自拟蒌实化瘀汤治疗阳虚痰瘀型胸痹的临床研究

目的 观察蒌实化瘀汤治疗阳虚痰瘀型冠心病心绞痛的临床疗效。方法 选择符合中西医诊断标准的劳力性心绞痛病例120例，随机分为蒌实化瘀汤治疗组（治疗组）及复方丹参滴丸对照组（对照组），疗程均为3个月，观察冠心病心绞痛症状、心电图情况及每周硝酸甘油使用量等方面的改善情况。结果 两组所用药物对冠心病心绞痛症状、每周硝酸甘油使用量以及心电图方面均具有良好的疗效，且治疗组优于对照组，P〈0．05。结论 萎实化瘀汤治疗阳虚痰瘀型冠心病心绞痛疗效显著，能明显减少心绞痛的发作，改善临床症状。     

辨证治疗冠心病心绞痛180例

冠心病心绞痛是中老年人常见、多发病。笔者自2000年1月2000年12月以中医辨证治疗冠心病心绞痛180例，疗效满意，现报告如下。     

补阳还五汤治疗冠心病心绞痛58例

冠心病心绞痛中医辨证为气虚血瘀型者颇多,笔者临床中运用补阳还五汤治疗冠心病心绞痛属气虚血瘀证患者,疗效满意,现报道如下。临床资料病例来源于本院2002年4月~2005年10月住院和门诊病人,冠心病心绞痛诊断符合WHO制定的“缺血性心脏病的命名及诊断标准”。中医辨证符合2002年     

冠心病心绞痛蒙医证型诊断标准研究

目的对冠心病心绞痛的蒙医证型进行统计学分析，筛选对证型诊断有意义的指标，制定冠心病心绞痛蒙医证型的诊断标准。方法按照西医冠心病心绞痛诊断标准选入病例，进行临床观察并填写病例观察表，对每份观察表信息进行辨证并做出相应的证型诊断；根据证型分组，进行统计学分析，筛选对证型诊断有意义的指标。结果经对410例患者资料进行辨证分析，冠心病心绞痛蒙医证型分布为楚斯型358例，粘邪型23例，胃痧型29例。通过对各证型之间的症状及辅助检查指标进行统计分析，制定出了冠心病心绞痛蒙医证型的诊断标准。结论本研究通过病证结合临床研究模式总结了冠心病心绞痛的蒙医证型诊断标准，为蒙药的合理应用提供了理论基础。     

血府逐瘀胶囊治疗冠心病心绞痛临床观察

自1999年1月～2000年10月，笔者采用血府逐瘀治疗冠心病心绞痛取得较好疗效，观察报告如下。 1 临床资料 冠心病心绞痛11例均按1979年中西医结合防治冠心病、心绞痛及心律失常座谈会所制……     

银丹心脑通软胶囊治疗气滞血瘀型冠心病心绞痛临床观察

银丹心脑通软胶囊是由行气活血、化瘀通络作用的银杏叶、灯盏细辛、三七、冰片、丹参和健脾消滞的绞股蓝、大蒜、山楂等组成。临床主要用于气滞血瘀引起的冠心病心绞痛、高脂血症等。2005年7月-2006年5月，笔者选择通心络胶囊作为对照，对气滞血瘀型冠心病心绞痛进行临床观察，现报告如下。     

补阳还五汤治疗气虚血瘀型心绞痛52例

补阳还五汤治疗气虚血瘀型心绞痛５２例戴小华，周宜轩，俞兴群，卓秀珍，汪玲近５年，我们采用补阳还五汤对５２例气虚血瘀型心绞痛患者进行治疗，取得了较好疗效，现报告如下。临床资料根据１９７９年全国中西医结合防治冠心病心绞痛、心律失常座谈会所制定的诊断参考标...     

血府逐瘀胶囊治疗冠心病心绞痛临床观察

自1999年1月～2000年10月，笔者采用血府逐瘀治疗冠心病心绞痛取得较好疗效，观察报告如下。 1 临床资料 冠心病心绞痛11例均按1979年中西医结合防治冠心病、心绞痛及心律失常座谈会所制……     

