糖尿病患者糖化血红蛋白控制情况与血液流变学指标相关性分析

目的探讨糖尿病患者糖化血红蛋白(HbA1c)检测数据与血液流变学指标的相关性分析,为其治疗和预防提供参考依据。方法选取2型糖尿病患者142例作为研究对象,根据HbA1c检测结果分成两个不同水平组:A组(69例,控制良好)、B组(73例,控制不佳)。选择同期体检健康者70例作为对照(C组),对3组HbA1c、血液流变学及生化指标检测结果进行对比分析。结果血液流变相关指标除血细胞比容和红细胞变形指数在3组之间差异无统计学意义外(P0.05),其他指标在3组之间差异均有统计学意义(P0.05)。A、C组间比较,血浆黏度、红细胞刚性指数差异无统计学意义(P0.05),余下各指标在不同组之间的差异均有统计学意义(P0.05)。2型糖尿病患者无论HbA1c水平如何,其血液流变指标、三酰甘油及总胆固醇均高于健康人,当患者HbA1c水平控制不佳时,其各指标升高程度更加明显。结论糖尿病患者大多存在血液流变学指标异常,建议临床针对糖尿病患者长期监测HbA1c水平,严格观察血液流变学各项指标的改变,以指导临床治疗达到早期血管保护,以及起到预防糖尿病并发症发生的效果。     

Individualised treatment goals in diabetes care

OBJECTIVES: To examine 1) patients' characteristics according to the treatment goal chosen at diabetes diagnosis, and 2) the association between individualised goals for glycated haemoglobin (HbA1c), blood pressure (BP) and lipids, and the risk factor level subsequently achieved. DESIGN: Follow-up study embedded in a multifaceted intervention study directed at doctors encouraging individualised goal-setting in newly diagnosed diabetic patients aged > or = 40 years. SETTING: General practice. SUBJECTS: In all, 243 general practitioners and 674 patients participated. MAIN OUTCOME MEASURES: Risk factors for diabetic complications. RESULTS: Relatively young age, low diagnostic plasma glucose, low BMI, a moderate or high level of physical activity and normoalbuminuria were associated with a treatment goal of good control at diagnosis. After 5 years, median HbA1c was 8.2%, 8.6% and 8.0% in patients with a goal of good, acceptable and poor control, respectively. Patients with a goal of good control versus those with a goal of acceptable control had a lower HbA1c level in a regression analysis adjusted for age, sex, HbA1c at diagnosis, BMI, total cholesterol, fasting triglycerides, BP, physical activity, smoking status and diabetes duration. We found no association between goals and the level of BP and lipids. CONCLUSION: Doctors tend to pursue normoglycaemia in relatively young patients with low blood glucose, low BMI, high activity level and normoalbuminuria. Patients for whom a goal of normoglycaemia was chosen at diagnosis achieved favourable glycaemic control at 5-year follow-up. Whether doctors choosing the goals were good at predicting future glycaemic control, or whether goal-setting is an important motivational factor in achieving optimal glycaemic control needs to be explored.     

Efficacy of five-element gymnastics in glucose and lipid control in Taiwanese patients with type 2 diabetes

The purpose of this quasi-experimental study was to determine the efficacy of Five-Element Gymnastics (FEG) in controlling glycosylated hemoglobin (HbA1C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) at the 8th and the 16th weeks of intervention for patients with type 2 diabetes in Taiwan. FEG consolidates several traditional Chinese exercises including Qigong, Xiang Gong, and martial arts with gymnastics. The experimental group (n = 31) practiced FEG at home for 16 weeks. The control group (n = 35) maintained usual activities. FEG was associated with decrease of HbA1C, TG, and LDL-C levels at the 8th week and continuous decrease of HbA1C through the 16th week. FEG could be an exercise choice for patients with type 2 diabetes.     

