复方利血平氨苯蝶啶与厄贝沙坦氢氯噻嗪的降压疗效比较

目的 观察复方利血平氨苯蝶啶片与厄贝沙坦氢氯噻嗪片治疗轻中度原发性高血压的临床疗效. 方法 66例1级和2级高血压患者随机分为观察组(34例)和对照组(32例),分别给予复方利血平氨苯蝶啶和厄贝沙坦氢氯噻嗪1~2片/d.结果 治疗2周时2组对收缩压和舒张压的降压作用已经发挥显著效应, 用药12周时达最大效果,2组治疗后血压与治疗前比较均明显下降,差异有非常显著意义(P<0.01). 复方利血平氨苯蝶啶组总有效率94.1%, 厄贝沙坦氢氯噻嗪组总有效率87.5%,2组总有效率相比差异有统计学意义(P<0.05). 2组收缩压和舒张压的下降幅度比较复方利血平氨苯蝶啶组大于厄贝沙坦氢氯噻嗪组,但差异无统计学意义(P>0.05). 血压降至<130/85 mm Hg者,复方利血平氨苯蝶啶组比例高于厄贝沙坦氢氯噻嗪组,2组相比差异有统计学意义(P<0.05). 结论 复方利血平氨苯蝶啶和厄贝沙坦氢氯噻嗪对轻中度原发性高血压的临床疗效明显,且耐受性良好.     

复方氨苯蝶啶的急性毒性及其保钾作用

目的：考察复方氨苯蝶啶的安全性及其保钾作用。方法：将NIH小鼠及SD大鼠分别用6%氨苯蝶啶、30%氢氯噻嗪和复方氨苯蝶啶混悬液灌胃,观察氨苯蝶啶、氢氯噻嗪及复方氨苯蝶啶的急性毒性及对尿钾的影响。结果：与氨苯蝶啶、氢氯噻嗪的急性毒性相比,复方氨苯蝶啶的急性毒性较低。氢氯噻嗪组排尿量和排钾量与对照组比较显著升高（P〈0.01）,氨苯蝶啶组排尿量增加不明显,但明显减少排钾（P〈0.01）;复方氨苯蝶啶组明显增加排尿量（P〈0.01）,排钾量略减少。结论：复方氨苯蝶啶的安全性好,氨苯蝶啶与氢氯噻嗪合用可增加利尿效应并预防低钾血症。     

HPLC法测定常药降压片中两组分的含量

目的：采用HPLC法分离常药降压片中硫酸双肼屈嗪、氢氯噻嗪、盐酸可乐定三组分，并对前两种组分进行定量分析。方法：色谱条件为：Kromasil C18色谱柱，流相为60mmol/L磷酸二氢钾－甲醇－乙腈（9：1：0．5），流速1ml/min，检测波长为274nm，线性范围：硫酸双肼屈嗪99．4－496．8μg/ml，r=0.9998;氢氯噻嗪80．0－400．0μg/ml，r=0.9999。结果：硫酸双肼屈嗪、氢氯噻嗪加样回收分别为99．64％和100．38％；RSD％均小于0．5％。     

复方利血平氨苯蝶啶片治疗高血压病的疗效观察

目的：观察复方利血平氨苯蝶啶片(原北京降压0号)对高血压病的治疗效果．方法：48例高血压病人进行本研究，并与复方降压片组相对照．治疗组(32例)给予复方利血平氨苯蝶啶片1‘1日1次，观察指标为血压下降幅度和高血压相关症状,7天为一个观察周期，4周为一疗程．结果：治疗组总有效率达87．50％，总有效率明显优于对照组．结论：在农村社区高血压病人管理中，复方利血平氨苯蝶啶片可作为抗1—2级高血压药物值得推广一试．     

老年性高血压患者服用复方利血平氨苯蝶啶片的疗效观察

目的观察复方利血平氨苯蝶啶片对老年性高血压的降压疗效和安全性.方法对确诊为老年性高血压80例,治疗前停用其它降压药物,给予复方利血平氨苯蝶啶片口服,每日1次,每次1片;治疗2周后,观察其血压、心率变化和药物副反应.结果治疗后血压显著下降(p均<0.01);显效率为78.8%,有效率14.8%,无效率6.4%,总有效率为93.6%;个别人有恶心、纳差、头胀,未见明显副反应.结论该药疗效好且安全,是治疗老年性高血压的理想药物.     

