护理延伸服务对乳腺癌患者术后功能锻炼依从性的影响

目的观察护理延伸服务对乳腺癌患者术后功能锻炼依从性的影响,并探究其临床护理满意度。方法选择从2013年6月~2015年6月于我院接受治疗的85例乳腺癌患者作为本次实验对象,根据护理方案不同,分为研究组和对照组。对照组40例患者给予常规护理方案,研究组45例患者给予延伸护理方案。观察干预前后两组患者生存质量评分的比较情况;并比较两组患者功能锻炼的依从率及优良率。结果护理后,研究组患者的生存质量总分评分为(88.7±6.1)分,显著高于对照组患者的(81.5±4.6)分,两组比较,差异具有统计学意义(t=6.0829,P0.05);护理后,两组患者的功能锻炼依从率、优良率比较,差异均具有统计学意义(x_1~2=11.3585,x_2~2=3.9954;P0.05)。结论护理延伸服务可以显著地改善乳腺癌患者术后的生存质量,患者的功能锻炼依从率以及优良率显著提高,适合临床长期推广应用。     

腰背肌锻炼的依从性对青年早期腰椎间盘突出症疗效的影响

目的观察腰背肌锻炼的依从性对青年早期腰椎间盘突出症患者疗效的影响。方法选取青年早期腰椎间盘突出症患者50例,对严格遵从护嘱完成腰背肌锻炼的患者（治疗组）23例和未能严格遵从护嘱进行腰背肌锻炼的患者（对照组）27例进行回顾性比较分析。结果治疗组治愈10例,有效12例,无效1例,总有效率95．65％;对照组治愈7例,有效14例,无效6例,总有效率77．77％,两组疗效比较差异有统计学意义（P〈0．05）。结论腰背肌锻炼依从性好的青年早期腰椎间盘突出症患者疗效显著。     

针对性心理护理对创伤性骨折患者术后心理状况及锻炼依从性的影响

目的探讨针对性心理护理对创伤性骨折患者术后心理状况及锻炼依从性的影响。方法选择我院2012年1月至2013年7月收治的创伤性骨折患者110例,根据护理方法的不同分为对照组和观察组,每组55例,对照组进行常规护理干预,观察组在对照组的基础上,根据患者的心理特征变化实施针对性心理护理干预,比较两组患者的心理状况和功能锻炼依从性。结果护理后,两组SAS评分和SDS评分均较治疗前降低,观察组SAS评分和SDS评分显著低于对照组,差异均有统计学意义;观察组功能锻炼依从性显著高于对照组,差异有统计学意义。结论针对性心理护理干预有助于改善创伤性骨折患者术后心理状态和提高功能锻炼依从性,值得进一步研究。     

情志护理对提高肾病综合征患儿服药依从性的效果观察

目的探讨情志护理对提高肾病综合征患儿服药依从性的效果。方法将本院收治的108例肾病综合征患儿根据随机原则分至对照组(n=54例)和观察组(n=54例),对照组患儿采取常规护理,观察组患儿采取情志护理干预,比较两组患儿的服药依从性。结果对照组患儿不依从11例,不完全依从22例,完全依从21例,依从率为79.63%;观察组患儿不依从5例,不完全依从25例,完全依从24例,依从率为90.74%;经χ~2检验,观察组患儿依从率显著高于对照组,P <0.05。结论在肾病综合征患儿施以情志护理干预,可有效提高患儿的服药依从性,对提高药物治疗疗效具有十分重要的意义。     

COPD患者对无创呼吸机的依从性影响因素研究及护理措施探讨

目的 探究影响COPD患者对无创呼吸机依从性的因素并研究护理干预效果.方法 对我院2009至2011年间收治的56例COPD患者随机分为实验组和对照组各28例,两组使用同样的无创呼吸机进行机械通气,实验组在此基础上进行护理干预,比较两组患者依从性.结果 实验组患者依从治疗24例,不依从治疗4例,依从率85.7％;对照组依从治疗19例,不依从治疗9例,依从率67.9％.实验组患者依从率高于对照组,差异有显著性(P＜0.05).结论 护理干预能有效消除患者恐慌焦虑心理,改善使用体验,提高COPD患者对无创呼吸机使用的依从性.     

