口腔粘膜鳞状细胞癌患者血浆及肿瘤组织中cAMP和cGMP水平…

用放射免疫方法测定了１６名口腔粘膜鳞癌患者肿瘤组织，癌旁正常口腔粘膜组织，外周血浆及１６名正常人外周血浆中ｃＡＭＰ和ｃＧＭＰ含量，并初步探讨了ｃＡＭＰ，ｃＧＭＰ与口腔鳞癌发病的关系。结果显示：与对照组相比，鳞癌患者癌组织中的ｃＡＭＰ水平显著降低）Ｐ＜０．０１），ｃＧＭＰ含量升高（Ｐ＜０．０５），ｃＡＭＰ／ＣＧＭＰ比例下降（Ｐ＜０．０５），而血浆中的ｃＡＭＰ，ｃＧＭＰ含量则无明显改变（Ｐ＜０．０５）     

Dyract与玻璃离子水门汀治疗楔状缺损的疗效比较

目的对Ｄｙｒａｃｔ与玻璃离子水门汀（ＧＩＣ）治疗楔状缺损的临床疗效进行比较。方法用Ｄｙｒａｃｔ充填９２例３１２颗楔状缺损的患牙,ＧＩＣ充填１４５例３４６颗患牙,定期随访两年,观察形态、密合度、边缘着色、色泽、继发龋、牙龈炎症、牙髓反应七个方面的治疗效果。结果半年内两者临床效果无差异（Ｐ＞０．０５）,１年后有显著差异（Ｐ＜０．０５）,２年后有高度显著差异（Ｐ＜０．００５）。且Ｄｙｒａｃｔ在形态、色泽、密合度、继发龋、牙龈炎症等５个方面均优于ＧＩＣ（Ｐ＜０．０５）,其中以前两者为甚（Ｐ＜０．００５）。结论Ｄｙｒａｃｔ的远期疗效优于ＧＩＣ。     

钛材专用烤瓷粉的理化性能研究

通过与ＴｉＢｏｎｄ的对比，分析了Ｔｉ－ｃｅｒａｍｉｃ的理化性能。结果表明，Ｔｉ－ｃｅｒａｍｉｃ压缩强度及径向抗张强度与ＴｉＢｏｎｄ无统计学差别（Ｐ＞０．０５），弯曲强度ＴｉＢｏｎｄ明显高于Ｔｉ－ｃｅｒａｍｉｃ（Ｐ＜０．０１），但化学稳定性Ｔｉ－Ｃｅｒａｍｉｃ优于ＴｉＢｏｎｄ（Ｐ＜０．０１）。     

口腔鳞癌患者免疫功能测定及其临床意义

本文从分子学水平和细胞学水平，对３０例口腔鳞癌患者，及相应的正常对照者，做血浆ｃＡＭＰ、ｃＧＭＰ含量及外周血Ｔ淋巴细胞亚群测定。血浆ｃＡＭＰ、ｃＧＭＰ含量测定发现，口腔鳞癌患者ｃＡＭＰ明显低于正常对照者（Ｐ＜０．０１），而ｃｏＭＰ和ｃＡＭＰ／ｃＧＭＰ无明显差异（Ｐ＞０．０５），提示口腔鳞癌患者ｃＡＭＰ抑制肿瘤细胞生长的能力低下，与全身其他部位癌症基本一致。Ｔ淋巴细胞亚群测定发现，口腔鳞癌患者与正常人存在明显差异，主要表现为口腔鳞癌患者ＣＤ３↓（Ｐ＜０．０５），ＣＤ８↑（Ｐ＜０．０１），ｃＤ４／ＣＤ８↓（ｐ＜０．０１），提示口腔鳞癌患者细胞免免疫功能紊乱，免疫平衡失调。     

口腔粘膜鳞状细胞癌患者血浆及肿瘤组织中cAMP和cGMP水平的初步观察

用放射免疫方法测定了１６名口腔粘膜鳞癌患者肿瘤组织、癌旁正常口腔粘膜组织、外周血浆及１６名正常人外周血浆中ｃＡＭＰ和ｃＧＭＰ含量，并初步探讨了ＣＡＭＰ、ｃＧＭＰ与口腔鳞癌发病的关系。结果显示：与对照组相比，鳞癌患者癌组织中的ｃＡＭＰ水平显著降低（Ｐ＜０．０１），ｃＧＭＰ含量升高（Ｐ＜０．０５），ｃＡＭＰ／ＣＧＭＰ比值下降（Ｐ＜０。０５），而血浆中的ｃＡＭＰ、ｃＧＭＰ含量则无明显改变（Ｐ＞０．０５）．本研究结果提示口腔鳞癌组织中存在有ｃＡＭＰ、ｃＧＭＰ含量与代谢的异常。这可能与口腔鳞癌的发生、发展等有关，并对研究口腔癌肿的发病机制有一定实际意义。     

