慢性肾炎患者血、尿表皮生长因子的检测及意义

目的 探讨慢性肾炎患者血、尿表皮生长因子(EGF)含量的变化及意义.方法 用放射免疫法测定尿EGF含量.结果 肾功能正常组血、尿EGF均显著高于对照组,肾功能不全组尿EGF显著高于肾功能不全组和对照组,肾功能正常组血EGF浓度与对照组无显著性差异,肾功能不全组血EGF显著高于肾功能正常组和对照组.结论 EGF在慢性肾炎的病变发生、发展中可能有重要的意义,尿EGF含量可以作为判断慢性肾炎肾小球及肾小管损伤的指标之一.     

提高中医药治疗慢性肾炎疗效的几个环节

慢性肾炎是临床常见肾病 ,占泌尿系疾患的 2 1.6 3% [1]。因其易发展为慢性肾功能衰竭 ,故积极正确地治疗慢性肾炎 ,是防止和延缓肾功能衰竭的首要任务 ,本人认为重视以下几个方面对慢性肾炎的治疗具有积极意义。1　重视病因多元性目前 ,西医对慢性肾炎的病因尚不太清楚。认为部分为急性链球菌感染后肾炎迁延不愈、病程在一年以上 ,可转入慢性肾炎 ;但大部分慢性肾炎并非由急性肾炎迁延而致 ;其它细菌及病毒感染亦可引起慢性肾炎。中医学虽无慢性肾炎的病名 ,但从其发病特点、临床表现分析 ,属水肿、腰痛、尿血、虚劳等病证范畴 ,对其病因的…     

慢性肾功能不全20例临床疗效观察

慢性肾炎可出现肾功能不全,至晚期肾功能损害严重。实践证明,中医中药对慢性肾功能不全有一定疗效,现将20例慢性肾炎肾功能不全的治疗观察结果总结如下：     

咋用中药治疗慢性肾炎

慢性肾炎是慢性肾小球肾炎的简称。该病是由多种因素导致的一种临床常见的自身免疫性疾病，也是导致肾功能衰竭的最主要原因。慢性肾炎多见于成年人，一般呈进行性发展倾向。该病患者的主要临床表现是：     

益气助阳中药对慢性肾炎病人肾小球滤过功能及血β_2—微球蛋白的影响

慢性肾炎是一种临床常见病,随着病情的进展,病人会逐步出现肾功能减退。而延缓慢性肾炎病人肾功能减退,是提高疗效,改善预后的关键。肾炎益气液是著名肾病专家吕仁和教授的经验方,具有益肾助阳的功用。我们观察了肾炎益气液改善慢性肾炎病人肾小球滤过功能的作用,取得满意疗效。     

慢性肾炎肾血流量变化分析

目的:对慢性肾炎患者1 356例进行肾血流量分析,得出慢性肾炎病程长短、临床分型及肾功能与肾血流量的关系。方法:患者行同位素肾图检查。结果:患者病程越长,其肾血流量越低;肾病型与肾功能正常组患者肾血流量无显著性差异(P>0.05)。慢性肾炎普通型和高血压型比肾功能正常组肾血流量显著降低(P<0.01);慢性肾炎肾功能正常的患者与代偿期、失代偿期患者比较其肾血流量均具有显著性差异(P<0.05)。结论:肾血流量大小可反映肾功能的损害程度。     

慢性肾炎患者心率变异性改变

目的：通过心率变异性测定了以了解慢性肾炎患者自主神经功能状态,并探讨其机理和临床意义。方法：对20名正常人,40名肾功能正常期、18名肾功能不全代偿期、21名肾功能不全失代偿期、19名肾功能衰竭期和14名尿毒症期的慢性肾炎患者,进行了心率变异性测定。心率变异性以SDNN、SDANNindex、SDNNindex和rMSSD作为观察指标。结果：慢性肾炎患者随着肾功能损害程度的加重,SDNN、SDANNindex、SDNNindex、rMSSD逐渐降低。结论：慢性肾炎患者随着肾功能的减退,心率变异性下降,自主神经调节功能下降,有可能增加心血管事件的发生。     

慢性肾小球疾病的中医治疗概述

慢性肾小球疾病(简称慢性肾炎)是由多种原因所致的表现为多种病理类型的一组肾小球疾病,临床表现以缓慢进展的肾功能减退,伴有蛋白尿、血尿和高血压为特征.慢性肾炎是临床广为多见的一种肾脏疾病,可引起不同程度的肾功能损伤,大多数慢性肾炎病因尚不清楚,起病即呈慢性,疾病跨度大、危害性严重,是临床常见病、多发病.     