HPLC测定复方利血平片中氢氯噻嗪的含量

目的:建立高效液相法测定复方利血平片中氢氯噻嗪含量的方法.方法:采用Agilent Eclipse XDB-C18(4.6 mm×150 mm,5 μm)色谱柱;流动相:乙腈-甲醇-水(10:10:80);检测波长:271 nm;流速1.0 ml/min;柱温:28℃.结果:氢氯噻嗪在0.041 4～0.828 0μg范围内与峰面积呈良好的线性关系(r=0.999 9),平均回收率为99.31%,RSD=0.60%(n=6).结论:本方法简便、准确、重现性好,可用于复方利血平片中氢氯噻嗪的质量控制.     

浅析北京降压0号

北京降压0号,具有降压和轻度镇静作用,适用治疗轻、中度高血压。其组成为:利血平0.1mg,硫酸双肼屈嗪12.5mg,氢氯噻嗪12.5mg,氨苯喋啶12.5mg,氯氮3mg。本药配方原理从三方面着手,即基础降压;协同降压;中枢神经调整以改善症状。1基础降压硫酸双肼屈嗪和利血平是基础降压药,抑制细小动脉收缩而使血压下降。其中硫酸双肼屈嗪通过松弛动脉平滑肌,使周围血管舒张,血压下降。而利血平能使交感神经节后纤维末梢贮存的传导介质去甲肾上腺素减少乃至耗竭,使发自中枢的兴奋传导受阻,不能到达效应器,失去收缩血管,兴奋心脏的作用。这两种红色物合用,降压…     

HPLC法测定复方四嗪利血平片中氢氯噻嗪的含量

目的：建立高效液相法测定复方四嗪利血平片中氢氯噻嗪含量的方法。方法：采用Diamonsil-C18（6．0mm×150mm,5μm）色谱柱;流动相：甲醇-水-磷酸盐缓冲液（30：66：4）（0．05mol／L磷酸二氢钾溶液,用磷酸调节pH至3．0）;检测波长：272nm;流速：1．0ml／min。结果：氢氯噻嗪在0．0896-0．0896μg范围内与峰面积呈良好的线性关系（r=0．9999）,平均回收率为98．92％,RSD=0．60％（n=6）。结论：本方法简便、准确、重现性好,可用于复方四嗪利血平片中氢氯噻嗪的质量控制。     

口服复方利血平氨苯蝶啶致体位性低血压

患者，女，80岁，诊断患冠心病、高血压病（持续波动在180／100mmHg之间）而入院治疗。2005年5月20日早餐给予13服复方利血平氨苯蝶啶（本品为复方制剂、北京双鹤药业股份有限公司、国药准字H11022335）1粒qd。服药后1h患者从床上坐起突感头晕、四肢无力、脸色苍白、胸闷、虚汗淋漓。立即予以平卧位，测血压110／60mmHg、脉搏82次／min、呼吸20次／min。考虑体位性低血压，给予冲服葡萄糖水200ml，约30min后症状缓解，测血压140／75mmHg，第2天早餐再次服用复方利血平氨苯蝶啶后又出现上述症状，血压降至105／60mmHg，经相同处理后症状缓解。停用复方利血平氨苯蝶啶改用其它降压药物未再出现类似不良反应。     

复方氢氯噻嗪片剂的质量控制

目的:对自制复方氢氯噻嗪片剂中缬沙坦及氢氯噻嗪两种药物建立系统、全面的质量控制方法,保证该药品质量稳定、可控。方法:采用高效液相色谱法测定两种药物的含量,色谱柱为Kromasil-C18柱(Φ200 mm×4.6 mm,5μm),乙腈-水-冰醋酸(500∶500∶1)为流动相,检测波长为230 nm,流速为0.5 mL/min,进样量为20μL,柱温为室温。结果:缬沙坦含量为标示量的94.55%,在10~40μg/mL的浓度范围内与峰面积呈良好的线性(r=0.999 6,n=9),平均回收率为100.05%,RSD=1.25%(n=9)。氢氯噻嗪含量为标示量的96.63%,在5~20μg/mL的浓度范围内与峰面积呈良好的线性(r=0.999 2,n=9),平均回收率为100.24%,RSD=0.82%(n=9)。结论:高效液相色谱法专属性好,操作方便,结果准确,重现性好,能有效地控制复方氢氯噻嗪片剂中两种药物的质量。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.