基于PC机的频谱心电图分析方法

介绍了频谱心电图分析的基本原理以及基于PC机的频谱心电图分析的实现方法，详细讨论了在实际应用中应注意的问题，并给出了实例分析。     

12导联频谱心电图检查在爆发型病毒性心肌炎诊断中的应用

目的 分析12导联频谱心电图(FCG)检查在爆发型病毒性心肌炎诊断中的临床应用价值.方法 选取拟诊爆发型病毒性心肌炎120例,采用Wilson连接方式,分别做心电图和频谱心电图,并对检测结果进行分析.结果 120例病例中,54例拒绝行心肌、心内膜或心包(活检或病理)或心包穿刺检查.诊断检出率55%.12导联心电图异常者79例(65.8%);12导联频谱心电图异常者99例(82.5%);心电图和频谱心电图同时异常者69例(57.5%).12导联频谱心电图的检出率大于12导联心电图.12导联频谱心电图发现室性期前收缩37例;房性期前收缩29例;交界性期前收缩7例,I度房室传导阻滞8例;Ⅱ度I型房室传导阻滞6例;Ⅱ度Ⅱ型房室传导阻滞4例;心肌缺血8例,其中前壁异常2例、下壁异常3例、AVF区异常3例,而12导联心电图并未发现.结论 12导联频谱心电图对爆发型病毒性心肌炎的早期诊断比心电图更敏感,可避免部分心肌炎的误诊,值得临床推广.     

频谱心电图与静息心电图对早期诊断冠心病的对比分析

冠心病是危及中老年人健康重要疾病之一,其诊断方法较多。 本文通过对频谱心电图及静息心电图比较分析,探讨频谱心电图对冠心病的早期诊断的价值。 1 资料与方法 我院对1990年7月至1992年1月来我科就诊的343例中老年患者同时进行静息心电图与频谱心电图检查。男202例,女141例。经1979年世界卫生组织所确定冠心病诊断标     

浅析心肌炎在心电综合分析系统的表现

目的 探讨心肌炎在心电综合分析系统的表现及与普通心电图的结果对比.方法 采用自身对照的方法,分别对13例患者进行心电综合分析系统及普通心电图检查.结果 心电综合分析系统的各项结果与普通心电图对比:频谱心电图、心率变异性及心向量图有显著差异(P<0.05).结论 心电综合分析系统比普通心电图对心肌炎诊断的帮助有更大的临床意义.     

频谱心电图在心脏疾患中的应用

<正> 我们用BIE频谱心电图检查仪对240名患者进行了检查,结果阳性率占871.75％,提示频谱心电图对各种疾病引起的心肌缺血检出率高于普通心电图。对诊断心脏病疾患、冠心病等有较高的诊断价值。 资料:本组240例均为我院近两年患者,其中男123例,女117例,年龄8—76岁,平均48.65岁。使用北京市科学技术研究院科力总公司生产的BIE频谱心电图仪,导联线的连接同普通心电图机。主要指标是功率谱中1/     

正常人心房电活动的频谱分析

正常人心房电活动的频谱分析四川省卫生管理干部学院（６１００４１）吴青，胡文尧随着微机技术在医学领域的渗透，采用电子计算机对心电信号进行频谱分析已成为当前高频心电图研究的热点。目前国内外研究的现状大都局限在心室电活动的ＱＲＳ波进行频谱分析，对于心房除极...     