拔除不同双尖牙对面部软硬组织的影响

目的 探讨拔除不同双尖牙对面部软硬组的影响。方法 对１０例拔除四个第一双尖牙（拔４４组）和１０例拔除四个第二双尖牙（拔５５组）的患者治疗前后的Ｘ线头影进行测量分析。结果 拔４４组：上下切牙突度及上下唇突度明显减少（Ｐ〈０．００１）；拔５５组：上切牙突度明显减少（Ｐ〈０．０１），下切牙突度及上下唇突度减少不明显（Ｐ〉０．０５）；两组比较：上下切牙内收及上下唇内收，拔４４组均大于拔５５组（Ｐ〈０．０１     

口腔颌面部肿瘤患者T淋巴细胞亚群及细胞因子检测的临床意义

本文对４０例口腔颌面部恶性肿瘤及２０例良性肿瘤患者同时进行外周血Ｔ淋巴细胞亚群、ｓＩＬ－２Ｒ及ＴＮＦ三项指标检测，结果表明，１．良性、恶性患者均有ＣＤ３值明显下降（Ｐ＜０．０５、ｐ＜０．０ｌ），ｃＤ４／ＣＤ８比值明显下降（ｐ＜０．００ｌ），ＣＤ８值明显上升（Ｐ＜０．００１），并且良性高于恶性患者（ｐ＜０．０５），ｃＤ４值恶性患者有下降趋势（ｐ＞０．０５）。２．恶性患者ｓＩＬ－２Ｒ水平明显高于正常人（ｐ＜０．０１），也高于良性患者（ｐ＜０。０５）。３．ＴＮＦ水平三组尚无明显差异（Ｐ＞０。０５）。４．三项检验指标与恶性肿瘤临床分期有一定相关趋势。提示：Ｔ淋巴细胞亚群、ｓＩＬ－２Ｒ检测对口腔颌面部恶性肿瘤诊断及预后判断具有一定参考价值，ＴＮＦ检测的临床意义尚须进一步研究。     

激光处理牙釉质,牙本质与复合树脂的粘结研究

对脉冲钕玻璃激光辐射离体牙釉质，牙本质进行表面扫描电镜观察及测定辐射面与光固化复合树脂间粘结强度。结果表明：激光处理牙轴质表面呈云絮状熔融，与复合树脂粘结强度高于对照组，有非常显著性差异（Ｐ〈０．０１），低于酸蚀组，有显著性差异（Ｐ〈０．０５），激光处理牙本质表面呈重叠蜂窝状熔融，与复合树脂粘结强度高于对照组，有非常显著性差异（Ｐ〈０．０１），与酸蚀组无显著性差异（Ｐ〉０．０５），激光处理牙釉质及     

0.5%PVP-I龈下冲洗对龈下微生物的作用

目的　观察０．５ ％ 聚维酮碘（ＰＶＰ－Ｉ）龈下冲洗后龈下微生物组成的变化,并与０．５％ 洗必太进行对比研究。方法　选取临床诊断为中、重度牙周炎的患者１１ 例,共计４５ 颗患牙,牙周袋深≥４ｍ ｍ 。将含有患牙的不同象限随机分组,分别采用：（１）０．５ ％ ＰＶＰ－Ｉ;（２）０．５％ 洗必太（ＣＨ） ;（３）０．９ ％ 生理盐水５ｍｌ 进行一次性龈下冲洗。冲洗前及冲冼后２４ 小时分别采集龈下菌斑行刚果红染色涂片,高倍视野下（×１００） 观察龈下微生物组成的变化。结果　０ ．５％ ＰＶＰ－Ｉ龈下冲洗２４ 小时后龈下菌细胞密度降低,球菌比率升高,杆菌比率降低（ Ｐ＜ ０．０１）,螺旋体比率未见明显改变,与ＣＨ 组间比较无统计学上差异。效果均明显优于生理盐水组。结论　０．５％ ＰＶＰ－Ｉ龈下冲洗短期即可减少龈下微生物的量,并使微生物组成发生有益的转化,与０．５ ％ 洗必太可达到相同的效果。     

