思美泰治疗肝内胆汁瘀积性病毒性肝炎43例体会

目的：观察思美泰治疗胆汁瘀积性病毒性肝炎的疗效。方法：43例肝内胆汁瘀积性病毒性肝炎患者用思美泰治疗,疗程为4周。结果：思美泰对瘀胆型肝炎皮肤瘙庠的有效率为86．67％,对慢性肝炎合并肝内胆汁瘀积患者皮肤瘙痒、纳差的有效率为88．24％。思美泰治疗后,瘀胆型肝炎和急、慢性肝炎合并肝内胆汁瘀积患者血清总胆红素（STB）、血清结合胆红素（SCB）、ALT、AST的降幅明显,治疗后ALP的下降有显著性意义P〈0．05,STB、SCB的复常率显著提高,瘀胆型肝炎和慢性肝炎合并肝内胆汁瘀积患者ALT的复常率较显著提高,慢性肝炎合并肝内胆汁瘀积患者血清白蛋白在治疗后的增高显著。结论：思美泰治疗胆汁瘀积性病毒性肝炎疗效较好,没有明显不良反应。     

腺苷蛋氨酸治疗淤胆型肝炎164例疗效观察

目的：观察腺苷蛋氨酸治疗淤胆型病毒性肝炎的疗效；方法：164例淤胆型病毒性肝炎患者随机分为A组（治疗组）、B组（对照组）两组，分别用腺苷蛋氨酸和门冬氨酸钾镁治疗，疗程为4周；结果：腺苷蛋氨酸对淤胆型病毒性肝炎的总有效率为95％，与对照组有明显差异，对淤胆型肝炎患者皮肤瘙痒、纳差的有效率分别为85％、83％，与对照组差异有显著性（P＜0．05），腺苷蛋氨酸治疗后，淤胆型肝炎的血清总胆红素（STB）、血清结合胆红素（SCB）、总胆汁酸（TBA）、ALT、AST的降幅明显高于对照组（P＜0．05），STB、SCB、TBA的复常率显著高于对照组（P＜0．05）；结论：腺苷蛋氨酸治疗淤胆型肝炎疗效较好，优于门冬氨酸钾镁，没有明显不良反应。     

前列腺素E_1治疗肝内胆汁淤积性病毒性肝炎疗效观察

目的 观察前列腺素E_1治疗肝内胆汁淤积性病毒性肝炎疗效。方法 67例肝内胆汁淤积性病毒性肝炎患者随机分为A(治疗组)、B(对照组)两组,分别用前列腺素E_1(PGE_1)和强的松治疗,疗程均为4周。结果 前列腺素E_1治疗后,淤胆型肝炎和急、慢性肝炎合并肝内胆汁淤积患者血清总胆红素(TBIL)的降幅与对照组相仿(P>0.05);ALT的复常率较对照组差异有显著意义(P<0.01)。结论 前列腺素E_1治疗肝内胆汁淤积性病毒性肝炎疗效较好,不良反应较小,容易控制。     

思美泰联合低分子肝素钠治疗老年戊型病毒性肝炎肝内淤胆105例疗效观察

目的：评价思美泰联合低分子肝素钠治疗老年戊型病毒性肝炎肝内淤胆的疗效。方法：105例老年戊型病毒性肝炎肝内淤胆患者随机分为治疗组和对照组,对照组52例,采用思美泰（腺苷蛋氨酸,美国雅培制药公司产品）1000mg加5％葡萄糖溶液250ml静脉滴注,每日1次;治疗组53例,在对照组治疗的基础上同时腹壁皮下注射低分子肝素钠针（浙江杭州赛诺菲民生制药有限公司产品）4000U,1次／d。两组治疗均连续4周,观察并比较两组治疗前后的症状、体征和肝功能变化等情况。结果：治疗组与对照组疗效、血清生化指标均有明显差异（P〈0．01）。结论：临床将思美泰联合低分子肝素钠用于治疗老年戊型病毒性肝炎肝内淤胆的患者能有效改善其症状、体征、肝功能及预后,适合于临床广泛应用。     

比较思美泰治疗肝内胆汁淤积的临床疗效并探讨其与剂量的关系

目的比较思美泰治疗肝内胆汁淤积的临床疗效,并探讨其与剂量的关系;方法对90例肝内胆汁淤积患者的临床资料进行回顾性分析,对思美泰治疗妊娠肝内淤积症、慢性乙型肝炎高胆红素血症、淤胆型肝炎的TBL、C-GT、ALT变化进行比较,对思美泰对慢性乙型肝炎高胆红素血症不同程度黄疸的影响进行分析,同时分析不同思美泰剂量治疗慢性乙型肝炎高胆红素血症后的TBL水平变化;结果妊娠肝内淤积症患者的血清TBL、C-GT、ALT水平下降幅度显著优于慢性乙型肝炎高胆红素血症组患者(P0.05);黄疸分级在(TBL171-260Lmol/L)和(TBL260Lmol/L)黄疸患者的TBL下降水平显著优于(TBL80-170Lmol/L)黄疸患者(P0.05);2.0g/d思美泰组治疗慢性乙型肝炎高胆红素血症的黄疸下降显著优于1.0g/d组(P0.05)。结论在对胆汁淤积肝病高胆红素血症患者进行治疗时,思美泰具有比较显著的临床疗效,早期足量应用效果更佳理想。     

