不孕女性孕前体质量指数对妊娠结局的影响

目的 本研究旨在阐明不孕女性孕前体质量指数（BMI）对首次进行IVF/ICSI新鲜周期妊娠结局的影响。方法 回顾性分析2010—2018年期间首次接受IVF-ET/ICSI新鲜胚胎移植的7656例不孕症患者的临床资料，比较不同孕前体质量指数组的妊娠结局。结果 体质量过低患者比体质量正常患者发生原发不孕症的比例更高（P<0.001），可获得优质胚胎的周期数显著低于正常体质量组（P<0.05）；超重及肥胖患者不孕年限更长且排卵障碍者占比更高（P<0.01）；各组的胚胎着床率、临床妊娠率、活产率及早产率无显著性差异（P>0.05）；与正常组相比，超重组与肥胖组流产率显著升高（P<0.05），尤其是晚期流产率显著升高（P<0.05）。BMI升高与流产、早产、剖宫产及妊娠并发症（妊娠糖尿病、妊娠高血压）呈正相关。Logistic回归分析表明，孕前BMI升高与流产风险增加相关（aOR·1.921,95%CI:1.158～3.186,P=0.011）。结论 孕前BMI升高与女性生育潜力降低、流产风险增加及妊娠并发症发生率升高有关。     

腹腔镜与开腹根治术对进展期胃癌患者的近期疗效、 应激水平、免疫功能影响的差异性研究

目的 探讨腹腔镜与开腹根治术对进展期胃癌患者的近期疗效、应激水平、免疫功能影响的差异。方法 收集2015年1月~2017年10月我院收治的行腹腔镜或开腹根治性切除术的141例胃癌患者临床资料。根据手术方式的不同,将患者分为腹腔镜组79例,开腹组62例。从近期疗效、应激水平相关指标、免疫功能指标、肿瘤微转移指标等方面比较两种手术方式的差异。结果 ①与开腹组相比,腹腔镜组患者术中失血量较少,术后排气时间及住院时间较短,但住院费用较高,差异有统计学意义（P＜0.05）。但两组患者的术后并发症发生率及并发症类型差异无统计学意义（P＞0.05）。②两组患者WBC计数、外周血N%在所有时间点差异均无统计学意义（P＞0.05）。腹腔镜组外周血CRP水平、COR水平在术后1 d、术后3 d两个时间均小于开腹组,差异有统计学意义（P＜0.05）。与开腹组相比,腹腔镜组腹引液IL-6水平在术后所有时间点均较小,差异有统计学意义（P＜0.05）。③两组患者外周血IgG、IgA、IgM、C4水平在所有时间点差异均无统计学意义（P＞0.05）。与开腹组相比,腹腔镜组患者外周血C4水平在术后1 d、术后3 d较高,差异有统计学意义（P＜0.05）,其他时间点两组患者C4水平差异无统计学意义（P＞0.05）。腹腔镜组患者腹引液IL-10水平在术后所有时间点均高于开腹组,差异有统计学意义（P＜0.05）。④手术结束时,腹腔镜组腹腔冲洗液CEA水平、DDC水平均小于开腹组,差异具有统计学意义（P＜0.05）。结论 对于进展期胃癌,与开腹手术相比,腹腔镜治疗具有术后恢复快、应激创伤小、免疫抑制功能低、肿瘤微转移几率小等优点。     

