早期小剂量猪肺磷脂注射液联合鼻塞式持续气道正压通气预防早产儿呼吸窘迫综合征的临床观察

目的观察早期应用小剂量猪肺磷脂注射液联合鼻塞式持续气道正压通气(nCPAP)预防高危早产儿(30³4周)呼吸窘迫综合征(NRDS)的临床效果。方法选取2010年1月—2013年12月收治的高危早产儿230例。将所有早产儿随机分为观察组(120例)和对照组(110例)。观察组早产儿采用小剂量猪肺磷脂注射液联合nCPAP,对照组早产儿仅采用nCPAP。观察2组早产儿的血气分析改善情况、NRDS发生率、机械通气率、病死率、并发症发生率、用氧时间、住院时间、住院费用等。结果与用药前比较,用药后2组PaO_2、pH值及Sa02均升高,血PaCO_2降低,且观察组变化幅度均大于对照组,差异均有统计学意义(P<0.05)。观察组NRDS发生率(8.3%)、并发症发生率(8.3%)、机械通气率(4.2%)及病死率(0)均低于对照组(30.9%、46.4%、37.3%、9.1%),差异均有统计学意义(P<0.05)。观察组总用氧时间、住院时间均短于对照组,住院费用低于对照组,差异有统计学意义(P<0.05)。结论早期应用小剂量猪肺磷脂注射液联合nCPAP预防3034周)呼吸窘迫综合征(NRDS)的临床效果。方法选取2010年1月—2013年12月收治的高危早产儿230例。将所有早产儿随机分为观察组(120例)和对照组(110例)。观察组早产儿采用小剂量猪肺磷脂注射液联合nCPAP,对照组早产儿仅采用nCPAP。观察2组早产儿的血气分析改善情况、NRDS发生率、机械通气率、病死率、并发症发生率、用氧时间、住院时间、住院费用等。结果与用药前比较,用药后2组PaO_2、pH值及Sa02均升高,血PaCO_2降低,且观察组变化幅度均大于对照组,差异均有统计学意义(P<0.05)。观察组NRDS发生率(8.3%)、并发症发生率(8.3%)、机械通气率(4.2%)及病死率(0)均低于对照组(30.9%、46.4%、37.3%、9.1%),差异均有统计学意义(P<0.05)。观察组总用氧时间、住院时间均短于对照组,住院费用低于对照组,差异有统计学意义(P<0.05)。结论早期应用小剂量猪肺磷脂注射液联合nCPAP预防30³4周高危早产儿NRDS效果较好,可有效改善血气指标,降低NRDS并发症发生率、机械通气率及病死率,缩短住院时间,值得临床推广应用。     

晚期早产儿呼吸窘迫综合征临床分析

目的通过对患有重症新生儿呼吸窘迫综合征(NRDS)的晚期早产儿进行回顾性分析,进一步了解其临床特点及不同分娩方式对疾病的影响。方法将67例确诊为重症呼吸窘迫综合征并需要气管插管机械通气治疗的晚期早产儿分为剖宫产组及经阴分娩组,分析两组患儿的一般临床资料,并比较两组患儿的发病时间、机械通气时间、用氧时间、并发症发生情况、住院时间及转归情况。结果 67例患儿中剖宫产组患儿占61.2%,且发病早,肺部感染及颅内出血发生率高、住院时间长,而经阴分娩组机械通气时间及用氧时间较剖宫产组长。两组患儿转归无明显差异。结论剖宫产较经阴分娩的晚期早产儿更易出现重症呼吸窘迫综合征,且易合并肺部感染及颅内出血;经阴分娩患儿因发病时间晚易被忽视,所以要加强呼吸管理以改善预后。     

