子宫动脉栓塞术治疗子宫肌瘤42例临床分析

目的 探讨子宫动脉栓塞术（UAE）治疗子宫肌瘤的疗效。方法 选择42例子宫肌瘤患者,以Seldinger技术完成单侧股动脉插管,根据数字减影血管造影（DSA）检查结果,选用管径为4－5F（1F=0.33mm)的脾管、肝管或cobra导管,或选用3F微导管,插管至双侧子宫动脉并经DSA检查证实后,以携带有抗生素的明胶海绵颗粒栓塞该处血管。结果 DSA检查发现,子宫肌瘤血液供应丰富。UAE治疗6－12个月后,子宫肌瘤患者的临床症状明显缓解,月经量减少26．3％－75．2％;UAE治疗后第12个月、第18个月肌瘤体积分别缩小77．7％、83．0％,子宫体积分别缩小54．9％、62．7％。术后有不同程度的下腹痛、低热,持续1－3周,经对症处理后症状逐渐消失。结论 UAE可有效地缩小肌瘤及子宫的体积,并明显改善子宫肌瘤患者的临床症状。     

子宫动脉栓塞治疗子宫肌瘤的疗效和并发症分析

目的　探讨选择性子宫动脉栓塞治疗子宫肌瘤的临床疗效和并发症的发生情况。方法　 2 0 0 0年 10月～ 2 0 0 2年 5月选择 4 0例子宫肌瘤患者用PVA颗粒做栓塞剂行子宫动脉栓塞 ,栓塞后定期评价临床疗效和并发症 ,彩超监测子宫和最大肌瘤体积。根据SCVIR制订的并发症分级系统 ,评价并发症的严重性。结果　4 0例患者行子宫动脉栓塞 ,平均随访 18 9个月 ,97%临床症状改善。子宫和最大肌瘤体积平均缩小 4 3 8%和6 3 5 %。栓塞前子宫和最大肌瘤体积的中位数为 2 4 3 4cm3和 14 8cm3,栓塞后 6个月中位数为 10 7 1cm3和4 1 1cm3,(P <0 0 0 1)。 88 5 %的并发症为A、B级 ,1例 (2 5 % )D级并发症为阴道排瘤继发感染再入院治疗。7例 (17 5 % )较严重的栓塞后综合征。 1例 (2 5 % ) 2年后复发。 4例 (10 0 % )卵巢功能衰竭 ,发生在栓塞后2～ 18个月。 2 0例 (5 0 0 % )患者阴道排液。 92 5 %患者对治疗的结局表示满意。结论　子宫动脉栓塞治疗子宫肌瘤能有效的改善症状 ,缩小瘤体 ,失败率低 ,严重并发症少。术前严格选择适应症 ,术后预防感染是降低并发症的关键。     

子宫动脉栓塞术治疗子宫腺肌病的中远期临床疗效观察

目的探讨子宫动脉栓塞术(UAE)治疗子宫腺肌病(AM)的中远期疗效。方法对189例AM患者行UAE治疗,术前1个月及术后1、2、3、6、12、18个月及以后每年1次随访观察痛经、月经量的变化。结果(1)随访情况:UAE术后具有完整随访资料者168例,随访率88·9%,平均随访时间(50±15)个月。9例患者因痛经治疗无效或复发等原因而切除子宫。(2)痛经症状的变化:168例患者中,159例术前有痛经症状,UAE治疗后131例(82·4%,131/159)为临床有效,28例(17·6%,28/159)为临床无效,8例(5·0%,8/159)复发。AM合并和未合并子宫肌瘤患者的痛经临床有效率分别为92·9%(39/42)、78·6%(92/117),两者比较,差异无统计学意义(P>0·05);局灶型和弥漫型AM患者的痛经临床有效率分别为82·4%(75/91)、82·4%(56/68),两者比较,差异无统计学意义(P>0·05)。(3)月经量的变化:在168例患者中,93例为月经量过多,UAE术后78例月经量恢复正常,10例出现月经量过少,1例出现暂时性闭经,2例月经量无变化,2例出现月经稀少;74例为月经量正常,术后57例月经量无变化,15例出现月经量过少,2例出现子宫性闭经;1例为月经量过少的患者,术后月经量恢复正常。结论UAE治疗AM具有较好的中远期疗效。     