慢性阻塞性肺疾病患者年龄及体质量指数与肺功能的关系

目的：揭示慢性阻塞性肺疾病发作期患者体质量指数（body mass index,BMI）、年龄与肺功能的关系。方法：选择慢性阻塞性肺疾病患者,测量其体质量及身高并检测其肺功能。比较营养不良组（BMI＜18.5）、正常组（18.5≤BMI＜24）、超重组（24≤BMI＜28）、肥胖组（BMI≥28）患者肺功能之间的关系;同时将患者分为老年组（年龄≥65岁）和非老年组（年龄≤64岁）,同样方法比较这两组患者的肺功能状态;检测BMI和年龄与肺功能之间的相关性。结果：营养不良组和正常组、超重组、肥胖组相比,第1秒用力呼气量占预计值的百分比（forced expiratory volume in on second, FEV1%）均存在统计学意义（P＜0.01）;正常组和超重组、肥胖组相比,FEV1%差异无统计学意义（P＞0.05）;超重组和肥胖组相比,差异无统计学意义（P＞0.05）。营养不良组与超重组、肥胖组相比,FEV1/用力肺活量（forced vital capacity, FVC）的比值差异均存在统计学意义（P＜0.01）;正常组和超重组、肥胖组相比,FEV1/FVC的差异有统计学意义（P＜0.05）。FEV1%老年组与非老年组相比,差异有统计学意义（P＞0.05）,而FEV1/FVC老年组与非老年组相比,差异有统计学意义（P＜0.05）;FEV1%和BMI呈正相关（r=0.22, P＜0.01）、FEV1/FVC和BMI呈正相关（r=0.29,P＜0.01）,年龄和FEV1%无显著相关性（r=-0.12,P＞0.05）,而年龄和FEV1/FVC呈负相关（r=-0.17, P＜0.05）。结论：慢性阻塞性肺疾病患者FEV1/FVC与患者的体质量指数和年龄均存在相关性,而体质量指数对FEV1%的影响不及对FEV1/FVC的影响,年龄对FEV1%的影响不大。     

针刺配合拔罐治疗单纯性肥胖的临床效果观察

目的 观察针刺配合拔罐治疗单纯性肥胖的临床效果。方法 回顾分析2017年3月~2018年3月我院接诊的36例单纯性肥胖患者临床资料,将患者随机分为观察组和对照组各18例,对照组采用针刺治疗,观察组在对照组治疗基础上配合拔罐治疗,观察对比两组临床治疗疗效、治疗前后体质量、BMI、腹壁皮质厚度、不同疗程临床治愈率以及不良反应情况。结果 观察组治疗总有效率为88.89%,高于对照组的72.22%,差异有统计学意义（P＜0.05）。治疗后两组患者体质量、BMI、腹壁皮脂厚度均较治疗前改善,且观察组优于对照组,差异有统计学意义（P＜0.05）;治疗10次、20次、30次后观察组治愈率高于对照组,差异有统计学意义（P＜0.05）。结论 针刺配合拔罐治疗单纯性肥胖疗效确切,临床患者体质量、体质量指数、腹壁厚度改善显著,且不同疗程临床治愈率均较高,可获得理想的治疗效果。     

无气腹腹腔镜技术在宫内妊娠合并良性肿瘤中的应用

目的:探讨无气腹腹腔镜技术在宫内妊娠合并妇科良性肿瘤手术中的有效性和安全性。 方法:选择80例宫内妊娠合并妇科良性肿瘤患者,随机将其分为对照组和观察组,各40例,对照组采用全身麻醉CO2腹腔镜手术,观察组采用硬膜外麻醉无气腹腔镜手术联合保胎治疗。观察指标包括手术前后血气分析和血流动力学变化、手术时间、术后排气时间、苏醒时间及心肺功能。 结果:两组患者动脉血氧分压、动脉血氧饱和度和pH值比较均无差异（P>0.05）;观察组术后动脉血二氧化碳分压和碱剩余值无明显变化,而对照组则明显升高（P<0.05）,组间比较差异有统计学意义（P<0.05）。观察组术后平均收缩压、舒张压和心率与麻醉前比较均无差异（P>0.05）,但对照组术后与麻醉前比较均明显升高（P<0.05）,组间比较差异有统计学意义（P<0.05）。观察组手术时间、术后排气时间和苏醒时间均明显缩短,差异有统计学意义（P<0.05）。观察组未出现明显手术并发症,对照组共发生5例皮下气肿。观察组术后肺顺应性与麻醉前比较无差异（P>0.05）,但对照组术后与麻醉前比较明显降低,差异有统计学意义（P<0.05）,组间比较差异有统计学意义（P<0.05）。 结论:在硬膜外麻醉状态下无气腹腹腔镜技术对宫内妊娠患者心肺功能影响小,手术时间短,苏醒时间早,术后保胎成功率明显提高。     