唇腭裂术后牙弓形态的测量分析

作者对３０名单侧完全性唇腭裂术后患者及３０名同龄正常儿童的牙弓形态进行了测量分析。结果发现唇腭裂术后儿童的牙弓形态有以下特征：上颌牙弓后段宽度明显小于正常同龄儿童（Ｐ＜０．０ｌ）。上颌牙弓前段宽度、上颌牙弓长度、上颌牙弓周长亦小于正常同龄儿童（Ｐ＜０．０５）。下颌牙弓长度则大于正常同龄儿童下颌牙弓长度（Ｐ＜０．０５）。下颌牙弓前、后段宽度、下颌牙弓周长等与正常同龄儿童相比无显著差异（Ｐ＞０．０５）。     

替牙期骨性Ⅲ类单侧完全性唇腭裂患者修复术后口周力的分布特征

目的:通过与同龄非唇腭裂正常 儿童比较,研究替牙期骨性Ⅲ类单侧完全性唇腭裂(unilateral cleft lip and palate,UCLP)患者上下颌不同位点口周力的特征。 方法:选取替牙期6～12岁UCLP患者20例(男14例,女6例)为UCLP组;同龄正常 儿童21例(男14例,女7例)为对照组。采用口周肌压力采集系统测量每个研究对象息止 位时双侧上下颌中切牙、尖牙或乳尖牙、第一前磨牙或乳磨牙、第一恒磨牙的唇颊、舌腭侧龈缘的口周力。使用SPSS 25.0统计软件对数据进行统计分析。 结果:1．UCLP组上颌口周力裂侧大于非裂侧( P<0.05),下颌口周力两侧无差异( P>0.05)。2. UCLP组上颌口周力大于对照组( P<0.05),两组上颌唇颊侧的口周力均在第一前磨牙/乳磨牙区最大,在中切牙区最小。3. UCLP组下颌唇颊侧口周力小于对照组( P<0.01),下颌中切牙舌侧区UCLP组大于对照组( P<0.05)。4. UCLP组上颌牙弓内外口周力差值大于对照组( P<0.05),下颌差值小于对照组( P<0.01)。 结论:替牙期骨性Ⅲ类UCLP患者口周力较同龄非唇腭裂正常 儿童存在异常。     

The prevalence of tongue lesions in Malaysian dental outpatients from the Klang Valley area

Oral Diseases (2011) 17 , 210–216 Objectives: To determine the prevalence of tongue lesions in Malaysian dental outpatients from the Klang Valley area. Subjects and Methods: A cross sectional study was conducted on 600 Malaysian outpatients (257 men, 343 women, mean age, 37.7 years) attending the Primary Dental Care Unit at the Faculty of Dentistry, University of Malaya. Demographic and medical data were recorded for all respondents. Results: One hundred eighty‐one patients (30.2%) (81 men, 100 women, mean age 42.0 years) were diagnosed with at least one tongue lesion (n = 207) at the time of examination. Of these, 24 patients (4%) had two or more tongue lesions present synchronously. Seven different lesions were diagnosed: fissured tongue (13.8%), crenated tongue (7.8%), pigmented tongue (6.2%), geographic tongue (2.2%), ankyloglossia (1.7%), hairy tongue (1.0%) and median rhomboid glossitis (0.2%). Their racial prevalences were Malays (n = 65, 10.8%), Indians (n = 62, 10.3%), Chinese (n = 53, 8.8%) and other race (n = 1, 0.2%). A significant relationship was observed between crenated tongue and race; between four types of tongue lesions (fissured tongue, geographic tongue, crenated tongue and pigmented tongue) and age; and between fissured tongue and gender (P < 0.05). Conclusions: Distribution characteristics of tongue lesions in Malaysians are important as local reference data in the daily clinical practice.     

