脉搏波无创血压测量技术与有创血压测量技术临床对比及应用前景

目的对比脉搏波无创血压测量技术与有创血压测量技术的临床效果及其应用前景。方法选择冠脉造影患者120例,随机数字法分为对照组与观察组各60例,对照组经周围动脉将导管送至腋动脉,有创测量其中心动脉压;观察组利用四管通道连接脉搏波无创血压计,测量左、右侧肱动脉无创血压,记录两组收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)及脉压(PP),比较两组血压值,并采用相关系数(ICC)与Bland-Altman分析两组血压值的相关性。结果两组SBP、DBP、MAP、PP差异均无统计学意义(均P>0. 05);两组SBP与DBP的ICC值分别为0. 98(95%CI 0. 97～1. 00)和0. 96(95%CI 0. 90～0. 98);Bland-Altman分析发现SBP和DBP的差值均值均接近0值参考线。结论脉搏波无创血压测量技术能准确反映患者血压状况,更加安全、简便。     

联合测量腰臀围比值(或腰围)和血压可预测代谢综合征

目的代谢综合征(MS)包括多种组成成分,可导致心血管疾病和糖尿病。本研究目的是明确哪一种成分对MS的贡献最大。方法根据1999年WHO的MS工作定义对1994年全国糖尿病防治协作组调查的15 564例年龄≥25岁的中国成人资料进行分析;胰岛素抵抗定义为HOMA-IR指数超过本组糖耐量正常人群(年龄25 ~74岁)的第75百分位数。用logistic逐步回归方法分析MS各组分对MS贡献大小。结果(1)本人群MS患病率为64.35%,标化患病率为59.00%。(2)年龄、性别、收缩压(SBP)、舒张压(DBP)、腰臀围比值(WHR)(或腰围)、体重指数(BMI)与MS独立正相关,相关强度从高至低顺序依次为WHR(或腰围)、SBP、DBP、性别(女>男)、BMI、年龄,这些变量预测本人群MS的一致性达93.8%。WHR、BMI、SBP、DBP预测本人群MS的一致性为90.2%;若以腰围代替WHR,则一致性为86.2%;若去掉BMI,则一致性达86.1%。(3)在其它因素不变时, WHR每增加0.05、腰围每增加5 cm、SBP每增加10mm Hg(1 mm Hg=0.133 kPa)、DBP每增加5 mm Hg、BMI每增加5 kg/m2分别可增加本人群MS风险3.35倍、1.87倍、1.52倍、1.46倍、1.34倍。结论在临床实践中,联合测量腰臀围比值(或腰围)和血压可作为一项快速评估MS的简易指标。     

冠心病患者经导管测量中心动脉血压与经袖带测量肱动脉血压的比较研究

目的研究经导管测量主动脉根部血压(中心动脉压)与经袖带测量肱动脉血压间的差异。方法采用介入方法分别记录主动脉根部中心动脉收缩压、舒张压。同步经袖带测量左臂肱动脉无创血压两次,取其平均值,分别记录收缩压、舒张压,然后进行对比分析。结果中心动脉收缩压与肱动脉收缩压差异无显著性,P=0.908。中心动脉舒张压较肱动脉舒张压低7.85mmHg(P<0.001),舒张压净差异变化值在65岁以上组较65岁以下组更为明显(P<0.01)。结论袖带肱动脉收缩压能准确反应中心动脉收缩压变化,袖带肱动脉舒张压较中心动脉舒张压高,差异随年龄增加而加大。     

连续3次偶测血压的变异程度及影响因素

目的观察短时间内3次偶测血压值的变异程度及其影响因素.方法由经过专门培训的医务人员、在21℃室温下,连续测量2 020名成年居民(25～90岁,男994例,女1 026例)3次血压,以最大和最小值的差值作为收缩压变异度(△SBP)和舒张压变异度(△DBP).同时记录年龄、性别、身高、体重、腰围、臀围.计算体重指数(BMI)、向心性肥胖指数(WHR)、脉压(PP),并分析其对血压变异度的影响.结果1.△SBP＞10 mm Hg者占20%,△DBP＞5 mm Hg占33.4%.2.女性△SBP高于同年龄段男性,而△DBP两性间无明显差异.3.半数人群首测SBP最高(男48.5%、女53.1%),该亚组△SBP亦最大.结论1.即使严格依照血压测量规程,10 min内连续3次的血压测值变异较大.2.女性和增龄是△SBP增大的影响因素.     