缚服肾病 为期不再遥远——访中医肾病专家黄文政教授

肾,是人体最 主要的排泄器官。它能通过生成尿液排出大量的代谢终产物,而且还具有多种生理功能。一旦肾脏出了毛病,后果是非常严重的。急性肾炎可发生水肿、高血压和尿的改变,重症可出现心力衰竭和急性肾功能衰竭。慢性肾炎可由急性肾炎发展而来(但多数病人无急性肾炎史)。各种慢性肾炎病发展到晚期可导致肾功能衰竭、尿毒症,直接威胁病人的生命。所以,防治肾病也是当前社会关注的热点之     

前列地尔治疗慢性肾小球肾炎40例疗效观察

慢性肾小球肾炎(简称慢性肾炎)又称弥漫性硬化性肾小球肾炎, 是各种类型肾小球肾炎发展到晚期的结果,大多数患者有不同程度的高血压和肾功能损害, 临床上主要是对症治疗.笔者应用前列地尔(前列腺素E1,PGE1)治疗慢性肾炎40例,获得满意疗效,现作报道.     

Acute glomerulonephritis

Glomerulonephritis is an important cause of renal failure thought to be caused by autoimmune damage to the kidney. While each type of glomerulonephritis begins with a unique initiating stimulus, subsequent common inflammatory and fibrotic events lead to a final pathway of progressive renal damage. In this article the different forms of inflammatory glomerulonephritis and their diagnosis are discussed. In a review of therapy both immediate life saving treatment given when glomerulonephritis causes acute renal failure and more specific treatments designed to modify the underlying mechanisms of renal injury are considered.     

浅谈情境教学法在中西医结合肾脏病临床教学中的应用与研究

慢性肾小球肾炎和慢性肾功能衰竭为中西医结合肾脏病教学中的基础核心课程,将情境教学法引入其教学过程,既能使学生在课堂上得到临床实践的机会,又能使医学课程的教学摆脱枯燥乏味,激发学生兴趣,从而大大提高医学生的临床实践能力.     

Medical causes and histological pattern of glomerulonephritis

Glomerulonephritis (GN) is one of the commonest causes of chronic renal failure (CRF) and end stage renal failure (ESRF). The outcome largely depends on the underlying medical cause, clinical findings and histological appearance. 1188 patients were taken in this study. Of these, 980 had primary and 208 secondary GN. Commonest histological types of primary GN were mesangial proliferative glomerulonephritis (31%) and membranous nephropathy (21%). Among patients with secondary GN, predominant cause was lupus nephritis (76%) followed by poststreptococcal GN (18%). Clinically, nephrotic syndrome was present in 54%, hypertension in 39% and renal failure in 28%. But clinical pictures were variable among different histological types of GN.     

PAI-1在慢性肾脏病肾小球的表达及意义

目的 研究肾小球纤溶酶原激活物抑制剂-1(PAI-1)在IgA系膜增生性肾小球肾炎、非IgA系膜增生性肾小球肾炎、膜性肾病、局灶增生硬化性肾小球肾炎、微小病变性肾病患者肾组织的表达情况,探讨其表达水平与肾脏病理变化及临床资料之间的关系.方法 采用免疫组化法和计算机图文分析系统对45例入选疾病组和5例正常对照组的PAI-...     

