Cor triatriatum associated with partial anomalous pulmonary venous connection to the coronary sinus: Echocardiographic and angiocardiographic features

Summary An infant girl is described who had cor triatriatum and partial anomalous pulmonary venous connection of the left pulmonary veins to the coronary sinus, the first report of this combination of lesions. The infant also had a Dandy-Walker malformation and multiple facial and intrathoracic hemangiomas. The cardiac diagnosis was made by two-dimensional echocardiography. Cardiac catheterization and angiography confirmed the findings and also demonstrated a persistent left superior vena cava draining to the coronary sinus. The infant underwent successful surgical repair. Partial anomalous pulmonary venous connection and left superior vena cava not infrequently are associated with cor triatriatum. Although two-dimensional echocardiography is sensitive for the detection of cor triatriatum, preoperative cardiac catheterization is necessary to identify unequivocally systemic and pulmonary venous connections.     

人胰腺导管腺癌组织及癌旁组织双向电泳图谱的差异分析

目的:探讨人胰腺导管腺癌组织和癌旁组织之间差异的表达蛋白。方法:利用双向凝胶电泳（2-DE）对8例胰腺导管腺癌组织和癌旁组织的总蛋白进行分离,并用质谱仪对两组间差异蛋白质点进行肽指纹谱和串联质谱鉴定。利用蛋白质印迹分析和免疫组化法检测差异蛋白在胰腺癌和癌旁组织的表达。结果:2-DE显示,肿瘤组织中有28个蛋白质点表达上调,17个表达下调。上述蛋白质点经质谱鉴定得到30个蛋白质,包括酶类、抗氧化蛋白、信号转导蛋白、钙结合蛋白、结构蛋白及分子伴侣等。Western blot和免疫组化结果显示差异表达蛋白annexin II在胰腺癌组织中表达上调,与2-DE结果一致。结论:以2-DE为基础的蛋白质组学技术是研究肿瘤的一种重要手段。本实验所得的annexin II等差异表达蛋白可能成为潜在的诊断胰腺癌的分子标志或控制肿瘤生长的治疗靶点。     

超声诊断甲状腺腺瘤与单发结节性甲状腺肿的价值

目的　探讨超声在甲状腺腺瘤与单发结节性甲状腺肿鉴别诊断中的价值。方法　对两种疾病的二维及彩色多普勒声像图进行分析并比较。结果　甲状腺腺瘤与单发结节性甲状腺肿比较 ,甲状腺大小、结节大小、结节内回声及周围回声组间差异均无统计学意义 (P >0 .0 5 ) ;结节边缘晕环及结节内部和周边血流信号差异有显著性 (P <0 .0 5 )。结论　单发结节性甲状腺肿易误诊为腺瘤 ,结节边缘晕环及结节内部和周边血流信号对鉴别诊断可提供帮助     

Two-dimensional echocardiography in the diagnosis of intracardiac masses: A prospective study with anatomic validation

The accuracy of two-dimensional echocardiography in the detection of intracardiac masses was verified in 334 patients who underwent cardiac catheterization in our laboratory over 21 consecutive months. A complete two-dimensional echocardiographic (2DE) examination was performed a day before catheterization. The presence or absence of a mass was verified at surgery in 77 patients who successively underwent mitral or aortic valve replacement (51), left ventricular aneurysmectomy with or without myocardial revascularization (25), and resection of atrial myxoma (2). In 32 patients 2DE revealed the presence of a mass-left or right atrial thrombi in 12, left atrial myxoma in 2, left ventricular thrombi in 16, and endocardial vegetations in 2. The other 45 patients were free of intracardiac masses on 2DE. Anatomic verification at surgery revealed the presence of an intracardiac mass in 34 patients. In 30 (true positives) of these, 2DE revealed the mass as well, and in 4 (false negatives) the presence of a mass had not been identified by 2DE. In 2 patients (false positives) the predicted mass was not found at surgery. Absence of a mass was correctly predicted by 2DE in 41 patients (true negatives). Thus 2DE detected intracardiac masses with sensitivity of 88.2% and a specificity of 95.3%. We recommend that 2DE be performed in all patients prior to hemodynamic study and/or cardiac surgery to enable safer management of patients with intracardiac masses during cardiac catheterization and/or cardiac surgery.     

抗性家蝇蛹期多肽的双向电泳分析

分析抗性家蝇蛹期多肽，以了解蛋白质变化情况。方法：对家蝇的抗性株、对照株和敏感株蛹体内的多肽进行了聚丙烯酸胺凝胶电泳分析。结果：抗性株具有一特异的多肽点，且有3个多肽点在量上明显多于对照株。结论：杀虫剂的作用可使抗性家蝇体内的蛋白在质和量上发生改变。