甘精胰岛素联合阿卡波糖对老年2型糖尿病患者血糖及β细胞功能的影响

目的观察甘精胰岛素（IG）联合阿卡波糖治疗老年2型糖尿病（T2DM）的降糖效果及对13细胞功能的影响。方法将90例口服药联合治疗空腹血糖（FPG）控制不佳的老年rr2DM患者,随机分为甘精胰岛素（IG）联合阿卡波糖组和中性鱼精蛋白锌胰岛素（NPH）组。治疗12周后比较两组治疗前后FPG、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlC）、空腹C肽及餐后2hC肽水平。并对两组低血糖发生率进行比较。结果治疗12周后两组FPG、2hPG、HbAlc均下降,IG联合阿卡波糖组低血糖发生较NPH组少,治疗后c肽升高显著,与NPH组比较差异有统计学意义（P〈0．05）。结论甘精胰岛素联合阿卡波糖能较好地控制老年2型糖尿病患者血糖及糖化血红蛋白,且低血糖发生率较低,与NPH比较,安全性更高。     

β_2-MG、HbA1c和CysC检测在糖尿病早期肾损伤诊断中的临床意义

目的探讨β_2微球蛋白(β_2-MG)、血红蛋白(HbA1c)及胱抑素C(CysC)检测在糖尿病早期肾损伤诊断中的临床意义。方法选取2015年1-11月该院内科收治的70例糖尿病肾病患者(DN组)和110例单纯糖尿病患者(DM组)作为研究对象,与同期50例健康体检自愿者(对照组)进行对比研究。比较3组β_2-MG、HbA1c、CysC、血肌酐(SCr)及尿素(Urea)水平。结果DM组与对照组相比,SCr、Urea水平差异无统计学意义(P0.05),而DM组β_2-MG、HbA1c及CysC水平显著高于对照组(P0.05);DN组β_2-MG、HbA1c、CysC、SCr及Urea均显著高于对照组和DM组,差异有统计学意义(P0.05)。DN组β_2-MG、HbA1c、CysC单一检测及3项联合检测的阳性率均显著高于DM组,差异有统计学意义(P0.05)。结论对于糖尿病患者,β_2-MG、HbA1c及CysC能够较好反映其肾功能的早期损伤,三者联合检测有利于糖尿病的治疗和病情监测。     

体力活动对增生性糖尿病视网膜病变患者玻璃体积血的安全性分析

目的 通过对比发生玻璃体积血与无明显玻璃体积血增生性糖尿病视网膜病变（PDR）患者不同体力活动形式及强度的差异,探讨体力活动对PDR患者的安全性及潜在价值。方法 首次在开封市中心医院开封眼病医院就诊的无明显纤维组织增生的PDR患者67例,其中31例无明显玻璃体积血PDR患者为对照组,36例发生玻璃体积血（<1月）患者为研究组。采用国际体力活动量表（IPAQ）统计患者玻璃体积血发生前的体力活动。同时记录患者年龄、病程、最佳矫正视力（BCVA）、身高、体重指数（BMI）、糖化血红蛋白、血脂、血压。 调查出血诱因,比较两组间体力活动的差异。结果 36例发生玻璃体积血患者中未见体力活动直接诱发玻璃体积血病例;研究组大量患者部分体力活动缺失,中、重体力活动、总体力活动、能量消耗、休闲及运动相关体力活动时间及人数显著低于对照组(P＜0.05);研究组静坐时间显著延长,睡眠时间显著缩短,BMI、甘油三酯、收缩压显著高于对照组(P＜0.05)。结论 不同体力活动未见诱发玻璃体积血;不同体力活动对无明显纤维组织增生PDR患者可能是安全和有益的;减少静坐时间、改善睡眠质量值得提倡。     

Habitual physical activity in adult IDDM patients. A study with portable motion meters.

The objective of this study was to assess the habitual physical activity of insulin-dependent diabetes mellitus (IDDM) patients on intensive insulin therapy. This case-control study consisted of 34 IDDM patients (14 on multiple injection therapy, 20 on continuous subcutaneous insulin infusion [CSII], and control subjects matched for sex, age, weight, height, body mass index, smoking behavior, and occupational status). Seven IDDM patients were studied before and after changing from multiple injection to CSII therapy. All patients were well controlled according to HbA1c. Portable motion meters were used to assess habitual physical activity during 7 consecutive days with appreciable reproducibility (coefficient of variation 1.24%) and agreement to standardized activity protocols (r = 0.96, P < 0.001). Habitual physical activity was similar in IDDM patients on injection treatment and in controls, respectively. CSII-treated patients exhibited on the average 17% less habitual physical activity than control subjects (P < 0.05). Changing from multiple injection therapy to CSII lowered habitual physical activity insignificantly in seven patients. There was no indication of decreasing physical exercise (e.g., sports) by CSII in this patient group. No correlations were found between habitual physical activity and HbA1c or body mass index, respectively. Habitual physical activity is similar in IDDM patients on multiple injection therapy and control subjects, but may decrease by CSII therapy.     

