Oncogenes, Oncogenesis, and Oxygen Radicals

The role that free radicals in general and oxygen radicals in particular play in carcinogenesis has attracted considerable attention in recent years. The oxygen radicals are undesirable but inevitable products of aerobic metabolism in the normal living cell. The cellular antioxidant defense system maintains an appropriate balance between necessary oxidative events and those that are excessive. When this critical balance cannot be maintained because of the overloading of the cellularredox system, oxygen radicals can induce cell damage. They can influence carcinogenesis by inducing DN A damage from direct oxidation or indirectly from DNA-binding products of lipid peroxidation. Oxygen radicals can induce conformational changes in the plasma membrane by lipid peroxidation and protein degradation, thus influencing membrane-associated cellular activities. They are capable of affecting membrane-bound protein kinases, growth factors and their receptors, and, therefore, signal transduction and oncogene activation. Thus, the oxygen radicals can have a major influence on oncogenes and oncogenesis. (C)1990 Academic Press.Inc.     

Colon,rectum and anus

930530 Experience with colonoscopic polypec-tomy in 716 patients.YAO Liqing(姚礼庆),etal.Dept Surg,Zhongshan Hosp,Shanghai MedUniv,Shanghai,200000.Chin J Digest 1992; 12(6):330—332.Seven hundred and sixteen patients with 1356coloreetal polyps were treated with eolonoscopicpolypectomy.Most polyps were located in therectum(441,34.3%)and sigmoid colon(552,     

Symptom,sign and syndrome

930191 A study on platelet aggregability andblood lipids in migraine.TAN Yongji(谈永基),et al.Instit Neurol,Shanghai Med Univ,200040.Chin J Nerv & Ment Dis 1992;18(4):210-212.The ADP induced platelet aggregate rates(AR),serum cholesterol(CH),triglyceride(TG)and high-density lipoprotein(HDL)were determined in both 42 migraineurs duringheadache-free intervals and 35 controls.Whencomparing AR of migraineurs with that in con-trols,there was a highly significant increase inAR in the migraine patients at the slope,30 sec-onds and 1 minutes.There were no significantdifferences in the levels of blood CH,TG or     

ence and Technology, Har

paper proposes a new adaptive watermarking algorithm based on the combination of discrete wavelet transform and dis- crete cosine transform. Torus Scrambling technique can keep watermarking’s security. Then zig- zag scanning is used to transform the watermarking image into one dimensional sequ     

Pleura,mediastinum and diaphragm

930514 A new method of detecting diaphrag-matic muscle fatigue—Studies on analysingchest—abdominal breathing movement by theelectric impedance respirograph.WANG Wei(王为),NIU Ruji(牛汝辑)。Tongji Hosp,TongjiMed Univ,Wuhan,430000.Chin J Physic Med1993;15(1):5—9.In order to diagnose diaphragmatic muscle fa-tigue(DMF)by electric impedance respirograph(IRG),chest—abdominal breathing movementcurves of 72 patients with COPD and 80 normalindividuals were recorded on IRG(one—dimen-sional graph).It expressed a chest—abdominal     

Symptom,sign and syndrome

930605 A study on clinical evaluation of theSHH for SAH.SONG Donglin(宋东林),et al.Dept Neurol,General Hosp,Air Force,PLA.,Beijing,100036.Chin J Nerv & Ment Dis 1993;19(1):6-8.The clinical evaluation of subhyaloid hemor-rhage(SHH)in 609 cases with subarachnoidhemorrhage(SAH)was studied by analysing 62patients with SHH(in both eyes in 35 cases andone eye in 27 cases).A comparision study be-tween the SHH group and non-SHH group wasmade,showing that the clinical symptoms in theSHH group were more severe,and had higher in-tracranial pressure and higher mortality.The au-topsy showed that in the 6 cases of SHH with oneeye the damaged eye was located on the same sidewith ruptured intracranial aneurysm.     