≤34周早产剖宫产69例分析及近远期并发症随访

目的　探讨早产分娩方式对≤孕 34周早产儿的近远期并发症影响及寻求早产的最佳分娩途径。方法　 6 9例住院的≤孕 34周剖宫产病例与随机抽取同期同孕周的阴道分娩病例 93例进行回顾性分析 ,比较两种分娩方式对孕妇的影响及早产儿近期并发症 (包括新生儿窒息、新生儿呼吸窘迫综合征、颅内出血和死亡 )和远期影响 (包括身高、综合学习能力 )。结果　妊高征组的窒息率、新生儿呼吸窘迫综合征 (NRDS)发生率较前置胎盘组低(P <0 0 5 ) ;臀位分娩时剖宫产组的预后较阴道分娩好 (P <0 0 5 ) ;剖宫产组出生的早产儿重度窒息率 ,NRDS、脑出血发生率、病死率均低于阴道分娩组 (P <0 0 5 ) ,但综合学习能力比率较高 ;轻度窒息率、缺血缺氧性脑病 (HIE)及目前身高两组差异无显著性 (P >0 0 5 )。结论　随着NICU发展及新生儿救治水平的提高 ,剖宫产不是低体重早产儿的禁忌证 ,在合并母儿病理产科的情况下 ,及时转运至有条件的医院 ,剖宫产分娩更有利于预防早产儿近远期严重并发症的发生     

不同分娩方式对晚期早产儿呼吸系统疾病发生及预后的影响

目的对比不同分娩方式对晚期早产儿呼吸系统疾病发生率及预后的影响。方法该研究以2017年1月至2018年12月于该院妇产科分娩的397例晚期早产儿作为观察样本,根据分娩方式的不同将其分为自然分娩组(93例)与选择性剖宫产(ECS)组(217例)与急诊剖宫产组(87例),对比各组晚期早产儿呼吸系统疾病发生率以及预后情况。结果 ECS组新生儿呼吸系统疾病发病率为41.01%(89/217),急诊剖宫产组发病率为40.23%(35/87),自然分娩组发病率为18.28%(17/93),自然分娩组明显低于其他两组,差异具有统计学意义(P0.05)。自然分娩组中共出现缺血缺氧性脑病5例,肺炎3例,畸形1例,死亡1例,预后明显优于其他两组,差异具有统计学意义(P0.05)。结论 ECS与急诊剖宫产晚期早产儿的呼吸系统疾病发病率明显高于自然分娩早产儿,且预后不良,应尽量控制剖宫产率。     

晚期早产儿呼吸窘迫综合征高危因素及临床特点分析

目的 比较早、晚期早产儿呼吸窘迫综合征(RDS)的特点,探讨晚期早产儿RDS的高危因素和临床特点.方法 选择2014年1月至2015年1月在该院住院240例早产儿RDS,根据胎龄分为两组,<34周为早期早产儿组(143例),34~36+6为晚期早产儿组(97例).回顾性分析早产儿RDS的基本情况、围生期高危因素、临床特点、治疗及预后.结果 晚期早产儿组分娩方式以剖宫产为主,剖宫产率达83.51%,明显高于早期早产儿组(P<0.05).晚期早产儿组因先兆子宫破裂行剖宫产致早产的发生率较高(27.84%);肺表面活性剂(PS)及无创辅助通气治疗效果较早期早产儿差,且机械通气率高,通气时间长;肺动脉高压发生率、宫内感染的发生率亦高于早期早产儿组(P<0.05).结论 晚期早产儿RDS以产程未发动的剖宫产为主,宫内感染可能为其高危因素,PS应用有效,但较早期早产儿效果差;晚期早产儿机械通气率较高,但预后良好.     

晚期早产儿近期呼吸系统并发症高危因素分析

目的 探讨晚期早产儿发生近期呼吸系统并发症的危险因素.方法 选取2011年1月至2014年12月我院收治的112例发生了近期呼吸系统疾病的晚期早产儿为观察组,随机选取同期收治的112例未发生此类疾病的晚期早产儿为对照组,分别对两组患儿的临床资料进行分析,筛选出晚期早产儿发生近期呼吸系统并发症的危险因素.结果 单因素分析结果显示,晚期早产儿发生近期呼吸系统并发症与妊娠高血压综合征、前置胎盘、胎盘早剥、母孕晚期发热、胎膜早破、羊水污染、宫内窘迫以及出生时有窒息史、小于胎龄儿、剖宫产、多胎率、脓毒血症有关(P<0.05).将上述因素纳入多元Logistic回归分析显示,母孕晚期发热、胎膜早破、宫内窘迫、剖宫产、多胎率、有窒息史、脓毒血症,是晚期早产儿发生近期呼吸系统并发症的危险因素(P<0.05),具有预警功能.结论 尽早对晚期早产儿近期呼吸系统并发症各危险因素进行有效监测与随访,可及时对患儿进行合理的干预,从而有效降低晚期早产儿近期呼吸系统疾病的发生率与死亡率.     

