西沙必利联用西咪替丁治疗功能性消化不良

目的探讨功能性消化不良的治疗方法.方法128例功能性消化不良患者,随机分为治疗组66例和对照组62例,治疗组给予西沙必利5mg,tid,饭前15～30min,po,西咪替丁800mg,qd,夜间服,连服4周.对照组给予西咪替丁800mg,qd,夜间服,连服4周.结果治疗组有效率97.0%,对照组有效率77.5%,经Ridit检验,差异有极显著性(P＜0.01).结论西沙必利联用西咪替丁治疗功能性消化不良疗效好,副作用少.     

小剂量红霉素治疗小儿功能性消化不良33例疗效观察

目的探讨小剂量红霉素治疗小儿功能性消化不良的治疗效果。方法将66例功能性消化不良患儿随机分成治疗组33例和对照组33例,两组均在常规处理的同时,对照组予吗叮林每次0.3mg/kg,每日3次口服;治疗组给予红霉素口服,剂量为10mg/(kg.d),3次/日,两组疗程均为5天,对两组疗效进行评价。结果:治疗组总有效率90.90%;对照组总有效率60.60%,两组疗效差异有统计学意义,P<0.01。结论小剂量红霉素治疗小儿功能性消化不良具有良好的治疗效果。     

黛力新与西沙必利联合治疗功能性消化不良患者43例疗效观察

目的评价黛力新与西沙必利联合治疗功能性消化不良的疗效。方法随机将86例功能性消化不良患者分为治疗组和对照组,在心理干预的基础上,两组均给予西沙必利5mg,3次/d,餐前30min口服,治疗组加用黛力新1片,1次/d,晨服,疗程均为4周。结果治疗组有效率为88.4%,明显高于对照组;治疗组3个月的复发率为16.3%,明显低于对照组;两组比较差异均有显著性(P<0.01或P<0.05)。结论黛力新与西沙必利联合治疗功能性消化不良,疗效满意,用药安全,值得临床推广应用。     

西沙必利联合阿米替林治疗功能性消化不良90例疗效观察

目的 探讨西沙必利联合阿米替林治疗功能性消化不良(FD)的疗效.方法 将180例FD随机分为治疗组和对照组各90例,两组均服用西沙必利10 mg,3次/d,餐前30 min服用,治疗组加阿米替林25 mg,1次/d,睡前口服.疗程均为8周.结果 治疗组有效率80%,对照组有效率50%,两组疗效比较差异有统计学意义(P＜0.05).结论 西沙必利联合阿米替林治疗FD安全有效.     

小儿消食颗粒联合布拉氏酵母菌治疗小儿功能性消化不良的临床研究

目的:探讨小儿消食颗粒联合布拉氏酵母菌治疗小儿功能性消化不良的临床疗效.方法:选择2019年7月至2021年1月该院收治的功能性消化不良患儿126例,采用随机数字表法分为对照组(63例,采用布拉氏酵母菌治疗)和观察组(63例,采用小儿消食颗粒联合布拉氏酵母菌治疗).两组患儿均治疗4周.观察两组患儿的临床疗效、不良反应发...     

西沙必利联合帕罗西汀治疗功能性消化不良的疗效观察

目的：探讨西沙必利联合帕罗西汀治疗功能性消化不良的临床疗效。方法选取2011年12月—2013年12月在于都县人民医院接受功能性消化不良治疗的患者124例,随机分为观察组和对照组,每组62例。观察组患者给予西沙必利口服治疗,对照组患者给予西沙必利联合帕罗西汀治疗,比较两组患者的临床疗效和不良反应发生情况。结果观察组患者总有效率（96.8%）高于对照组（90.3%）,不良反应发生率（1.6%）低于对照组（9.7%）,差异有统计学意义（ P<0.05）。结论西沙必利联合帕罗西汀治疗功能性消化不良的临床疗效确切,不良反应少。     

复合凝乳酶胶囊联合四联活菌片对小儿功能性消化不良治疗疗效及细胞因子影响

目的 分析复合凝乳酶胶囊联合四联活菌片治疗小儿功能性消化不良临床疗效,及对患儿细胞因子的影响.方法 选取2017年9月至2020年8月我院收治的106例小儿功能性消化不良患儿,将其随机分为对照组和观察组,每组53例.两组患儿均予以常规药物及四联活菌片治疗,观察组再予以复合凝乳酶胶囊治疗,均连续用药2周.每日询问观察患儿...     

