老年高血压患者炎症标志物水平的研究

目的探讨老年高血压患者C反应蛋白（CRP）、白细胞介素-6（IL-6）和同型半胱氨酸（Hcy）水平变化及意义。方法老年高血压患者（高血压组）84例,老年健康体检者（健康对照组）36例,常规检测受试者的血压、空腹血糖和血脂,同时检测血清CRP、IL-6和Hcy水平。结果与健康老年人群相比,老年高血压患者中CRP、IL-6和Hcy永平明显高于健康对照组,差异均有统计学意义（P〈0．05）。结论血清CRP、IL-6和Hcy水平的检测可能对高血压的预防、诊断及治疗有一定,临床指导意义。     

血清炎性因子浓度对急性脑出血恶化的预测价值

目的揭示和比较血清C-反应蛋白、白介素-1β、白介素．6、肿瘤坏死因子-α浓度对脑出血急性期早期神经功能恶化的预测价值。方法选取86例急性基底节区出血患者作为病例组和86例健康体检者作为对照组。记录脑出血患者入院时血肿量、脑室出血、NIHSS评分及早期神经功能恶化等临床资料。采用ELISA法测定血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子-α浓度。统计分析这些炎性因子对早期神经功能恶化的预测价值。结果经独立样本t检验,病例组（或脑室出血患者或早期神经功能恶化患者）血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．仅浓度均较对照组（或非脑室出血患者或非早期神经功能恶化患者）明显增高（均P〈0．05）。行Pearson相关检验,人院时血肿量及NIHSS评分与血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．仪浓度均显著正相关性（均P〈0．05）。ROC曲线分析显示,血清C-反应蛋白、白介素-1β、白介素-6、肿瘤坏死因子．d浓度对急性期早期神经功能恶化均有显著预测价值,且它们的曲线下面积比较,差异均无统计学意义（均P〉0．05）。结论C-反应蛋白、白介素-113、白介素-6、肿瘤坏死因子．理可能参与脑出血急性期早期神经功能恶化的炎症反应过程,临床检测这些因子可更好预测早期神经功能恶化的发生。     

Associations between change in C-reactive protein and serum lipids during statin treatment

Hypolipidaemic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) treatment reduces cardiovascular risk and is also associated with the reduction of C-reactive protein (CRP) concentrations. However, there is scant data concerning the relationship between CRP and lipid changes during statin treatment. We studied 60 hypercholesterolaemic coronary patients who participated in the Treat to Target (3T) study comparing atorvastatin and simvastatin. Serum lipids and CRP (with a sensitive method) were measured before treatment at baseline and after 12 months of statin treatment. Low-density lipoprotein (LDL) cholesterol was substantially decreased and high-density lipoprotein (HDL) cholesterol increased during statin treatment. CRP decreased significantly (sign test P = 0.03) during treatment, and the changes of CRP were significantly associated with changes in HDL cholesterol (r = ?0.45; P < 0.001) and apolipoprotein A1 (r = ?0.40; P < 0.001) but not with changes in LDL cholesterol or triglycerides. The change in HDL cholesterol explained 20% of the change in CRP during statin treatment. The results are in line with previous suggestions that HDL has anti-inflammatory properties.     

Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis

Purpose

To prospectively evaluate the performance of procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP) as percentage of baseline (POB) in predicting hospital survival, we studied 64 consecutive, postoperative patients with severe sepsis.

Materials and Methods

Plasma PCT, IL-6, and CRP were serially measured from day 1 (onset of sepsis) to day 14 in parallel with clinical data until day 28. Multivariate logistic regression and univariate analysis of predictive accuracy of PCT-, IL-6-, and CRP-POB were performed. Newly derived binary prediction rules were evaluated by calculating sensitivity, specificity, positive predictive value, and negative predictive value.

Results

In survivors, PCT and IL-6 significantly decreased from days 1 to 14, whereas CRP did not. In nonsurvivors, the inflammation markers mostly increased within the second week. At day 7, logistic regression analysis revealed PCT-POB as an independent determinant for survival. Especially, PCT-POB not exceeding 50% and PCT-POB not exceeding 25% with CRP-POB not exceeding 75% on day 7 indicated a favorable outcome with a positive predictive value/sensitivity of 75%/97% and 92%/67%, respectively. In comparison, pretest likelihood to survive by day 28 and observed survival rate were 60% and 67%, respectively.

