利福喷丁、异烟肼、吡嗪酰胺、乙胺丁醇四联治疗初治涂阳肺结核患者的效果

目的:观察利福喷丁、异烟肼、吡嗪酰胺、乙胺丁醇四联治疗初治涂阳肺结核患者的效果。方法:选取98例初治涂阳肺结核患者为研究对象,按照随机数字表法分为观察组与对照组各49例。对照组采用利福平、异烟肼、吡嗪酰胺和乙胺丁醇四联治疗,观察组采用利福喷丁、异烟肼、吡嗪酰胺和乙胺丁醇四联治疗,比较两组痰涂片转阴率、空洞闭合率、病灶吸收率和不良反应发生率。结果:治疗后,观察组痰涂片转阴率为93.88%,明显高于对照组的77.55%,差异有统计学意义(P<0.05);观察组空洞闭合率为95.92%,明显高于对照组的83.33%,差异有统计学意义(P<0.05);观察组病灶吸收率为97.96%,明显高于对照组的83.67%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:利福喷丁、异烟肼、吡嗪酰胺和乙胺丁醇四联治疗初治涂阳肺结核患者可提高痰涂片转阴率、空洞闭合率和病灶吸收率,效果优于利福平、异烟肼、吡嗪酰胺和乙胺丁醇四联治疗效果。     

利福喷丁治疗初治涂阳肺结核患者的疗效观察

目的:探讨利福喷丁治疗初治涂阳肺结核患者的有效性和安全性。方法:将124例初治涂阳肺结核患者分为两组,利福喷丁组62例患者采用利福喷丁+异烟肼+吡嗪酰胺+乙胺丁醇的治疗方案;利福平组62例患者采用利福平+异烟肼+吡嗪酰胺+乙胺丁醇的治疗方案。用药9个月后比较两组痰涂片转阴率、空洞闭合、病灶吸收有效率及不良反应发生率。结果:治疗后利福喷丁组患者痰转阴率、病灶吸收有效率、空洞闭合有效率均高于利福平组,差异均有统计学意义(P<0.05);利福喷丁组患者胃肠道反应、皮疹、肝功能异常和白细胞减少不良反应发生率均低于利福平组,差异有统计学意义(P<0.05)。结论:利福喷丁治疗初治涂阳肺结核疗效优于利福平治疗疗效。     

内消瘰疬丸联合左氧氟沙星治疗耐多药肺结核的 临床疗效分析

目的： 观察内消瘰疬丸与左氧氟沙星联合治疗耐多药肺结核(MDR-TB)的效果。方法：复治涂阳的573例耐多药肺结核患者,随机分为对照组（278例）和治疗组（295例）;治疗方案：吡嗪酰胺、盐酸乙胺丁醇、对氨基水杨酸异烟肼和利福喷汀,治疗组联合内消瘰疬丸和左氧氟沙星,对照组只联合左氧氟沙星,疗程均为12个月。结果： 治疗中途因药物不良反应终止治疗13例,其中治疗组5例（2.81%）,对照组8例（2.18%）,治疗组中以胃肠道反应为主,对照组以肝功能损伤为主,对照组实际完成275例,治疗组实际完成285例。疗程结束时,对照组的痰菌阴转率为55.6%,治疗组痰菌阴转率为78.6%,治疗组高于对照组(P<0.05);治疗组病灶吸收有效率（显著吸收和吸收）为78.9%,空洞闭合有效率（闭合和缩小）为83.9%,病灶吸收有效率及空洞闭合有效率均明显高于对照组(P<0.05)。结论： 内消瘰疬丸联合左氧氟沙星等二线抗痨药治疗耐多药肺结核,有利于痰菌阴转、病灶吸收和空洞闭合,并且药物不良反应发生率低。     

肺结核治疗中利福喷丁与利福平的药效比较研究

目的:研究并对比治疗肺结核患者时使用利福喷丁与利福平的治疗效果。方法:收集肺结核患者共103例,根据患者入院日期的单双号数分为50例对照组和53例观察组,对照组患者使用利福平进行治疗,观察组使用利福喷丁进行治疗,将两组患者的明显吸收率、痰菌转阴率、空洞闭合率以及不良反应发生率进行观察和对比。结果:观察组患者的明显吸收率明显高于对照组,观察组患者的痰菌转阴率显著高于对照组,观察组患者的空洞闭合率显著高于对照组,观察组的不良反应发生率显著低于对照组(P均0.05)。结论:在肺结核患者的治疗过程中使用利福喷丁,能够保证治疗效果,且患者的不良反应发生率低,更加安全可靠,值得推广应用。     

肺结核治疗中利福喷丁与利福平的药效比较研究

目的：研究并对比治疗肺结核患者时使用利福喷丁与利福平的治疗效果。方法：收集肺结核患者共103例,根据患者入院日期的单双号数分为50例对照组和53例观察组,对照组患者使用利福平进行治疗,观察组使用利福喷丁进行治疗,将两组患者的明显吸收率、痰菌转阴率、空洞闭合率以及不良反应发生率进行观察和对比。结果：观察组患者的明显吸收率明显高于对照组,观察组患者的痰菌转阴率显著高于对照组,观察组患者的空洞闭合率显著高于对照组,观察组的不良反应发生率显著低于对照组（P 均＜0．05）。结论：在肺结核患者的治疗过程中使用利福喷丁,能够保证治疗效果,且患者的不良反应发生率低,更加安全可靠,值得推广应用。     