口腔黏膜病和口腔症状与炎症性肠病的相关性研究

目的:研究炎症性肠病(inflammatory bowel disease,IBD)的活动性、病程、用药类型与口腔黏膜病和口腔症状的关系。方法:采用横断面研究对389例IBD患者[265例克罗恩病(CD组)和124例溃疡性结肠炎(UC组)]和265例健康者(对照组)进行问卷调查和口腔黏膜检查。数据分析运用χ2检验和Logistic回归。结果:CD组沟纹舌的患病率比对照组增加(P=0.021),其患病风险增加7.76倍。相比对照组,CD和UC组口干和口腔异味的发生率均明显增加(P<0.05),口干的发生风险分别增加1.98倍和1.48倍,口腔异味的发生风险分别增加0.96倍和0.72倍。活动期CD患者复发性阿弗他溃疡和沟纹舌的患病率比缓解期者增加(P=0.048,P=0.009)。口腔扁平苔藓的患病率随CD病程的延长而增加(P=0.035)。CD组中应用氨基水杨酸制剂者口腔黏膜异常检出率比免疫抑制剂者增加(P=0.003)。结论:IBD患者口腔黏膜病的患病风险和口腔症状的发生风险增加,并与IBD的活动性、病程、用药类型相关,亟需口腔卫生宣教和多学科综合治疗。     

Haematological and immunological features of patients with fissured tongue syndrome

Blood samples from 40 patients with fissured tongue syndrome (FTS) were examined, and the results were compared with those of 20 healthy control subjects. FTS was diagnosed when a) the patient had a fissured tongue with smooth-surfaced papillae (n = 25) or b) the patient had geographic tongue and some relatives had fissured tongue (n = 15). These tongue forms were verified also histologically. To evaluate the possibility of systemic disorders in patients with FTS we determined the whole blood picture and levels of vitamin B12, serum folate, serum ferritin, and immunoglobulins (IgA, IgG, IgM, IgE). None of the patients with FTS nor any of the controls were found to be anaemic. The mean levels of serum vitamin B12, ferritin and folate were, however, slightly lower in the patient group than in the controls. These findings suggest that anaemia does not play a primary role in the aetiology of fissured tongue syndrome. The most striking haematological findings were the decreased thrombocyte and leucocyte counts in patients with fissured tongue syndrome compared with the control subjects. Furthermore, the lymphocyte count and serum IgG were low in the patient group. When the two patient groups were compared no differences were found. These observations are discussed from the standpoint of deficiency in the immunological defence mechanism of patients with fissured tongue syndrome.     

替牙期单侧完全性唇腭裂患者下颌骨体积的测量分析

目的　比较替牙期单侧完全性唇腭裂（unilateral complete cleft lip and palate,UCLP）患者裂隙侧与非裂隙侧下颌骨体积的差异,并将两者分别与非唇腭裂（non cleft lip and palate,NCLP）儿童单侧下颌骨体积比较,以研究唇腭裂对下颌骨生长发育的影响。方法　选取2012—2016年于青岛大学附属医院口腔正畸科就诊的替牙期UCLP患者25例作为UCLP组,另选同期就诊的替牙期NCLP儿童25名作为NCLP组。对所有研究对象的头颅部进行锥形束CT（cone-beam CT,CBCT）扫描,获取影像数据,利用Mimics 17.0软件对下颌骨进行三维重建。比较两组双侧的下颌升支、体部及半侧下颌骨体积,并将UCLP组裂隙侧和非裂隙侧的上述测量指标分别与NCLP组进行比较。结果　（1）UCLP组裂隙侧下颌升支体积大于非裂隙侧,差异有统计学意义（t = 2.192,P < 0.05）;而下颌体部及半侧下颌骨的体积比较,差异无统计学意义（均P > 0.05）;NCLP组两侧的下颌升支、体部及半侧下颌骨体积差异均无统计学意义（均P > 0.05）。（2）UCLP组裂隙侧与非裂隙侧的下颌升支体积均小于NCLP组,UCLP组非裂隙侧半侧下颌骨体积小于NCLP组,差异均有统计学意义（t值分别为-2.938、-3.325、-2.023,P < 0.05）。结论　替牙期UCLP患者两侧下颌骨体积存在差异,裂隙侧下颌升支体积大于非裂隙侧,且替牙期UCLP患者下颌骨的生长发育较NCLP儿童差。     

