Graves病硫脲类药物治疗所致甲减（附32例临床分析）

Ｇｒａｖｅｓ病硫脲类药物治疗所致甲减（附３２例临床分析）广东省广宁县人民医院内科（５２６３００）梁如庆广州军区广州总医院内分泌科王国华，林延德Ｇｒａｖｅｓ病（弥漫性甲状腺肿伴甲状腺功能亢进症）的治疗方面，鉴于多数患者对手术有顾虑，同位素碘治疗尚不能普...     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

自制幼儿口垫在临床胃镜检查中的作用

近年来，幼儿将硬币、游戏机币、钮扣等小物件吞入食管、胃内的病例时有发生。行胃镜取幼儿食管及胃内异物时。建立口通道常有困难，市售口垫直径过大，难以放入幼儿口部且质地过硬，容易对幼儿口唇造成损害，再就是长度过短，不能压住幼儿舌体。笔者从2001年用自制口垫很好地解决了这些问题。     

老年人高血压性脑出血急性期T淋巴细胞亚群的检测及初步探讨

老年人高血压性脑出血急性期Ｔ淋巴细胞亚群的检测及初步探讨王国华，张秀华，白颖哈市第一医院神经科王文宝哈市第一医院血液病研究所祁威，方俊兰哈市第十医院神经科自从１９７９年Ｒｅｉｎｈｅｒｚ获得淋巴细胞单克隆抗体以来，使人们对Ｔ淋巴细胞亚群及其临床意义逐渐...     

饮食服务业58241名从业人员HBV感染状况调查分析

目的　了解饮食服务业从业人员乙型肝炎病毒感染状况。方法　应用ELISA方法对 5 82 4 1名饮食服务业从业人员进行了血清HBsAg、抗 HBc、HBeAg和抗 HBe检测。结果　 2 0 0 0～ 2 0 0 4年饮食服务业从业人员血清HBsAg、抗 HBc、HBeAg和抗 HBe总阳性率呈逐年下降趋势 ,依次为 4 .39%、3. 85 %、3. 4 7%、2. 84 %和 2 4 3% ,其差异有统计学意义 (χ2 =88. 4 1,P <0 . 0 1) ,每间隔 1年及其以上的两个年度的阳性率之间的差异均有统计学意义(均P <0. 0 1)。结论　饮食服务业从业人员HBV感染率呈逐年下降趋势。     

清胃散加味治疗腮腺炎的体会

流行性腮腺炎是由腮腺炎病毒所引起的急性呼吸道传染病 ,好发于儿童时期 ,亦可见于成人。1　资料与方法1.1　一般资料 :从 1999年 5月至 2 0 0 2年 7月共治疗病例12例 ,其中男性 9例 ,女性 3例 ,年龄 5～ 41岁。1.2　治疗方法 :1处方 :当归 15 g,生地黄 2 0 g,黄连 10 g,升麻 15 g,丹皮 12 g,石膏 (先煎 ) 3 0 g,麻黄 9g,板蓝根 10g。 2用法 :先煎石膏 3 0 min,再入他药 ,煎药用水超过药面2 cm高 ,煎煮 2次后 ,将药液混合均匀 ,分早晚服。服药 2～5剂。2　结　　果痊愈 8例 ,有效 3例 ,无效 1例 ,总有效率为 91.7%。3　讨　　论流行性腮腺炎…     

肝硬化患者糖代谢变化的观察

为探讨肝硬化患者糖代谢变化的特点，对４６例肝硬化患者进行了空腹血糖、糖化蛋白、胰岛素和Ｃ肽含量的测定。结果显示肝硬化患者空腹血糖、糖化蛋白及胰岛素含量均明显高于正常对照组，变化程度与肝硬化病情程度相关。ＣｈｉｌｄＣ级患者血清Ｃ肽低于正常对照组。提示胰岛素代谢异常在肝硬化患者糖代谢紊乱中起一定作用。     

新生儿窒息心电图改变及其意义

本文对我院1992年6月～1996年10月72例新生儿窒息患儿心电图进行观察分析，以此指导临床用药。临床资料本组男37例，女35例；早产儿16例，足月小样儿9例，足月新生儿47例。轻度窒息49例，重度23例。观察时间：出生2d内有心电图异常者，治疗1wk后复查。新生儿窒息患儿心电图表现