103例频谱心电图与常规心电图对照分析

为探讨频谱心电图的临床价值 ,我们对 1 0 3例进行频谱心电图与常规心电图检查 ,并进行对照分析 ,现报道如下。1　资　　料本组资料取自锦铁材料厂 1 0 3名职工进行普查筛选冠心病。其中男性 65人。女性 3 8人 ,年龄均在 3 5～ 4 5岁之间。按临床症状分为 :无症状组 80例 ,有可疑冠心病症状组 2 3例。 (根据国际心脏病学会和协会及世界卫生组织制定的冠心病诊断标准。)2　方　　法频谱心电图检查 :采用 HBD— 型机。检测方法 :以 V5作为 X通道 , 作为Y通道。双通道同步采样 ,连续采样时间达 1 2 5秒 ,将心电信号由时域转换为频域 ,经计…     

频谱心电图检查在儿童心肌炎诊断中的价值

目的探究频谱心电图检查在儿童心肌炎诊断中的价值。方法选择2017年1月至9月于我院就诊的心肌炎患儿,共500例,现按照入院编号随机分为两组,每组250例。对照组给予心电图检查,观察组进行频谱心电图检查,比较两组患者的异常率和诊断符合率。结果观察组异常率明显比对照组高,差异有统计学意义(P0.05);尽管对照组的诊断符合率高于对照组,但是无统计学意义(P0.05)。结论在诊断儿童心肌炎的过程中,与心电图检查相比,利用频谱心电图检查更加适合早期诊断,在具体诊断过程中需要将二者有机结合起来,值得临床应用。     

信号平均心电图频谱时间标测分析结果的重复性研究

对信号平均心电图频谱时间标测分析方法的重复性进行研究与时域分析进行了比较。结果显示：频谱时间标测分析ＸＹＺ导联正常因子的近期重复性为好或极好，ＸＺ导联正常因子的远期重复性为好或极好，Ｙ导联的远期重复性略差。时域分析中仅ＱＲＳＴ的远，近期重复性好。     

单纯性肥胖儿童频谱心电图和甲襞微循环的变化（摘要）

单纯性肥胖儿童频谱心电图和甲襞微循环的变化（摘要）于秀芝王武凌张国萍郭俊玲夏蕾张春红近年来，我们对单纯性肥胖病儿进行了频谱心电图和甲襞微循环检查，以探讨肥胖对儿童心血管系统和微循环的影响。现将结果报告如下。临床资料本组３０例，男１６例，女１４例，年龄...     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Role of myeloid differentiation factor 88 in HSP60 signal transduction in dendritic cells

Objective: To explore the role and mechanism of myeloid differentiation factor88 (MyD88) in HSP60 signal transduction in dendritic cells. Methods:Mouse DCs were cultured from murine bone marrow cells. The DC marker CD11c was detected by flow cytometry, then DCs were divided into control group, HSP60 groupand RNA interference group. Control group was cultured under normal condition, and HSP60 group was cultured with 10 μg/ml of HSP60. RNA interference group was first cultured with MyD88 siRNA forl2 hours and then HSP60 was added into the culture mixture. All groups were cultured for 48 hours. Immunochemistry was used to detect the concentration of MyD88 and NF- κB. Western blot was used to detect the concentration of MyD88. Flow cytometry and mixed lymphocyte reaction (MLR) were used to detect the phenotype and functional properties of DCs. ELISA was used to detect the concentration of TNF-α, IFN-γ and IL-12 in the supernatant. Results:The expression of CD11c in marine bone marrow DCs was 88.76%. HSP60 stimulation increased the expression of CD80, CD86, MHC-Ⅱ in DCs and TNF-α, IFN-γ, IL-12 secretion in the supematant. HSP60 stimulation also increased the level of MyD88 in the cytoplasm and promoted the shift of NF-κB to karyon and the proliferation of allogeneic T cells. MyD88 siRNA could decreaseMyD88 and inhibit these effects induced by HSP60. Conclusion:HSP60 activates DCs through MyD88-dependent pathway. MyD88 plays a critical role in HSP60 signal transduction. Inhibition of MyD88 may be a novel way for treating disease correlated with HSP60.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

股骨远端粉碎性骨折双板固定的生物力学研究

目的探讨治疗股骨远端粉碎性骨折的新方法。方法应用10件成人鲜尸股骨,造成股骨远端髁间、髁上粉碎性骨折,内侧采用聚乙烯板、外侧采用钢板双向固定,分别作压缩、弯曲、扭转等生物力学实验研究。另取10件标本进行单向外侧钢板固定作为对照。结果双向固定组抗弯曲、扭转能力显著增强(P<0.01),抗压缩能力也较单侧固定组强(P<0.05)。结论双向固定治疗股骨远端粉碎性骨折有明显的应用价值。     