血压正常高值人群心血管危险因素和脉搏波传导速度

目的 探讨血压正常高值人群血管脉搏波速度与心血管危险因素的关系.方法 选择血压正常人群195例,分为两组:理想血压组90人(BP＜120/80 mm Hg);正常高值组105人(BP:120～139/80～89 mm Hg).应用脉搏波速度(PWV)测定仪对所有入选者同时测定颈-桡动脉脉搏波速度(C-RP-WV),颈-股动脉脉搏波速度(C-FPWV),并测身高、体重、体重指数(BMI)、腰围等,同时抽取空腹肘部静脉血测定血糖(BG)、血脂、内皮素(ET)、一氧化氮(NO)和胰岛素(INS)的浓度.结果 1)两组间各因素比较BMI、腰围、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、极低密度脂蛋白(VLDL)、BG、ET、NO、胰岛素抵抗指数(HOMA-IR)、C-RPWV、C-FPWV存在统计学差异,P均＜0.05.2)PWV与各因素的简单相关(Pearson)分析示:C-FPWV与年龄、SBP、DBP、腰围、TG、胆固醇(CHO)、VLDL、BG、ET、NO、HO-MA-IR相关.C-RPWV与年龄、腰围、SBP、DBP、TG、VLDL、BG、ET、NO、HOMA-IR相关.3)多因素回归分析示:C-FPWV=4.635 0.035 SBP 0.047 age 0.290 TG-0.099 BMI 0.010 ET-0.009 NO 0.076HOMA-IR.R2=0.514.C-RPWV=3.161 0.033 DBP 0.034 age 0.313 BG 0.012 ET-0.009 NO.R2=0.274.结论 1)血压正常高值者已经存在动脉弹性的减退.2)血压正常高值者动脉弹性的减退与内皮功能失调、血糖、血脂水平、胰岛素抵抗密切相关.     

血压正常高值人大动脉顺应性的变化

目的探讨血压正常高值人群大动脉顺应性的变化。方法选择年龄相似血压正常的健康者及没有任何靶器官损害的Ⅰ～Ⅱ级高血压患者191例,分为3组:正常血压组64人;正常高值组75人;高血压组52人。应用脉搏波速度(PWV)测定仪对所有入选者进行同时测定颈动脉桡动脉(CRPWV),颈动脉股动脉的脉搏波速度(CFPWV),及血压、身高、体重、体重指数(BMI)、腰围、臀围、腰臀围比值、心率(HR)等。结果CFPWV、CRPWV在正常组(8.9±1.6)m/s和(8.8±1.1)m/s、血压正常高值组(9.7±1.6)m/s和(9.7±1.4)m/s,高血压组3组中分别为(10.0±1.4)m/s和(10.3±1.5)m/s。方差分析示,3组间各因素比较除年龄、心率外均存在统计学差异。两组间的SNK检验示:血压正常高值组的身高、体重、BMI、腰臀围比值,CRPWV及CFPWV均大于正常组,P<0.05;而年龄、脉压(PP)、心率无统计学差异,P>0.05。正常高值组与高血压组的比较,CRPWV有明显的统计学差异,P<0.05。血压正常的健康人(血压正常高值组和理想血压组)的PWV与各因素的简单相关(Pearson)分析示:CRPWV与收缩压(SBP)、舒张压(DBP)、身高、HR相关;CFPWV与年龄、SBP、PP、BMI相关。CFPWV、CRPWV多因素逐步线性回归分析示:CFPWV与年龄、SBP、身高、体重关系密切;CRPWV与DBP、HR紧密相关。结论1、血压正常高值患者已经存在动脉顺应性的减退;2、血压正常人群的动脉顺应性随年龄、血压、HR的增高而减退。     

