喉癌中Fas、FasL和Fas相关死亡结构域蛋白的表达及其意义

目的研究细胞凋亡调控因子Fas、FasL和Fas相关死亡结构域蛋白（Fas-associated death domain protein,FADD）基因在喉癌中的表达及其意义。方法免疫组化法检测喉癌及癌旁组织中Fas、FasL和FADD表达。结果喉癌组织中Fas、FADD阳性表达率显著低于癌旁组织,FasL阳性表达率显著高于癌旁组织（P〈0.05）;高分化鳞状细胞癌（简称鳞癌）Fas阳性表达率显著高于中低分化鳞癌（P〈0.05）,高分化鳞癌FasL阳性表达率显著低于中低分化鳞癌（P〈0.05）;FADD阳性表达率与肿瘤有无淋巴结转移密切相关（P〈0.05）。Fas与FADD蛋白表达之间呈显著正相关（r=0.43,P〈0.05）。结论检测喉癌组织中Fas、FasL、FADD表达对评价喉癌的恶性程度、预后及治疗有重要意义。     

KAI1/CD82在喉癌组织中的表达及其临床意义

目的：探讨KAI1／CD82在喉癌组织中的表达水平及与患者临床病理特征的关系。方法：选取61例喉癌患者手术切除的病理组织标本（喉癌组）及61例癌旁组织标本（对照组），应用免疫组织化学法检测KAI1／CD82的表达水平。结果：喉癌组KAI1／CD82的表达水平低于对照组（P〈0.05）；肿瘤原发灶KAI1／CD82表达水平高于淋巴结转移灶（P〈0.05）；KAI1／CD82的表达水平与喉癌患者的淋巴结转移密切相关（P〈0.05），但在不同年龄、临床分期及组织分化程度的患者之间的表达差异无统计学意义（P〉0.05）。结论：KAI1／CD82的表达在喉癌的转移过程中具有一定作用，可作为预测肿瘤转移潜能的指标。     

Dickkopf-1和GATA-6在喉癌中的表达及意义

目的：研究Dickkopf-1和GATA-6蛋白在喉癌组织中的表达,探讨二者在喉癌发生、发展中的作用及二者的相关性。方法：应用免疫组织化学方法（SP法）检测48例喉癌组织及48例相应癌旁组织、20例非喉癌患者喉部正常黏膜组织中Dickkopf-1和GATA-6蛋白的表达情况。结果：①Dickkopf-1蛋白在喉癌组织中的阳性表达率明显低于癌旁组织和正常喉部黏膜组织（P〈0.05）;②GATA-6蛋白在喉癌组织中的阳性表达率明显高于癌旁组织和正常喉部黏膜组织（P〈0.05）;③Dickkopf-1和GATA-6蛋白在喉癌组织中的表达与喉癌淋巴结转移、临床分期、病理分级有相关性（P〈0.05）;④喉癌组织中Dickkopf-1蛋白表达和GATA-6蛋白表达呈负相关（r=-0.490,P〈0.01）。结论：Dickkopf-1和GATA-6蛋白的表达与喉癌的发生、发展有关。     

扁桃体和腺样体肥大患儿心理行为特征的对照研究

目的：扁桃体和腺样体肥大对儿童心理行为的影响。方法：采用湖南医科大学龚耀先1986年修订的Achenbach儿童行为量表对97例扁桃体和腺样体肥大患儿进行心理行为的检测。结果：扁桃体和腺样体肥大儿童心理行为异常检出率明显高于对照组。扁桃体和腺样体肥大患儿心理行为的总粗分均显著高于对照组,差异有统计学意义（P〈0．01）。男孩主要表现在分裂性、交往不良、强迫性、多动、违纪方面,女孩主要表现在体诉、多动、攻击方面,均差异有统计学意义（均P％0．01）。行扁桃体切除术和腺样体切除术3个月后,对患儿进行第2次测试,术后男孩在分裂性、抑郁、强迫性、体诉方面分数及总粗分明显低于术前值,差异有统计学意义（P〈0．05）。女孩在抑郁,强迫分裂性、违纪、攻击、残忍方面分数及总粗分明显低于术前值,差异有统计学意义（P〈0．05）。心理行为异常检出率与患儿年龄呈正相关。结论：扁桃体和腺样体肥大对患儿的心理行为有比较明显的影响,应加强对扁桃体和腺样体肥大患儿的心理行为干预。     