REASSESSMENT OF DEFIBRASE IN TREATMENT OF ACUTE CEREBRAL INFARCTION： A MULTICENTER, RANDOMIZED, DOUBLE-BLIND,PLACEBO-CONTROLLED TRIAL

Objoctive To evaluate the efficacy and safety of defibrase in patients with acute cerebral infarction by a large sample, multicenter, randomized, double-blind, placebo-controlled clinical trial. Mothods Patients with acute cerebral infarction within 12 hours of stroke onset were randomly assigned to receive either an initial intravenous infusion of defibrase 15 U plus normal saline 250 mL or 250 mL of normal saline only. Subsequent infusions of defibrase 5 U or placebo （normal saline） were given on the 3rd, 5th, 7th, and 9th day, respectively. Both groups received standard care of acute cerebral infarction. The primary efficacy outcome was functional status （Barthel Index） at 3 months after treatment. Safety outcome were bleeding events and mortality rate. Secondary outcome included Chinese Stroke Scale （CSS） score at 14 days and recurrence rate of stroke at 1 year. A total of 1053 patients were enrolled at 46 centers from September 2001 to July 2003, and 527 patients were randomly assigned to receive defibrase and 526 to receive placebo. A similar proportion of patients in both groups completed a full course of treatment. There was a significantly greater proportion of favorable functional status （Barthel Index 1≥95） in defibrase group than in placebo group at 3 months （52.2% vs. 42.8%, P 〈 0.01）, and the proportion of dependent functional status （Barthel Index ≤60） was a little lower in defibrase group compared with placebo group （27.7% vs. 32.4%）. These differences were more obvious among patients who were treated within 6 hours of stroke onset. Patients in defibrase group had better improvement with respect to CSS score than those in placebo group at 14 days （P 〈 0.05）. Recurrence rate of stroke at 1 year was lower in the defibrase group compared with placebo group （6.2% vs. 10.1%, P = 0.053）. Patients in defibrase group had higher risk of extracranial bleeding events （4.7% vs. 1.5%, P 〈 0.01 ） and a tendency of higher risk of symptomatic intracranial hemorrhage. The hemorrhage incidence was higher in patients with fibrinogen level 〈 130 mg/dL than ≥ 130 mg/dL （10.6% vs. 3.8%, P 〈 0.05）. Mortality rate at 3 months were slightly higher in defibrase group than placebo group （5.9% vs. 4.2%）. Conclusions The defibrase is effective to improve neurological function and function of daily living for patients with acute cerebral infarction within 12 hours of symptom onset. The efficacy was even better for acute cerebral infarction within 6 hours of onset. The increased risks of intra- and extracranial hemorrhage during defibrase administration were related to the plasma fibrinogen level.     

Recent advancement on autoantigens, autoantibodies and inflammatory cells in subepidermal autoimmune bullous diseases

Subepidermal autoimmune bullous diseases （SABD） are some autoimmune skin diseases that can present in a variety of forms and can be a challenging disease to treat. An overview of the different forms of SABD are discussed including bullous pemphigoid （BP）, epidermolysis bullosa acquisita （EBA）, cicatricial pemphigoid （CP）, bullous systemic lupus erythematosus （BSLE）, and Anti-p200 pemphigoid. Emphasis on recent advancement is presented. In recent years, improved knowledge of the mechanisms of intercellular and cell-matrix adhesion has led to better understanding of the blistering process in some SABD. Defects of such structures cause the subepidermal bullous diseases and have also led to the discovery of new diseases （e.g. anti-p200-pemphigoid）. Recent studies have outlined the important role of autoantibodies, mast cell lymphocytes and their cytokines in pathogenesis of SABD.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.