Conclusions

Prediction rules of decrease in PCT-POB on day 7 in combination with CRP-POB may serve to monitor efficacy and guide duration of therapy in critically ill patients.     

Effects of infectious disease on plasma lipids and their diagnostic significance in critical illness

BACKGROUND: Plasma lipids can be affected by acute illnesses. The present study attempts to characterize the impact of infectious disease on plasma lipids in critical illness. It also aims to determine the value of plasma lipid routine measurements in the diagnosis of infection in critical illness in comparison to markers of infection and acute phase reactants. MATERIALS AND METHODS: An observational study was carried out in 101 critically ill patients admitted consecutively to a medical intensive care unit in a university medical centre. Levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and additional variables were measured in blood samples taken on the day of admission. RESULTS: In critically ill patients significantly lower levels of HDL-C and TC were found in infectious disease patients compared to non-infectious disease patients (P < 0.001). No significant differences in levels of TG were found between infectious and non-infectious disease patients. Using receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) value for HDL-C and TC in the diagnosis of infection was 0.791 (P < 0.001) and 0.730 (P < 0.001), respectively. At a cutoff value for HDL-C of 相似文献   

脑外伤性癫痫患者炎性细胞因子和C反应蛋白变化及其临床意义

目的探讨脑外伤性癫痫患者炎性细胞因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)的变化及意义。方法选自2009年1月至2012年1月收治的脑外伤并发癫痫的患者37例,采用采用酶联免疫吸附法检测检测患者外周血中第1、3、5、7 d时IL-2、IL-6、TNF-α和CRP的水平,同时选同期20例健康人群作为对照组。结果两组1、3、5、7 d IL-2、IL-6、TNF-α和CRP水平比较差异有显著性(P<0.05,P<0.01)。脑外伤性癫痫中度、重度组IL-2、IL-6、TNF-α和CRP水平均显著高于轻度组(P<0.05)。结论脑外伤性癫痫患者外周血中IL-2、IL-6、TNF-α和CRP水平显著升高且IL-2、IL-6、TNF-α和CRP水平与病情严重程度有关,提示炎性因子与CRP对癫痫的发作有影响。     

后腹腔镜肾囊肿去顶术对机体应激反应的影响

目的 :探讨后腹腔镜肾囊肿去顶减压术对机体的应激反应。方法 :将 3 5例肾囊肿患者随机分成后腹腔镜组与开放手术组。分别于术前 2 4h和术后第 1、3天测定血白细胞总数 (WBC)、血清C -反应蛋白 (CRP)和白细胞介素 -6(IL -6)的浓度 ,并比较两组的平均手术时间、术中出血量、术后平均引流量、术后镇痛用药量、术后发热率、术后平均住院日和费用。结果 :开放手术组术后第 1天WBC计数比术前明显升高 (P <0 .0 5) ,后腹腔镜组升高不明显 (P >0 .0 5)两组术后第 1、3天血清CRP和IL -6水平显著高于术前 (P <0 .0 5) ,但开放手术组血清CRP和IL -6均显著高于后腹腔镜组 (P <0 .0 1)。与开放手术相比 ,后腹腔镜手术具有出血少 ,引流量少 ,术后发热率低 ,用药少、住院日短等优点。结论 :后腹腔镜肾囊肿去顶术对机体的应激反应较开放手术低 ,有望替代传统开放手术     

Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials

ObjectivesWe carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of L-arginine on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6) and TNFα.MethodsA systematic search was carried out in PubMed, Embase, Scopus, Cochrane library databases and ISI web of sciences to retrieve the RCTs which examined the effect of L-arginine supplementation on inflammatory biomarkers up to October 2019, with no language and time restriction. Meta-analysis was performed using a random effects model, and I2 index was used to evaluate the heterogeneity.ResultsSearch yielded 2452 publications. Eleven RCTs were eligible. Results indicated that L-arginine supplementation had no significant effect on inflammatory biomarkers including CRP, IL-6 and TNFα. However, when subgroup analysis was performed, we found that L-arginine supplementation increased CRP levels in subjects with ages >60 years old, participants with baseline circulating CRP levels >3 mg/dl, patients with cancer and when used in enteral formula.ConclusionResults of the present meta-analysis indicated that L-arginine supplementation increased the circulating concentrations of CRP in subjects with ages >60 years old, subjects with higher levels of CRP, patients with cancer and when used in enteral formula. Therefore, L-arginine should be used with caution in these subjects. However, further well designed, large-scale studies are needed.     