血压正常高值人大动脉顺应性的变化

目的探讨血压正常高值人群大动脉顺应性的变化.方法选择年龄相似血压正常的健康者及没有任何靶器官损害的Ⅰ～Ⅱ级高血压患者191例,分为3组正常血压组64人;正常高值组75人;高血压组52人.应用脉搏波速度(PWV)测定仪对所有入选者进行同时测定颈动脉-桡动脉(C-RPWV),颈动脉-股动脉的脉搏波速度(C-FPWV),及血压、身高、体重、体重指数(BMI)、腰围、臀围、腰臀围比值、心率(HR)等.结果C-FPWV、C-RPWV在正常组(8.9±1.6)m/s和(8.8±1.1)m/s、血压正常高值组(9.7±1.6)m/s和(9.7±1.4)m/s,高血压组3组中分别为(10.0±1.4)m/s和(10.3±1.5)m/s.方差分析示,3组间各因素比较除年龄、心率外均存在统计学差异.两组间的S-N-K检验示血压正常高值组的身高、体重、BMI、腰臀围比值,C-RPWV及C-FPWV均大于正常组,P＜0.05;而年龄、脉压(PP)、心率无统计学差异,P＞0.05.正常高值组与高血压组的比较,CRPWV有明显的统计学差异,P＜0.05.血压正常的健康人(血压正常高值组和理想血压组)的PWV与各因素的简单相关(Pearson)分析示C-RPWV与收缩压(SBP)、舒张压(DBP)、身高、HR相关;CFPWV与年龄、SBP、PP、BMI相关.C-FPWV、C-RPWV多因素逐步线性回归分析示C-FPWV与年龄、SBP、身高、体重关系密切;C-RPWV与DBP、HR紧密相关.结论1、血压正常高值患者已经存在动脉顺应性的减退;2、血压正常人群的动脉顺应性随年龄、血压、HR的增高而减退.     

血压正常高值人群心血管危险因素和脉搏波传导速度

目的探讨血压正常高值人群血管脉搏波速度与心血管危险因素的关系。方法选择血压正常人群195例,分为两组:理想血压组90人(BP<120/80mmHg);正常高值组105人(BP:120～139/80～89mmHg)。应用脉搏波速度(PWV)测定仪对所有入选者同时测定颈桡动脉脉搏波速度(CRPWV),颈股动脉脉搏波速度(CFPWV),并测身高、体重、体重指数(BMI)、腰围等,同时抽取空腹肘部静脉血测定血糖(BG)、血脂、内皮素(ET)、一氧化氮(NO)和胰岛素(INS)的浓度。结果1)两组间各因素比较BMI、腰围、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、极低密度脂蛋白(VLDL)、BG、ET、NO、胰岛素抵抗指数(HOMAIR)、CRPWV、CFPWV存在统计学差异,P均<0.05。2)PWV与各因素的简单相关(Pearson)分析示:CFPWV与年龄、SBP、DBP、腰围、TG、胆固醇(CHO)、VLDL、BG、ET、NO、HOMAIR相关。CRPWV与年龄、腰围、SBP、DBP、TG、VLDL、BG、ET、NO、HOMAIR相关。3)多因素回归分析示:CFPWV=4.635 0.035SBP 0.047age 0.290TG-0.099BMI 0.010ET-0.009NO 0.076HOMAIR。R2=0.514。CRPWV=3.161 0.033DBP 0.034age 0.313BG 0.012ET-0.009NO。R2=0.274。结论1)血压正常高值者已经存在动脉弹性的减退。2)血压正常高值者动脉弹性的减退与内皮功能失调、血糖、血脂水平、胰岛素抵抗密切相关。     