护理干预对婴幼儿雾化吸入依从性的影响

目的探讨了护理干预对婴幼儿雾化吸入依从性的影响。方法分析我院进行雾化吸入的90例患儿的临床资料,分为对照组和干预组,对照组采取常规护理,干预组在常规护理的基础上进行护理干预,比较两组的依从性和意外情况。结果干预组患儿雾化吸入总依从率为93．33％,对照组患儿雾化吸入总依从率为57．78％,干预组依从性显著优于对照组,差异有显著性（P〈0．05）。干预组意外情况发生率为2．22％,对照组意外情况发生率为15．56％,干预组显著低于对照组,差异有显著性（P〈0．05）。结论护理干预能有效的提高婴幼儿雾化吸入依从性,有助于提高雾化吸入的质量及临床疗效,值得推广。     

护理干预对糖尿病患者治疗依从性的影响

目的：观察系统性的护理干预对糖尿病患者治疗依从性及治疗效果的影响。方法：2008年1-10月将90例糖尿病患者随机分为干预组和对照组各45例。干预组由专门护士进行健康宣教及跟踪督导。对照组单纯进行常规健康教育,不进行系统的护理干预。所有患者统一随访,随访内容包括服药依从性和就诊依从性,并观察治疗效果。结果：干预组服药依从率、就诊依从率明显优于对照组,血糠控制达标率亦明显高于对照组,P〈0．05。结论：护理干预能提高糖尿病患者的治疗依从性和药物疗效。     

老年骨质疏松性骨折的危险因素分析及护理对策

目的探讨老年骨质疏松性骨折的相关危险因素及护理对策。方法选取我院2010年5月～2012年9月收治的60例老年骨质疏松性骨折患者作为研究对象,按照随机数字表法分为干预组与对照组各30例,干预组患者在对照组常规护理基础上加用干预性护理措施,治疗4周后,比较两组患者的治疗依从性和总有效率。结果干预组总依从率、总有效率均明显高于对照组,差异具有统计学意义(P0.01)。结论对老年骨质疏松性骨折患者实施干预护理措施,可以有效提高治疗依从性和临床疗效,值得临床推广应用。     

人性化护理干预在核苷类药物治疗慢性乙型肝炎中的应用观察

目的探讨人性化护理干预在核苷类药物治疗慢性乙型肝炎中的效果观察。方法选取我院2015年1月至2016年3月收治的慢性乙型肝炎患者64例,随机分为治疗组和对照组,每组32例。对照组患者采用普通的一般护理,治疗组患者实施人性化护理,对比分析两组患者的治疗效果、疾病知识掌握情况、用药依从性。结果治疗组患者治疗有效率93.75%,对照组患者治疗有效率78.13%;治疗组患者疾病知识掌握情况、用药依从率明显高于对照组,差异具有统计学意义(P<0.05)。结论人性化护理干预应用在核苷类药物治疗慢性乙型肝炎护理中,可以明显提升临床疗效和治疗依从性,值得临床进一步开展。     

护理干预对提高结核病患者从医行为的影响

目的探讨护理干预对提高结核病患者从医行为的影响。方法选取2011年1月至2011年12月在本科治疗的结核病患者192例,随机分成对照组96例,观察组96例,对照组给予常规的临床治疗指导,观察组在常规临床治疗指导的基础上进行系统的护理干预,比较两组患者治疗依从性情况。结果经分别治疗,观察组优48例,良44例,中4例,差0例,优良率95.83%;对照组优16例,良40例,中30例,差10例,优良率58.33%。经统计学分析,两组患者的治疗依从优良率有显著性差异,P<0.05,有统计学意义。结论给予结核病患者进行系统的护理干预治疗,可有效提高患者的治疗依从性,提高治疗效果,值得临床推广使用。     

Nachweis einiger Heilmittel in der Kniegelenksynovialflüssigkeit

Zusammenfassung Mittels Gaschromatographie und Dünschichtchromatographie wiesen die Autoren 11 Substanzen nach, welche durch Injektion oder nach Verabreichung per os in die Kniegelenksynovialflüssigkeit eindrangen. In ihrer Aufstellung konnten sie eine direkte Beziehung zwischen Struktur sowie chemischphysikalischen Eigenschaften der Substanz und ihrer Fähigkeit, aus dem Blut in die Kniegelenksynovialflüssigkeit einzudringen, nicht nachweisen, außer der Tatsache, daß Substanzen mit starker Affinität zu Eiweißstoffen erst in höheren Dosen nachweisbar waren.     