Prevalence and distribution of oral lesions: a cross-sectional study in Turkey

OBJECTIVES: The purpose of this study was to evaluate the prevalence and distribution of oral lesions (OLs) in Turkish population. SUBJECTS AND METHODS: In this cross-sectional study, 765 residents (F/M: 375/390) were selected by the cluster sampling method and examined according to WHO criteria. RESULTS: Excessive melanin pigmentation (6.9%) was the most common lesion in the study population. The tongue lesions observed in this study were as follows: fissured tongue (5.2%), varices (4.1%), hairy tongue (3.8%), geographic tongue (1.0%), atrophic tongue papillae (0.7%) and ankyloglossia (0.3%). The denture-related lesions were denture stomatitis (4.3%), suction irritation (0.8%), denture hyperplasia and torus palatinus as bony lesion (0.5%) and traumatic ulcers (0.3%). In regression analysis, being 65 years old and over was found as a statistically significant risk factor for the occurrence of pigmentation, fissured tongue, varices, hairy tongue, denture stomatitis and petechiae (P < 0.05). CONCLUSIONS: Pigmentation, fissured tongue and denture stomatitis were observed to be the most common lesions in Turkish population. Elderly population was a significant risk factor for occurrence of some OLs.     

The relationship of distinct craniofacial features between Turner syndrome females and their parents

The present study aimed to assess the relationship of craniofacial features between females with Turner syndrome (TS) and their parents. Lateral cephalograms of 63 TS females and 80 family members with normal karyotype were analysed using 13 linear and eight angular cephalometric measurements. The statistical differences of the measurements between adult TS females and their mothers (n = 41) and between adult TS females and their adult sisters (n = 27) were calculated to define the distinct craniofacial features of subjects with TS. Regression models were computed to assess the association of distinct craniofacial features between TS females and their parents (n = 41 for mothers and n = 12 for fathers).Distinct craniofacial features of the subjects with TS were an increased cranial base flexion, shortened posterior cranial base length (S-Ba), retrognathic maxilla and mandible (相似文献   

放疗和高压氧辅助治疗对狗下颌纯钛种植体周围骨组织沉积率的影响

目的：观察放疗和高压氧（hyperbaric oxygen，HBO）辅助治疗对狗下颌纯钛种植体周围骨组织沉积率影响。方法：8只成年雄性杂种狗，拔除双侧下颌第三、第四前磨牙和第一磨牙，形成无牙区。拔牙后3个月，用电子直线加速器照射一侧下颌无牙区，单一剂量15Gy。另一侧不接受照射，作为对照。放疗后3个月，狗双侧下颌无牙区植入纯钛种植体各4枚，其中2枚种植体在局部使用骨形成蛋白（bone morphogenetic protein，BMP）与透明质酸钠的复合物。以四环素和二甲酚橙作为荧光标记物，自种植体植入术第一天起注射。放疗后2个月，将8只狗随机分为2组，每组4只。其中1组在种植术前后接受HBO辅助治疗。种植术后1．5个月和3个月分别处死4只动物取材。结果：在1．5个月取材组，沉积率在放疗与非放疗间差别明显（P=0．041〈0．05）；在HBO辅助治疗与无HBO辅助治疗组间有差别（沉积率2 P=0．015〈0．05；沉积率3P=0．041〈0．05）。在3个月取材组，沉积率在HBO辅助治疗与无HBO辅助治疗组间统计学上有明显差别（P=0．002〈0．01）。结论：放疗可以降低种植体周围骨组织的骨沉积率，HBO辅助治疗可以影响放疗后狗下颌种植体周围骨组织的骨沉积率。     

Treatment of midline cleft of the mandible-A 2-stage approach

Midline clefts of the lower lip and mandible are rare congenital anomalies. They may present as complete or incomplete in nature along with associated bifid tongue and ankyloglossia. Some may present with cleft of lower lip, cleft of mandible, fissured tongue, absent hyoid bone, cleft of manubrium sterni, or an extremely rare anomaly known as Tessier cleft no. 30. We present this unique case of midline cleft of the lower lip (incomplete) and mandible (complete) with initial soft-tissue surgery for the lower lip. The hard-tissue surgery for this case is deferred at a later date, and the reasons are discussed.     

40例舌癌组织VEGF表达及微血管密度观察

目的:探讨血管内皮生长因子(VEGF)表达及微血管密度(MVD)与舌癌组织临床病理指标的关系.方法:40例手术切除的舌癌原发病灶蜡块标本常规切片,免疫组化染色法观察各标本VEGF表达及MVD.结果:VEGF阳性表达的舌癌组织有较高的微血管密度(p＜0.01);VEGF表达和MVD在淋巴结转移组间有显著性差异(p＜0.01)、病理分型组间有显著性差异(p＜0.05),而在原发病灶临床分级组间差异无统计学意义(p＞0.05).结论:VEGF表达和MVD与舌癌病理分型及淋巴转移关系密切,可作为预测性检测指标.