聚乙烯乙醇与真丝线段栓塞子宫动脉治疗子宫肌瘤的临床研究

目的 :评价聚乙烯乙醇 (polyvinylalcohol,PVA)与真丝线段栓塞子宫动脉治疗子宫肌瘤的临床疗效及副反应。方法 :50例子宫肌瘤患者随机分为PVA与真丝线段栓塞两组。采用Seldinger方法经皮股动脉穿刺 ,血管造影确认子宫动脉及肌瘤所在部位后 ,超选择性子宫动脉插管并经导管注入PVA颗粒或真丝线段 ,阻断子宫肌瘤血供。治疗前后均用B超测量子宫肌瘤体积。结果 :两组患者月经量恢复正常和明显减少 ,总有效率为 97.73% ;术后 3个月和6个月肌瘤体积较治疗前缩小 4 5.81%和 51.80 % ,差异有高度显著性 (P <0 .0 1)。两组月经量和子宫肌瘤体积变化差异无显著性。两组的主要副反应是术后缺血性盆腔疼痛。术后发热症状 ,真丝线段组明显高于PVA组 (P <0 .0 5) ,无严重并发症发生。结论 :使用PVA或真丝线段超选择性子宫动脉栓塞治疗子宫肌瘤创伤小 ,近期临床疗效好 ,远期疗效有待进一步观察     

子宫肌瘤子宫动脉栓塞术后疗效判定时间点研究

目的探讨子宫动脉栓塞术(UAE)治疗子宫肌瘤术后疗效合适的判定时间点。方法选取南方医科大学南方医院及广州市第一人民医院1999—2012年因子宫肌瘤行UAE治疗的具有相对完整随访资料的397例病例,术前及术后1、3、6、9个月、1年分别观察并记录子宫肌瘤体积变化及月经量改变情况。结果 UAE术后各时间点较术前相比,子宫肌瘤体积均显著缩小(P=0.000);UAE术后6个月较术后1个月及3个月时子宫肌瘤体积均显著缩小(P=0.000;P=0.002),而与术后9个月及1年相比,差异无统计学意义(P=0.673,P=0.104)。UAE术后6个月时月经量过多的患者月经量改善百分比与术后1个月、3个月差异均有统计学意义(P=0.026,P=0.044),但与术后9个月及术后1年相比,差异无统计学意义(P=0.495;P=0.099)。结论 UAE术后6个月是评价子宫肌瘤UAE术后疗效较为合适的时间。     

子宫动脉栓塞治疗子宫肌瘤的临床疗效观察

传统治疗子宫肌瘤的方法是行子宫肌瘤切除术、子宫切除术、子宫肌瘤溶解术及子宫肌瘤冷冻切除术等 ,1999年 6月至 2 0 0 2年 6月我们对有明显症状的子宫肌瘤患者 37例行子宫动脉栓塞治疗 ,效果良好 ,报告如下。1　资料与方法1.1　病例选择　 37例患者 33～ 5 2岁 ,平均 4 0岁 ,均有月经量明显增多及经期延长症状 ,15例有不同程度的贫血 (HGB<12g/L) ,19例因肿块有明显压迫症状 ,3例已婚未育。患者均经B超诊断 ,2 1例行CT强化扫描 ,10例行MRI扫描。患者术前 3d用抗生素治疗 ,栓塞前再次行盆腔超声扫描以核实病变。1.2　栓塞　Seldinger…     

超选择性子宫动脉栓塞术治疗子宫腺肌病痛经68例分析

目的探讨超选择性子宫动脉栓塞术(UAE)对子宫腺肌病痛经的临床疗效。方法对郑州大学第二附属医院妇产科2005年1月至2009年11月68例资料完整的采用UAE治疗有痛经的子宫腺肌病患者进行回顾性分析。术后1、3、6、12个月及以后每年1次随访观察并记录患者痛经缓解程度、月经量改变、血红蛋白变化及子宫体积变化情况。结果 UAE术后平均观察(36.3±12)个月。患者痛经缓解临床有效率为86.8%(59/68)、临床无效率为8.8%(6/68)、复发率4.4%(3/68);66例月经过多者UAE后月经量不同程度减少,1例出现闭经。子宫体积呈进行性缩小。结论 UAE治疗子宫腺肌病具有微创、安全、简单的特点,对于有痛经的患者疗效显著。     

子宫动脉栓塞术治疗粘膜下子宫肌瘤62例临床分析

目的:探讨子宫动脉栓塞术(UAE)治疗粘膜下子宫肌瘤的临床疗效。方法:回顾性分析UAE治疗粘膜下子宫肌瘤患者6 2例的疗效及临床转归。结果:6 2例患者随访1～6 3月,全部患者经量及经期恢复正常,粘膜下子宫肌瘤经阴道自然脱落排出4 0例,钳夹排出16例,进行性缩小消失4例,体积缩小>80 % 2例。术中、术后有不同程度的下腹痛(6 2例)、低热(12例)、阴道分泌物增多(6 2例,经对症处理后症状逐渐消失。结论:UAE可有效治疗粘膜下子宫肌瘤,并显著改善粘膜下子宫肌瘤的临床症状。     

