全文获取类型
收费全文 | 358篇 |
免费 | 19篇 |
国内免费 | 27篇 |
专业分类
儿科学 | 2篇 |
基础医学 | 41篇 |
临床医学 | 27篇 |
内科学 | 6篇 |
神经病学 | 19篇 |
特种医学 | 26篇 |
外科学 | 200篇 |
综合类 | 52篇 |
预防医学 | 6篇 |
药学 | 9篇 |
中国医学 | 12篇 |
肿瘤学 | 4篇 |
出版年
2023年 | 6篇 |
2022年 | 6篇 |
2021年 | 19篇 |
2020年 | 10篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 7篇 |
2016年 | 8篇 |
2015年 | 9篇 |
2014年 | 22篇 |
2013年 | 15篇 |
2012年 | 18篇 |
2011年 | 29篇 |
2010年 | 31篇 |
2009年 | 22篇 |
2008年 | 22篇 |
2007年 | 13篇 |
2006年 | 19篇 |
2005年 | 17篇 |
2004年 | 11篇 |
2003年 | 10篇 |
2002年 | 11篇 |
2001年 | 17篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
排序方式: 共有404条查询结果,搜索用时 296 毫秒
1.
胸椎黄韧带骨化症手术并发硬脊膜损伤或脑脊液漏的原因分析及防治 总被引:30,自引:2,他引:28
目的:分析胸椎黄韧带骨化症(ossification of ligamentum flavum,OLF)手术并发硬脊膜损伤或脑脊液漏的原因,并探讨其防治方法。方法:对103例手术治疗的胸椎OLF患者中并发硬脊膜损伤或脑脊液漏病例的临床资料进行回顾性分析。结果:30例发生硬脊膜损伤,发生率为29.13%;22例术后发生脑脊液漏,发生率为21.36%,其中21例患者经以俯卧位为主的综合治疗后痊愈,1例发生伤口全层裂开,二次手术后痊愈。结论:硬脊膜损伤或脑脊液漏是胸椎OLF手术易发生的并发症;俯卧位为主的综合治疗是治疗术后脑脊液漏的有效方案,但患者较痛苦,有待改进。 相似文献
2.
Prof. Dr. Bernhard Tillmann 《Operative Orthopadie und Traumatologie》1992,4(3):181-184
Ohne Zusammenfassung
相似文献
3.
4.
以硫酸二乙酯(DES)诱变处理黄色短杆菌(Brevibacteriumflavum)XQ5122,得到突变株V3-36<Leu ̄1、α-AB ̄r、AHV ̄r),在10%葡萄糖培养基中可积累2.3%L-缬氨酸。以亚硝基胍(NTG)诱变V4-153,得到一株突变株(Leu ̄1、α-AB ̄r、AHV ̄r、2-TA ̄r),再进行单菌落分离,得到突变株ZQ-2,能在培养基中积累L-缬氨酸4.2%~4.5%,最高达5.57%. 相似文献
5.
Combined laparoscopic and endoscopic treatment of perforated gastroduodenal ulcer using the ligamentum teres hepatis (LTH) 总被引:2,自引:2,他引:0
We propose a novel technique for laparoscopic treatment of perforated gastroduodenal ulcers. The principle of this procedure involves the closure of the perforated ulcer using the ligamentum teres hepatis (LTH). The LTH is cut near its umbilical end and then dissected up to the site of its hepatic insertion. The umbilical extremity of LTH is grasped with a Dormia noose passed through the ulcerated perforation via a gastroscope. Using the noose, the LTH is pulled through the ulcerated perforation until its volume fits and completely closes the perforation. This laparoscopic technique was performed in 15 patients (12 M, 3 F) with anterior perforated duodenal ulcer revealed within the previous 6 h. The procedure could not be performed in three cases: diameter of the perforation exceeding 1.5 cm (n=1), general purulent peritonitis (n=2). In the other 12 cases, closure of the ulcerated perforation with the LTH was realized without technical difficulty. The postoperative course was uncomplicated. The posttreatment comfort was excellent; the mean period of hospitalization was 10 days (range, 8–14 days). An endoscopic examination carried out following 5 weeks of anti-H2 treatment showed that cicatrization of the ulcer was good and that no pyloric stenosis remained. These initial results suggest that laparoscopic treatment of perforated gastroduodenal ulcer using the LTH is a simple procedure which can be performed with general assurance of success in patients whose perforated ulcers have occurred quite recently. As the laparoscopic procedure is less aggressive than a laparotomy, it enhances the postoperative comfort of patients and prevents the risk of parietal complications. Compared to laparoscopic endosuture this procedure is simple, effective, easier, and particularly adapted to large ulcerated perforation or when an ulcer's edges are tough or friable, tending to tear when knots are tied.Presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Nashville, TN, USA, 18–19 April 1994. 相似文献
6.