复方甘草酸苷联合短程化疗治疗初治空洞性肺结核42例

目的 :探讨复方甘草酸苷联合短程化疗对初治空洞型肺结核的病灶吸收率、空洞闭合率及痰菌阴转率的影响,总结其临床意义。方法:将80例初治空洞型肺结核患者分为两组,其中治疗组42例,对照组38例,两组均采用标准短程化疗(2HRZE/4HR)方案治疗,治疗组则在其原有治疗的基础上加用复方甘草酸苷治疗,通过观察病灶吸收率、空洞闭合率、痰菌阴转率等情况,对临床疗效进行分析。结果:治疗组病灶吸收总有效率为83.3%,对照组总有效率为73.7%,两组差异有统计学意义;治疗组空洞闭合总有效率为76.2%,对照组为68.4%,两组差异有统计学意义;治疗组痰菌阴转率为87.5%,对照组为76.9%,两组差异有统计学意义。结论:复方甘草酸苷联合短程化疗对初治空洞型肺结核治疗效果明显,能够促进病灶吸收,提高空洞闭合,加速痰菌阴转,无明显不良反应,安全可靠,值得临床推广应用。     

左氧氟沙星联合利福喷丁治疗复治肺结核病疗效观察

目的观察左氧氟沙星联合利福喷丁在复治肺结核病治疗中的疗效。方法采用随机配对分组将172例复治肺结核病患者分为治疗组、对照组,每组各86例。治疗组给予左氧氟沙星联合利福喷丁治疗,对照组用左氧氟沙星联合利福平治疗。结果治疗8个月后,两组的治疗效果进行比较。治疗组痰菌阴转率、疗程结束时痰菌培养阳性率、病灶总吸收率和空洞闭合率均明显优于对照组。结论含左氧氟沙星联合利福喷丁方案在复治肺结核病治疗中,更有助于痰菌阴转、病灶吸收和空洞闭合。     

乌体林斯辅助抗结核药物治疗肺结核患者的疗效分析

目的探讨乌体林斯辅助抗结核药物治疗肺结核的疗效,为肺结核的临床用药提供依据。方法将72例肺结核患者随机等分为对照组和观察组,两组均给予为期6个月的常规抗结核方案治疗,仅观察组加用乌体林斯;分析两组治疗前、治疗6个月后的肺部病灶、空洞变化情况,治疗1、2、3及6个月的痰培养和痰涂片的转阴情况和治疗前后的血清超敏C反应蛋白(hs-CRP)水平及观察用药期间的不良反应。结果观察组的肺部病灶吸收率高于对照组(66.67%vs.50.00%,P<0.05),肺部空洞减少率高于对照组(80.56%vs.61.11%,P<0.05),病灶"明显吸收"和空洞"闭合"的例数均多于对照组(P<0.05);治疗后的痰培养转阴率和涂片转阴率均高于对照组,除治疗6个月的痰培养和痰涂片及治疗3个月的痰涂片外(P<0.05),其余均为P<0.01;治疗后的hs-CRP水平低于对照组[(22.08±3.46)mg/L vs.(29.31±3.62)mg/L,P<0.05]。两组的不良反应发生率均较低且无统计学差异,未发现过敏性休克、血常规、肝肾功能等异常。结论乌体林斯辅助抗结核药物治疗肺结核的效果较好,可促进病灶吸收和空洞闭合,提高痰菌转阴率,不良反应低,患者可耐受。     

利福布汀治疗耐多药肺结核的疗效观察

目的评价利福布汀治疗耐多药肺结核的临床疗效。方法将我院收治的76例MDR-TB患者随机分为治疗组(38例)和对照组(38例),对照组治疗方案为力克肺疾、乙胺丁醇、左氧氟沙星、丙硫异烟胺、阿米卡星;治疗组在此基础上加用利福布汀,疗程18个月。观察2组痰菌阴转率、病灶吸收率、空洞闭合率等情况。结果疗程结束时,治疗组痰菌阴转率为81.6%,高于对照组的60.5%(P<0.05);治疗组病灶吸收率和空洞闭合率分别为86.8%和59.7%,对照组病灶吸收率和空洞闭合率分别为68.4%和42.3%,治疗组高于对照组,差异有统计学意义(P<0.05)。结论利福布汀治疗MDR-TB疗效显著,值得应用推广。     

利福喷丁与利福平治疗肺结核的疗效比

目的:比较利福喷丁与利福平治疗肺结核的临床治疗效果.方法:选取2015年1月至2015年12月在该院住院时采取利福喷丁、异烟肼、吡嗪酰胺和乙胺丁醇治疗的77例肺结核患者作为利福喷丁组,同时选取早期采用利福平、异烟肼、吡嗪酰胺和乙胺丁醇治疗的67例肺结核患者作为利福平组,并比较两组患者临床治疗效果.结果:利福喷丁组患者空洞闭合率、痰菌转阴率以及病症总吸收率等显著高于利福平组(P＜0.05);利福喷丁组患者治疗后不良反应发生率低于利福平组(P＞0.05).结论:利福平和利福喷丁均是治疗肺结核的常用药物,然而利福喷丁临床效果以及治疗安全性均优于利福平.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.