一次性包皮环切缝合器与吻合器治疗包皮过长和包茎的临床疗效对比

目的:探讨一次性包皮环切缝合器与吻合器治疗包皮过长和包茎的治疗效果。方法:将2013年2月至2015年10月就诊我院的包茎和包皮过长患者,按手术方法分为一次性包皮环切缝合器组与吻合器组,对比一次性包皮环切缝合器与吻合器治疗包茎与包皮过长的疗效,并对两组临床资料进行对比。结果:两组患者手术时疼痛评分无明显差异(P均0.05);手术时间、术中出血、术后疼痛评分、手术并发症、伤口愈合时间、术后包皮外观满意度及治疗费用的差异有统计学意义;包皮环切缝合器治疗包茎与包皮过长手术在术后疼痛评分、手术并发症、伤口愈合、术后外观满意度方面优于吻合器,而包皮吻合器在手术时间、手术中出血、手术费用方面优于缝合器(P均0.05)。结论:包皮环切缝合器治疗包茎与包皮过长手术在术后疼痛评分、手术并发症、伤口愈合、术后外观满意度方面优于吻合器,而包皮吻合器在手术时间、手术中出血、手术费用方面优于缝合器。术前可依据患者的需要及经济条件等充分的解释并选择个性化的手术方式。     

一次性包皮切割缝合器在成人包皮环切术中的应用

目的:观察使用一次性包皮切割缝合器治疗成人包皮过长、包茎的安全性及有效性。方法:选取2013年8月至2016年3月进行包皮环切术的377例成人患者为观察对象,其中包皮割缝合器手术256例(观察组),传统包皮环切术121例(对照组)。观察两组手术时间、术中出血量、术后24h疼痛评分、术后美观度及术后并发症发生情况,并作对比分析。结果:观察组在手术时间、术中出血、术后24h疼痛评分、术后包皮水肿、术后感染方面优于对照组。术后出血、切口延迟愈合方面两组无明显差异。术后对阴茎外观满意度观察组高于对照组。结论:一次性包皮切割缝合器治疗成人包皮过长操作简单、并发症少、外观美观,值得临床推广应用。     

一次性包皮环切缝合器与吻合器治疗包皮过长和包茎的临床对比研究

目的:探讨一次性包皮环切缝合器与吻合器治疗包皮过长和包茎的临床对比研究。方法:选择我院2014年3月至2016年12月期间收治的包皮过长、包茎患者102例,根据手术方法不同分为缝合组53例与吻合组49例。缝合组采用一次性包皮环切缝合器治疗,吻合组采用一次性包皮环切吻合器治疗。比较两组手术时间、创口愈合时间、外观满意度、失血量,术中和术后24h VAS评分,及术后并发症情况。结果:缝合组手术时间长于吻合组,创口愈合时间快于吻合组,外观满意度优于吻合组,均有统计学差异(P0.05);而两组失血量比较无统计学差异(P0.05);两组术后24h VAS评分较术中增加,有统计学差异(P0.05);缝合组术后24h VAS评分低于吻合组,有统计学差异(P0.05);缝合组并发症发生率(5.66%)低于吻合组(22.45%),有统计学差异(P0.05)。结论:一次性包皮环切缝合器治疗包皮过长和包茎效果优于一次性包皮环切吻合器,具有重要研究意义,值得进一步推广应用。     

应用一次性包皮环切缝合器与传统包皮环切术的临床对比研究

目的:对比应用一次性包皮环切缝合器的包皮环切缝合术与传统包皮环切术治疗包皮过长或包茎的临床疗效。方法:回顾性分析我院泌尿外科采用包皮环切缝合术(n=140)和传统包皮环切术(n=110)治疗包皮过长或包茎250例患者临床资料,比较两种术式的手术时间、术中出血量、术后1h视觉模拟疼痛评分、伤口愈合时间、外观满意度及术后并发症。结果:包皮环切缝合术在手术时间、术中出血量、术后1h视觉模拟疼痛评分及外观满意度上明显优于传统包皮环切术(P0.05),两者在伤口愈合时间及术后并发症上差别无统计学意义(P0.05)。在术后并发症分类上,包皮环切缝合术组的术后水肿发生率低于传统包皮环切术组(P0.05),前者的术后出血、术后感染及术后裂开发生率与后者无明显差异(P0.05)。结论:包皮环切缝合术操作简单方便、手术时间短、出血少、术后疼痛轻,同时外观满意度高,对于包皮过长或包茎可作为首选术式。     