VCAM-1表达在上下呼吸道一致性的研究

目的：探讨血管内皮细胞黏附分子（VCAM-1）在呼吸道变应性炎症患者中的表达和意义。方法：将39名患有变应性鼻炎并哮喘的患者和21例仅患有变应性鼻炎的患者分成两组,取鼻腔黏膜和支气管黏膜进行活组织病理检查,并用免疫组织化学的方法对VCAM-1的表达进行检测。结果：变应性鼻炎并哮喘组支气管黏膜中嗜酸粒细胞数显著高于变应性鼻炎组（t=12．81,P〈0．01）,变应性鼻炎组鼻腔黏膜中VCAM-1阳性细胞比例与变应性鼻炎并哮喘组相比差异无统计学意义。变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例显著高于变应性鼻炎组（t=9．43,P〈0．01）,变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例和支气管黏膜嗜酸粒细胞数呈显著正相关（r=0．788,P〈0．01）。结论：VCAM-1表达的上调,导致呼吸道变应性炎症的蔓延。     

慢性扁桃体炎与扁桃体肥大患者扁桃体中铁和锌含量的研究

目的　通过测定扁桃体组织中铁和锌元素的含量来研究这两种元素在慢性扁桃体炎和扁桃体肥大发病机制中扮演的角色。方法　选取40例在我院行扁桃体切除术的患者,根据病史、临床特征和病理学表现分为扁桃体肥大组和慢性扁桃体炎组。用微波消解-石墨炉原子吸收法测定其扁桃体组织中铁和锌的含量。结果　铁和锌的含量在扁桃体肥大组和慢性扁桃体炎组中均有显著性差异（t 铁=3.89,t 锌=3.63,P 均＜0.001）。扁桃体肥大组中铁和锌的含量均高于慢性扁桃体炎组。结论　扁桃体组织中铁和锌含量的降低会导致扁桃体炎反复发作。     

变应性鼻炎患者转录因子GATA-3和细胞间黏附分子-1的表达及其相关性的实验研究

目的：探讨变应性鼻炎患者鼻黏膜组织中转录因子GATA3和细胞间黏附分子-1（ICAM-1）的表达及关系。方法：通过逆转录多聚酶链反应（RTPCR）和酶联免疫吸附试验（ELISA）,检测32例变应性鼻炎患者和12例对照鼻黏膜组织中GATA3和ICAM1的表达。结果：PCR反应后变应性鼻炎患者和对照鼻黏膜组织中GATA3相对密度分别为0．632±0．121和0．131±0．024;ICAM-1的含量为（237．5±37．3）pg／mg和（121．7±22．4）pg／mg;GATA-3与ICAM-1的表达呈正相关关系（r=0．8128,P〈0．05）。结论：GATA-3参与了变应性鼻炎病理过程中ICAM1的过度表达,对变应性鼻炎的发生、发展具有重要的意义。     

血管细胞黏附分子-1及P-选择素在喉咽癌中的表达及与微血管密度的相关性研究

目的：检测喉咽癌组织中血管细胞黏附分子-1（vascular cell adhesion molecule-1，VCAM-1）及P-选择素的表达及其与微血管密度（mierovessel density，MVD）间的关系，探讨VCAM-1及P选择素在喉咽癌血管生成中的意义。方法：用免疫组织化学方法检测40例喉咽癌组织和10例正常口咽部黏膜组织中VCAM-1、P选择素及CD34表达并计数MVD。结果：VCAM-1及P-选择素在喉咽癌组织中的表达率显著高于正常口咽部黏膜组织（P〈0．01）；喉咽癌组织的MVD值显著高于正常口咽部黏膜组织（P〈O．01），MVD值与有无淋巴结转移密切相关（P〈0．01）；VCAM-1及P-选择素表达阳性组MVD值显著高于表达阴性组（P〈0．01），且VCAM-1及P-选择素表达均与MVD呈正相关（P〈0．05）；在喉咽癌淋巴结转移组中，VCAM-1及P选择素的表达呈正相关关系。结论：VCAM-1及P-选择素在喉咽癌组织中的高表达在肿瘤的浸润和转移中起重要作用，并与肿瘤血管生成有关．     