Chronic renal failure in Jamaican children

In order to document the incidence, aetiology and outcome of chronic renal failure in Jamaican children, paediatric surgeons and hospital based paediatricians island-wide were contacted, and the nephrology records at the island's paediatric nephrology centres searched for data on children < 12-year-old with chronic renal failure diagnosed for the first time between January 1985 and December 2000. Thirty-four children were identified, 21 were male. The cumulative annual incidence of chronic renal failure was 3.2 per million children aged < 12 years. The incidence is likely underestimated, as some children may have been undiagnosed and/or not referred. Glomerulonephritis was the commonest cause of chronic renal failure (50%) followed by obstructive uropathy, reflux nephropathy, renal dysplasia and chronic pyelonephritis (41.2%). Five children (14.7%) had reflux nephropathy (post obstructive in four). Half the children were already in chronic renal failure at time of presentation. Mortality was 65%. In Jamaica, childhood chronic renal failure is due mainly to potentially treatable diseases. Local physicians should be more aware of potentially progressive renal diseases and their prevention. Earlier referral of difficult cases for nephrological consultation is recommended. A paediatric dialysis/transplant programme is needed.     

CHRONIC RENAL FAILURE - PITFALLS IN DIAGNOSIS

Chronic renal failure means progressive and irreversible destruction of nephrons involving almost every organ system of the body. Early diagnosis of the disease and conservative therapy can slow down progression towards end stage renal disease. Nocturia/polyuria, anaemia, hypertension, osteodystrophy, reduced kidney size and associated acute renal failure are features which help physician in an early diagnosis. Detailed evaluation of these features has been suggested.KEYWORDS: Anaemia, Chronic, Osteodystrophy, Polyuria, Renal failure     

慢性肾衰竭大鼠模型的建立

目的 建立两种慢性肾衰竭大鼠模型,观察瘦素蛋白在大鼠组织、器官中的表达.方法 建立两种慢性肾衰竭CRF动物模型:(1)大鼠肾大部分切除诱发肾衰(Platt法).(2)腺嘌呤诱发大鼠慢性肾衰竭的动物模型(Yokozawa法).分别测定血清中血尿素氮(BUN),血肌酐(Scr)Ca2+、P5+等含量.取肾脏组织,HE染色,行免疫荧光,检测瘦素蛋白在两种慢性肾衰竭大鼠模型中的表达情况.结果 模型组大鼠血清中血尿素氮(BUN),血肌酐(Scr)等含量明显升高,免疫荧光检测显示两种模型大鼠肾脏组织瘦素蛋白的表达.结论 成功建立两种慢性肾衰竭CRF动物模型,显示不同模型组织部位的瘦素蛋白的表达.为进一步探讨瘦素蛋白在动物体内的生物学作用提供实验基础.     

中医药治疗慢性肾衰竭临床及实验研究进展

慢性肾衰竭为临床常见病,近年来中医药在延缓慢性肾衰竭进程中进行了广泛的研究,取得了满意的疗效。文章对近年中医药治疗慢性肾衰竭的临床及实验研究作一综述。     

银杏叶片灌肠治疗对慢性功能肾衰竭大鼠模型肾功能影响的实验研究

目的：探讨银杏叶片灌肠治疗慢性肾衰竭大鼠的作用及护理措施的实施。方法：通过SPF级SD雄性大鼠48只,随机分为4组,建立慢性肾功能衰竭大鼠模型,并结合灌肠速度、时间、灌肠液的温度护理措施的应用,观察银杏叶片灌肠后模型大鼠体重变化,血尿素氮（BUN）、肌酐（Scr）、24h尿蛋白量、血液学及生化等肾功能的变化。结果：银杏叶片灌肠结合恰当的护理措施能显著降低血BUN、Scr及24h尿蛋白量,改善血液中电解质水平。结论：银杏叶片灌肠能够减轻大鼠慢性肾衰症状并延缓肾衰进程。结合恰当的护理措施,可为银杏叶片中药灌肠治疗慢性肾功能不全提供实验依据。     

Zhang Qi＇s Experience in Treating Chronic Renal Failure

Chronic renal failure is a result of the parenchymatous injury of kidney and progressive exacerbation due to many reasons.It is a svstematic clinical syndrome caused by the disturbance in excreting metabolites,adjusting water-electrolyte and acid-base balance as well as production and inactivation of active substances of endocrine.Prof Zhang Qi has rich clinical experience in treating renal failure.A report follows.