中医药古籍文献实体标注规范探索

针对中医药古籍文献进行语义标注,以《健康信息学—中医药学语言系统语义网络框架》中医药学语言系统的语义网络框架为标准,参考清代医籍的语料分类模式,结合中医古籍文献的特点,面向中医临床证治主题,选取与临床诊疗密切相关的“病—证—治—方—药”术语,探索性标注9类语料实体,提出中医药语料实体标注流程规范、总原则,并同时基于标注实践对在标注过程中产生的易混淆的实体进行进一步细化区分,以期为中医药文献语料实体标注研究提供参考,帮助研究人员快速、准确地进行知识检索与获取。     

Wendan Decoction(温胆汤) for Treatment of Schizophrenia: A Systematic Review of Randomized Controlled Trials

Objective: To assess the beneficial and adverse effects of Wendan Decoction(温胆汤, WDD) for the treatment of schizophrenia. Methods: Five electronic databases were searched until May 2014, including the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, the Chinese Scientist Journal Database, Pub Med, and the Cochrane Central Register of Controlled Trials in the Cochrane Library. The randomized controlled trials(RCTs) testing WDD against placebo, antipsychotic drugs, or WDD combined with antipsychotic drugs against antipsychotic drugs alone were included. Study selection, data extraction, quality assessment, and data analyses were conducted according to the Cochrane standards. Results: Thirteen RCTs(involving 1,174 patients) were included and the methodological quality was evaluated as generally low. The pooled results showed that WDD combined with antipsychotic drugs were more effective in clinical comprehensive effect, Positive and Negative Syndrome Scale(PANSS) scores and Brief Psychiatric Rating Scale scores compared with antipsychotic drugs alone. However, WDD had less effectiveness compared with antipsychotics in clinical comprehensive effect; and WDD was not different from antipsychotic drugs for PANSS scores. The side effects were significantly reduced in the intervention group compared with the control group. Conclusions: WDD appears to be effective on improving symptoms in patients with schizophrenia. However, due to poor methodological quality in the majority of the included trials, the potential benefit from WDD needs to be confirmed in rigorous trials and the design and reporting of trials should follow the international standards.     

数据库技术辅助的文献检索与筛选方案研究

目的 为解决目前文献检索与筛选中存在的问题,提出一种基于数据库技术的文献检索与筛选方案.方法 以"中药引起的药物性肝损伤"文献检索与筛选为例,利用Access数据库结构化查询语言(SQL)的查询视图功能,通过关键词查询文献标题,按照不同层次、主题以及步骤,逐层递进筛选文献.人工复核筛选结果,同时完成关键词迭代,获得最终...     

近10年中医药科技评价研究现状与趋势分析

目的:通过文献分析,对近10年中医药科技评价研究现状以及该领域研究热点进行分析,为科研人员开展相关研究提供参考依据。方法:基于CNKI数据库资源,经检索、筛选、纳入、分析,获得文献计量学特征,分析文献内容。结果:检索获得中医药科技评价相关文献136篇,文献累积量趋势图显示中医药科技评价研究正在受到越来越多的人关注,分析该领域研究热点内容为:绩效评价、成果及成果转化评价、文献质量评价。结论:中医药科技评价研究越来越受到科研人员的关注,如何在借鉴其他科技评价工作的基础上开展具有中医药特色的科技评价对促进中医药发展具有重要意义。     

药物致肝损伤数据集的比较研究

目的 调研并对比药物性肝损伤（DILI）数据集的数据来源、DILI风险评估与药品分类方法,为DILI数据集构建及临床、科研、监管等部门提供参考。方法 选取包含药品数量在300以上且对DILI严重程度进行评估的5个数据集（DILIrank, DICIst, Liver Tox, Suzuki, Greene）,比较分析其数据来源、数据量、DILI风险评估方法以及药品分类。结果 数据来源包括药品标签、文献、网络数据库、临床/注册中心病例、监管机构等多个渠道;LiverTox包含药品数量最多,DILIrank与其他数据集的重合度最高,DILIrank和LiverTox分类更详细;DILI风险评估按照肝损伤的严重程度及发生概率分类,并通过专家意见或因果关系评估量表确定DILI。结论 高质量数据集与其数据来源、数据数量、评估方法及药品分类有关;中国药物性肝损伤数据集尤其是中药DILI数据集需完善。