肺表面活性蛋白A在变应性鼻炎鼻黏膜及鼻息肉组织中的表达及意义

目的：肺表面活性蛋白A（SP—A）在呼吸道中发挥重要的宿主防御作用。本研究的目的是了解SP-A在变应性鼻炎鼻黏膜和鼻息肉组织中的表达情况,探讨SP—A在上呼吸道炎症反应性疾病中发挥的作用。方法：采用免疫组织化学方法和间接免疫荧光法分别检测11例变应性鼻炎患者鼻黏膜组织（变应性鼻炎组）、15例鼻息肉患者的息肉组织（鼻息肉组）和7例行鼻中隔偏曲矫正术患者的中鼻甲组织（对照组）中SP-A的表达。结果：免疫组织化学方法结果显示变应性鼻炎组及鼻息肉组中SP—A的表达明显高于对照组（P〈0．05）,变应性鼻炎组及鼻息肉组黏膜下嗜酸粒细胞的数量明显高于对照组（P〈0．05）,变应性鼻炎组及鼻息肉组中SP-A的表达与黏膜下嗜酸粒细胞的数量均呈正相关（r分别为0．81,0．55）;免疫荧光法结果显示SP—A在变应性鼻炎组及鼻息肉组黏膜上皮细胞内的绿色荧光强度高于对照组（P〈0．05）。结论：SP-A可能参与了变应性鼻炎与鼻息肉的炎症反应过程。SP—A在上呼吸道炎症性疾病中的表达,为今后寻找新的治疗方法提供理论思路。     

黏蛋白在鼻息肉及变应性鼻炎中的基因表达水平的研究

目的：探讨5种人黏蛋白基因（MUC2、MUC5AC、MUC5B、MUC18、MUC19）在鼻息肉和变应性鼻炎中的基因表达水平及临床意义。方法：采用RT-PCR及实时荧光定量RT-PCR,检测35例鼻息肉、18例变应性鼻炎患者下鼻甲及18例正常人黏蛋白基因（MUCS）在下鼻甲黏膜上皮的基因表达水平。结果：RT-PCR及实时荧光定量RT-PCR的结果表明,MUC5AC、MUC5B在鼻息肉组和变应性鼻炎组中的表达高于对照组（P〈0.05）,鼻息肉组与变应性鼻炎组及对照组间表达差异均无统计学意义（P〉0.05）。MUC2、MUC18在3组中的表达差异无统计学意义（P〉0.05）。MUC19在变应性鼻炎组中的表达高于鼻息肉组和对照组（P〈0.05或P〈0.01）。结论：MUC5AC和MUC5B在鼻息肉、变应性鼻炎的黏液过度分泌过程中具有重要意义;MUC19在变应性鼻炎的黏液过度分泌过程中也有重要意义,但是对鼻息肉患者的黏液分泌没有明显作用;未发现MUC2、MUC18在变应性鼻炎的黏液过度分泌过程中起明显作用。     

Clinical significance of elevated serum sICAM-1 in patients with nasopharyngeal carcinoma]