晚期早产儿的临床研究及危险因素探讨

目的分析晚期早产儿的一般情况、并发症及危险因素。方法收集2009年本院出生以及外院出生,生后需在本科住院的晚期早产儿资料,采用SPSS13．0分析。结果晚期早产儿共508例,331例发生并发症,以高胆红素血症（43．1％）最常见,不同胎龄平均住院费用、住院时间有明显差异;胎龄、出生体重、双胎是发生并发症的保护因素,男性是危险因素。结论晚期早产儿易发生多种并发症,以高胆红素血症最常见,临床医生需密切观察,及时处理。     

肺表面活性物质对不同胎龄呼吸窘迫综合征早产儿的疗效

目的探讨肺表面活性物质(PS)对不同胎龄呼吸窘迫综合征(RDS)早产儿的疗效差异,以及应用PS预防RDS的最佳时机。方法选择2003年1月至2011年8月入院胎龄28～35周的早产儿207例,其中应用PS 93例(应用组),未应用PS 114例(未应用组)。比较两组不同胎龄早产儿的患病率、5 d内病死率、机械通气时间、氧疗时间、住院时间以及主要并发症的发生情况。结果应用组RDS患病率比未应用组降低了27.0%(P<0.05)。应用组5 d病死率(5.94%)比未应用组(17.7%)明显降低(P<0.05);应用组机械通气时间、氧疗时间比未应用组明显减低(P<0.05);但住院时间两组无显著性差异(P>0.05)。应用组肺出血,肺炎发生率均低于未应用组(P<0.05)。结论应用PS可减少RDS患病率,降低早产儿的病死率,缩短机械通气时间和氧疗时间,减少肺出血、呼吸机相关性肺炎的发生率。     

双胎妊娠89例围产结局分析

目的 分析双胎妊娠的围产结局,防治妊娠期各种并发症,探讨有利于分娩的时机和方式.方法 对2003年1月～2007年1月营口市内住院分娩的89例双胎妊娠围产结局进行回顾性分析.结果 双胎妊娠期并发症早产发生率最高,占48.31%;足月儿围生期病死率与早产儿围生期病死率差异具有非常显著性意义(P＜0.01);阴道顺产组和剖宫产组的新生儿窒息率、病死率与阴道助产组差异具有非常显著性意义(P＜0.05),而剖宫产组新生儿窒息率和病死率与阴道顺产组差异无显著性意义(P＞0.05).结论 及早发现并积极治疗各种妊娠期并发症,防止早产的发生,选择适宜的分娩时机和恰当的分娩方式能够降低双胎围产儿窒息率和病死率.     

二次妊娠合并瘢痕子宫产妇剖宫产并发症情况56例分析

目的研究分析二次妊娠合并瘢痕子宫产妇剖宫产的并发症情况。方法选取我院于2015年12月至2017年6月收治的二次妊娠合并瘢痕子宫产妇56例为实验组,以及二次妊娠初次剖宫产产妇56例为对照组,两组产妇均实施剖宫产分娩方式,记录并比较两组产妇的并发症发生率、手术时间等临床指标。结果实验组产妇有34例出现并发症,其中盆腔粘连发生率最高,其次为产后出血,总发生率为60.71%,对照组有3例出现并发症,其中产后出血发生率最高,总发生率5.35%,实验组的产后出血、盆腔粘连以及总发生率均显著高于对照组(P0.05);两组产妇均手术顺利,无脏器损伤且未发生产妇或胎儿死亡例,实验组中初次行横切口剖宫产产妇的分娩时间、手术时间显著长于初次行纵切口剖宫产产妇,术中失血量显著多于初次行纵切口者,且差异具有统计学意义(P0.05)。结论二次妊娠合并瘢痕子宫产妇剖宫产并发症发生率显著高于正常二次妊娠初次剖宫产,且初次妊娠的剖宫产方法对再次妊娠行剖宫产术后并发症的发生情况有影响。     

Epidemiology of respiratory distress and the illness severity in late preterm or term infants: a prospective multi-center study