参红饮治疗冠心病心绞痛40例

冠心病是临床常见病、多发病。笔者近3年来采用参红饮治疗气阴两虚型冠心病心绞痛伴血压偏低者40例，疗效满意，并与单用西药治疗的38例作对比观察，现报告如下。     

冠心病心绞痛中医证型分布在性别上的差异性

目的：从性别上探讨冠心病心绞痛中医证型分布特点，以寻求其中医证型分布规律，为临床诊疗提供依据。方法：对2006年4月～2007年11月经冠状动脉造影确诊为冠心病心绞痛的87例患者进行临床回顾性分析，根据证型分布特点进行统计学分析。冠状动脉造影采用Judkins法，由有经验的心内科介入医生及放射科医生共同完成诊断报告。中医证型的诊断由有经验的中医心内科医生完成，以中国中西医结合学会心血管学会1990年10月修订《冠心病中医辨证标准》作为诊断标准，证型可以叠加。结果：男性虚证18例，女性35例，两者比较P〈0．05，差异有统计学意义；男性实证53例，女性43例，两者比较P〈0．05，差异有统计学意义。结论：冠心病心绞痛患者，女性以虚证居多，男性以实证居多。     

通冠散加减治疗冠心病心绞痛76例

近年来，本人采用自拟通冠散加减治疗冠心病心绞痛76例，效果显著，现报道如下。     

银屑病分型论治浅解

银屑病又名牛皮癣，中医称之为白疙，是一种常见易复发的慢性炎症性皮肤病，以云母状鳞屑、红膜症、点状出血为临床特征。近年来，银屑病发病呈上升趋势，其初期有明显的季节性，呈冬重夏轻，无论男女老幼皆可发病，目前病因未明，尚缺乏有效的治疗方法。自2000年以来，我们根据银屑病的临床表现，将其辨证分型为：血热毒盛，寒湿侵袭、脉络瘀阻、血虚风燥、肝肾亏虚等五型，对证治疗取得了比较明显的疗效，现予介绍，以求同道斧正。     

中西医结合治疗膝关节骨性关节炎78例

膝关节骨性关节炎是中老年人的常见病、多发病。主要表现为膝关节疼痛、肿胀、功能障碍，严重影响患者的工作和生活。自2000年以来，采用玻璃酸钠注射液膝关节腔内注射配合手法治疗膝关节骨性关节炎78例，取得较好疗效。     

平胃散加减治疗胃脘痛

胃脘痛是常见多发病。疼痛的主要部位是在上腹近心窝处，但不能与心痛混为一谈。它属现代医学的急、慢性胃炎、胃十二指肠溃疡、慢性肝炎的上腹疼痛等病的范畴。     

Regulative Effects of Auricular Acupuncture,Moxibustion and Chinese Herbs on Immunologic Function in the D-Galactose-induced Aging Mouse

Objective： To observe the regulative effect of auricular acupuncture, moxibustion and Chinese herbs on immunologic function in the D-galactose-induced aging mouse and to probe the feasibility and possible mechanisms for delaying aging, so as to provide experimental basis for acupuncture, moxibustion and Chinese herbs for delaying aging. Methods： Aging mouse model was established by subcutaneous injection of D-galactose, and treated by auricular acupuncture, auricular acupuncture plus moxibustion, and auricular acupuncture plus Chinese herbs respectively for 6 weeks and then serum interleukin-2 （IL-2） and IL-6 contents and splenic lymphocyte transformation rate were compared among the groups. Results： Compared with the young group, the serum IL-2 level and the splenic lymphocyte transformation rate significantly decreased and the IL-6 level significantly increased in the aging mouse. After treatment by auricular acupuncture, auricular acupuncture plus Chinese herbs, especially auricular acupuncture plus moxibustion, the serum IL-2 level and the splenic lymphocyte transformation rate significantly increased, and the IL-6 level significantly decreased as compared with the model group. Conclusions： Combined application of auricular acupuncture, moxibustion and Chinese herbs can improve the decline or dysfunction of immunological function in the aging organism to a certain extent.     

Cytological and biochemical studies during the progression of alloxan-induced diabetes and possible protection of an aqueous leaf extract of Costus afer

Some plants have proven efficacy in the management of diabetes mellitus, of which Costus afer is one. This study was designed to evaluate the cytological and biochemical properties, and comparative ameliorating effects, of an aqueous extract of Costus afer Ker Gawl.（Costaceae） leaf and glibenclamide（GBM）, in liver, kidney, and pancreatic injury induced by alloxan. Thirty male albino rats were divided into six weight-matched groups. Group one served as the negative control（non-induced and non-treated, control）, while groups 2–6 were alloxan-induced diabetic groups. Group 2 served as a positive control（induced and non-treated, IC）, groups 3–5 were treated with different doses of the extract（375, 750, and 1 125 mg/kg body weight） and glibenclamide, respectively. Body weight, absolute and relative organ weights, food and fluid intake, levels of serum glucose and liver enzymes and kidney parameters were calculated and compared. Hepatocytes, renal tubules, and pancreatic cells of diabetic rats, in diabetic non-treated and treated rats were harvested and examined histopathologically. There was dose dependent amelioration on the injuries induced by alloxan on both hepatocytes, renal tubules, and pancreatic cells after treatment with Costus afer. The glucose level was reduced significantly in the Costus afer treated diabetic rats compared with the non-treated diabetic group. Costus afer leaves seem to be effective against diabetic cell injury induced in rat liver, kidney, and pancreas.     