奥美拉唑小剂量治疗功能性消化不良的效果分析

目的探讨小剂量奥美拉唑治疗功能性消化不良的临床疗效。方法收集本院2009年7月至2010年12月的功能性消化不良患者68例,随机分成2组,观察组35例,对照组33例,观察组使用10mg/d,对照组使用西沙必利5mg/次,每日3次,以2周为1个疗程,评价2组,对比治疗前后胃部灼烧、餐后腹胀其嗳气等临床症状的改善程度。结果 2组治疗后胃部灼烧、餐后腹胀症状评分均有明显下降,具有统计学差异(P<0.05),嗳气、上腹部疼痛症状评分观察组有明显下降,具有统计学差异(P<0.05),对照组评分下降无统计学差异(P>0.05)。结论小剂量奥美拉唑治疗功能性消化不良的疗效理想,副作用少,可作为功能性消化不良的首选药物。     

神曲消食口服液联合穴位贴敷治疗小儿功能性消化不良临床研究

目的 探讨神曲消食口服液联合穴位贴敷治疗小儿功能性消化不良的临床疗效.方法 选取唐山市丰润区人民医院2017年3月至2019年3月收治的功能性消化不良患儿120例,随机分为观察组和对照组,各60例.两组患儿均予穴位贴敷治疗,观察组患儿加服神曲消食口服液,两组均连续治疗14 d.结果 观察组总有效率为91.67％,显著高...     

多潘立酮联合乳酶生治疗小儿功能性消化不良的临床观察

目的 探讨多潘立酮联合乳酶生治疗小儿功能性消化不良的临床疗效.方法 选取我院自2008年3月至2010年7月收治的236例功能性消化不良患儿的临床资料,随机分为观察组（多潘立酮与乳酶生治疗组）和对照组（多潘立酮治疗组）各118例,治疗周期均为8周,比较两组患儿的治疗效果.结果 观察组治愈68例,有效47例,总有效率为9...     

卡马西平联用尼美舒利相关粒细胞缺乏症

1例78岁男性患者因带状疱疹神经痛、慢性阻塞性肺疾病合并感染,给予头孢唑肟钠（2.25 g静脉滴注,1次/d）、卡马西平（0.2 g口服,2次/d）、尼美舒利（100 mg口服,2次/d）、二羟丙茶碱（0.5 g静脉滴注,1次/d）、甲钴胺（0.5 mg口服,3次/d）、地塞米松（5 mg,静脉滴注1次）、盐酸哌替啶（25 mg,肌内注射1次）和盐酸布桂嗪（100 mg,肌内注射3次）等药物治疗。第7天,停用头孢唑肟钠,改为磷霉素钠（8 g静脉滴注,1次/d）。第11天,血常规检查示白细胞计数1.6×10^9/L,中性粒细胞0.03,中性粒细胞绝对值0.1×10^9/L,淋巴细胞绝对值0.9×10^9/L。立即停用所有药物,给予对症支持治疗。第15天,外周血白细胞计数0.9×10^9/L,中性粒细胞0.02,中性粒细胞绝对值0.1×10^9/L,淋巴细胞绝对值0.7×10^9/L。行骨髓穿刺检查,诊断为粒细胞缺乏症。第17天患者出现右肺气胸、肺不张。第20天出现急性呼吸衰竭、多脏器衰竭合并重症感染,经抢救无效死亡。     

颅脑损伤患者并发肺部感染的护理体会

目的：为了使并发肺部感染的病人更多、更好、更早的痊愈。方法：通过对32例颅脑外伤并发肺部感染病人的严密观察,采取更换体位、超声雾化、有效排痰训练等有效的护理措施干预,从而控制了肺部感染。结果：痊愈17例,占53.1%;显效12例,占37.5%,无效2例,占6.2%;死亡1例,占3.1%;实践证明,有效的护理干预对提高患者治疗成功率有着重要意义。     

Satisfaction with information and its relationship with adherence in patients with chronic pain