Colon,rectum and anus

930135 Induction of expression of HLA anti-gens,carcinoembryonic antigen and oncogeneproduct on human colorectal cancer cell lineswith interferon-γ.WANG Ling(王聆),et al.Immunol Instit,Shanghai 2nd Med Univ.Chin J     

Colon, rectum and anus

970341 Serum concentration of hyaluronic acid in pa-tients with colorectal cancer. XU Hongwei(许洪卫), etal. Dept Surg, Changzheng Hosp, 2nd Milit Med Uniu,Shanghai, 200003. Chin J Dig 1996; 16(6): 329-331. Objective: To find Out the relationship of serumhyaluronic acid and colorectal cancer. Method: UsingELISA, serum concentration hyaluronic acid(HA)was     

Neuroanatomy, neurophysiology and neuropathology

970391 A study on mutation and polymorphism ofWilson's disease gene with polymerase chain reaction-single strand conformation polymorphism. WANG Li-juan(王丽娟), et al. Dept Neurol, 1st Affili Hosp, SunYat-sen Med Univ, Guangzhou, 510080. Chin J Neurol1997; 30(1): 8-11. Objective: To detect the mutation and polymor-     

Colon,rectum and anus

950328 Stepwise regression analysis on affective fac-tor of the changes in gastrin and somatostatin in col-orectal cancer patients.WANG Yuanhe(王元和),etal.2nd Milit Med Univ,Shanghai,200003.Med J ChinPLA 1995:20(1):48-51.Gastrin and somatostatin (SS) levels in peripheralblood,tumor and its surrounding mucosa were deter-mined in 40 colorectal cancer patients by RIA with theserum gastrin (SG),plasma SS(PS),tumor SS(TS)or cancer-adjacent mucosa (CAMS)SS(CAMS)lev-els were taken as dependent variables and the remain-ing variables(including gastrin and SS levels,age and     

Pleura,mediastinum and diaphragm

900129 Treatment of malignant pleural effu-sions with large bore catheter closed drainageand sclerosing agent instillation:A report of 90cases.WEI Jian(魏鉴),et al.Dept Chest,Tian-jin Cancer Hosp & Instit,Tianjin.Chin J ClinOncol 1992;19(5):354-357.From Feb.1977 to Nov.1987 there were 90cases of malignant pleural effusions treated.Allwere identified cytologically or pathologically.There were 62 males and 28 females.Thepatients' age ranged from 16 to 78 years with a     

Heroin Abuse and Nitric Oxide, Oxidation,Peroxidation, Lipoperoxidation

ＩＮＴＲＯＤＵＣＴＩＯＮＩｔｉｓｗｅｌｌｋｎｏｗｎｔｈａｔｈｅｒｏｉｎａｂｕｓｅｉｓｎｏｗｏｎｅｏｆｔｈｅｍｏｓｔｓｅｒｉｏｕｓａｎｄｈａｚａｒｄｏｕｓｓｏｃｉａｌａｎｄｍｅｄｉｃａｌｉｓｓｕｅｓｉｎｔｈｅｗｏｒｌｄａｎｄｉｎＣｈｉｎａ(Ｋｎｉｇｈｔｅｔａｌ.,1988;ＪｉａｎｇａｎｄＷａｎ,1992;Ｓｍｉｔｅｔａｌ.,1996;Ｚｈｏｕｅｔａｌ.,1994ａ,1994ｂ,1995).Ｉｔｈａｓｂｅｅｎｐｏｉｎｔｅｄｏｕｔｔｈａｔｔｈｅｌｅｖｅｌｏｆｕｒｉｎａｒｙ　　Ａｂｂｒｅｖｉａｔｉｏｎ:βＣＡＲ:βｃａｒｏｔｅｎｅ,ＣＡＴ:ｃ…     

Clinical, pathologic and genetic studies on mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes.

Ｃｌｉｎｉｃａｌ，ｐａｔｈｏｌｏｇｉｃａｎｄｇｅｎｅｔｉｃｓｔｕｄｉｅｓｏｎｍｉｔｏｃｈｏｎｄｒｉａｌｍｙｏｐａｔｈｙ，ｅｎｃｅｐｈａｌｏｐａｔｈｙ，ｌａｃｔｉｃａｃｉｄｏｓｉｓａｎｄｓｔｒｏｋｅ┐ｌｉｋｅｅｐｉｓｏｄｅｓＧｕｏＹｕｐｕ郭玉璞，Ｇｕｏ...     

DNA Damage, Apoptosis and C-myc, C-fos, and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

INTRODUCTION Selenium, an important nutritional trace element, is an essential component of glutathione peroxidases and thioredoxin reductases. Selenium-dependent glutathione peroxidases and thioredoxin reductases protect the body from cellular metabolism…     

Protein,carbohydrate and lipid metabolism

930043 Analysis of familial aggregation ofserum lipids.WANG Jianhua(王建华),et al.Tianjin Med Coll,Tianjin,300070.Chin J Car-diol 1992;20(4):234-236.