高血压病患者脉搏波传导速度与动态血压各指标的相关性分析

目的:探讨高血压病患者脉搏波传导速度(PWV)与动态血压(ABPM)各指标的相关性。方法:对200例高血压病患者按年龄分为非老年高血压患者(年龄60岁)和老年高血压患者(年龄≥60岁)两组;每组中再按PWV正常值分为9 m/s和≥9 m/s两组。收集相关临床资料,测量身高、体质量、腰围、臀围,检测PWV和ABPM,计算24 h平均脉压(PP)、脉压指数(PPI)、体质量指数(BMI)、腰臀比(WHR),分析ABPM的各值及其他有关因素与PWV的相关性。结果:与非老年高血压病患者比较:老年高血压病患者WHR、PP、PPI、PWV显著升高(P0.05,P0.01);这两组中PWV≥9 m/s的患者,SBP、DBP、PP、PPI均高于同组内PWV9 m/s的患者,组内比较有显著差异性(P0.05,P0.01);经Pearson相关分析:PPI与PWV相关系数r值(0.501)大于SBP、DBP、PP的r值(0.398、-0.251、0.418)。结论:高血压病患者PPI与PWV密切相关,在反映大动脉硬化程度上PPI优于动态血压其他指标。     

社区老人群血脂1401例现况调查

目的了解顺德容桂地区1401例老年人血脂现况。方法对顺德区容桂街道整群随机抽样,随机抽取2个村。对村中60岁以上的常住人口全部进行调查。总人数1503人,被调查且资料完整的1401人(68.12±6.64)岁其中男性579人,女性822人,60～69岁867人(占61.9%),70～79岁430人(占30.7%),80岁以上104(占7.4%)。调查的项目有年龄、性别、总胆固醇(TC)、甘油三酯(TG)、身高、体重、腰围(WC)、臀围(HC)、空腹血糖(FC)、血压、既往史,并计算出体重指数(BMI)、腰臀围比(WHR)和腰围身高比(WHtR)。结果 (1)高脂血症现患率42.8%,男女之间差异明显(P<0.01),女性高于男性,各年龄组间差异不明显。高脂血症加上血脂边缘升高的1 122人,占总数的80.1%。(2)与正常血脂者相比,高脂血症者FG、BMI、SBP、DBP、WC、WHR、WHtR更高(P<0.05)。(3)Pearson相关性分析发现,高脂血症与FG、BMI、WC、WHR、WHtR、SBP、DBP明显相关(P<0.01)。结论 (1)顺德容桂地区1401例老年人群高脂血症现患率42.8%,女性高于男性。(2)高脂血症与高FG、BMI、WC、WHR、WHtR、SBP、DBP相关。     

Epidemiologic surve of blood lipid level among 1401 residents aged≥60 years in rong-gui community

Objectives To investigate prevalence of blood lipid level among 1401 residents aged≥60 years in rong-gui community.Methods 1401 ones(579 males,822 females, (68.12±6.64)years Of total 1503 residents aged≥60 years in the 2 villages which were randomly exampled in rong-gui community were investigated.867 ones aged among 60-69 years(61.9%),430 ones aged among 70-79 years (30.7%),104 ones aged≥60 years(7.4%).Investigative items included age,sex,total cholesterol(TC),triglyceride (TG),body height,body weight,waist circumference(WC), hip circumference(HC),fasting plasma glucose(FG),blood pressure,history of past illness,body mass index(BMI), waist hip ratio(WHR),waist height ratio(WHtR).Results (l)Of total 1401 residents,Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male(P<0.01), The difference among three age groups were not significant, the combined prevalence of hyperlipemia and borderline hyperlipemia was 80.1%.(2)The FG、BMI、SBP、DBP、WC、WHR、WHtR of residents with hyperlipemia were higher than ones with normal blood lipid level(P<0.01).(3)By Pearson correlation analysis,we found that hyperlipemia was obviously correlated with FG,BMI,WC,WHR,WHtR, SBP,DBP.Conclusions(1)Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male.(2) hyperlipemia were obviously correlated with higher FG、BMI、WC、WHR、WHtR、SBP、DBP.     