体重指数对腹腔镜下妇科手术后舒芬太尼镇痛效果的影响

目的探讨不同体重指数(BMI)对使用舒芬太尼术后镇痛效果的影响。方法纳入我院2018年1~12月行腹腔镜下妇科手术后采用舒芬太尼镇痛的患者174例,根据BMI的不同将其分为3组:BMI<18.5 kg/m 2为偏瘦组,BMI 18.5~23.9 kg/m 2为正常体重组,BMI 24~27.9 kg/m 2为超重组,每组58例。所有患者均采用舒芬太尼静脉自控镇痛(PCIA),配方为舒芬太尼2μg/kg+格拉司琼6 mg+生理盐水,总量为200 mL。比较分析术后各组患者疼痛NRS评分、镇痛泵按压次数、平均动脉压(MAP)、心率(HR)及不良反应发生情况[镇静状态评分≥1分,恶心、呕吐、瘙痒NRS评分>3分,呼吸抑制(呼吸频率≤8次/分钟或SpO2<90%)]。结果正常体重组和超重组术后6 h NRS评分均低于偏瘦组,差异具有统计学意义(P<0.05),正常体重组和超重组间比较差异无统计学意义(P>0.05);正常体重组和超重组患者术后6、24 h镇痛泵的按压次数均少于偏瘦组,差异有统计学意义(P<0.05)。术后3组患者恶心、呕吐、镇静状态、瘙痒及呼吸抑制发生率比较差异无统计学意义(P>0.05)。术后3组患者MAP及HR比较差异无统计学意义(P>0.05)。结论BMI是影响舒芬太尼术后镇痛效果的因素之一。     

腹腔镜和开腹手术治疗化脓性阑尾炎的对比研究

目的探讨腹腔镜阑尾切除术治疗化脓性阑尾炎的临床应用价值。方法回顾分析113例化脓性阑尾炎的手术治疗病例,其中行腹腔镜阑尾切除术61例（LA组）,行开腹阑尾切除术52例（OA组）。比较两组的手术时间、术中出血量、术后肛门排气时间、术后疼痛程度、术后住院时间、切口感染率和住院费用。结果 LA组中有4例中转开腹。LA组的住院费用和术中出血量高于OA组（P〈0.05）,术后疼痛程度和切口感染率较OA组低（P〈0.05）。两组患者在手术时间、术后住院时间和术后肛门排气时间的差异无统计学意义（P〉0.05）。结论腹腔镜和开腹手术治疗化脓性阑尾炎各有优势,临床工作中应根据患者具体病情和医师的手术经验合理选用。     

超声引导下腰方肌阻滞联合丙泊酚麻醉在腹腔镜结直肠癌根治术中的应用

目的:研究超声引导下腰方肌阻滞联合丙泊酚麻醉在腹腔镜结直肠癌根治术中的应用价值。方法:选取90例择期进行腹腔镜结直肠癌根治术患者作为研究对象，随机分为观察组和对照组，各45例。对照组采用传统腰麻联合丙泊酚麻醉，观察组采用超声引导下腰方肌阻滞联合丙泊酚麻醉，比较两组患者术中（麻醉后5、15、30、60 min）收缩压（SBP）、舒张压（DBP）、心率（HR）和术后不同时间段的疼痛评分（VAS评分），以及加用镇痛药情况和肠道恢复排气时间和术后48 h内不良反应发生情况。结果:两组患者SBP、DBP、HR组间、不同时间点及交互差异均有统计学意义（P<0.05），且观察组麻醉后上述指标波动较对照组小（P<0.05）；麻醉前，两组患者皮质醇、肾上腺素水平无显著差异（P>0.05），麻醉后各时间点观察组患者上述指标水平均显著低于对照组（P<0.05）；两组患者VAS评分组间、不同时间点及交互差异均有统计学意义（P<0.05），且观察组术后各时间点VAS评分均显著低于对照组（P<0.05）；观察组不良反应发生率显著低于对照组（8.89% vs 24.44%, P<0.05）；观察组患者加用镇痛药的人数、剂量和肠道恢复排气时间均显著少于对照组（P<0.05）。结论:超声引导下腰方肌阻滞联合丙泊酚麻醉在腹腔镜结直肠癌手术中具有良好、稳定的麻醉效果，可有效缓解患者疼痛，减少术后不良反应发生。     