甘精胰岛素和二甲双胍联合治疗对初诊2型糖尿病患者炎症因子的影响

目的 观察甘精胰岛素与二甲双胍联合治疗对初诊2型糖尿病(T2DM)患者炎症因子的影响.方法 对110例新诊断的T2DM患者进行甘精胰岛素(起始剂量10 U/d)与二甲双胍(0.5 g,每天3次)联合治疗(T2DM组),疗程12周.另入选100例同期进行健康体检的正常人群为正常对照组.观察2组研究对象基线血糖指标空腹血糖(FPG)、餐后2 h血糖(2 hPG)和糖化血红蛋白(HbA_1c)以及炎症因子C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)的差异,并比较T2DM组治疗前后血糖指标和炎症因子的变化.结果 观察前T2DM组的血糖指标及炎症因子明显高于对照组(P均＜0.05),其他基础临床资料没有差异(P均＞0.05).经甘精胰岛素和二甲双胍联合治疗12周后,T2DM组的血糖指标明显改善,FPG:治疗前(14.8±3.9)mmoL/L,治疗后(6.6±2.1)mmol/L;2 hPG:治疗前(17.6±3.3)mmol/L,治疗后(8.3±1.2)mmoL/L;HbA1c:治疗前(9.6±2.7)%,治疗后(6.5±0.8)%(t值分别为7.40、8.37、3.98,P均＜0.01).炎症因子水平也显著下降,CRP:治疗前(8.8±2.5)mg/L,治疗后(5.5±1.4)mg/L;TNF-α:治疗前(2.9±0.6)ng/L,治疗后(1.6±0.2)ng/L;IL-6:治疗前(170.3±22.2)pg/L,治疗后(105.9±14.6)pg/L(t值分别为4.61、3.52、5.68,P均＜0.05).结论 甘精胰岛素与二甲双胍联合治疗可以改善初诊T2DM患者的糖代谢,降低患者炎症因子的水平.     

血清IL-6、IL-18及CRP水平在新生儿缺氧缺血性脑病中变化及意义

目的探讨血清白细胞介素(IL)-6、IL-18及C反应蛋白(CRP)水平在新生儿缺氧缺血性脑病(HIE)中的变化及其临床意义。方法分别应用酶联免疫吸附法和免疫透射比浊法检测100例HIE新生儿血清IL-6、IL-18及CRP水平,并与100例健康新生儿(对照组)进行比较。结果 HIE组与对照组相比较,血清IL-6、IL-18及CRP水平均明显升高(P0.01),且随临床分级程度加重逐渐升高;血清CRP水平与血清IL-6、IL-18水平均呈正相关(r=0.663、0.725,均P0.01),IL-6与IL-18水平呈正相关(r=0.783,P0.01)。结论 IL-6、IL-18及CRP在HIE发生发展过程中可能起重要作用,且与HIE病变严重程度和临床变化有较密切的关系,对病情和预后判断有重要价值。     

Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury

OBJECTIVE: To determine the relation between serologic markers of information and clinical characteristics of people with chronic spinal cord injury (SCI). DESIGN: Cross-sectional study. SETTING: Academic medical center SCI outpatient clinic. PARTICIPANTS: Convenience sample of 37 men with chronic SCI and 10 healthy control subjects. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). RESULTS: The following results achieved statistical significance at P less than .05. Asymptomatic chronic SCI patients differed from referent controls with respect to serum CRP levels but not IL-6 or TNF-alpha. In SCI patients, higher levels of CRP correlated negatively with hemoglobin and albumin levels. A longer time since injury correlated with lower TNF-alpha values, whereas higher TNF-alpha levels correlated with higher serum albumin. Pressure ulcers and indwelling urinary catheters were associated with higher mean levels of CRP but not of the cytokines TNF-alpha and IL-6. Intermittent urinary catheterization was associated with lower levels of CRP when compared with other methods of bladder management. CONCLUSIONS: Asymptomatic people with long-term SCI, especially those with indwelling urinary catheters, showed serologic evidence of a systemic inflammatory state. There was no evidence of an elevation in proinflammatory cytokines. Detection of an ongoing systemic inflammatory response in apparently healthy people with indwelling urinary catheters and small skin ulcers further supports the aggressive pursuit of catheter-free voiding options and pressure ulcer healing.     

Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin,interleukin-6, and C-reactive protein

Objective To evaluate markers of infection in critically ill neonates and children, comparing lipopolysaccharide-binding protein (LBP) with procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP).Design and setting Prospective, observational study in the level III multidisciplinary neonatal and pediatric intensive care unit.Patients Sixty patients with systemic inflammatory response syndrome (SIRS) and suspected infection classified into two groups: SIRS/sepsis (n=33) and SIRS/no sepsis (n=27). We included 29 neonates aged less than 48 h (neonates <48 h), 12 neonates older than 48 h (neonates >48 h), and 19 children. Median disease severity was high in neonates aged under 48 h and moderate in neonates aged over 48 h and children.Interventions Serum LBP, PCT, IL-6, and CRP were measured on two consecutive days. Area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, specificity, and predictive values were evaluated.Results Serum LBP was higher in patients with SIRS/sepsis than in patients with SIRS/no sepsis. AUC for LBP on the first day of suspected infection was 0.89 in the younger neonates, 0.93 in the older neonates, and 0.91 in children.Conclusions In critically ill neonates aged under 48 h LBP on the first day of suspected infection is a better marker of sepsis than IL-6 and PCT, and is similar to CRP. In critically ill neonates aged over 48 h and children LBP is a better marker than IL-6 and CRP, and is similar to PCT.     

Increased levels of serum transferrin receptor and serum transferrin receptor/log ferritin ratios in men with prostate cancer and the implications for body-iron stores

The serum transferrin receptor (sTfR) is a sensitive indicator of iron-deficiency erythropoiesis that is not affected by inflammation. Concentrations of this molecule are inversely correlated with body-iron stores, and increased body-iron stores are associated with an increased risk of cancer of the liver and lungs. However, an association between iron status as assessed on the basis of sTfR and prostate cancer has not been previously investigated. We measured sTfR and serum ferritin by means of an enzyme immunoassay in 27 men with newly diagnosed, untreated prostate cancer and in 72 controls. Our study population ranged in age from 38 to 78 years. The mean serum ferritin concentration in men with prostate cancer was 44.8% lower than that in men without this tumor ( P < .05). In contrast, the mean values of sTfR and sTfR/log serum ferritin were 32% and 60% higher, respectively, in men with prostate cancer than in those without this tumor ( P < .05). Differences between groups persisted after we took into account inflammation (alpha 1-acid glycoprotein > 1 g/L, C-reactive protein > 10 mg/L; P < .05). Among the entire study population and among men without inflammation, a higher percentage of subjects (29%-31%) than of controls (14%-22%) had sTfR values greater than 8 mg/L, suggestive of iron-deficiency erythropoiesis ( P < .05). The odds ratios for men with prostate cancer to have sTfR values of less than 2.9 mg/L (suggestive of increased body-iron stores) was 0, compared with 1.745 to 3.65 for the same men to have sTfR values greater than 8 mg/L. sTfR was negatively correlated with log ferritin ( r = -.422, P < .05) but did not correlate with tissue inflammation, tumor stage, or acute-phase proteins. It appears that prostate cancer is not associated with increased body-iron stores.     