子宫动脉栓塞术治疗子宫肌瘤的研究进展

随着医学科学的飞速发展，动脉栓塞介入治疗子宫肌瘤法引起了国内外学者的关注。子宫动脉栓塞术(uterine artery embolization，UAE)常采用Seldinger法，即在局部麻醉下行股动脉穿刺，置入4F或5F的cobra导管，在X线数字减影血管造影(DSA)下通过同轴导丝的引导，超选择性插管至子宫动脉并注入栓塞剂的一种介入性治疗技术。目前已有大量的临床研究报道，认为该方法安全、创伤小、并发症少，能在短期内控制子宫肌瘤导致的月经量过多、过频、经期延长等临床症状，使子宫肌瘤体积缩小,     

子宫动脉栓塞术治疗子宫腺肌病的临床观察

目的探讨子宫动脉栓塞术(uterine artery embolization,UAE)治疗子宫腺肌病的临床疗效。方法选择2003年4月至2006年4月北京仁和医院48例子宫腺肌病患者,以改良的Seldinger s技术完成双子宫动脉超选择插管并栓塞,观察术后1个月、3个月和6个月的疗效。结果 48例患者中,UAE治疗后临床症状全部缓解;患者治疗前活动能力丧失程度、疼痛分级与治疗后比较,差异有统计学意义(P0.01);48例患者术后月经量为术前的(51.2±18.3)%,差异具有统计学意义(P0.01);所有患者贫血改善,术后3个月均恢复正常;术后6个月子宫体积平均缩小46.6%(P0.01),病灶体积平均缩小65.2%(P0.01);卵巢内分泌激素无明显变化(P0.05)。结论 UAE治疗子宫腺肌病近期疗效显著,且微创、安全、副反应少。     

子宫肌瘤动脉栓塞术后的病理学变化

目的　探讨子宫肌瘤动脉栓塞术 (UAE)后的病理学变化。方法　 1 999年 6月至 2 0 0 3年 1 0月对广州市第一人民医院 4 86例子宫肌瘤患者行UAE治疗 ,栓塞剂选择PVA或KMG颗粒 ,其中对 4 9例术后获取的肌瘤标本进行病理学观察。结果　UAE后坏死的肌瘤肉眼观早期呈紫黑色 ,中期呈黄白色 ,晚期呈黄色或金黄色 ,假包膜明显增厚 ,在妊娠期更加明显 ;不同直径的肌瘤UAE后在光镜下观察到的坏死时间不同 :直径 0 2～1 0cm、4 0～ 5 0cm、6 0～ 9 0cm及大于 1 0 0cm的肌瘤在UAE后分别于 1 4d、1 8h、1 2h和 6h可观察到明显的坏死 ;UAE后肌瘤、假包膜明显坏死而正常肌层未见明显坏死 ,假包膜内可见含铁血黄素沉积。结论　UAE可导致各种大小的肌瘤坏死 ,肌瘤坏死的时间与肌瘤的大小呈反比。     

Laparoscopic Management of a Rudimentary Uterine Horn

Study Objective

To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl.

Treatment of uterine arteriovenous malformation by myometrial lesion resection combined with artery occlusion under laparoscopy: a case report and literature review

Uterine arteriovenous malformation (AVM) is an uncommon, potentially life-threatening condition, and the primary therapeutic method is embolization. We describe a case of a 36-year-old woman with acquired uterine AVM accompanied by abnormal vaginal bleeding. The diagnosis was established by Doppler flow ultrasonography combined with magnetic resonance arteriography. Because this uterine AVM was extensive and multiple, uterine arterial embolization could not be considered. We therefore employed a combined method under laparoscopy, in which the uterine arteries were first occluded, then uterine myometrial lesions were resected and abnormal pelvic blood vessels were ablated. Finally, the uterus was reconstructed with an intact uterine cavity. Abnormal vaginal bleeding was successfully stopped after operation, but amenorrhea due to uterine adhesions occurred. This method is suitable for the treatment of uterine AVM with extensive and multiple lesions, but it should be chosen cautiously for women of reproductive age with AVM and fertility requirement.     