穴位贴敷联合经皮穴位电刺激对腹腔镜术后胃肠蠕动功能的

目的:探讨穴位贴敷联合经皮穴位电刺激对腹腔镜术后胃肠蠕动功能的影响。方法:选取拟择期实施腹腔镜手术的116例患者为研究对象,根据简单随机数表法将所有研究对象分为观察组（58例）和对照组（58例）。两组患者均行腹腔镜手术,观察组给予穴位贴敷联合经皮穴位电刺激治疗,对照组仅给予经皮穴位电刺激治疗。比较两组患者的治疗效果、胃肠蠕动功能相关指标、术前术后胃动素水平、术后3 d内恶心呕吐及腹胀发生率。结果:观察组有效率显著高于对照组（96.55% vs 79.31%, P<0.05）。观察组胃肠蠕动恢复时间、首次排气时间及首次排便时间均短于对照组（P<0.05）。两组患者术前胃动素水平比较,差异无统计学意义（P>0.05）;观察组胃动素水平术后第1、2天显著低于术前（P<0.05）,第3天与术前比较差异无统计学意义（P>0.05）;对照组术后第1、2、3天胃动素水平显著低于术前（P<0.05）;观察组术后第1、2、3天胃动素水平均高于对照组（P<0.05）。观察组术后3 d内恶心呕吐、腹胀发生率均低于对照组（P<0.05）。结论:穴位贴敷联合经皮穴位电刺激能够有效改善腹腔镜术后胃肠蠕动功能,提升胃动力,促使胃肠蠕动功能尽快恢复,减少术后恶心呕吐及腹胀发生,有较好的临床推广应用价值。     

不同入路下腹腔镜根治性远端胃切除术治疗胃癌的效果对比

目的:分析不同入路下腹腔镜根治性远端胃切除术在胃癌患者中的应用效果.方法:收集2018年5月至2020年10月期间本院采用不同入路腹腔镜根治性远端胃切除术治疗的74例胃癌患者临床资料,将其中采用左侧入路腹腔镜根治性远端胃切除术治疗的37例患者纳入A组;将采用右侧入路的37例胃癌患者纳入B组.分析比较两组的围术期指标(手术时间、术中出血量、淋巴结清扫数量与出院时间),随访6 m的胃癌复发情况以及术后并发症发生率.结果:A组手术时间与出院时间长于B组,术中出血量高于B组,淋巴结清扫数量少于B组(P<0.05).两组复发率、术后并发症发生率比较均无显著差异(P>0.05).结论:右侧入路腹腔镜根治性远端胃切除术与左侧入路相比,可缩短手术时间,增加淋巴结清扫数、减少术中出血量,促进术后恢复,且左侧与右侧入路均具备较高的安全性.     

Comparative Study of Laparoscopy-Assisted versus Open Subtotal Gastrectomy for pT2 Gastric Cancer

Purpose: Laparoscopy-assisted distal gastrectomy (LADG) is a widely accepted surgery for early gastric cancer. However, its use in advanced gastric cancer has rarely been studied. The aim of this study is to investigate the feasibility and survival outcomes of LADG for pT2 gastric cancer. Materials and Methods: Between January 2004 and December 2009, we evaluated 67 and 52 patients who underwent open distal gastrectomy (ODG) and LADG, respectively, with diagnosis of pT2 gastric cancer. The clinicopathological characteristics, postoperative outcomes, and survival were retrospectively compared between the two groups. Results: There were statistically significant differences in the proximal margin of the clinicopathological parameters. The operation time was significantly longer in LADG than in ODG (207.7 vs. 159.9 minutes). There were 6 (9.0%) and 5 (9.6%) complications in ODG and LADG, respectively. During follow-up periods, tumor recurrence occurred in 7 (10.4%) patients of the ODG and in 4 (7.7%) patients of the LADG group. The 5-year survival rate of ODG and LADG was 88.6% and 91.3% (p=0.613), respectively. In view of lymph node involvement, 5-year survival rates were 96.0% in ODG versus 97.0% in LADG for patients with negative nodal metastasis (p=0.968) and 80.9% in ODG versus 78.7% in LADG for those with positive nodal metastasis (p=0.868). Conclusion: Although prospective study is necessary to compare LADG with open gastrectomy for the treatment of advanced gastric cancer, laparoscopy-assisted distal gastrectomy might be considered as an alternative treatment for some pT2 gastric cancer.     

