幽门螺杆菌在不同湿度环境下生活人群感染差异性的研究

目的 探讨幽门螺杆菌在不同湿度环境中生活人群感染的差异性。方法 使用免疫胶体金法分别对来自汶川三江地区的137例健康体检者和来自成都周边农村地区320例健康体检者进行幽门螺杆菌感染的血清学筛查。结果 汶川三江地区人群幽门螺杆菌感染率为26.28%,成都周边农村地区人群幽门螺杆菌感染率为16.88%,差异有统计学意义(P＜0.025)。并且排除了民族构成对人群幽门螺杆菌感染率的影响。结论 不同湿度环境下人群幽门螺杆菌感染率存在差异,高湿度环境可能是导致人群幽门螺杆菌感染率增高的因素之一。     

2220例健康体检人群幽门螺杆菌感染状况分析

目的了解健康体检人群幽门螺杆菌(HP)的感染状况及其相关因素,探讨相关防护措施,为HP的防治提供依据。方法选择2013-06—2014-05来我院健康体检人群2 220例为调查对象,采用尿素13C和14C呼气试验,监测该人群HP感染率,进行统计学分析。结果 2 220例体检者的HP总感染率为43.56%,男女性别间比较差异有统计学意义(P0.05),不同年龄段之间HP感染差异有统计学意义(P0.05)。结论体检人群HP感染率较高,社会因素、饮食习惯及环境因素对HP感染产生显著影响,应引起重视,加强预防及治疗。     

淄博地区铁路系统幽门螺杆菌感染的调查分析报告

目的探讨幽门螺杆茼感染的途径以及与年龄、性别、职业等的关系。方法采用胶体金法检测被调查者的血清（血浆）内幽门螺杆菌尿素酶的含量；并把被调查者分为三组：年龄组、性别组、职业组。结果健康体格检人群是幽门螺杆菌感染与年龄无显著相关性，与性别、职业有显著相关性。结论正常人群通过体检方式检测出幽门螺杆菌抗体阳性者为感染人群或既往感染者，讨论其感染原因以及与职业、年龄、性别的相关性；与胃癌、胃外其他疾病的联系；给出合理的预防建议。避免感染或再感染。     

北京地区1814例健康体检者尿素【14C】呼气试验结果分析

目的了解北京地区健康体检者幽门螺杆菌感染现状。方法对在我院健康体检中心做尿素【14C】呼气试验的1814例测试结果进行统计分析。结果受检测的1814例体检者中,未受幽门螺杆菌感染的有943例,占51．98％;检测出幽门螺杆菌感染者871例,占48．02％。结论此次调查显示,北京地区部分健康体检人群幽门螺杆菌感染现状不容乐观,提早做好消化道疾病的预防。     

健康人群血清PG定量检测和Hp感染的临床意义

目的 探讨健康体检人群的血清胃蛋白酶原(PG)与幽门螺杆菌(Hp)现症感染状况的关系。评估年龄、性别和幽门螺杆菌状态对胃蛋白酶原检测的影响以及建立胃蛋白酶原检测结果和幽门螺杆菌血清学检测在健康体检人群中的临床应用。方法 采用胶体金法对800例查体者进行Hp感染检测。采用化学发光微粒子免疫检测法进行血清PGI和PGII测定并计算PGI/II比值,定量检测人血清或血浆中的PG水平。结果 体检人群Hp感染率为50.63%; 性别与Hp感染率差异无统计学显著性意义(P>0.05); 年龄段与Hp感染率差异有统计学显著性意义(P<0.05),40～60岁Hp阳性率最高; 血清PGI和PGII水平在Hp阳性者中高于Hp阴性者(P<0.05)。PGI/II比值在Hp阳性者中低于Hp阴性者(P<0.05)。结论 健康体检人群中,年龄、性别和Hp感染状态与血清PG水平有一定关联。 其中Hp感染状况与血清PG水平及PG异常率密切相关,因此Hp与PG水平检测相结合可用于健康体检人群的普查筛选。     

北京地区1814例健康体检者尿素[14C]呼气试验结果分析

目的 了解北京地区健康体检者幽门螺杆菌感染现状.方法 对在我院健康体检中心做尿素[14C]呼气试验的1814例测试结果进行统计分析.结果 受检测的1814例体检者中,未受幽门螺杆菌感染的有943例,占51.98％;检测出幽门螺杆菌感染者871例,占48.02％.结论 此次调查显示,北京地区部分健康体检人群幽门螺杆菌感染现状不容乐观,提早做好消化道疾病的预防.     

