美国临床肿瘤学会年度报告——2005年临床肿瘤学进展

2005年临床肿瘤学进展是由美国临床肿瘤学会（the American Society of Clinical Oncology，ASCO）发布的第一份关于各类肿瘤在治疗、筛查和预防方面最重要进展的独立年度报告。展示了2005年各种肿瘤的主要临床研究进展。     

流式细胞术在临床检验中的应用前景

流式细胞术(FCM)已成为当今临床实验中最重要的工具之一，它在细胞生物学、肿瘤学、血液学、免疫学、遗传学领域得到日益广泛的应用。为临床检验学发展提供了新的视觉和强有力的手段。     

显示凋亡小体的两种改良新方法

细胞凋亡是病理学，肿瘤学，免疫学研究最活贵州原领域之一，而凋亡小体的出现则是细胞凋亡最重要的形态学标志；本文介绍了两种经过改良的显示细胞凋亡小体的组织化学方法，具有染色结果稳定，定位清晰，对比度强，染液保存时间较长等优点。     

显示调亡小体的两种改良新方法

细胞调亡是病理学、肿瘤学、免疫学研究最活跃的领域之一，而凋亡小体的出现则是细胞凋亡最重要的形态学标志：本文介绍两种经过改良的显示细胞调亡小体的组织化学方法，具有染色结果稳定、定位清晰、对比度强、染液保存时间较长等优点。     

达观致远 直路而行——对话储大同

12年前，他牵头创建了中国抗癌协会临床肿瘤学协作委员会（CSC0），推动CSCO成为继美国临床肿瘤学会和欧洲临床肿瘤学会之后的世界第三大临床肿瘤学术组织，完成了中国肿瘤界全面与国际接轨的历史使命。     

唯物辩证法在临床肿瘤学教学中的思考

肿瘤教学中蕴藏着深厚的哲学思想，探讨其中蕴藏的辨证思想是为了更好提高肿瘤学的教学质量，培养出具有科学思维观的新型肿瘤学人才，以适应现代医学的发展．在肿瘤学的教学过程中，应加强肿瘤学教学系统性，强调肿瘤的综合治疗．     

变革的前夜

回眸2008，非小细胞肺癌（non-small cell lungcancer，NSCLC）的治疗有什么重要的进展呢？美国临床肿瘤学会在刚刚出炉的年度进展报告中认为，西妥昔单抗联合化疗药物一线治疗晚期NSCLC（FLEX试验）是最重要的进展，因为它能提高晚期非小细胞肺癌21％的生存率。另一项值得关注的研究，     

谈医学高等院校开设肿瘤学课程的必要性

近年来，随着科学技术的发展，带来了肿瘤诊断及治疗技术的不断革命。但是单有先进的设备，并不意味着我国肿瘤学专业水平的提高，关键还应该有一大批优秀的肿瘤学专业人员，这样才能促进我国肿瘤学事业飞速发展。这就对我国的医学教育提出了新的课题：如何培养适应现代形势需要、知识全面的肿瘤学专业人才？目前，在我国医学高等院校中，大部分还未开设肿瘤学专业课程，使得毕业生的肿瘤学知识掌握得很少、很不全面。这不仅会造成病人的误诊误治，而且还严重制约着我国肿瘤学科的发展。为了适应目前的形势和临床实际的需要，笔者认为在医学…     

我国医学肿瘤学教育的现状与思考

我国医学肿瘤学教育亟待加强、改革和完善。文章就我国目前肿瘤学教育现状和肿瘤治疗中存在的问题进行了分析，并对肿瘤学教学的模式、方法、任务和目标进行了探讨。     

2005年临床肿瘤学重大进展

这一期《循证医学》要向大家郑重推荐的，是美国临床肿瘤学会公布的2005年临床肿瘤学进展报告。这一报告评估了2005年度发表在专业杂志上的研究成果和在重要学术会议上报告的结果．将那些改变了临床实践的研究列为该报告的主要内容，因此，熟读这一报告，无疑便把握了临床肿瘤学时代前进的步伐。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.