腹腔镜下肠系膜上动脉优先入路和上静脉入路在右半结肠癌治疗中的对比性研究

目的探讨对比肠系膜上动脉优先入路法和上静脉入路的腹腔镜手术治疗右半结肠癌的安全性及可行性。方法选择2015年1月至2018年12月于肇庆市第一人民医院手术治疗的右半结肠癌的患者76例,其中男性40例,女性36例;年龄49~66岁,平均年龄50.89岁;体质量指数(BMI)21.78~27.45 kg/m^2,平均BMI 24.79 kg/m^2;病程7~20个月,平均病程10.97个月;病灶位于结肠肝曲23例,升结肠23例,盲肠30例。依据肠系膜上动脉优先入路法及肠系膜上静脉优先入路法行腹腔镜手术根治,将患者分为观察组和对照组,每组38例。记录并分析两组患者所用手术时间、术中出血量、清扫淋巴结数量、阳性淋巴结个数及中转开腹例数;记录并分析两组患者接受手术后恢复排气排便时间、引流时间、引流量、镇痛时间、进食时间及住院时间情况;记录并分析两组患者术后早期肠梗阻、吻合口出血、吻合口瘘等短期并发症。结果两组患者的一般资料比较,差异均无统计学意义(P>0.05);与静脉优先入路方式相比,动脉优先入路方式清扫淋巴结总数和阳性淋巴结个数均显著增多,出血量显著减少(P<0.05);观察组引流时间长,引流量大,与对照组比较,差异有统计学意义(P<0.05);两组所用手术时间、中转开腹率、术后恢复排气和排便时间、镇痛时间、进食时间、住院时间和术后短期并发症总发生率差异均无统计学意义(P>0.05)。结论采用肠系膜上动脉优先入路的腹腔镜手术治疗右半结肠癌,能更彻底地清扫淋巴结从而彻底清除癌症病灶,保证肿瘤的根治程度,减少术后复发率,显著改善患者预后,同时未增加更多的手术风险,安全有效,可行性高。     

孕前体重指数对多囊卵巢综合征患者妊娠结局的影响

目的比较不同体重指数对多囊卵巢综合征（polycystic ovarian syndrome,PCOS）患者妊娠结局和新生儿结局的影响。方法回顾性分析2011年1月至2013年12月于首都医科大学附属北京妇产医院产科就诊的PCOS孕妇328例,按照孕前体重指数（body mass index,BMI）分为体重正常组（BMI 18．5～24．9kg／m^2）和超重及肥胖组（BMI≥25．0kg／m^2）,比较两组PCOS孕妇妊娠结局及新生儿结局等情况。结果超重及肥胖组的既往流产率和辅助生殖技术助孕妊娠比例、妊娠期糖尿病、妊娠期高血压疾病和胎盘早剥的发生率显著高于正常体重组（P〈0．05）;两组问胎膜旱破、胎儿生长受限、前置胎盘和产后出血等并发症无统计学差异（P〉0．05）;在分娩方式上,超重及肥胖PCOS孕妇与对照组相比顺产率低而剖宫产率高,早产和巨大儿的发生率也显著增加,差异具有统计学意义（P〈0．05）。结论孕前超重及肥胖的PCOS患者发生妊娠期并发症的风险增高,新生儿容易出现不良结局,对这类患者应加强健康管理,孕前即注意体重的控制以改善母婴结局。     

Effect of body mass index on mortality of patients with lymphoma undergoing autologous hematopoietic cell transplantation.