胰岛素强化治疗对胃癌手术病人血清IL-6、TNF-α及C-反应蛋白表达的影响

目的研究胰岛素强化治疗对胃癌手术病人白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）及C-反应蛋白（CRP）水平的影响，探讨其可能的抗炎机制。方法46例胃癌手术病人随机分为胰岛素强化治疗组（n=23，血糖控制在4．4～6．1mmoL／L）和常规治疗组（n=23，血糖控制在10．0～11．1mmoL／L），动态监测围手术期空腹血糖（FBG）、空腹胰岛素定量（FINS）、IL-6、TNF-α及CRP水平，并根据稳态模式评估法（HOMA）计算胰岛素抵抗指数（HOMA—IR），并对其与TNF-α、IL-6相关性进行分析。结果两组病人均无低糖血症发生，TNF—α、IL-6与HOMA—IR存在显著正相关（r=0．333～0．480，P〈0．05）；强化治疗组术后1、3d血清InHOMA-IR、IL-6、TNF—α明显低于常规治疗组（t=2．069～3．098，P〈0．05），术后1、3、7d的CRP明显低于常规治疗组（t=2．482～3．131，P〈0．05）。结论TNF—α、IL-6与外科胰岛素抵抗相关，胰岛素强化治疗可以拮抗术后机体的高炎状态，抗炎效应可能是胰岛素强化治疗改善病人预后的重要机制之一。     

Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study

C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease. In this study we sought to investigate the association between several nutritional and lifestyle factors and serum CRP concentration in a population-based study. We studied 359 individuals (172 women, 187 men; age range 18-75 years) randomly selected from the town hall's registers and assessed their daily dietary intake using a 3-day estimated-food record. The median serum CRP concentration was 1.40 mg/L (range <0.10-47.48 mg/L; geometric mean 1.20 mg/L). We noted significant and independent direct associations between CRP and age, body-mass index, female sex, and serum triglyceride concentration. Bivariate analysis showed a significant inverse association between CRP and many nutrients (e.g., carbohydrates, proteins, lipids, thiamine, pyridoxine, tocopherol, and folate), but multiple-regression analysis indicated that only the effect of dietary folate intake was not dependent on other factors. Differences in folate intake did not produce changes in plasma homocysteine concentration, and we detected no negative correlation between dietary folate intake and log homocysteine (r = .02, P = .711). Strong positive correlations between the intake of folate and numerous other nutrients were found. This population-based study shows that a higher folate intake, in addition to other known constitutive and lifestyle factors, is significantly associated with a lower serum CRP concentration.     

降钙素原在诊断骨科内置物术后感染性发热的临床意义

目的探讨降钙素原(proealeitonin,PCT)在诊断骨科内置物术后感染性发热中的临床意义。方法选择2013年1月—2014年1月我院骨科内置物术后发热患者56例,按诊断标准分为非感染发热组32例和感染发热组24例,均于术后发热当天及发热第3天采血查C反应蛋白(CRP)及PCT水平,并对CRP及PCT诊断术后感染性发热的真实性进行评价。结果两组发热当天和发热第3天CRP水平比较差异均无统计学意义(P0.05),而PCT水平比较差异均有统计学意义(P0.05)。以0.25 ng/L为临界值,发热当天及发热第3天血清PCT诊断术后感染性发热的敏感度、特异度均较CRP高。结论 PCT在鉴别骨科内置物术后发热性质方面较CPR更具有临床价值。     

Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model

Nerve injury and the consequent release of interleukins (ILs) are processes implicated in pain transmission. To study the potential role of IL-1 in the pathogenesis of allodynia and hyperalgesia, IL-1alpha and comparative IL-1beta, IL-6, and IL-10 mRNA levels were quantified using competitive RT-PCR of the lumbar spinal cord and dorsal root ganglia (DRG; L5-L6) three and seven days after chronic constriction injury (CCI) in rats. Microglial and astroglial activation in the ipsilateral spinal cord and DRG were observed after injury. In naive and CCI-exposed rats, IL-1alpha mRNA and protein were not detected in the spinal cord. IL-1beta and IL-6 mRNAs were strongly ipsilaterally elevated on day seven after CCI. In the ipsilateral DRG, IL-1alpha, IL-6, and IL-10 mRNA levels were increased on days three and seven; IL-1beta was elevated only on day seven. Western blot analysis revealed both the presence of IL-1alpha proteins (45 and 31 kDa) in the DRG and the down-regulation of these proteins after CCI. Intrathecal administration of IL-1alpha (50-500 ng) in naive rats did not influence nociceptive transmission, but IL-1beta (50-500 ng) induced hyperalgesia. In rats exposed to CCI, an IL-1alpha or IL-1 receptor antagonist dose-dependently attenuated symptoms of neuropathic pain; however, no effect of IL-1beta was observed. In sum, the first days after CCI showed a high abundance of IL-1alpha in the DRG. Together with the antiallodynic and antihyperalgesic effects observed after IL-1alpha administration, this finding indicates an important role for IL-1alpha in the development of neuropathic pain symptoms.     