幽门螺杆菌阳性患者健康知识认知的调查分析

目的 了解门诊体检患者对幽门螺杆菌感染相关知识的认知状况,分析造成认知差异的影响因素,为门诊开展幽门螺杆菌感染健康教育活动的方式方法提供依据。方法 采用自设问卷于2013年8月至2014年2月在门诊开展幽门螺杆菌感染相关知识调查。结果 调查对象为336例检测结果阳性患者, 16~、30~、50岁患者检出率分别为23.51%、34.82%、41.67%,差异有统计学意义(P0.01);对幽门螺杆菌主要传播途径(唾液传播、饮食不洁、不良卫生习惯)的正确认识率约为47.22%,初中以下文化程度者选择率达31.43%,高中及以上文化程度者选择率为68.57%。结论 门诊体检不同文化层次、不同职业患者对幽门螺杆菌感染的重视程度、相关知识了解情况存在偏差,应进行针对性的健康教育,以减少健康人群的幽门螺杆菌感染率。     

新疆阿合奇县柯尔克孜族人群幽门螺杆菌感染情况调查分析

目的：了解新疆阿合奇县当地柯族人群幽门螺杆菌（Hp）感染现状,并就性别、年龄、饮食习惯、生活环境等感染相关因素进行分析。方法随机抽取2013年4月至2013年7月来阿合奇县人民医院健康体检无胃病史柯族人群807例作为研究对象,采用胶体金法检测血清幽门螺杆菌尿素酶抗体。结果新疆阿合奇县柯族人群 Hp 感染率为24．29％,男性感染率为28．85％,女性感染率为20．67％,经χ2检验,Hp 阳性率男女差异有统计学意义（P ＜0.05）,经过数据分析,各年龄段 Hp 阳性率之间存在线性变化趋势,且阳性率随年龄增大而增加。结论新疆阿合奇县柯族人群 Hp 感染率较高,并随年龄的增大而增加。     

苏州地区健康体检人群幽门螺杆菌感染情况调查研究

目的了解苏州地区健康体检人群幽门螺杆菌(Hp)感染现状,并就性别、年龄、职业等感染相关因素进行分析。方法随机抽取2010年8至2011年9月来苏州市立医院体检的健康人群9 285例作为研究对象,年龄从20～80岁,采用胶体金法检测血清幽门螺杆菌尿素酶抗体。结果苏州地区体检人群Hp感染率为38.3%,男性与女性之间感染率差异有统计学意义(P<0.05)。不同年龄组之间的感染率差异有统计学意义(P<0.05),年龄在21～30岁的体检者,其Hp的感染率较低,为30.1%;年龄在41～70岁,感染率达高峰,且趋于稳定,其中41～50、51～60、61～70岁三个年龄段之间的体检者,感染率分别为42.6%、41.7%、42.7%。不同职业者之间的Hp感染率差异有统计学意义(P<0.05),医务人员的感染率最低(34.3%),其次是教师的感染率也较低(36.4%),司机和记者的Hp感染率较高,分别为41.8%、43.9%。结论苏州地区体检人群Hp感染低于全国水平,其感染与性别、年龄、职业因素均相关。     

上海市青浦区干部体检幽门螺杆菌感染情况调查

目的:了解上海市青浦区干部幽门螺杆菌感染情况及主要危险因素,为制订有效的干预措施提供科学依据.方法:通过集中体检对2008年7月～8月受检的311例进行卡式幽门螺杆菌检测,并对所得数据进行分析.结果:311例中感染幽门螺杆菌159例,感染率为51.13%(159/311),幽门螺杆菌感染与性别、年龄无关,与合并慢性胃炎、2型糖尿病、高脂血症、高血压病、口臭症有关.结论:青浦区干部幽门螺杆菌感染率较高,对合并上述慢性病患者应积极治疗,及早预防.     