High-dose therapy with autologous hematopoietic cell transplantation (auto-HCT) is frequently used to improve outcomes in lymphoma. However, small studies suggest a survival disadvantage among obese patients. Using a retrospective cohort analysis, we studied the outcomes of 4681 patients undergoing auto-HCT for Hodgkin or non-Hodgkin lymphoma between 1990 and 2000 according to body mass index (BMI). Four groups categorized by BMI were compared by using Cox proportional hazards regression to adjust for other prognostic factors. A total of 1909 patients were categorized as normal weight (BMI 18-25 kg/m2), 121 as underweight (BMI<18 kg/m2), 1725 as overweight (BMI>25-30 kg/m2), and 926 as obese (BMI>30 kg/m2) at the time of HCT. Outcomes evaluated included overall survival, relapse, transplantation-related mortality (TRM), and lymphoma-free survival. TRM was similar among the normal, overweight, and obese groups; the underweight group had a higher risk of TRM (relative risk [RR], 2.46; 95% confidence interval [CI], 1.59-3.82; P<0.0001) compared with the normal-BMI group. No differences in relapse were noted. Overall mortality was higher in the underweight group (RR, 1.48; 95% CI, 1.17-1.88; P=.001) and lower in the overweight (RR, 0.87; 95% CI, 0.79-0.96; P=.004) and obese (RR, 0.76; 95% CI, 0.67-0.86; P<.0001) groups compared with the normal-BMI group. In light of our inability to find differences in survival among overweight, obese, and normal-weight patients, obesity alone should not be viewed as a contraindication to proceeding with auto-HCT for lymphoma when it is otherwise indicated.     

体质量指数对锥形束CT引导的宫颈癌放疗分次间摆位误差的影响

目的：探讨体质量指数(BMI)对锥形束CT(CBCT)引导的宫颈癌放疗分次间摆位误差的影响。方法：选取2020年9月至2021年9月在四川省肿瘤医院进行治疗的90例宫颈癌患者为研究对象,根据患者BMI分为过轻组(BMI≤18.4 kg/m²)、正常组(18.5 kg/m²≤BMI≤23.9 kg/m²)、超重组(BMI≥24.0 kg/m²),各组例数均为30例,并将各组成员随机分为两组,分别为真空垫组(n=15)、热塑膜组(n=15),均在放疗前后对盆腔区域进行CBCT扫描,以获取患者摆位数据,判断放疗定位是否准确,并制定合理的放疗方案,分析不同BMI对宫颈癌放疗摆位误差的影响。结果：在不考虑BMI分组时,真空垫组及热塑膜组患者总体摆位误差比较,差异没有统计学意义(P>0.05);骨性配准宫颈癌患者X轴、Y轴摆位误差明显高于灰度配准者,Z轴摆位误差低于灰度配准(P<0.05);对BMI过轻患者摆位误差进行分析发现,过轻者真空垫固位X轴、Y轴摆位误差均小于热塑膜固位者(P<0.05...     

进展期右半结肠癌腹腔镜D3根治术手术时长对术后疗效的影响

目的 探讨进展期右半结肠癌患者行腹腔镜D3根治术的手术时长对术后临床疗效的影响。方法 横断面研究。纳入2018年1月—2020年8月广东省中医院行腹腔镜D3根治术治疗的94例进展期右半结肠癌患者,其中男46例、女48例,年龄16~93（64.2±16.1）岁,TNM分期Ⅱ45例、Ⅲ期49例。患者均行腹腔镜右半结肠癌D3根治术,手术时间100~327（198.9±53.4）min。根据患者手术时间,分别选择在手术时长20百分位数（152 min）、40百分位数（180 min）、60百分位数（205 min）和80百分位数（237 min）4个时间节点,分别分为≤该节点时长和>该节点时长2组。比较不同时间节点2组患者临床基线资料和围手术期指标（包括术中出血量、术后首次排气时间、术后住院时间,以及术后并发症发生情况）。结果 94例患者均顺利完成手术,无中转开腹者,术中、住院期间无一例死亡。94例患者术中出血量10~200 mL,术后首次排气时间1~5 d,术后住院时间3~21 d。术后并发呼吸道感染3例,切口感染4例,吻合口漏2例,腹腔积液4例,肠梗阻2例。不同时间节点2组患者性别、年龄、肿瘤大小和BMI等临床基线资料比较,差异均无统计学意义（P值均>0.05）;60百分位数、80百分位数2个时间节点患者的肿瘤分期组间比较差异均有统计学意义（χ²=6.79、6.86,P值均<0.05）。围手术期指标比较,60百分位数2组患者的术后住院时间和80百分位数2组患者的首次排气时间、术后住院时间、术后总并发症发生率差异均有统计学意义（P值均<0.05）,其他各组的各项观察指标差异均无统计学意义（P值均>0.05）。结论 进展期右半结肠癌患者行腹腔镜D3根治术治疗,随着手术时间的延长,患者术后恢复时间增加,并发症发生率升高。     