Background The severity of respiratory distress was associated with neonatal prognosis. This study aimed to explore the clinical characteristics, therapeutic interventions and short-term outcomes of late preterm or term infants who required respiratory support, and compare the usage of different illness severity assessment tools.Methods Seven neonatal intensive care units in tertiary hospitals were recruited. From November 2008 to October 2009, neonates born at ≥34 weeks＇ gestational age, admitted at 〈72 hours of age, requiring continuous positive airway pressure （CPAP） or mechanical ventilation for respiratory support were enrolled. Clinical data including demographic variables, underlying disease, complications, therapeutic interventions and short-term outcomes were collected. All infants were divided into three groups by Acute care of at-risk newborns （ACoRN） Respiratory Score 〈5, 5-8, and 〉8.Results During the study period, 503 newborn late preterm or term infants required respiratory support. The mean gestational age was （36.8±2.2） weeks, mean birth weight was （2734.5±603.5） g. The majority of the neonates were male （69.4%）, late preterm （63.3%）, delivered by cesarean section （74.8%）, admitted in the first day of life （89.3%） and outborn （born at other hospitals, 76.9%）. Of the cesarean section, 51.1% were performed electively. Infants in the severe group were more mature, had the highest rate of elective cesarean section, Apgar score 〈7 at 5 minutes and resuscitated with intubation, the in-hospital mortality increased significantly. In total, 58.1% of the patients were supported with mechanical ventilation and 17.3% received high frequency oscillation. Adjunctive therapies were commonly needed.Higher rate of infants in severe group needed mechanical ventilation or high frequency oscillation, volume expansion,bicarbonate infusion or vasopressors therapy （P 〈0.05）. The incidence of complications was also increased significantly in severe group （P 〈0.05）. The in-hospital mortality in the severe group was significantly higher than other two groups （P〈0.05）. ACoRN Respiratory Score was correlated with Score for Neonatal Acute Physiology-Version Ⅱ （SNAP-Ⅱ） （P〈0.01）. High gestational age, high SNAP-Ⅱ score and oxygenation index （OI）, and Apgar score at 5 minutes 〈5 were independent risks for death.Conclusions Neonatal respiratory distress is still a common cause of hospitalization in China. Illness severity assessment is important for the management. ACoRN Respiratory Score which correlated with SNAP-Ⅱ score is easy to use and may be helpful in facilitating the caregivers in local hospital to identify the early signs and make the transfer decision promptly.     

456例孕妇早产的原因及早产儿结局分析

目的探讨降低早产儿死亡率的方法。方法回顾分析456例孕妇早产的原因和510例围生儿的结局。结果胎膜早破和多胎妊娠是引起早产的主要因素,重度妊高征、前置胎盘、胎盘早剥和妊娠合并心脏病是引起医源性早产的最常见原因。在有规律产前检查的早产病例中,新生儿的死亡率明显降低。临产前应用地塞米松肌注或静注,产后加强新生儿护理,可降低早产儿的并发症和死亡率。结论早产是新生儿发病和死亡的主要原因,肺透明膜病、窒息和颅内出血是早产儿死亡的主要原因,早产不是剖宫产的禁忌证,对于不可避免的医源性早产,规律的产前检查和适当的诊治能够取得良好的妊娠结局。     

A study of caesarean section cases with special reference to maternal and neonatal outcome.

Two hundred cases of lower uterine segment caesarean section were studied in SSKM Hospital and IPGME&R, Calcutta (a referral hospital) during the period 1986-1987. All were unselected cases of which 192 were booked and 8 were unbooked. The maximum number of caesarean sections were done in the age group of 21-30 years ie, in 154 cases (77.00%). Of total number of cases 53.5% were primigravida, and rest were multipara. Postoperative complications were noted in 42 cases (21%). Complications were more in unbooked and emergency cases ie, 7 (87.5%) and also in cases of antepartum haemorrhage (3 out of 8 cases) and where foetal distress (12 out of 51 cases) ie, prolonged labour, difficult labour was present. Neonatal mortality and morbidity (8 and 26 out of 154 total births respectively) were high in the age group of 21-30 years. Neonatal complications following caesarean section were found in 21.8% patients in emergency caesarean section and 15.5% in elective caesarean section. Neonatal morbidity was 15% and perinatal mortality was 4% in this study. Asphyxia (11 cases) and respiratory distress syndrome (10 cases) were more dangerous complications in caesarean section. There was no maternal mortality in this series.     