思美泰治疗慢性病毒性肝炎合并胆汁淤积疗效观察

目的：观察思美泰对慢性病毒性肝炎合并胆汁淤积的疗效。方法：将180例患者随机分为A治疗组、B治疗组、对照组各60例。对照组给予甘草酸二铵、还原型谷胱甘肽、门冬氨酸钾镁、维生素K1综合治疗。在综合治疗的基础上,A治疗组加用思美泰1 000 mg,B治疗组加用思美泰2 000 mg。观察三组治疗前后临床症状、体征及肝功能指标的变化。结果：A治疗组与B治疗组在改善临床症状、体征及肝功能指标方面与对照组比较差异有统计学意义（P〈0.05或P〈0.01）;B治疗组在降低TBIL、GGT、ALP方面与A治疗组比较差异有统计学意义（P〈0.05）;治疗过程中未发现思美泰相关的不良反应。结论：思美泰治疗慢性病毒性肝炎合并胆汁淤积效果较好,且适当增加剂量可提高疗效,安全性较好。     

硫酸镁联合丹参酮治疗病毒性肝炎导致的肝内胆汁淤积的疗效观察

目的 观察硫酸镁联合丹参酮治疗病毒性肝炎并发肝内胆汁淤积的疗效.方法 120例急、慢性病毒性肝炎并发肝内胆汁淤积患者随机分成两组各60例:A组采用硫酸镁联合丹参酮治疗;B组采用思美泰治疗.疗程均为4wk.结果 A组对急、慢性病毒性肝炎并发肝内胆汁淤积患者临床症状及体征改善的有效率分别为96.7%、90.0%,与B组比较无显著性差异(P>0.05).A组患者治疗后肝功能各项指标的改善与B组相当.结论 硫酸镁联合丹参酮治疗对急、慢性病毒性肝炎并发肝内胆汁淤积患者的疗效理想,在症状的改善、黄疸的消退和肝功能的恢复方面与思美泰的疗效相当,其价格低廉,更适合农村患者.     

腺苷蛋氨酸联合熊去氧胆酸治疗淤胆型病毒性肝炎的疗效观察

目的观察腺苷蛋氨酸联合熊去氧胆酸治疗肝内胆汁淤积性病毒性肝炎的临床疗效。方法选择急性淤胆型肝炎和慢性淤胆型肝炎患者132例,随机分为治疗组和对照组,每组各66例。治疗组给与腺苷蛋氨酸冻干粉针剂1000mg加入5%葡萄糖液250ml中静脉滴注,1次/d,熊去氧胆酸（尤思弗）250mg,2次/d口服,疗程均为4周。对照组采用门冬氨酸钾镁针剂30ml加入5%葡萄糖液250ml中静脉滴注,1次/d,疗程4周。观察症状、体征,并分别于2、4周复查肝功能,观察丙氨酸转氨酶（ALT）、天门冬氨酸转氨酶（AST）、血清总胆红素（STB）、血清结合胆红素（SCB）变化。结果两组治疗4周后乏力、腹胀、恶心、呕吐、肝区痛等症状均基本消失;治疗组的皮肤瘙痒的有效率、肝肿大回缩有效率以及肝功能主要指标下降幅度显著高于对照组,两组比较差异有统计学意义。结论腺苷蛋氨酸和熊去氧胆酸联合治疗无明显的毒副反应,其安全性和耐受性较好,是治疗淤胆型病毒性肝炎的有效方法。     

思美泰治疗急性淤胆型肝炎临床疗效观察

目的:探讨思美泰治疗急性淤胆型肝炎的疗效及机制。方法:将急性淤胆型肝炎分为治疗组与对照组。治疗组静滴思美泰,对照组茵栀黄静滴。结果:治疗组总有效率95.3％,对照组80.7％,两组经统计学处理有显著意义(P<0.05)。结论:思美泰是治疗急性淤胆型肝炎的理想药物。     

思美泰治疗重度瘀胆型病毒性肝炎的疗效观察

6 0例重度瘀胆型病毒性肝炎随机分为治疗组和对照组 ,分别采用思美泰和苦黄治疗 ,疗程 4～ 8周。思美泰组在减轻皮肤瘙痒、降低血清胆红素和降低ALP、rGT、TBA等方面以及综合疗效明显优于对照组 ,二者有显著性差异 (P <0 .0 5 )。认为采用思美泰治疗重度瘀胆型病毒性肝炎疗效确切。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.