Low Body Mass Index Is Associated with Increased Risk of Acute GVHD after Umbilical Cord Blood Transplantation in Children and Young Adults with Acute Leukemia: A Study on Behalf of Eurocord and the EBMT Pediatric Disease Working Party

Body mass index (BMI) may influence outcomes after allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of BMI on survival in children undergoing HSCT is not well defined, with conflicting results being reported on this issue. We analyzed 855 patients age 2 to 20 years with diagnosis of acute leukemia who underwent umbilical cord blood transplantation (UCBT) from 1990 to 2015. Patients were classified according to BMI as normal (fifth to 85th percentile), underweight (less than fifth percentile), overweight (85th to 95th percentile), and obese (>95th percentile) using growth charts for age and sex. All patients received single-unit UCBT after a myeloablative conditioning regimen. Diagnosis was acute lymphoblastic leukemia in 68% of the patients. Sixty-one percent of patients (n?=?523) were in the normal BMI category, 11% (n?=?96) were underweight, 16% (n?=?137) overweight, and 12% (n?=?99) obese. The cumulative incidence of grade II to IV acute graft-versus-host disease (aGVHD) was 35% (32% to 38%). According to pretransplantation BMI, aGVHD was 46% (33% to 59%) for underweight, 34% (31% to 42%) for normal, 36% (18% to 38%) for overweight, and 27% (15% to 37%) for obese (P?=?.04). In multivariate analysis, a BMI less than the fifth percentile was associated with higher incidence of acute grade II to IV GVHD compared with normal-BMI patients (hazard ratio,? 1.61; 95% confidence interval, 1.15 to 2.26; P?=?.006). Our results show that being underweight at the time of transplantation is associated with an increased risk of aGVHD, highlighting the importance of nutritional status before UCBT.     

Underweight Body Mass Index as a Predictive Factor for Surgical Site Infections after Laparoscopic Appendectomy

Purpose

Analyses of risk factors associated with surgical site infections (SSIs) after laparoscopic appendectomy (LA) have been limited. Especially, the association of an underweight body mass index (BMI) with SSIs has not been clearly defined. This study aimed to identify the impact of underweight BMI in predicting SSIs after LA.

Materials and Methods

The records of a total of 101 consecutive patients aged ≥16 years who underwent LA by a single surgeon between March 2011 and December 2012 were retrieved from a prospectively collected database. The rate of SSIs was compared among the underweight, normal and overweight and obese groups. Also, univariate and multivariate analyses were performed to identify the factors associated with SSIs.

Results

The overall rate of SSIs was 12.8%. The superficial incisional SSI rate was highest in the underweight group (44.4% in the underweight group, 11.0% in the normal group, and 0% in the overweight and obese group, p=0.006). In univariate analysis, open conversion and being underweight were determined to be risk factors for SSIs. Underweight BMI was also found to be a significant predictor for SSIs in multivariate analysis (odds ratio, 10.0; 95% confidence interval, 2.0-49.5; p=0.005).

Conclusion

This study demonstrated underweight BMI as being associated with SSIs after LA. Surgeons should be more cautious to prevent SSIs in patients that are underweight when performing LA.     

The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer

Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.

Graphical Abstract

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