包皮切割缝合器与商环及传统包皮环切术治疗包皮过长或包茎手术疗效及安全性分析

目的:比较分析通过传统的包皮环切手术、商环及包皮切割的缝合器对包皮过长或者包茎的手术治疗效果,并分析其安全性。方法:选取在2015年1月至2017年1月在平湖市中医院施包皮环切术的包皮及包茎患者446例,随机将其分为切割缝合器组175例(其中包皮过长143例、包茎32例),商环组184例,传统环切组87例。通过分析各项指标,来评价分析各组术式的疗效。结果:传统环切术组与商环组和切割缝合器组相比较,出血量显著变大,差异具有统计学意义(P0.05);手术耗时以及术后1h疼痛感,传统环切术组高于商环组和切割缝合器组,差异具有统计学意义(P0.05);伤口愈合时间传统环切术组明显短于商环组,差异具有统计学意义(P0.05);诊疗费用,切割缝合器组高于商环组高于传统环切术组,差异具有统计学意义(P0.05);7d后疼痛程度评分,传统环切术组低于商环组,高于切割缝合器组,差异具有统计学意义(P0.05);3组相比较,满意率传统环切术组低于商环组低于切割缝合器组,差异具有统计学意义(P0.05);感染率,切割缝合器组最低,商环组低于传统环切术组,阴茎水肿率商环组高于其他两组,出血并发症概率传统环切术组高于其他两组,差异具有统计学意义(P0.05);术后并发症传统环切手术组高于商环组,商环组高于切割缝合器组,差异具有统计学意义(P0.05)。结论:使用切割缝合器治疗包皮过长及包茎具有手术快捷、术后并发症少、创伤小等特点,临床效果好于传统环切术组及商环组,但是治疗费用较高,且临床范围小。商环环切术具有时间短,操作简单等优点,但拆环会引起疼痛,商环切口也需要长时间愈合;传统环切手术的费用比较少,适合的范围也较大,但手术步骤比较复杂,且对患者创伤较大,并发症多。患者适用何种诊疗方式,需要综合考虑。     

3种包皮环切术的临床疗效分析

目的探讨一次性包皮环切缝合器、商环和传统包皮环切术3种手术方式的临床效果,为包皮过长、包茎患者提供合适的手术方式。方法随机收集2016年1月至2018年12月鄂州市中心医院门诊收治的380例包皮环切术患者作为研究对象。其中一次性包皮环切缝合器包皮手术组(简称缝合器组)131例,商环包皮手术组(简称商环组)127例,传统包皮手术组(简称传统组)122例,分别比较手术时间、术中出血量、术后水肿、术后水肿消退时间、术后血肿、术后疼痛、术后感染、术后伤口裂开、愈合时间以及患者满意度。结果缝合器组、商环组在手术时间、术中出血量方面明显优于传统组(P<0.05);缝合器组、传统组在术后水肿、水肿消退时间方面优于商环组,差异具有统计学意义(P<0.05);传统组、商环组在术后血肿方面优于缝合器组,差异具有统计学意义(P<0.05);术后疼痛比较,缝合器组最优,商环组最差;3种手术方式在术后感染、伤口裂开、愈合时间方面差异无统计学意义(P>0.05);患者满意度为缝合器组最满意,商环组次之,传统组最差。结论 3种手术方式各有优缺点,总体上缝合器组优于商环组和传统组,患者可根据个人意愿选择相应手术方式。     