2型糖尿病患者糖化血红蛋白与颈动脉内-中膜层厚度的关系:Logistic及单核细胞中介效应检验

目的 研究2型糖尿病(T2DM)患者糖化血红蛋白(HbA1c)与颈动脉内-中膜层厚度(carotid inti-ma-media thickness,CIMT)的关系及单核细胞在HbA1c与CIMT间的中介作用.方法 选择2014年至2019年于华东疗养院体检的T2DM患者1 539例,根据CIMT的厚度分为正常组80...     

慢性心力衰竭合并糖尿病患者血浆BNP、CRP和HbA1c的表达及与心功能分级的相关性

目的分析慢性心力衰竭(CHF)合并糖尿病患者血浆脑钠肽(BNP)、C-反应蛋白(CRP)和糖化血红蛋白(HbA1c)的表达及与心功能分级的相关性。方法选取本院2019年4月至2020年10月收治且经临床确诊的144例CHF合并糖尿病患者作为研究组,心功能分级:Ⅱ级48例,Ⅲ级60例,Ⅳ36例。同期纳入90例本院门诊健康体检者作为对照组。比较不同组别血浆BNP、CRP和HbA1c水平,并分析上述因子水平与CHF合并糖尿病患者心功能的相关性。结果研究组血浆BNP、CRP、HbA1c水平及LVEDVI显著高于对照组,LVEF显著低于对照组,差异有统计学意义(P<0.05)。Ⅱ级组、Ⅲ级组、Ⅳ级组血浆BNP、CRP、HbA1c水平及LVEDVI均显著高于对照组,LVEF显著低于对照组,差异有统计学意义(P<0.05)。随着心功能下降,血浆BNP、CRP、HbA1c水平及LVEDVI逐渐上升,LVEF逐渐下降(P<0.05);BNP、CRP、HbA1c与LVEDVI呈显著正相关,与LVEF呈显著负相关,与心功能分级呈显著正相关(P<0.05)。结论CHF合并糖尿病患者的血浆BNP、CRP、HbA1c水平均明显上升,且与其心功能分级具有一定相关性,通过检测上述因子水平可有效评估患者心功能。     

Effect of motivational interviewing on self-management in patients with type 2 diabetes mellitus: A meta-analysis

ObjectiveThe objective of this meta-analysis was to evaluate the effect of motivational interviewing (MI) on self-management in patients with type 2 diabetes.MethodsRandomised controlled trials that assessed the effects of MI on self-management and HbA1c levels in patients with type 2 diabetes were systematically reviewed using multiple electronic databases. Weighted mean differences with 95% confidence intervals were calculated for continuous data.ResultsTen trials were included in this meta-analysis. The self-management ability of patients with type 2 diabetes who underwent MI was significantly better than that of patients in the control group (WMD, 2.37; 95% CI, 1.77–2.98; p < 0.00001). Subgroup analysis showed that short-term MI (≤6 months) resulted in a significant decrease in the HbA1c level (p < 0.05) but that this advantage was not present for relatively long-term MI (>6 months) (p > 0.05).ConclusionsMI was associated with improved self-management abilities among patients with type 2 diabetes, and short-term MI (≤6 months) effectively decreased the HbA1c level. The effect of long-term MI (>6 months) on the HbA1c level remains uncertain. Large-scale, higher-quality randomised controlled trials are needed to confirm the present findings.     

