共查询到20条相似文献,搜索用时 281 毫秒
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报告1例经典型Kaposi肉瘤。患者男,37岁。双手足反复出现结节伴肿胀6年,脓疱2个月。皮损组织病理示:真皮及皮下组织内散在分布肿瘤细胞团块,主要由血管内皮样细胞组成,伴管腔形成;部分区域肿瘤细胞呈梭形,可见红细胞外溢及含铁血黄素沉积,散在少量单一核细胞浸润。诊断:Kaposi肉瘤。 相似文献
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报告1例反应性血管内皮细胞增生症.患者女,53岁.反复发热2年,面部出现多发性水肿性红斑2个月.超声心动图检查示主动脉瓣畸形伴赘生物形成.皮损组织病理检查示真皮乳头层和网状层有许多增生和扩张的毛细血管,内皮细胞显著增生,管腔闭塞,可见纤维蛋白性血栓.内皮细胞均无不典型性,无核分裂相.免疫组化染色结果示CD34和波形蛋白阳性,而血管内皮生长因子、CD31、FⅧ、CD45RO、CD20均阴性. 相似文献
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患者,女,50岁。胸背部浸润性斑块、偶有疼痛15个月。27个月前诊断为乳腺浸润性癌ⅢB期(cT4N1M0)、腋窝淋巴结转移,予化疗及右侧乳腺癌改良根治术;术后8个月右侧胸背部及左侧胸部皮肤出现红肿伴瘙痒,面积逐渐扩大。左乳皮肤病理及免疫组化示癌细胞符合乳腺癌来源。诊断:乳腺癌皮肤转移。 相似文献
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报告1例老年头面部血管肉瘤。患者女,70岁,头皮额部结节、包块、囊肿,伴糜烂溃疡,经久不愈3年,经5次活检和免疫组化检验确诊为老年头面部血管肉瘤,予放疗和化疗取得较好的疗效。 相似文献
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A 42-year-old white male without prior skin disease presented 8 months ago with chest pain, fever, and coughing to his primary physician. At that point, he had no skin lesions. The diagnosis was made by standard blood tests. The patient completed treatment and was symptom free for 8 months until he presented to his physician again with skin lesions on his right cheek and extremities. The patient was referred to our dermatology clinic for further evaluation. A complete skin examination revealed lesions on his face, extremities, and back. The lesions on his right face were 8 x 10-mm erythematous papules and nodules coalescing into a plaque. A biopsy was taken from his right cheek lesions. 相似文献
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Cutaneous angiosarcoma is a rare aggressive tumour of capillary and lymphatic endothelial cell origin. It presents as multiple purple and red papules and nodules on the head and neck or the extremities. We report an 86-year-old woman with angiosarcoma arising on her chronically lymphoedematous right leg. The lymphoedema, secondary to chronic immobility, had developed gradually over 40 years. No other family members had lymphoedema. The patient presented with a plaque of friable tumour tissue on the lower right leg and dorsum of the foot, and satellite lesions on the knee and groin which initially appeared to be petechial haemorrhages. The satellite lesions in the groin grew into tumour nodules. There was no evidence of a preceding malignancy, nor any operative intervention to the affected limb or abdomen. Histological examination of all tumour specimens revealed moderately to poorly differentiated angiosarcoma. She died within 5 months of the first appearance of the skin nodules. 相似文献
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Kiyohara T Kumakiri M Kobayashl H Itoh K Lao LM Ohkawara A Nakmura H 《Journal of cutaneous pathology》2002,29(2):96-100
BACKGROUND: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart-Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype. METHODS: Herein, the clinicopathologic features of a 72-year-old-woman with spindle cell angiosarcoma are described. RESULTS: A 72-year-old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co-irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII-related antigen. Ultrastructurally, these malignant spindle cells contained Weibel-Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one-shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis. CONCLUSIONS: Radiation-induced lymphedema may be a factor in angiosarcoma associated with radiotherapy. 相似文献