Risk of complications in a second pregnancy following caesarean section in the first pregnancy: a population-based study

OBJECTIVE: To estimate the risks of maternal and perinatal morbidity and mortality in a second pregnancy, attributable to caesarean section in a first pregnancy. DESIGN AND SETTING: Cross-sectional analytic study of hospital births in New South Wales, based on linked population databases. PARTICIPANTS: 136 101 women with one previous birth who gave birth to a singleton infant in NSW in 1998-2002. MAIN OUTCOME MEASURES: Crude and adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for maternal and perinatal morbidity and mortality. RESULTS: 19% of mothers had a caesarean section in their first pregnancy. Compared with mothers who had had primary vaginal births, mothers who had had primary caesarean section and underwent labour in the second birth were at increased risk of uterine rupture (aOR, 12.3; 95% CI, 5.0-30.1; P < 0.0001), hysterectomy (3.5; 1.5-8.4; P < 0.01), postpartum haemorrhage (PPH) following vaginal delivery (1.6; 1.4-1.7; P < 0.0001), manual removal of placenta (1.3; 1.1-1.6; P < 0.01), infection (6.2; 4.7-8.2; P < 0.0001) and intensive care unit (ICU) admission (3.1; 2.1-4.7; P < 0.0001); among mothers who did not undergo labour (ie, had an elective caesarean section), there was a lower risk of PPH (0.6; 0.5-0.7; P < 0.0001) and ICU admission (0.4; 0.3-0.5; P < 0.0001). For infants there was increased risk of preterm delivery (1.2; 1.1-1.3; P < 0.0001) and neonatal intensive care unit admission following labour (1.6; 1.4-1.9; P < 0.0001) in the birth after primary caesarean section. The occurrence of stillbirth was not modified by labour. CONCLUSIONS: Caesarean section in a first pregnancy confers additional risks on the second pregnancy, primarily associated with labour. These should be considered at the time caesarean section in the first pregnancy is being considered, particularly for elective caesarean section for non-medical reasons.     

晚期早产儿小于胎龄儿围生期呼吸系统并发症的危险因素研究

背景　小于胎龄儿体格发育较适于胎龄儿差,易合并呼吸窘迫综合征、肺部感染、喂养不耐受、脑瘫、生长发育落后等并发症,其中晚期早产儿小于胎龄儿的呼吸系统疾病发生率显著高于适于胎龄儿,而关于晚期早产儿小于胎龄儿围生期呼吸系统并发症危险因素的相关研究目前相对较少。目的　探讨晚期早产儿小于胎龄儿围生期呼吸系统并发症发生情况及其相关危险因素。方法　选取河北北方学院附属第一医院2015年1月-2017年1月收治的100例晚期早产儿（剔除大于胎龄儿）的临床资料进行回顾分析。根据新生儿出生时体质量分为小于胎龄儿组（n=45）和适于胎龄儿组（n=55）,比较两组呼吸系统并发症的发生情况。另根据小于胎龄儿组中是否发生呼吸系统并发症分为疾病亚组（n=28）和非疾病亚组（n=17）,对母亲和新生儿可能的相关因素进行单因素分析。采用多因素Logistic回归分析晚期早产儿小于胎龄儿围生期呼吸系统并发症的危险因素。结果　小于胎龄儿组围生期呼吸系统并发症发生率高于适于胎龄儿组（62.2%与41.8%,χ2=4.122,P<0.05）。疾病亚组母亲相关因素中妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、胎盘早剥发生率及新生儿相关因素中脓毒症发生率高于非疾病亚组（P<0.05）。多因素Logistic回归分析显示,妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、新生儿脓毒症为发生呼吸系统并发症的危险因素（P<0.05）。结论　晚期早产儿小于胎龄儿围生期呼吸系统并发症发生率高于适于胎龄儿,妊娠期高血压、多胎妊娠、孕期感染、脐带异常、宫内窘迫、孕晚期发热、胎膜早破、窒息史、新生儿脓毒症是引起晚期早产儿小于胎龄儿围生期呼吸系统并发症的高危因素。     

