |
1999年 | 42篇 |
1998年 | 40篇 |
1997年 | 34篇 |
1996年 | 26篇 |
1995年 | 48篇 |
1994年 | 22篇 |
1993年 | 19篇 |
1992年 | 16篇 |
1991年 | 10篇 |
1990年 | 14篇 |
1989年 | 11篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 12篇 |
1984年 | 8篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1972年 | 2篇 |
排序方式: 共有5787条查询结果,搜索用时 15 毫秒
1.
2.
3.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
4.
5.
6.
7.
BackgroundHip Osteoarthitis (OA) risk is sport-specific and depends on frequency, intensity, and type of mechanic stress the hip is subjected to. This retrospective observational study aims to investigate the safety and performance of Hymovis (HYADD-4) injection, a hexadecyl (C-16) HA-derivative, when used to manage symptomatic hip OA in active middle-aged sportsmen over a 24-month observation period.MethodsThe retrospective analysis included clinical records of active sportsmen, aged between 40 and 65 years, and suffering from symptomatic Kellgren-Lawrence grade II to III hip OA, treated with two (24 mg/3 ml) Hymovis injections, two weeks apart, every 3–4 months, for two years. When available, data on MRI examination were included in the analysis as well as Heidelberg Sports Activity Score (HAS) and Copenhagen Hip and Groin Outcome Score (HAGOS) questionnaires.ResultsThirty patients (56.4 ± 7.3 years) were included in the study, sixteen cyclists and 14 tennis players. For all patients, HAS and most HAGOS scores improved significantly (p < 0.05) at the first control visit (4 months) and further improved over time. For all other scores an important clinical benefit was experienced by more than 50% of participants. No adverse events were recorded.ConclusionTreatment of hip OA in active sportsmen with Hymovis seems a safe and effective approach for the management of OA symptoms, by potentially protecting cartilage and subchondral bone from further damage. 相似文献
8.
9.
《Best Practice & Research: Clinical Rheumatology》2022,36(4):101810
Osteoarthritis (OA) is a highly prevalent joint disease that is associated with pain, loss of function, and high direct and indirect economic costs. The current therapeutic options are inadequate, providing only a moderate symptom relief without the possibility of disease modification. While treatment options and personalized medicines are increasing for many complex diseases, OA drug development has been impeded by the advanced state of disease at the time of diagnosis and intervention, heterogeneity in both symptoms and rates of progression, and a lack of validated biomarkers and relevant outcome measures. This review article summarizes the OA landscape, including therapies in development as potential OA treatments, potential biomarkers undergoing evaluation by the US Food and Drug Administration, and a summary of current OA treatment guidelines, with a particular focus on the knee OA. 相似文献
10.