Predictors of osteoarthritis following operative treatment of medial tibial plateau fractures

PurposeTo determine factors influencing the development of posttraumatic osteoarthritis (OA) following medial tibial plateau fractures and to evaluate concomitant injuries associated with these fractures.Materials and methodsA chart review of patients with operatively treated medial tibial plateau fractures admitted to our Level I trauma centre from 2002 to 2008 was performed. Of 63 patients, 41 participated in a clinical and radiographic examination. The mean age was 47 years (range 16–78) and the mean follow-up time was 7.6 (range 4.7–11.7) years. All patients had preoperative computed tomography (CT) scans and postoperative radiographs. At the end of follow-up, standing radiographs, mechanical axis, and CT scans were evaluated.ResultsOf the 41 patients, 24 had no or mild (Kellgren-Lawrence grade 0–2) OA and 17 had severe (grade 3–4) OA. Initial articular depression measured from preoperative CT scans was a significant predictor of OA (median 1.8 mm vs 4.5 mm, p = 0.009). Fracture line extension to the lateral plateau (p = 0.68) or fracture comminution (p = 0.21) had no effect on the development of posttraumatic OA, nor did articular depression at the end of follow-up (p = 0.68) measured from CT scans. Mechanical axis >4° of varus and ≥2 mm articular depression or step-off were associated with worse WOMAC pain scores, but did not affect other functional outcome scores. Six patients (10%) had permanent peroneal nerve dysfunction. Ten patients (16%) required LCL reconstruction and nine (14%) ACL avulsions were treated at the time of fracture stabilisation.ConclusionsThe amount of articular depression measured from preoperative CT scans seems to predict the development of posttraumatic OA, probably reflecting the severity of chondral injury at the time of fracture. Restoration of mechanical axis and articular congruence are important in achieving a good clinical outcome.     

补充维生素D对膝关节骨关节炎的治疗效果Meta分析

目的提供关于补充维生素D对膝关节骨关节炎影响的证据。方法计算机检索The Cochrane Library、PubMed、中国知网、中国生物医学数据库与万方数据库,搜集补充维生素D治疗膝关节骨关节炎的临床随机对照试验,检索时间为建库至2017年10月。采用Rev Man 5.3软件进行系统评价和Meta分析。结果最终纳入文献4篇,共1130例膝关节骨关节炎患者。Meta分析结果显示:补充维生素D对缓解膝关节疼痛具有统计学意义[SMD=-0.32,95%CI:(-0.63,-0.02)],在亚组分析中,无论低25(OH)D水平[SMD=-0.57,95%CI:(-1.41,0.27)]研究对象或高25(OH)D水平[SMD=-0.12,95%CI:(-0.28,0.04)]研究对象中补充维生素D对膝关节疼痛都没有显著影响。补充维生素D对胫骨软骨体积无影响[SMD=0.12,95%CI:(-0.05,0.29)]。在关节间隙结构改善方面差异无统计学意义[SMD=0.07,95%CI:(-0.08,0.23)]。结论目前缺乏强有力的证据来支持补充维生素D在膝关节骨关节炎患者中能对病情起到根本性作用。还需要进行更精心化设计的、更高质量的、样本量更大的、更长随访时间的临床随机对照试验来进一步明确补充维生素D对膝关节骨关节炎患者病情的影响。