Peroxisome proliferator-activated receptor gamma gene polymorphism is associated with serum triglyceride levels and body mass index in Japanese type 2 diabetic patients

Peroxisome proliferator-activated receptor gamma (PPARgamma) controls adipocyte differentiation and regulates lipid and glucose homeostasis. Therefore, the PPARgamma gene may affect insulin sensitivity and resistance. We analyzed the relationship between C/T exon 6 polymorphism of the PPARgamma gene and various clinical parameters in type 2 diabetic patients. There were no significant differences in the frequencies of genotype and allele between diabetic patients with and without nephropathy. Diabetic patients were divided into two groups: patients bearing at least one T allele (CT/TT), and patients with no T allele (CC). Levels of serum triglyceride and body mass index (BMI) were significantly higher in the CT/TT genotype group than in the CC genotype group. Since obesity affects insulin resistance, the diabetic patients were also divided into two groups: those with a BMI of <23, and those with a BMI of >23. In patients with a BMI of <23, there was no significant change in the levels of glycosylated hemoglobin A1c (HbA1c) between the CC and CT/TT genotype groups. However, in patients with a BMI of >23, HbA1c levels were significantly higher in the CT/TT genotype group than in the CC genotype group. It appears that the CT/TT genotype with PPARgamma gene polymorphism may contribute to higher BMI and higher serum triglyceride and HbA1c levels in Japanese type 2 diabetic patients.     

2型糖尿病患者糖化血红蛋白与血脂水平的研究

目的 研究2型糖尿病（T2DM ）患者糖化血红蛋白（HbA1c）与血脂之间的相关性,并探讨预防和治疗糖尿病并发症的新思路。方法 检测110例T2DM患者和104例体检健康者HbA1c、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（Apo-A1）、载脂蛋白B（Apo-B）的水平;根据HbA1c的水平进行分组,比较不同组间血脂的差异以及HbA1c与血脂的相关性。结果 T2DM 组与健康对照组各项检测结果 比较差异均有统计学意义（P＜0．01）;HbA1c与 TC、TG、LDL-C、Apo-B呈正相关（P＜0．05）,与HDL-C呈负相关（P＜0．05）,与Apo-A1无相关性。结论 HbA1c及血脂水平可作为监测T2DM 患者状况的指标;联合检测HbA1c和血脂对于制订T2DM患者诊疗方案及预防并发症具有重要的临床意义。     

短期胰岛素强化治疗对超重初诊2型糖尿病胰岛素抵抗的干预

目的探究非严重高血糖的超重初诊2型糖尿病患者采取短期胰岛素泵强化治疗能否获益,以及探讨强化治疗后的降糖方案。方法 120例超重(24≤BMI<28 kg/m2)初诊2型糖尿病患者随机分为3组,各40例:胰岛素泵+二甲双胍组(A组);胰岛素泵+预混入胰岛素组(B组);二甲双胍组(C组)。分别在治疗前、治疗2周及12周,测定糖化血红蛋白(HbA1c),口服75 g葡萄糖耐量(OGTT)空腹及2 h血糖(FBG、2 hPBG)、胰岛素(FINS、2hINS)、C肽(FCP、2 hCP),计算胰岛β细胞功能指数(HOMAβ)和胰岛素抵抗指数(HOMA IR)。结果治疗前3组间无统计学差异;治疗2周时A、B组FBG、2 hP BG、HbA1c、2 hINS、HOMA IR低于C组;治疗12周时A、B组2 hPBG、HbA1c低于C组;A组FINS、FCP、OGTT 2 hINS、HOMA IR低于B、C组;B组BMI高于A、C组,HOMAβ高于A组。结论短期胰岛素泵强化治疗有益于改善非严重高血糖超重初诊2型糖尿病患者的胰岛素抵抗,而强化治疗后二甲双胍续贯治疗更显优势。     

利拉鲁肽对2型糖尿病患者胰岛素抵抗的影响

目的探讨利拉鲁肽联合二甲双胍与单纯使用二甲双胍对2型糖尿病患者胰岛素抵抗的影响。方法收集30例2型糖尿病患者(使用利拉鲁肽联合二甲双胍治疗)为试验组,收集30例2型糖尿病患者(单纯使用二甲双胍治疗)为对照组,比较两组治疗前及治疗后3个月糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、血清脂联素、一氧化氮(NO)、内皮素(ET)水平变化情况。结果试验组HbA1c、HOMA-IR、NO、ET水平下降程度,以及血清脂联素水平上升程度均较对照组明显,差异均有统计学意义(P0.05)。结论利拉鲁肽较二甲双胍对2型糖尿病患者改善胰岛素抵抗的效果更为明显。     

Impact of computer-generated personalized goals on HbA(1c).