改良型一次性包皮切割缝合器的操作体会和临床疗效观察

目的:观察改良型一次性包皮切割缝合器的临床应用效果。方法:220例包皮过长患者,其中112例采用改良型一次性包皮切割缝合器进行手术(改良组),108例采用改良前一次性包皮切割缝合器进行手术(传统组)。对比两组手术时间,术中出血量,补缝率,20d内脱钉率,术后并发症情况。结果:改良组患者术后出血量为(1.15±0.62)m L,补缝率为0.89%,20d内脱钉率为99.11%,术后并发症发生率为30.36%,传统组患者术后出血量为(3.21±1.62)m L,补缝率为8.33%,20d内脱钉率和术后并发症发生率为89.81%和38.88%。两组比较均有显著性差异(P0.05),手术时间两组无显著性差异(P0.05)。结论:采用改良型一次性包皮环切缝合器手术可明显降低术中出血和术后并发症及增加脱钉率,值得推广。     

应用一次性包皮环切缝合器与商环治疗包皮过长的疗效比较

目的:探讨应用一次性包皮环切缝合器与商环治疗包皮过长临床疗效比较。方法:从疼痛程度、手术时间、术后恢复时间、出血情况及术后美观度这几个方面对以上两种术式进行比较。结果:一次性包皮环切缝合器治疗包皮过长在其疼痛程度、手术时间及术后愈合时间上比商环治疗包皮过长具有明显优势(P<0.05),在出血情况与外形美观度上与其相比无显著差异(P>0.05)。结论:应用一次性包皮环切缝合器与商环治疗包皮过长都具有手术操作简单、术后患者满意度高的特点,但在手术时间及愈合时间及出血情况及疼痛情况两者存有一定的差异。     

应用一次性包皮环切缝合器与传统包皮环切术、包皮环切吻合术的临床对比研究

目的:比较传统包皮环切术、包皮环切吻合术和包皮环切缝合术治疗包皮过长或包茎患者的临床疗效。方法:回顾性分析我院泌尿外科门诊采用传统包皮环切术(n=50)、包皮环切吻合术(n=49)和包皮环切缝合术(n=48)治疗包皮过长或包茎147例患者的临床资料,比较3种术式的手术时间、术中出血量、术后2h和7d视觉模拟疼痛评分、术后并发症、包皮水肿、创口愈合时间、患者对术后外观满意程度及围手术期费用等指标。结果:包皮环切吻合术和包皮环切缝合术在手术时间、术中出血量和外观满意度上要优于传统包皮环切术(P0.05)。传统包皮环切术和包皮环切缝合术在术后7d视觉疼痛模拟评分、创口愈合时间和术后水肿上要优于包皮环切吻合术(P0.05),在术后2h视觉疼痛模拟评分上差于包皮环切吻合术(P0.05)。传统包皮环切术、包皮环切吻合术和包皮环切缝合术的围手术期费用分别为(543.8±33.9)元、(1137.6±99.9)元、(1253.4±652.6)元,且3种术式存在显著性差异(P0.05)。结论:3种术式各有优缺点,包皮环切缝合术操作方法简单、手术时间短、出血量少、包皮外观满意度高、疼痛较轻、术后并发症少,但是伤口愈合时间较长,费用较高。     

包皮环切术中一次性包皮环切缝合器的应用价值研究

目的:探讨一次性包皮环切缝合器治疗包皮环切术临床价值,以期丰富治疗方法。方法:选取2010年11月至2016年7月146例包皮环切术患者为研究对象,分成两组,对照组73例,传统方法切除;观察组73例,一次性包皮环切缝合器切除。观察术后在手术时间、创口愈合时间和并发症等指标变化情况。结果:观察组在手术时间、出血量、VAS评分(术后24h和术后3d)、切口愈合时间均显著优于对照组,但手术费用显著高于对照组,两组比较有统计学意义(P0.05);对照组术后1周包皮无水肿占27.4%、中度水肿24.65%,切口美观度满意率41.1%、不满意率13.7%,观察组术后1周包皮无水肿占53.42%、中度水肿6.85%,切口美观度满意率67.12%、不满意率1.37%,两组比较差异显著(P0.05);对照组总并发症发生率为26.03%,观察组为2.74%,两组比较差异显著(P0.05)。结论:一次性包皮环切缝合器治疗包皮环切术恢复时间快、并发症少,但费用高。     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Deutliche Einschränkung der Lebensqualität bei Patienten mit Pemphigus vulgaris: Ergebnisse der deutschen Bullous Skin Disease (BSD)‐Studiengruppe