A placebo-controlled randomized trial of eradication of Helicobacter pylori in the general population: study design and response rates of the Bristol Helicobacter Project

The Bristol Helicobacter Project is an ongoing, pragmatic, double-blind placebo-controlled trial of the effect of Helicobacter pylori eradication on symptoms of dyspepsia, health utilization and costs, and quality of life in the adult population. Commencing in 1996, 27,536 individuals ages 20-59 years who were registered with seven primary care centers in Bristol and the surrounding areas in southwest England were invited to undergo a 13C urea breath test. There was no selection on the basis of symptoms and 23.5% had dyspepsia on entry to the study. A total of 10,537 people were tested (38.3% of those invited), 1636 tested positive (15.5% of those tested), and 1558 (95.2% of those who tested positive) were randomized to H. pylori eradication therapy or placebo. The rate of participation in the screening phase increased with age (odds ratio [OR]: 1.42 per decade, 95% CI: 1.31 to 1.54) and female gender (OR: 1.35, 95% CI: 1.27 to 1.43) but decreased with lower socioeconomic status (OR: 0.70, 95% CI: 0.56 to 0.86 comparing lowest with highest category). H. pylori prevalence increased with age (OR: 1.69 per decade, 95% CI: 1.51 to 1.89) and lower socioeconomic status (OR: 1.33, 95% CI: 1.05 to 1.69) but was lower in women (OR: 0.87, 95% CI: 0.76 to 1.00). Population-based trials of H. pylori eradication are feasible but necessitate screening large numbers of people to identify those who are infected and who may benefit from eradication. In the Bristol Helicobacter Project the rate of participation varied inversely with both social deprivation and the prevalence of the infection.     

幽门螺旋杆菌感染与大肠息肉的相关性

目的:探讨幽门螺旋杆菌感染与大肠息肉发生的相关性。方法:选择南京中医药大学附属中西医结合医院消化科2017年1月至2018年12月期间同时进行电子肠镜及幽门螺旋杆菌检查的住院患者共341例,分为肠息肉组及对照组,比较两组一般资料、幽门螺旋杆菌感染率及大肠息肉的个数、位置、大小、性质等。结果:肠息肉组幽门螺旋杆菌感染阳性率为59.1%,对照组幽门螺旋杆菌感染阳性率22.4%,差异有统计学意义(P<0.05)。肠息肉组中,大肠单发息肉患者幽门螺旋杆菌感染阳性率51.4%,多发息肉幽门螺旋杆菌感染阳性率69.8%,差异具有统计学意义(P<0.05)。幽门螺旋杆菌感染与患者年龄、性别及大肠息肉的位置、大小、性质无明显相关性(P>0.05)。结论:幽门螺旋杆菌感染可增加大肠息肉尤其是多发性大肠息肉的发病风险。     

Acute myocardial infarction andHelicobacter pylori seropositivity

Infectious agents including Helicobacter pylori, have been linked to coronary heart diseases on epidemiological and pathogenetic grounds. Classical risk factors fail to explain all the epidemiological variations of the disease. Our aim was to investigate the association of acute myocardial infarction with Helicobacter pylori infection in a case-control study by comparing a group of male patients with a control group of blood donors matched for sex and age. We investigated the classical cardiovascular risk factors in all patients. We studied 44 consecutive male patients, aged 40-65 years, admitted for acute myocardial infarction to the Coronary Care Unit at Novi Ligure Hospital in northern Italy. Helicobacter pylori infection was assessed by measurement of antibodies (IgG) against Helicobacter pylori in blood. Volunteer blood donors attending Molinette Hospital Blood Bank in Turin, northern Italy served as controls. Among the patients we investigated the presence of hypertension, cholesterol and glucose levels in serum, fibrinogen in plasma, smoking habits, and social class. Helicobacter pylori infection was present in 34 of 44 (77%) patients and in 183 of 310 (59%) controls (P<0.05); the odds ratio was 2.36 (95% confidence interval 1.08-5.31). Classical cardiovascular risk factors did not differ among patients with and without Helicobacter pylori infection. In conclusion, patients with acute myocardial infarction had a significantly higher prevalence of Helicobacter pylori infection than the control population. The classical risk factors for cardiovascular diseases were equally distributed among patients irrespective of their Helicobacter pylori status.     