OBJECTIVE: The public is increasingly aware of the importance of HbA(1c) testing, yet the vast majority of patients with diabetes do not know their HbA(1c) status or goal. We set forth to evaluate the impact of a system that provides uniquely formatted and personalized reports of diabetes status and goals on changes in HbA(1c) levels. RESEARCH DESIGN AND METHODS: A total of 150 patients with diabetes were randomized to receive either standard care or intervention inclusive of a computer-generated 11" x 17" color poster depicting an individual's HbA(1c) status and goals along with personalized steps to aid in goal achievement. All patients enrolled received diabetes education during the 3 months before enrollment. HbA(1c) was performed at baseline and 6 months. RESULTS: At baseline, there were no significant differences between patient groups in terms of age, sex, education level, race, and HbA(1c) or lipid levels. Among patients with baseline HbA(1c) > or =7.0%, there was an 8.6% (0.77% absolute) reduction in HbA(1c) among control subjects compared with a 17.0% (1.69% absolute) decline in the intervention group (P = 0.032). There were no differences between the control and intervention groups with respect to the frequency of patients experiencing any decline in HbA(1c) (63 vs. 69%, P = 0.87); among these patients experiencing a decline, the most substantial reductions were seen with the control group, which had a 13.3% (1.15% absolute) decline compared with the intervention patients, who reduced their HbA(1c) by 24.2% (2.26% absolute reduction; P = 0.0048). At study close, 77% of the patients had their poster displayed on their refrigerator. CONCLUSIONS: This unique and personalized computer-generated intervention resulted in HbA(1c) lowering comparable to that of hypoglycemic agents.     

小儿糖尿病的家庭护理干预效果观察与分析

[目的]探讨并分析小儿糖尿病家庭护理干预的效果。[方法]随机将糖尿病患儿82例分为对照组40例与干预组42例,对照组按常规治疗和护理,干预组在常规治疗和护理的基础上给予系统全面而个性化的家庭护理干预,半年后对两组患儿的糖化血红蛋白值(HbA1C)、饮食控制、遵医嘱用药、规律锻炼、自我监测等方面进行评价。[结果]干预组患儿的HbA1C与对照组比较,差异有统计学意义(P<0.01)。饮食控制、遵医嘱用药、规律锻炼、自我监测指标执行情况均高于对照组,差异有统计学意义(P<0.01)。[结论]正确家庭护理干预可有效控制小儿糖尿病病情,减少并发症发生。     

血清学指标对2型糖尿病患者疗效的评估价值

目的探讨血清学指标对2型糖尿病(T2DM)患者疗效的评估价值。方法选择2018年1月至2019年3月该院内分泌科确诊并收治的T2DM患者60例作为观察组,选择同期于该院体检的健康人52例作为对照组。均于入院时抽取静脉血检测超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)、糖化血红蛋白(HbA1c)水平。对观察组进行血糖控制治疗1个月,根据患者治疗后疗效情况分为有效组、基本有效组、无效组,比较3组患者hs-CRP、Lp-PLA2、HbA1c水平,采用Spearman相关分析hs-CRP、Lp-PLA2与HbA1c相关性,采用受试者工作特征(ROC)曲线分析比较hs-CRP、Lp-PLA2、HbA1c对T2DM患者病情转归的评估价值。结果观察组hs-CRP、Lp-PLA2、HbA1c水平高于对照组,差异有统计学意义(P<0.05);有效组hs-CRP、Lp-PLA2、HbA1c水平低于基本有效组,基本有效组hs-CRP、Lp-PLA2、HbA1c水平低于无效组,差异有统计学意义(P<0.05);HbA1c与hs-CRP、Lp-PLA2均呈正相关(P<0.05);hs-CRP、Lp-PLA2、HbA1c联合检测对T2DM病情转归的预测价值优于单独检测(P<0.05)。结论hs-CRP、Lp-PLA2、HbA1c可作为评估TWDM疗效和预后的敏感指标,且三者联合检测可进一步提高对该病患者近期病情转归的评估能力。     