The effects of sampling from a peripheral venous catheter compared to repeated venepunctures on markers of coagulation,inflammation, and endothelial function

Abstract

Peripheral venous (PV) catheters are often used for serial blood sampling, but studies suggest that PV catheters increase markers of coagulation activation and inflammation. Whether the increase is caused by irritation of the vessel wall or diurnal variation is unknown. We therefore compared the effects of a PV catheter and repeated venepunctures on markers of coagulation, inflammation, and endothelial function.

A PV catheter was inserted at 07:45 in a hand vein in 10 healthy subjects, and blood samples were collected at 8:00, 10:00, 12:00, and 14:00. In the contralateral arm, blood was simultaneously obtained by venepunctures. Measures of coagulation, i.e., activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, prothrombin fragment 1?+?2 (F1?+?2) and thrombin-antithrombin (TAT), inflammation, i.e., interleukin 6 (IL-6) and C-reactive protein (CRP), and endothelial function, i.e., plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator (tPA), von Willebrand factor (vWF), and tissue factor (TF) were measured in plasma.

The concentrations of TAT and F1?+?2 were significantly increased (10:00; p?<?.01, 12:00; p?<?.05, and 14:00; p?<?.01) in PV catheter samples compared with venepuncture samples. There was a minor increase in PT and INR and no increase in APTT, fibrinogen, CRP, PAI-1, tPA, vWF, and TF, with no differences between sampling methods. IL-6 concentrations increased in many PV catheter samples and venepuncture samples, but the response varied between the subjects.

Blood collection through a PV catheter induces coagulation activation, whereas endothelial function is not affected. More studies are needed to disclose the effect of blood sampling on IL-6.     

Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease

IntroductionThe inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established.ObjectivesThe study investigates the levels of C reactive protein (CRP), interleukin 1β (IL-1β) and stromal-derived factor 1α (SDF-1α) at the time of acute myocardial infarction (AMI) and at 1 and 6 months afterwards, compared with a control group.ResultsIn the acute phase of AMI, CRP and SDF-1α were significantly higher, while IL-1β showed lower levels compared with controls. CRP positively correlated with coronary stenosis severity (rho = 0.3, p=.05) and negatively related with left ventricle ejection fraction (LVEF) at 1 month (rho= −0.43, p=.05). IL-1β weakly correlated with the severity of coronary lesions (rho =0.29, p=.02) and strongly with LVEF (rho= −0.8, p=.05). SDF-1α, slightly correlated with LVEF at 1 month (rho = 0.22, p=.01) and with the severity of coronary atherosclerosis (rho= −0.41, p=.003).ConclusionsCRP, IL-1β and SDF-1α have important dynamic in the first 6 months after AMI and CRP and SDF-1α levels correlated with the severity of coronary lesions and LVEF at 1 month after the acute ischaemic event.     

IL-6、TNF-α、CRP在急性脑梗死患者血清中的表达及临床意义

目的检测白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)在急性脑梗死患者血清中的表达并分析其临床意义。方法2015年5月至2017年8月,选取100例急性脑梗死患者、100例健康体检者,分别设为观察组、对照组。观察组依据病情轻重、病灶大小分为重、中、轻度组,大、中、小灶组。对比组间IL-6、TNF-α、CRP表达情况。结果观察组血清IL-6、TNF-α、CRP水平明显高于对照组(P<0.05)。不同病情、病灶组间的血清IL-6、TNF-α、CRP水平比较,差异有统计学意义(P<0.05)。血清IL-6、TNF-α水平:重度组>中度组>轻度组(P<0.05);血清CRP水平:重度组>中、轻度组(P<0.05)。血清IL-6、CRP水平:大灶组>中灶组>小灶组(P<0.05);血清TNF-α水平:大灶组>中、小灶组(P<0.05)。结论IL-6、TNF-α、CRP在急性脑梗死患者血清中高表达,可能参与疾病的发生发展,临床应给予重视。