剖宫产术后再次妊娠分娩方式的选择

目的:探讨剖宫产术后再次妊娠分娩方式的选择。方法:剖宫产术后再次妊娠晚期分娩孕妇614例为观察组,分4组:A组为剖宫产术后阴道分娩组;B组为具备阴道试产条件但选择重复剖宫产分娩组;C组为第二次剖宫产分娩组(包括B组);D组为第三次及四次剖宫产分娩组。选择无剖宫产史晚期分娩孕妇376例为对照组,分为2组:阴道分娩组(E组)和首次剖宫产组(F组)。将A组与B组,A组与E组,C、D组与F组配对比较,对母婴并发症、手术时间及住院时间等进行回顾性分析。结果:A组产后出血量和住院时间均明显少于B组(P<0.01),2组产褥病率及新生儿窒息率差异均无统计学意义(P>0.05);A组与E组产后出血量、产褥病率、住院时间、新生儿窒息率及阴道助产率差异均无统计学意义(P>0.05),A组会阴切开率较E组明显升高(P<0.01);C组、D组与F组产后出血量、产褥病率、住院时间及新生儿窒息率差异均无统计学意义(P>0.05),F组手术时间和盆腹腔粘连率均明显少于C组(P<0.01),C组和F组手术时间和盆腹腔粘连率亦显著小于D组(P<0.01)。结论:剖宫产术后再次妊娠,经过严格评估、筛选,对符合阴道分娩条件的孕妇实施阴道试产是安全的,与再次剖宫产相比可明显缩短住院时间,减少母婴并发症。     

Impact of increased rate of caesarean section on perinatal outcome: sociolegal evaluation

Sharp rise in the caesarean section rate, over the past years has been causing lot of concerns. It is to be evaluated whether the decrease in perinatal mortality rate is due to the rising rate of caesarean section. Five hundred consecutive patients were selected on whom caesarean section had been performed. Both mother and baby were followed till they are discharged from the hospital. Foetal distress was the commonest indication in primigravidae who underwent caesarean section. The other indications of caesarean section in this study were breech, severe pre-eclampsia, eclampsia, cord prolapse, elderly primi, postdated, premature rupture of membrane, twin, compound presentation, meconium stained liquor. The occurrence of perinatal morbidity in caesarean section was 10% compared to 12% in vaginal delivery. Common causes of perinatal morbidity were asphyxia, prematurity, diarrhoea, septicaemia, jaundice, conjunctivitis and scalp injury. The occurrence of perinatal mortality in caesarean section was 3.8% compared to 3% in vaginal delivery. Causes of perinatal mortality were stillbirth, meconium aspiration syndrome, hypoxic ischaemic encephalopathy, prematurity and congenital malformation. In spite of safety of vaginal birth after caesarean section it continues to be underutilised. Good perinatal care proper screening and use of newer effective pharmacological agents improve the maternal progress as well as perinatal outcome without increasing the caesarean section rate.     

新生儿呼吸衰竭临床比较分析

目的:对新生儿呼吸衰竭患儿的基本情况、主要病因、临床治疗、预后等情况进行临床回顾性分析,以便总结临床治疗经验。方法:选择2010年1月-2011年12月我院ICU收治的NRF患儿67例进行回顾性分析,资料收集包括患儿的基本情况(胎龄、出生体重、性别、母亲产前疾病、出生时情况等)、疾病诊断、选择性的临床治疗情况、患儿预后等。67例新生儿呼吸衰竭患儿分成三组,胎龄<34周的早产儿,胎龄34～36周的晚期早产儿,胎龄37～42周的足月儿。结果:胎龄<34周的早产儿Apgar评分较其他组偏低(P<0.05)。引起新生儿呼吸衰竭的原发病,胎龄<34周的早产儿新生儿呼吸窘迫综合征占绝大多数(72.0%),晚期早产儿以新生儿呼吸窘迫综合征(41.7%)和肺炎(41.7%)多见,足月儿则以肺炎占半数(50.0%),差异有统计学意义(P<0.05)。新生儿呼吸衰竭治愈56例(83.6%);好转2例(3.0%);放弃治疗9例,病死率13.4%。胎龄<34周患儿住院时间(20.1±6.0)d比晚期早产儿和足月儿长[分别为(12.0±2.2)d及(10.7±2.5)d],有显著差异(P<0.05)。结论:新生儿呼吸衰竭主要由新生儿呼吸窘迫综合征及肺炎所至,应加强对不同时期新生儿呼吸衰竭原发病、多发病的认识。预后受原发疾病、胎龄、并发症诸多因素影响,新生儿呼吸衰竭的治疗持续气道正压通气呼吸支持很重要。