三木固脱汤治疗腰椎间盘突出症58例临床观察

腰椎间盘突出症是腰椎间盘发生退行性改变以后，在外力的作用下，导致椎间后部压力增高，发生纤维环破裂向后外侧突出，刺激后纵韧带或压迫神经根，引起腰腿疼痛的病症。属中医学“腰痛”和“痹证”范畴。从2001年3月～2007年3月，笔者运用自拟三木固脱汤为主治疗腰椎间盘突出症而致腰腿疼痛，取得较好的疗效，现将资料完整的58例报道如下。     

王采文以补肾活血法治疗复发性流产验案1则

<正>王采文副主任医师是全国著名老中医朱南孙教授的学术继承人,从医30余年,在中医药治疗妇科病方面有丰富的经验。笔者有幸侍诊,学习王老师治疗妇科疾病的临床经验,现举王老师治疗复发性流产验案1则,并初步分析其辨证论治思路。1病案实录严某,女,30岁。初诊日期:2010年10月28日。患者曾2次流产,末次流产2008年10月。平素月经规则,30天1行,经量少,2~3日净,经色暗;末次月     

Effect of Zhuyeshigao granule on tumor necrosis factor-a and inter- leukins serum protein levels in rats with radiation esophagitis

OBJECTIVE： To investigate the effects of Zhuyesh- igao granule （ZSG） on tumor necrosis factor-a （TNF-a）, interleukin-1 （IL-1）, IL-2, IL-6, and IL-8 in rats with radiation esophagitis. METHODS： Fifty Wistar rats were randomly divid- ed into five groups （10 rats in each group）： con- trol （without radiation）, saline-treated, and low, medium, and high-dose ISG-treated groups. Rats were given normal saline （10 mL/kg） or 1.15, 2.3, or 4.6 g/kg ZSG by intragastric administration once a day for 7 days. A rat model of radiation esophagi- tis was established by local irradiation of Co60 （490.25 cGy/min, totaling 30 Gy）. The administra- tion of ZSG was continued for another 7 days and on the 7th day post-irradiation, inferior vena cavablood was collected. The serum was separated, and TNF-a, IL-1, IL-2, 11_-6, and IL-8 protein levels were determined. RESULTS： Inflammatory response factors were found in the serum of each group. However, levels in ZSG-treated groups were significantly lower than in the saline-treated group （P〈0.05）. CONCLUSION： ZSG may prevent the development of radiation esophagitis, perhaps by inhibiting the generation and release of the inflammatory re- sponse factors TNF-a, IL-1, IL-2, IL-6, and IL-8.     

Correlativity between blood measures related to blood stasis block- ing collaterals and gene expression of angiotensin-converting en- zyme of renal cortex in diabetic rats and effect of stasis removing and collaterals dredging

OBJECTIVE： To investigate the correlativity between the changes of blood measures related to blood stasis blocking collaterals and gene expression levels of angiotensin-converting enzyme（ACE）and ACE2 ofrenal cortex in diabetic rats with stasis blocking collaterals syndrome, as well as the effectof stasis removing and collaterals dredging.METHODS： Male Sprague-Dawley rats were divided randomly into normal control group（C group）,high-carbohydrate-fat control group（H group） and streptozotocin（STZ）-injecting group. The diabeticrats were induced from rats in the STZ-injecting groupby high-carbohydrate-fat diet combined with STZ intraperitoneal injection, with sustained high-carbohydrate-fat diet fed afterwards, and were further divided into model group（M group）and Chinese medicine of stasis removing and collaterals dredging group（Z group）. Rats in the Z group were fed with stasis-removing-and-collaterals-dredging herbal granule suspension intragastrically daily for 16 weeks, while drinking water of corresponding volume was administrated to the rats in other groups. At the end of the 16 th week after successful establishment of models, the ultrastructures of glomeruli in different groups were detected by a transmission electron microscopy; and blood measures related to blood stasis blocking collaterals, including lipid profile and blood viscosity measures, were tested, as well as the relative gene expressions of ACE and ACE2.RESULTS： Changes in ultrastructures of glomeruli in the M group were characterized by lack of clarity in structure and occasional thickening of glomerular basement membrane and extensive fusion in foot processes. The correlation analysis showed that there were positive correlations between lipid profile, blood viscosity, and the ACE mRNA expression levels in the M group（P〈0.05）, except for cholesterol. And except for triglyceride, the blood measures were in negative correlation with the ACE2 mRNA expression levels in the M group（P〈0.05）.Compared with the C