血压水平与腰身指数、瘦素的相关分析

目的：探讨血压水平与腰身指数、瘦素的相关性。方法：对2006年12月至2007年7月人疗养院体检的军地疗养员共702人，测量身高、体质量、腰围、血压，用放射免疫法检测瘦素，并按不同水平血压分为正常血压组（324例）、正常高值血压组（232例）、高血压组（146例）三组进行分析。结果：随着血压增高，腰身指数、瘦素水平也增高，三组之间两两比较均有非常显著性差异（P〈0.001）；相关性分析显示，腰身指数和体重指数与收缩压、舒张压、脉压差、瘦素明显相关（r=0．302-0.466，P〈0.001；r=0．262～0．353．P〈0.001），但腰身指数的相关性优于体重指数。结论：腰身指数、体重指数、瘦素均可作为血压水平的预测和评估指标，从简易而准确的角度看．腰身指数更具实用性。     

体重及脂肪分布与高血压病关系的流行病学研究

目的:探讨体重及脂肪分布与高血压病的相关性。方法:采取整群随机抽样的方法选择徐州市大屯社区259位中年居民为调查对象,运用病例对照研究,测量体重指数(BM I)、腰臀比(WHR)、腰围(W C)、臀围(HC)等参数数值,并作统计学处理。结果:(1)高血压组中的体重、体重指数、腰围、臀围、腰臀比高于对照组(P<0.05);高血压合并冠心病组中的腰围、臀围高于对照组(P<0.05);(2)腰臀比与年龄、收缩压、舒张压、尿酸、血糖、甘油三酯、体重呈正相关(r=0.17~0.305,P<0.05);体重指数与收缩压、舒张压、尿酸、甘油三酯、腰围、臀围呈正相关(r=0.299~0.670,P<0.05);(3)腹部肥胖型在各病例组中所占的比例明显高于对照组(P<0.05)。结论:超重、肥胖尤其是腹部肥胖型是高血压病的危险因素。     

A preliminary evaluation of the mean arterial pressure as measured by cuff oscillometry

BACKGROUND: The brachial artery (BA) mean blood pressure (MBP) is now readily available using the oscillometric technique. In contrast to the auscultatory method where MBP is calculated from the systolic (SBP) and diastolic blood pressure (DBP), oscillometric MBP is measured separately from either SBP or DBP. Because the peripheral MBP is free of amplification, it is nearly the same throughout the entire arterial tree and could represent the corresponding aortic pressure. The oscillometric brachial MBP could therefore serve as a surrogate for aortic MBP and might be a valuable non-invasive risk predictor. METHODS: This study compares the oscillometric BA pressures with simultaneously and directly recorded aortic pressures in 100 patients. RESULTS: These results show that, over a wide range of cuff pressures, the oscillometric MBP, whether alone or with age in multiple regression, predicts aortic pressure better than the SBP or DBP do, with a better correlation coefficient (r = +0.91), low aortic-cuff MBP difference (-0.79 mm Hg) and the lowest s.d. of the individual differences (+7.2 mm Hg). CONCLUSIONS: These results are preliminary and need to be confirmed by larger studies. If confirmed, the predicted aortic pressures should be calculated and displayed by the oscillometric BP devices, the goal being to develop better non-invasive cardiovascular (CV) risk predictors.     

Association between anthropometric measures of obesity and subclinical atherosclerosis in Bangladesh

Background

Anthropometric measures such as waist–hip-ratio (WHR), waist-height-ratio (WHtR), waist circumference, Mid-upper arm circumference (MUAC), and upper thigh circumference, have been linked to the risk of cardiovascular disease (CVD). However, their relationships with subclinical atherosclerosis are unclear. Studies in normal-weight populations, especially in Asian countries where leanness is prevalent, are lacking.

Methods

We conducted a cross-sectional study to assess the associations of WHR, WHtR, waist circumference, hip circumference, body mass index (BMI), MUAC and upper thigh circumference with carotid intima-media thickness (cIMT) among 562 middle-aged participants free of CVD in rural Bangladesh.