□ Due to the nature of chronic pain it would be expected that patients are highly adherent to their pain medication. However, results from this study have shown that 23 per cent of patients often or always avoid using their pain medication, 13.4 per cent often or always alter dosages, and 10.3 per cent often or always stop taking their medication for a while. This suggests intentional non‐adherence to pain medication □ Less than 50 per cent of respondents were satisfied with information provided on side effects, what to do if side effects occur, and possible interactions with other medication □ Patients' satisfaction with information about their medication was related to self‐reported adherence; greater satisfaction was associated with higher self‐reported adherence     

Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation

PURPOSE: Stage II and III adenocarcinoma of the rectum has an overall 5-year survival rate of approximately 50%, and tumor recurrence remains a major problem despite an improvement in local control through chemotherapy and radiation. The efficacy of chemoradiation therapy may be significantly compromised as a result of interindividual variations in clinical response and host toxicity. Therefore, it is imperative to identify those patients who will benefit from chemoradiation therapy and those who will develop recurrent disease. In this study, we tested whether a specific pattern of 21 polymorphisms in 18 genes involved in the critical pathways of cancer progression (i.e., drug metabolism, tumor microenvironment, cell cycle regulation, and DNA repair) will predict the risk of tumor recurrence in rectal cancer patients treated with chemoradiation. PATIENTS AND METHODS: A total of 90 patients with Stage II or III rectal cancer treated with chemoradiation were genotyped using polymerase chain reaction (PCR)-based techniques for 21 polymorphisms. RESULTS: A polymorphism in interleukin (IL)-8 was individually associated with risk of recurrence. Classification and regression tree analysis of all polymorphisms and clinical variables developed a risk tree including the following variables: node status, IL-8, intracellular adhesion molecule-1, transforming growth factor-beta, and fibroblast growth factor receptor 4. CONCLUSION: Genomic profiling may help to identify patients who are at high risk for developing tumor recurrence, and those who are more likely to benefit from chemoradiation therapy. A larger prospective study is needed to validate these preliminary data using germline polymorphisms on tumor recurrences in rectal cancer patients treated with chemoradiation.     

甘草酸单铵结合氦-氖激光治疗银屑病62例

目的用甘草酸单铵结合低能量氦-氖激光,观察治疗银屑病患者。方法62例寻常型银屑病患者,分为两组,A组用低能量氦-氖激光血管内照射,同时用甘草酸单铵静脉滴注,共36例;B组仅用甘草酸单铵,共26例。通过30d治疗。结果总有效率82.2%,其中A组有效率88.9%,B组73.1%(经Ridit检验,U＝2.76,P＜0.01),两组差异有极显著性意义。结论甘草酸单铵结合氦-氖激光治疗银屑病,比单用甘草酸单铵效果好。     

A fetus with meckel-gruber syndrome associated with isomerism

Abstract. Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal malformation. As far as we know, the rate of incidence for the syndrome is 0.02 per 10,000 births. It is estimated that Meckel-Gruber syndrome accounts for 5% of all neural tube defects in Finland. Objective. The aim of this study is to present a case of a fetus with Meckel-Gruber syndrome associated with complete left isomerism. Method. The fetus was obtained after medical interruption of the pregnancy during the fifteenth gestational week. The mother was 36 years old and in a consanguineous marriage. The antenatal ultrasound examination revealed a polymalformative syndrome, leading to a postmortem examination. The fetopathological study of the fetus was conducted at the Centre for Maternity and Neonatology, Tunis, Tunisia, in 2008. Results. The female fetus had a significantly deformed ballooning abdomen, pes equinovarus, flexion of the wrist and a total posterior cleft palate. The central nervous system abnormalities were occipital encephalocele, cystic dilatation of the fourth ventricle, agenesis of corpus callosum and hydrocephalus. The study of the internal organs found dextrocardia, irregular lobulation of the lungs, left isomerism, and polysplenia. The microscopic examination revealed bilateral cystic dilation of the kidneys, fibrous proliferation of the liver and ectasic dilatation of the billiary ducts, representing a ductal plate malformation of the liver. Conclusion. The case is diagnosed with Meckel-Gruber syndrome associated with complete left isomerism, cleft palate and possibly Dandy-Walker syndrome.