高尿酸血症与2型糖尿病合并血管并发症的相关性研究

目的探讨高尿酸血症和合并2型糖尿病患者血管并发症的相关危险因素。方法选取体检健康者97例纳入对照组,单纯2型糖尿病组103例和2型糖尿病合并高尿酸血症组78例。比较3组受试者空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1、ApoB、肌酐(Cr)、尿酸(UA),同时留取晨尿检测尿微量清蛋白(UMA)及体质量指数(BMI),并研究高尿酸血症和糖尿病相关并发症的相关性。结果单纯2型糖尿病组FPG、TG、Cr、UMA、HbA1c水平均高于对照组(P0.05);2型糖尿病合并高尿酸血症组BMI、FPG、TG、TC、LDL-L、UMA、Cr、HbA1c均高于对照组(P0.05);2型糖尿病合并高尿酸血症组BMI、TG、Cr、UMA、HbA1c均高于单纯2型糖尿病组(P0.05)。2型糖尿病合并高尿酸血症组患者的糖尿病肾病、下肢动脉斑块发病率明显高于单纯2型糖尿病组,差异有统计学意义(P0.05)。结论 2型糖尿病合并高尿酸血症组患者比单纯2型糖尿病患者更易发生血脂异常,2型糖尿病合并高尿酸血症组患者糖尿病肾病、下肢动脉斑块发病率也明显高于单纯2型糖尿病患者。     

A randomized controlled trial of a nurse short-message service by cellular phone for people with diabetes

BACKGROUND: Nurse's education using telemedicine results in a decrease in blood glucose levels in patients with type 2 diabetes. OBJECTIVE: To investigate the effectiveness of an educational intervention that used both the cellular phone and the Internet to provide a short-messaging service (SMS) relating to plasma glucose levels. METHODS: Twenty-five patients were randomly assigned to an intervention group and 26 to a control group. The intervention was applied for 12 weeks. The goal of the intervention was to keep blood glucose concentrations close to the normal range. Patients in the intervention group were asked to access a website by using a cellular phone or to wiring the Internet and input their blood glucose levels every day. Participants were sent the optimal recommendations by both cellular phone and the Internet weekly. RESULTS: Patients in the intervention group had a mean decrease in glycosylated haemoglobin (HbA(1)c) levels of 1.15% and those in the control group had a mean increase of HbA(1)c levels of 0.07% (p=0.005). There was a significant mean change in the 2hrs post-meal glucose (2HPMG) level for the intervention group (p<0.05), with a mean change of -4.7mmol/l. The mean change in the control group was not significant. CONCLUSION: This educational intervention using the Internet and an SMS by cellular phone improved levels of HbA(1)c and 2HPMG.     

2型糖尿病患者糖化血红蛋白与脉搏波传导速度及内皮依赖性血管舒张功能的关系研究

目的 探讨2型糖尿病患者不同糖化血红蛋白(HbA1c)水平与踝臂动脉脉搏波传导速度(baPWV)及内皮依赖性血管舒张功能(FMD)的关系.方法 对338例2型糖尿病患者按HbA1c水平分为正常组(A组,HbA1c≤6.0％,74例),正常高值组(B组,6.0％＜HbA1c≤6.5％,102例)和升高组162例(C组,HbA1c ＞6.5％),测量BaPWV及FMD作为反映大动脉硬度及血管舒张功能的指标.结果 与A组比较,B、C组BaPWV明显增高[(1734±343)cm/s与(1537±313)cm/s;1853±364)cm/s与(1537±313)cm/s;P均＜0.001),与B组比较,C组BaPWV明显升高[(1853±364)cm/s与(1734±343)cm/s;P=0.006).与A组比较,B、C组FMD明显减低[(4.20±3.13)％与(5.29±3.92)％;(4.09±2.79)％与(5.29±3.92)％;P均＜0.01)].直线相关分析显示,BaPWV与HbA1c水平呈正相关(r=0.53,P＜0.01),与FMD水平呈负相关(r=-0.25,P＜0.01).Logistic回归分析显示,HbA1c(OR 32.19,95％ CI 11.26 ～53.12;P ＜0.001)与年龄(OR 14.21,95％ CI 11.43～17.00;P ＜0.001)、收缩压(OR7.36,95％CI 6.12 ～8.59;P ＜0.001)和胆固醇(OR 40.31,95％ CI 9.97～70.64;P=0.009)为影响BaPWV的独立危险因素.结论 2型糖尿病患者BaPWV与HbA1c水平密切相关,将HbA1c控制在理想水平是降低大动脉硬化的手段之一.