OBJECTIVE: To study the expression of serum sICAM-1(soluble intercellular adhesion molecule-1) and tissue ICAM-1 in nasopharyngeal carcinoma and its clinical significance. METHODS: Expression of ICAM-1 in frozen sections of 20 normal nasopharyngeal mucosa and 54 nasopharyngeal carcinoma samples were studied with immunohistochemical technique, and levels of serum sICAM-1 in 54 patients with nasopharyngeal carcinoma (NPC group) and 32 healthy adults (normal group) by ELISA. RESULTS: Positive expression (45/54) of tissue ICAM-1 and levels (2,044.48 +/- 640.05) microgram/L of serum sICAM-1 in NPC group were significantly higher than that of 2/20 and (313.70 +/- 114.98) microgram/L in normal group (P < 0.01, respectively), and there was a positive relationship between the expression of tissue ICAM-1 and levels of serum sICAM-1 in nasopharyngeal carcinoma(P < 0.05). The levels (2,177.31 +/- 642.13) microgram/L of serum sICAM-1 in patients with III-IV stages were higher than those (1,847.25 +/- 308.15) microgram/L in I-II stages (P < 0.05), and those (1,678.89 +/- 685.01) microgram/L in patients with no lymph node metastasis lower than that (2,134.34 +/- 609.60) microgram/L in lymph node metastasis (P < 0.05). The levels of serum sICAM-1 decreased significantly from (2,211.42 +/- 717.59) microgram/L to (926.55 +/- 207.72) microgram/L in disappearance of tumor and metastatic lymph node after radiotherapy (P < 0.01). CONCLUSION: sICAM-1 might be involved in the cellular immunopathogenesis of nasopharyngeal carcinoma, and the measurement of the serum sICAM-1 may reflect ability of neoplasm cell in freedom from host immunological surveillance. Dynamic measurement of serum sICAM-1 may be a useful objective index to evaluate NPC prognosis and curative effects.     

Expression of intercellular adhesion molecule (ICAM)-1 in adenoid cystic carcinoma of the head and neck

OBJECTIVES/HYPOTHESIS: Adenoid cystic carcinoma of the head and neck (ACCHN) is characterized by late recurrence and frequent distant metastasis. Tumor attack by cytotoxic T lymphocytes and macrophages is mediated by the interaction of leukocyte function-associated antigen (LFA)-1 on lymphocytes with intercellular adhesion molecule (ICAM)-1 on the tumor surface. Thus, the reduced expression of ICAM-1 on tumor cells could contribute to their escape from host immune surveillance. To investigate the relationship between the clinical features of ACCHN and host immune surveillance, the expression of ICAM-1 and infiltration of T/natural killer (NK) cells and macrophages were immunohistochemically examined. STUDY DESIGN: Retrospective analysis of immunohistochemical tumor characteristics and clinical outcome. METHODS: Immunohistochemical study of ICAM-1, T/NK cells, and macrophages was performed on paraffin sections of 42 patients with ACCHN. The expression of T/NK cells and macrophages was represented by T-cell-restricted antigen (TIA)-1 and CD68 expression, respectively. The expression of these molecules and clinical features were analyzed. RESULTS: Of 42 ACCHN cases, 15, 9, and 15 patients were classified as ICAM-1 high, TIA-1 high, and CD68 high, respectively. The TIA-1 expression scores in ICAM-1-low patients were significantly lower than those in ICAM-1-high patients (1.3 +/- 3.7 vs. 8.3 +/- 12.7, P =.0031). The CD68 expression scores in ICAM-1-low patients were also significantly lower than those in ICAM-1-high patients (9.6 +/- 9.6 vs. 21.1 +/- 17.6, P =.0047). Moreover, ICAM-1-high patients had a significantly better disease-free survival rate (P =.043). CONCLUSIONS: Reduced expression of ICAM-1 may promote immune evasion and metastasis, resulting in poor prognosis in ACCHN.     

喉鳞癌组织Fas和FasL蛋白表达及临床意义

目的 :探讨Fas、FasL蛋白在喉鳞癌 (LSCC)组织中的表达及意义。方法 :采用SABC免疫组化法检测 4 2例LSCC及 2 0例手术切缘正常组织中Fas及FasL ,并与LSCC病理分级、临床分期及颈淋巴结转移相比较。结果 :Fas及FasL在LSCC中阳性率分别为 4 7.6 %和 6 4 .3% ,与在正常喉组织阳性率 90 .0 %和 2 0 .0 %相比 ,差异有显著性意义 (P <0 .0 5 )。Fas阳性率与肿瘤分级分期无显著相关性 (P >0 .0 5 ) ,与肿瘤转移有关 (P <0 .0 5 ) ;FasL阳性率与肿瘤分级、分期及转移密切相关 (P <0 .0 5 )。Fas与FasL的表达无显著相关性。结论 :Fas及FasL表达异常可能参与喉鳞癌的发生和发展 ;检测Fas与FasL可望作为判定喉鳞癌预后的潜在指标。     