Nakama S Kikuchi M Yashiro T Sakamoto A Kikkawa I Ookami H Saita K Hoshino Y 《Medical molecular morphology》2005,38(3):173-180
Ossification or calcification of the ligamentum flavum (LF) is relatively common in the middle and lower cervical, thoracic, and lumbar spine but extremely rare in the upper cervical region. This clinical fact suggests that there exist local factors promoting or preventing ossification or calcification of LF. However, little is known about the differences in the ultrastructure and cellular alterations of the LF between the different spinal levels, even in the cervical spine. With electron microscopy, we examined samples of LF collected surgically from the upper and lower cervical spine regions; we then studied the apoptotic appearance of ligament cells using a preferential labeling method. We found direct evidence of apoptosis of ligament cells in the LF. Apoptosis was more apparent in the upper region samples than in the lower region samples. The spaces around the normal fibroblasts were filled with thick collagen fibrils, but the collagen fibrils disappeared around the apoptotic bodies and thin fibrils were formed. The difference of the level of apoptosis may correlate to the ultrastructual difference of LF, and our data will benefit further investigations seeking to clarify the mechanism of various pathological conditions in the human LF. 相似文献
7.
Ei Kawahara Yoshio Oda Shogo Katsuda Isao Nakanishi Kunihiko Aoyama Katsuro Tomita 《Virchows Archiv : an international journal of pathology》1991,419(5):373-380
Summary Thickened ligamenta flava obtained from 14 patients with spinal canal stenosis were examined with special reference to type VI collagen. The characteristic histological finding in the thickened area was rupture of normal elastic fibre meshwork with resultant fibrosis which usually appeared hyaline. Using an immunohistological method, collagen types VI, I and III were found to be present in the hyaline matrix. Ultrastructural study revealed many microfilamentous structures of type VI collagen admixed in loosely packed, banded collagen fibres. With differential salt precipitation of pepsin-extracted collagen the existence of type VI collagen was confirmed by SDS-polyacrylamide gel electrophoresis analysis and Western blotting analysis using anti-type VI collagen antibody. Quantification of type VI collagen in pepsin-extracted crude collagen samples by an inhibition enzyme-linked immunosorbent assay showed an increasing amount of type VI collagen in the thickened ligamenta flava compared to the normal ligaments. Thus, increase of type VI collagen is the main contribution to the thickening of the ligamentum flavum. This may represent an adaptational and reparative process associated with disruption of elastic fibres. 相似文献
8.
Summary An anatomic and embryologic study of congenital absence of the pericardium and the relationship of the ligamentum arteriosum to this defect was carried out by the authors. A case report is presented to clinically correlate the anatomic and radiologic findings in this anomaly. The authors propose that visualization of the ligamentum arteriosum by computed tomography is a characteristic sign for congenital absence of the left pericardium.
Absence congénitale de péricarde, ses relations avec le ligament artériel
Résumé Les auteurs ont effectué une étude anatomique et embryologique de l'absence congénitale du péricarde et des relations entre le ligament artériel et cette absence. Ils rapportent une observation à propos de laquelle ils établisent les corrélations cliniques des données anatomiques et radiologiques de cette variation. Ils suggèrent que la visualisation du ligament artériel par tomodensitométrie soit interprétée comme un signe caractéristique de l'absence congénitale du péricarde gauche.相似文献
9.
Lora L. Brown MD 《Pain practice》2012,12(5):333-341
Background: Epidural steroid injections (ESIs) are commonly used to treat low back pain, including symptomatic lumbar spinal stenosis (LSS). Reports on LSS treatment with ESIs have not differentiated between neurogenic claudication, which is believed to result from nerve root compression, and lumbar radicular pain, thought to be caused by inflammation. While there is overlap between these groups, the clinical relevance of ESI treatment cannot be generalized between these 2 distinct diseases with completely different pathophysiological causes. Methods: This was a double‐blind, randomized, prospective study of ESI vs. the mild procedure in patients with symptomatic LSS, conducted at a single pain management center. Patient reported outcome measures included Visual Analog Scale, Oswestry Disability Index, and Zurich Claudication Questionnaire (ZCQ) patient satisfaction. Results: Thirty‐eight patients were randomized into 2 treatment groups, 21 in mild and 17 in ESI. At 6‐ and 12‐week follow‐up, patients treated with mild reported significantly greater pain decrease over time (P < 0.0001), and significantly greater functional mobility improvement over time (P < 0.0018) than ESI patients. At week 6, mild ZCQ patient satisfaction score of 2.2 indicated a higher level of satisfaction than for ESI with a score of 2.8. In addition, 12‐week ZCQ satisfaction score was 1.8, demonstrating sustained near‐term satisfaction in the mild group. No major mild or ESI device or procedure‐related complications were reported. Conclusions: This study demonstrated that in LSS patients suffering with neurogenic claudication, mild provides statistically significantly better pain reduction and improved functional mobility vs. treatment with ESI. 相似文献
10.
Murat Yilmaz Orhan Kalemci Hakan Yilmaz Necdet M. Palaz 《International journal of surgery case reports》2013,4(8):645-647
INTRODUCTIONSymtomatic lumbar ligamantum flavum calcification is quite rare in the young age group.PRESENTATION OF CASEThe authors report a case of young adult with diagnosis of lumbar spinal stenosis, presenting with leg pain and neurological deficits. Computerized tomography (CT) scan and magnetic resonance (MR) imaging studies revealed ossification of the ligamantum flavum as the causative factor of the disease and the patient recovered completely after the decompressive operation.DISCUSSIONIt is emphasized that attention should be given to this rare etiological factor of lumbar spinal stenosis.CONCLUSIONComplete relief can be achieved with early and adequate surgery. 相似文献