Economic evaluation of H. pylori eradication

A review of economic evaluation studies of Helicobacter pylori eradication was performed. As a result of the high quality and quantity of data emerging, the eradication therapy for patients with gastric or duodenal ulcer was considered to be less costly and more effective than conventional therapy in a Japanese clinical setting. Furthermore, population-based Helicobacter pylori screening was seemed to have the potential to produce important health benefits at a reasonable cost, especially in Japan. Controlled studies are needed to quantify the impact of Helicobacter pylori eradication on the risk of gastric cancer to confirm it.     

Helicobacter pylori infection in endoscopic biopsy specimens of gastric cancer: a preliminary evaluation in a high risk population of kashmir valley

Objective: The aim of the present study was to assess the prevalence of Helicobacter pylori (H. pylori) infection in Kashmiri patients with gastric cancer and to compare this with a matched control population.Methods: Fifty patients with gastric cancer and thirty age/sex matched controls were included in the study. All the subjects were hailing from Kashmir Valley. For detection of H. pylori, biopsy specimens were used both from cases and controls.Results: An insignificant association was shown between H. pylori and both intestinal and diffuse type of gastric cancer.Conclusions: The data provides support against the significant association between H. pylori and gastric cancer in this part of world, a place where the age standardized incidence of gastric cancer is alarmingly high. We conclude that other factors like personal and special dietary habits of Kashmiri population may be more important for the development of gastric cancer.     

The management of young dyspeptic patients in the era of Helicobacter pylori

The management of young dyspeptic patients remains controversial in the modern Helicobacter pylori era. The use of non-invasive screening for H. pylori in one proposed strategy has demonstrated a substantial reduction in the endoscopy workload by excluding H. pylori negative patients under the age of 45 years with uncomplicated dyspepsia. An alternative screening strategy proposes a 'test and treat' approach, with H. pylori positive patients proceeding directly to an empirical course of eradication therapy. Ednoscopy would be reserved for patients who failed to respond symptomatically or who were H. pylori negative on intial screening. At present there are few data available from clinical studies of putting the 'test and treat' policy into practice. Although there is likely to be a role for screening young dyspeptic patients for H. pylori in primary care, subsequent management requires well-planned studies in order to assess the benefits of any particular strategy.     

Epidemiology of peptic ulcer disease in the aged in Japan

The population in Japan is now decreasing, however, the population older than 65 years old is increasing remarkably in the recent years. The old people with peptic ulcer may hospitalize for longer period than that of younger. The serious complications such as bleeding, perforation and obstruction may affect the period of hospitalization. In 1983, Helicobacter pylori was found and identified. The eradication of Helicobacter pylori causes a decrease of ulcer recurrence and the lower prevalence rate of Helicobacter pylori in the younger people may decrease the incidence of peptic ulcer in the near feature. Thus, the people older than 65 years old with a high risk for peptic ulcer will increase, although the infection rate of Helicobacter pylori will decrease. The actual number of peptic ulcer in the old people may decrease, however, the percentage of old people with peptic ulcer against total population may increase, although it is very difficult to predict the incidence of peptic ulcer diseases in the future.     

舟山群岛地区幽门螺杆菌耐药情况临床研究

目的 研究对舟山群岛地区幽门螺杆菌对克拉霉素、阿莫西林、甲硝唑、左旋氧氟沙星的耐药情况。方法 采用Kirby-baner药敏纸片法对2006年9月至2007年3月因胃肠道症状而于我院胃镜室接受胃镜检查患者胃粘膜分离出的185株Hp菌株进行药敏测试。采用Mann-Whitney U和Kruskal-Wallis H秩和检验法分析Hp对抗生素的耐药情况,及其与患者年龄、性别及疾病种类的关系。结果 各药的耐药情况分别为：克拉霉素28.1％、阿莫西林32.4％、甲硝唑99.5％、左氧氟沙星0.5％，并且各抗生素的耐药率与患者的性别、疾病及年龄间均无统计学差异。结论 舟山群岛地区对甲硝唑的耐药率明显高于其他地区，而对左旋氧氟沙星耐药率较低