Synthesis,Cytotoxicity and Antileishmanial Activity of Some N-(2-(indol-3-yl)ethyl)-7-chloroquinolin-4-amines

We report herein the condensation of 4,7-dichloroquinoline (1) with tryptamine (2) and D-tryptophan methyl ester (3) . Hydrolysis of the methyl ester adduct (5) yielded the free acid (6) . The compounds were evaluated in vitro for activity against four different species of Leishmania promastigote forms and for cytotoxic activity against Kb and Vero cells. Compound (5) showed good activity against the Leishmania species tested, while all three compounds displayed moderate activity in both Kb and Vero cells.     

Emerging drugs for epilepsy

Epilepsy affects ≤ 1% of the world's population. Antiepileptic drugs (AEDs) are the mainstay of treatment, although more than a third of patients are not rendered seizure free with existing medications. Uncontrolled epilepsy is associated with increased mortality and physical injuries, and a range of psychosocial morbidities, posing a substantial economic burden on individuals and society. Limitations of the present AEDs include suboptimal efficacy and their association with a host of adverse reactions. Continued efforts are being made in drug development to overcome these shortcomings employing a range of strategies, including modification of the structure of existing drugs, targeting novel molecular substrates and non-mechanism-based drug screening of compounds in traditional and newer animal models. This article reviews the need for new treatments and discusses some of the emerging compounds that have entered clinical development. The ultimate goal is to develop novel agents that can prevent the occurrence of seizures and the progression of epilepsy in at risk individuals.     

盐酸达泊西汀中甲磺酸甲酯、甲磺酸乙酯及甲磺酸异丙酯的顶空毛细管GC-ECD法测定

建立了衍生化顶空毛细管气相色谱-电子捕获检测器(ECD)法测定盐酸达泊西汀中的甲磺酸甲酯(MMS)、甲磺酸乙酯(EMS)和甲磺酸异丙酯(IMS).应用碘化钠衍生技术,使用PW-5毛细管柱,载气为氮气,ECD检测,程序升温.MMS、EMS和IMS分别在0.03～0.30、0.05～0.50和0.05～0.50 μg/ml浓度范围内线性关系良好,平均回收率分别为63.5％、100.3％和96.2％,最低检测限分别为0.30、0.50和0.50 ng/ml.     

Lung disease and PKCs

The lung offers a rich opportunity for development of therapeutic strategies focused on isozymes of protein kinase C (PKCs). PKCs are important in many cellular responses in the lung, and existing therapies for pulmonary disorders are inadequate. The lung poses unique challenges as it interfaces with air and blood, contains a pulmonary and systemic circulation, and consists of many cell types. Key structures are bronchial and pulmonary vessels, branching airways, and distal air sacs defined by alveolar walls containing capillaries and interstitial space. The cellular composition of each vessel, airway, and alveolar wall is heterogeneous. Injurious environmental stimuli signal through PKCs and cause a variety of disorders. Edema formation and pulmonary hypertension (PHTN) result from derangements in endothelial, smooth muscle (SM), and/or adventitial fibroblast cell phenotype. Asthma, chronic obstructive pulmonary disease (COPD), and lung cancer are characterized by distinctive pathological changes in airway epithelial, SM, and mucous-generating cells. Acute and chronic pneumonitis and fibrosis occur in the alveolar space and interstitium with type 2 pneumocytes and interstitial fibroblasts/myofibroblasts playing a prominent role. At each site, inflammatory, immune, and vascular progenitor cells contribute to the injury and repair process. Many strategies have been used to investigate PKCs in lung injury. Isolated organ preparations and whole animal studies are powerful approaches especially when genetically engineered mice are used. More analysis of PKC isozymes in normal and diseased human lung tissue and cells is needed to complement this work. Since opposing or counter-regulatory effects of selected PKCs in the same cell or tissue have been found, it may be desirable to target more than one PKC isozyme and potentially in different directions. Because multiple signaling pathways contribute to the key cellular responses important in lung biology, therapeutic strategies targeting PKCs may be more effective if combined with inhibitors of other pathways for additive or synergistic effect. Mechanisms that regulate PKC activity, including phosphorylation and interaction with isozyme-specific binding proteins, are also potential therapeutic targets. Key isotypes of PKC involved in lung pathophysiology are summarized and current and evolving therapeutic approaches to target them are identified.