Background: Pemphigus vulgaris is a potentially life‐threatening autoimmune disorder of the skin and mucous membranes characterized by antibodies against epidermal adhesion molecules. Clinically characteristic are painful chronic blisters or erosions of mucous membranes and skin. There are no published studies on the impact o this disease on quality of life. Patients and methods: This registration was performed within the scope of the German BSD (Bullous Skin Disease) study group, from November 1997 until January 2002. A total of 36 patients with the first diagnosis of pemphigus vulgaris were registered at the university hospitals of Dresden, Erlangen, Kiel, Mannheim, München and Würzburg. Thirty of the 36 (83 %) patients participated in the quality of life questionnaire utilizing the German version of ‘Dermatology Life Quality Index’ (DLQI) provided by A. Y. Finlay. The DLQI varies from 0 to 30 with an increased DLQI score indicating a decrease in quality of quality. Results: The overall DLQI total score of 10 ± 6,7 in the investigated pemphigus patients was significantly increased in comparison to other skin diseases. Conclusions: These results suggest that the DLQI can be a very useful additional outcome criteria for clinical studies with pemphigus vulgaris and in the treatment of these patients.     

Mutations in mevalonate pathway genes in patients with familial or sporadic porokeratosis

Porokeratosis comprises heterogeneous keratinization disorders that are characterized by one or more atrophic patches surrounded by a ridge‐like cornoid lamella. In this study, we evaluated seven families affected by porokeratosis and five sporadic patients of the disease in a Chinese population. We performed Sanger sequencing of exons and flanking intron–exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9. In five familial and three sporadic patients, we detected six variations, including four novel mutations (MVD c.1A>G; p.Met1?, c.916G>A; p.Ala306Thr, c.1013+1G>A, and PMVK c.65A>G; p.Lys22Arg) and two recurrent mutations (MVD c.746T>C; p.Phe249Ser, and MVK c.1028T>C; p.Leu343Pro). We then applied I‐TASSER and iGEMDOCK to assess these variants for probable functional impacts. The findings of this study extend the mutation spectrum of porokeratosis and provide further evidence for the genetic basis of this disease.     

Occupational allergic contact dermatitis caused by decorative plants

12 cases of occupational allergic contact dermatitis caused by decorative plants were diagnosed in a 14-year period. The patients were middle-aged, and their average exposure time was 13 years. The plant families and plants causing occupational contact dermatitis were Compositae (5 patients: chrysanthemum, elecampane, gerbera, feverfew), Alstroemeriaceae (5 patients, Alstroemeria ), Liliaceae (4 patients; tulip, hyacinth). Amaryllidaceae (2 patients: narcissus) and Caryophyllaceae (2 patients; carnation, cauzeflower). The known chemical allergens causing dermatitis were tuliposide-A and sesquiterepene lactones, such as alantolactones and parthenolide, in the Liliaceae and Compositae families. 7 of the 12 patients were able to continue their work; 5 were not because of severe relapses of skin symptoms. The plant allergen and extract series currently available are of great help in the diagnosis.     

[Translated article] Pruritus in Dermatology: Part 1—General Concepts and Pruritogens

Pruritus is the most common symptom of dermatologic and systemic diseases. The diagnosis of pruritus is clinical, although additional tests may be necessary to identify or confirm the cause. Translational medicine has led to the discovery of new mediators of itch, or pruritogens, as well as new receptors. Knowing how to properly recognize the main pathway that mediates itch in each patient is the key to successful treatment. Although the histaminergic pathway predominates in conditions like urticaria or drug-induced pruritus, it is the nonhistaminergic pathway that predominates in nearly all other skin diseases covered in this review. Part 1 of this 2-part review discusses the classification of pruritus, additional testing, the pathophysiology of itch and the pruritogens implicated (including cytokines and other molecules), and central sensitization to itch.