细胞间黏附分子-1在喉癌间质淋巴细胞中的表达及其临床意义

目的:探讨细胞间黏附分子1(ICAM1,CD54)在喉癌间质淋巴细胞中的表达及临床意义。方法:采用免疫组织化学SP法测定5例正常人喉组织、30例喉癌癌旁不典型增生组织和78例喉癌组织标本中ICAM1的表达。ICAM1主要定位于核膜,表达强度按阳性细胞数计算。结果:ICAM1主要表达于喉癌间质淋巴细胞核膜上,在正常人喉上皮、癌旁不典型增生及喉癌细胞中无表达。Ⅰ、Ⅱ期喉癌组织中淋巴细胞ICAM1的表达明显高于Ⅲ、Ⅳ期(P<0.05);伴颈淋巴结转移的喉癌组织淋巴细胞ICAM1表达明显低于无颈淋巴结转移者(P<0.05)。ICAM1高表达病例3、5年生存率明显高于ICAM1低表达者(P<0.05)。结论:喉癌组织中淋巴细胞ICAM1表达与喉癌的发展、转移及预后有关。     

The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis

ObjectiveFractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples.MethodsThe study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C > T (T280 M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated.ResultsFractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p < 0.05).ConclusionFractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis.     

豚鼠实验性变应性鼻炎最轻持续炎性反应模型的建立

目的 建立豚鼠实验性变应性鼻炎最轻持续炎性反应(minimal persistent inflammation,MPI)模型,并初步探讨其病理机制及意义.方法 60只健康雄性Hartley系豚鼠,随机分为A～D共4组,每组15只.A组为阳性对照组,B组为实验组即MPI组,C组为阴性对照组,D组为空白对照组.首先以含卵清蛋白和氢氧化铝凝胶的生理盐水混合液对A、B、C 3组行基础致敏和强化致敏,再分别用1%和0.01%的卵清蛋白溶液或生理盐水长期鼻腔激发.D组始终以生理盐水进行致敏和激发.观察豚鼠鼻腔激发后症状(喷嚏)变化并检测鼻黏膜中嗜酸粒细胞(eosinophils,EOS)浸润程度及上皮细胞内细胞间黏附分子1(intercellular adhesion molecule 1,ICAM-1)的表达情况.结果 MPI模型组在以l%卵清蛋白溶液激发时,喷嚏平均次数明显多于D组(P<0.05),而与A、C组相比差异无统计学意义(P值均>O.05);改用0.01%卵清蛋白溶液鼻腔激发后,变应性鼻炎症状基本消失,与D组相比差异无统计学意义(P>0.05),但鼻黏膜内仍有少量EOS浸润,EOS计数明显多于D组(P相似文献   

喉鳞状细胞癌患者预后的多因素分析

目的：探讨影响喉鳞状细胞癌患者预后的主要因素。方法：采用免疫组织化学SP法检测79例喉鳞状细胞癌患者肿瘤组织和10例癌旁正常组织中细胞s期激酶相关蛋白（Skp2）、p27、上皮细胞钙黏素（E-cad）、r连环素（α-cat）的表达，并对可能影响喉鳞状细胞癌患者预后的12项临床病理因素进行单因素和多因素分析。结果：①Skp2在喉鳞状细胞癌和癌旁正常组织中的表达率分别为53，16％和0，p27分别为30．38％和90．00％，E-cad分别为34．18％和100，00％，α-cat分别为40．51％和100，00％，其差异均有统计学意义（P〈0．05或P〈0．01）。②本组患者总的5年生存率为58．75％，Skp2蛋白低表达组的5年生存率（72．18％）显著高于高表达组（44．17％）（P〈0.01）；p27蛋白高表达组的5年生存率（72．98％）显著高于低表达组（51．13％）（P〈O．01）；E-cad及α-cat阳性表达组的5年生存率（分别为63．80％和81．74％）显著高于阴性表达组（分别为50.68％和41．09％）（P〈0．05和P〈0．01）。③单因素分析显示：病理分级，颈淋巴结转移，临床分期，T分期，复发，Skp2、p27、E-cad及α-cat表达对患者预后的影响均有统计学意义（P〈0．05或P〈0．01）；多因素分析显示：复发、Skp2及α-cat表达为影响患者预后的独立因素（P〈0．05或P〈O．01）。④Skp2和p27蛋白表达之间存在着负相关关系（P〈0.01）；p27和α-cat蛋白表达之间、E-cad和α-cat蛋白表达之间存在正相关关系（均P〈0．01）。结论：复发、Skp2及α-cat表达为影响喉鳞状细胞癌患者预后的重要因素。     

