红皮病120例病因分析

目的：探讨红皮病的病因及并发感染的情况。方法：回顾性分析120例红皮病患者的临床资料。结果：120例患者中73．3％红皮病继发于原有皮肤病，其他致病原因依次为药物过敏、肿瘤，部分原因不明。28．3％并发感染的红皮病患者中，41～60岁组和〉60岁年龄组的感染率高于≤40岁年龄组，差异有统计学意义（P均〈0．05）；血浆白蛋白降低组患者感染率高于血浆白蛋白正常组患者，差异亦有统计学意义（P〈0．01）。结论：红皮病病因多种多样，不能忽视非常见病因的存在。随着年龄的增长和血浆白蛋白的降低，红皮病患者的感染率增加，应注意皮肤护理及早期支持治疗。     

外阴Pinkus纤维上皮瘤

报告1例外阴Pinkus纤维上皮瘤。患者女，71岁。左大阴唇外侧斑块10余年。皮肤科检查见左大阴唇外侧一2cm×2cm灰黑色浸润性斑块．质地中等，边缘清楚，表面散在红色点状糜烂面，无明显渗液。皮损组织病理检查：棘层下方大量基底样细胞增生．增生的细胞呈条索状嵌入真皮增生的纤维间质中，彼此吻合形成网状，基底细胞胞核大而深染，胞质少，呈嗜碱性，表皮基膜完整，真皮内有以淋巴细胞为主的大量炎性细胞浸润。诊断：外阴Pinkus纤维上皮瘤。     

Epidemiological evidence of carcinogenicity of sunbed use and of efficacy of preventive measures

The International Agency for Research on Cancer classified, in July 2009, exposure to artificial tanning devices (sunbeds) as carcinogenic to humans. This classification was based on evidence from epidemiological and experimental animal studies. The present chapter will review these epidemiological evidences. The summary risk estimates from 27 epidemiological studies obtained through a meta‐analysis showed an increased risk of melanoma: summary relative risk (SRR) = 1.20 [95% confidence interval (CI) 1.08–1.34]. The risk was higher when exposure took place at younger age (SRR = 1.59; 95% CI 1.36–1.85). The risk was independent of skin sensitivity or population and a dose response was evident. A meta‐analysis of 12 studies was conducted for non‐melanoma skin cancers and showed a significantly increased risk for basal cell carcinoma (SRR = 1.29; 95% CI 1.08–1.53) and for squamous cell carcinoma (SRR = 1.67; 95% CI 1.29–2.17). As for melanoma, the risk for other skin cancers increased for first exposures at young age. Epidemiological studies have gradually strengthened the evidence for a causal relationship between indoor tanning and skin cancer and they fit with prior knowledge on relationship between UV exposure and skin cancer. Additionally, several case–control studies provided consistent evidence of a positive association between use of sunbed and ocular melanoma, also with greater risk for first exposures at younger age. Preventive measures based on information on risk or by requiring parental authorization for young users proved to be inefficient in several studies. The significant impact of strong actions or total ban, such as performed in Iceland, or a total ban of sunbed use, as in Brazil or Australian states, needs to be further assessed.     

Pathogenesis of ulcerations in deficiency of prolidase. The role of angiopathy and of deposits of amyloid

The structure of the skin and the pattern of alteration in chronic ulcerations associated with deficiency of prolidase have been studied superficially in the past. We examined histologically several biopsies taken from apparently normal skin and from ulcerations afflicting a young woman with such a syndrome. Deposits of amyloid were found within the walls of medium-sized vessels and occasionally occluding their lumens. Impaired cutaneous microcirculation resulting from statis, moderate vasculitis, and abnormal structure of the dermis may be responsible for the regional preponderance of deposits of amyloid and ulcerations in the legs.     

953株支原体药敏试验结果分析

目的：分析深圳地区支原体对抗生素的敏感性，为临床治疗提供实验室依据。方法：采用法国梅里埃液体培养法进行解脲脲原体和人型支原体培养鉴定及药物敏感试验。结果：953例支原体阳性标本中，Uu阳性635例、Mh阳性55例、Uu＋Mh合并阳性263例。单独解脲脲原体阳性者对环丙沙星耐药率最高为87％，而单独人型支原体阳性或两者混合感染者对红霉素耐药率最高，分别为94．6％和85.16％。结论：支原体的药物敏感度检测，对于掌握支原体的流行状况和耐药程度，临床选择用药有重要的参考意义。