子宫肌瘤动脉内数字减影血管造影影像学特点及临床意义

目的 观察子宫骨瘤动脉内数字减影血管造影（IADSA）影像学特点。方法 对156例子宫肌瘤患者行子宫动脉栓塞术（UAE），通过术时DSA造影及术后DSA片观察子宫肌瘤DSA影像学特点。结果 156子宫肌瘤的血供均来自子宫动脉，共分3种类型：（1）Ⅰ型：一侧子宫动脉供血为主型，占53.2%（83／156）；（2）Ⅱ型：双侧子宫动脉供血为主型，占34.6%（54／156）；（3）Ⅲ型：单纯一侧子宫动脉供血型，占12.25(19/156)。子宫肌瘤的血管肉分两层，一层存在于子宫肌瘤的表面形成粗大的血管肉，另一层在子宫肌瘤的内部形成致密的毛细血管网。结论 子宫肌瘤属富血管性肿瘤，其血供来源于子宫动脉，由内外两层血管网组成。     

A comparison of uterine peristalsis in women with normal uteri and uterine leiomyoma by cine magnetic resonance imaging

Objective

The non-pregnant uterus shows wave-like activity (uterine peristalsis). This pilot study was intended to determine: (1) whether uterine peristalsis during the menstrual cycle is detectable by cine magnetic resonance imaging (MRI); (2) the effects of leiomyoma on uterine peristalsis.

Study design

Mid-sagittal MRI was performed sequentially with T2-weighted single-shot fast spin-echo (SSFSE) in 3 normal ovulatory volunteers and 19 premenopausal women with uterine leiomyoma. Direction and frequency of movement of the junctional zone were evaluated using a cine mode display.

Results

Junctional zone movement was identified in all subjects. Direction of uterine peristalsis in normal volunteers was fundus-to-cervix during menstruation, cervix-to-fundus during the periovulatory phase, and isthmical during the mid- and late-luteal phases. Abnormal peristaltic patterns were detected in three of five patients with uterine leiomyoma during menstruation and in the mid-luteal phase of the cycle, respectively.

Conclusion

Cine MRI is a novel method for evaluation of uterine peristalsis. Results of this pilot study suggest that abnormal uterine peristalsis during menstruation and the mid-luteal phase might be one of the causes of hypermenorrhea and infertility associated with uterine leiomyoma.     

Color Doppler evaluation of blood flow changes in leiomyomas after uterine artery ligation.

OBJECTIVE: To detect possible changes in main blood vessels within leiomyomas after uterine artery ligation using color Doppler sonography. METHOD: Blood flow in main leiomyoma blood vessels was measured before and after the procedure in 14 women who also had abnormal uterine bleeding, pelvic pain or pressure, and/or anemia. RESULTS: Of the 14 patients, 13 reported complete disappearance of preoperative pain or pressure and 1 reported significant relief. Within 1 week to 4 months after uterine artery ligation, major blood flow within leiomyomas had significantly decreased in all patients. Eight months after the procedure, 1 of the women became pregnant. CONCLUSION: Laparoscopic uterine artery ligation via a lateral retroperitoneal technique is a safe and effective treatment for leiomyomas. Color Doppler sonography verified the ability of the procedure to diminish blood flow within leiomyomas in all patients.     

A study of uterine inertia on the spontaneous of labor using uterine electromyography

ObjectiveThe purpose of this study is to analyze uterine electromyography burst patterns in patients with spontaneous labor and patients with uterine inertia.Materials and methodsUterine electromyography was recorded using 4 silver/silver chloride electrodes placed periumbilical. Thirty women in the spontaneous labor were enrolled. Uterine electromyography was also recorded from patients with uterine inertia before and after oxytocin treatment. EMG bursts were characterized by analysis of multiple variables including burst frequency, duration, root mean squared, amplitude, and total power.ResultsThere were significant reductions (P < .01) in all EMG burst characteristics. In addition, uterine electromyography parameters were all increased after oxytocin treatment and were comparable (P > .05) to patients in spontaneous labor.ConclusionsUterine electromyography can be used effectively to distinguish patients progressing with spontaneous labor from patients that develop uterine inertia. Uterine inertia is characterized by reduced EMG activity and failure of cervical dilation. Uterine electromyography is a quantitative, non-invasive assessment tool that contributes to the diagnosis, evaluation and management of patients with spontaneous labor and uterine inertia.     

Intraoperative ultrasound in reconstructive surgery for multiple uterine myomas

In this paper, we describe a case of successful surgical treatment of multiple uterine myomas in an open reconstructive operation with intraoperative ultrasound (IOUS) guidance. Eight nodules were removed during myomectomy. Three of them, the smallest nonpalpable tumors, were detected only by IOUS examination. The patient had remained asymptomatic and free of recurrence at follow-up 27 months postoperatively. Future studies in a larger number of series are needed before any final conclusions are reached about the effectiveness of IOUS during reproductive gynecologic procedures.     

Simplified Laparoscopic Sacrohysteropexy

Study Objective

To demonstrate a simplified technique of performing laparoscopic sacrohysteropexy for uterine prolapse.