细胞粘附分子在变应性鼻炎鼻甲粘膜中的表达及其意义

目的 :探讨变应性鼻炎鼻甲粘膜组织中细胞粘附分子的表达及其意义。方法 :对 2 0例慢性肥厚性鼻炎、2 4例变应性鼻炎非发作期和 2 0例变应性鼻炎发作期患者下鼻甲粘膜组织石蜡切片 ,用细胞间粘附分子 1(intercellularadhesionmolecule 1,ICAM 1)和淋巴细胞功能相关抗原 1(lymphocytefunction associatedantigen 1,LFA 1)单抗进行免疫组织化学染色 ,光镜观察。结果 :与变应性鼻炎非发作期和慢性肥厚性鼻炎相比 ,变应性鼻炎发作期鼻甲组织ICAM 1和LFA 1的表达增高 (P <0 .0 1)。结论 :变应性鼻炎发作期鼻甲粘膜组织中ICAM 1和LFA 1呈高表达 ,其参与了变应性鼻炎的炎症过程。细胞间粘附分子 (ICAM 1 LFA 1)是变应性鼻炎发生、发展的重要因素之一。     

Immunological study on the expression of HLA-DR antigen in tonsillar epithelium]

Because of the efficacy of tonsillectomy, palmoplantar pustulosis (PPP) has been regarded as a tonsillar focal infection. The immune mechanism underlying focal infection has been considered to be one of the autoimmune diseases mediated mainly by immunoglobulins, but this remains to be clarified. The present study demonstrates the expression of HLA-DR antigen in tonsillar epithelium. An HLA-DR positive area in the epithelium was computed by an image-analyzing program, and evaluated by means of comparisons among hypertrophic tonsil, recurrent tonsillitis, and tonsils with PPP. HLA-DR antigen appeared at high intensities in hypertrophic tonsils and with PPP. The positive areas were mutually related to aging in hypertrophic tonsil and recurrent tonsillitis. Then, the infiltrating lymphocytes in tonsillar epithelium were counted and compared with the intensity of HLA-DR expression. A close correlation was found between the appearance of HLA-DR antigens and activation of infiltrating T-lymphocytes, but no clear relationship was found between HLA-DR antigen intensity and the number of B-lymphocytes. From these findings, it seemed that, in the tonsils with PPP, high HLA-DR intensity was observed in the epithelium and T-lymphocyte infiltration and activation were prominent. Moreover, the pustules on the soles of PPP patients were investigated. T lymphocytic infiltration was already observable in the upper dermis and epidermis in the early stage. Generally speaking, CD4 positive cells were present in substantially greater number than CD8 positive cells. Many CD25 positive cells were also observed around the basement membrane. But there were few cells adjacent to the pustules. These findings indicate that cellular immunity may influence the formation of pustules in the early stage.     

鼻咽癌雌孕激素受体表达与远处转移的相关性

目的：探索雌孕激素受体——雌激素受体（ER）和孕酮受体（PR）表达与鼻咽癌远处转移的相关性，为预后判断提供参考指标。方法：用免疫组织化学SP法检测81例鼻咽癌患者的组织标本。结果：①ER和PR在鼻咽癌组织中的阳性表达率分别为35．8％和53．1％；②PR在T分期中其表达强度有统计学意义（P〈0．01），PR在Ⅳ。阳性表达率和表达强度均明显高于其他各期（均P〈0．01）；③ER和PR在远处转移患者（包括放疗前和放疗后）中的阳性表达率均明显高于放疗后无瘤生存5年以上患者（P〈0．01和P〈0．05）。结论：鼻咽癌组织中ER和PR阳性表达与远处转移呈正相关，阳性表达尤其强阳性者提示预后不良。内分泌治疗有可能减少或推迟远处转移的发生。