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老年人头面部血管肉瘤1例 总被引:10,自引:7,他引:3
报告1例老年人头面部血管肉瘤。患者男,93岁。临床表现为头皮紫红色浸润性斑块、结节1年。组织病理学检查和免疫组化染色证实为血管肉瘤。 相似文献
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O Yamasaki K Terao K Asagoe N Setsu K Arakawa J Arata K Iwatsuki 《European journal of dermatology : EJD》2001,11(6):584-586
An 81-year-old woman developed a necrotic plaque and a surrounding purple-red, irregularly shaped macule on her scalp. The diagnosis of angiosarcoma was confirmed histologically. A wide surgical excision was made followed by a split-thickness skin graft from her right buttock. Nine months later, she noticed a dark purple-red lesion on the donor site which grew rapidly into a large mass. Histological examination revealed irregular clefts and vascular channels lined by atypical endothelial cells. Lung metastasis and pneumothorax were also noted. The secondary tumor appeared to represent Koebner phenomenon in a patient with angiosarcoma of the scalp. 相似文献
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Khaled A. Murshed Aladdin Kanbour Mohammed Akhtar Samir Al Hyassat 《Journal of cutaneous pathology》2021,48(1):81-85
Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25‐year‐old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patient also had significant weight loss during the last 5 months along with an episode of generalized seizure. Chest computed tomography scan revealed an 8 cm anterior mediastinal mass. A skin punch biopsy from the right upper arm mass revealed a malignant neoplasm with morphology consistent with metastatic choriocarcinoma. Further work‐up revealed multiple lung and brain lesions. Ultrasound of the testes revealed no abnormalities. Several chemotherapy regimens were tried; however, there was no response and the disease showed progression. The patient died 6 months after initial presentation. 相似文献
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Jingru Sun Xiaoqing Liu Marshall E. Kadin Ting Li Ping Tu Yang Wang 《Journal of cutaneous pathology》2017,44(7):616-619
Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B‐cell lymphoma. T‐cell malignancy has rarely been associated with chronic lymph stasis. Here, we report a case of primary cutaneous anaplastic large cell lymphoma (pcALCL) with lymphatic spread associated with chronic lymphedema. The patient is a 56‐year‐old man who received orchiectomy and right inguinal lymphadenectomy for malignant seminoma 10 years ago, which led to prominent lymphedema of the right leg. He developed extensive skin nodules on the lymphedematous area for 3 months. Histopathology findings confirmed a diagnosis of pcALCL, which is a subtype of cutaneous T‐cell lymphoma characterized by the presence of CD30+ T cells. Intralymphatic infiltration of malignant cells is prominent. The pathogenesis of intralymphatic cutaneous anaplastic large cell lymphoma is largely unknown. Our case suggests that chronic lymphedema resulted in persistent CD4+ T‐cell inflammation, which then may contribute to the development of pcALCL. 相似文献
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患者,女,76岁,全身皮下多发结节伴右下肢皮肤溃烂2个月。皮损病理活检示(腹壁肿物):非霍奇金淋巴结,B细胞型,免疫表型符合DLBCL,生发中心来源。免疫组化:CD20弥漫连片(+),CD3散在(+),CD10(+),CD21显示FDC网消失,Ki67(80%)。胸腹部增强CT示胃窦十二指肠占位性病变,胃镜检查取胃窦部病变活检示:(胃窦小弯、大弯)非霍奇金B细胞淋巴瘤,考虑DLBCL或其他高侵袭性类型;免疫组化:粘膜腺体间弥漫的淋巴样细胞侵润性生长,CD20连片阳性,Ki67(90%)。我院血液科诊断为非霍奇金淋巴瘤(弥漫大B细胞型)IV期IPI,评分5分 继发皮肤受累。患者家属拒绝治疗,患者出院1周后死亡。 相似文献