Results

After adjusting for age and sex, WHR and waist circumference but not BMI showed a positive significant association with cIMT. In multivariate analysis, each standard deviation (SD) increase of WHR (0.08) or WHtR (0.07) was associated with an 8.96 μm (95% CI, 1.12–16.81) or 11.45 μm (95%CI, 0.86–22.04) difference in cIMT, respectively, after controlling for age, sex, BMI, smoking status, education level, and systolic blood pressure (SBP). The associations of WHR and WHtR with cIMT were independent of the influence of other anthropometric measures. The associations of other anthropometric measures and cIMT were not apparent.

Conclusions

In our relatively lean, healthy Asian population, WHR and WHtR appear to be better predictors of early atherosclerosis than other common surrogates of adiposity.     

Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study

OBJECTIVE: To determine the relation between fat distribution and blood pressure, independent of body mass index. DESIGN: Cross-sectional, population-based study. PARTICIPANTS AND METHODS: Participants, 9936 men and 12,154 women aged 45-79 years, were recruited from general practices in Norfolk, United Kingdom for the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study. Participants filled in a health and lifestyle questionnaire and their blood pressure and anthropometry were measured at a clinic. We mainly used waist-hip ratio (WHR) to assess body fat distribution. RESULTS: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) increased linearly across the whole range of waist-hip ratio in both men and women. The relation was independent of age, body mass index (BMI) and other covariates. Separately, waist and hip circumferences were positively related to SBP and DBP. When adjusted for BMI, waist circumference was positively related to SBP (in women) and DBP (in both men and women), whereas hip circumference was inversely related to SBP (but not DBP) in both men and women. Stratifying by tertiles of waist and hip circumference, age- and BMI-adjusted SBP and DBP were highest among those with high waist and small hip circumference measures. CONCLUSION: Waist-hip ratio was independently related to blood pressure. Waist-hip ratio could reflect the separate and opposite relations of waist and hip circumferences on blood pressure. Characterizing patterns of fat distribution may have implications in the assessment and control of obesity-related blood pressure elevation.     

原发性高血压患者血压变异性与早期肾功能损害的相关性研究

目的：观察原发性高血压（EH）患者血压变异性与尿微量白蛋白/尿肌酐比值的相关性。方法：随机选择60例EH患者作为EH组,按照24h平均动脉压均值高度又分为3个亚组,即EH1组（90.2～106.6mmHg）、EH2组（106.6～118.3mmHg）及EH3组（118.3～143.7mmHg）,各亚组均20例,另选择15例健康正常人作为健康对照组。监测所有研究对象在日间、夜间及24h收缩压变异性和舒张压变异性,以晨尿微量白蛋白/尿肌酐比值作为早期肾功能损害的指标,研究其相关性。结果：两组均存在血压变异性,与健康对照组比较,EH组日间、夜间及24h收缩压变异性[日间：（12.62±2.96）比（17.62±3.27）,夜间：（8.32±2.14）比（11.63±2.35）,24h：（11.23±2.25）比（18.35±2.94）]和舒张压变异性[日间：（10.32±2.41）比（12.48±2.85）,夜间：（9.52±2.00）比（11.59±3.12）,24h：（10.68±2.16）比（13.45±3.00）]均明显增大（P均〈0.01）。双变量相关分析显示EH组及EH各个亚组的日间、夜间及24h收缩压和舒张压的血压变异性均与尿微量白蛋白/尿肌酐比值均呈正相关（r=0.217～0.485,P〈0.05）。结论：原发性高血压患者血压变异性与早期肾脏损伤密切相关,改善血压变异性对预防早期肾功能损害有益。     

原发性高血压患者血压水平与早期肾损害的相关性研究

目的探讨原发性高血压患者脉压(PP)、SBP、DBP及平均动脉压(MAP)与早期肾损害的关系。方法选择180例初诊或停药2周以上的原发性高血压患者进行PP、SBP、DBP和MAP检查,以血β2微球蛋白(β2-MG)水平>2.6mg/L作为肾损害的标准,分为肾损害组和非肾损害组,其中肾损害组84例,非肾损害组96例。将两组血压参数进行比较,并与血β2-MG水平进行相关性分析。结果(1)肾损害组PP[(59±10)mmHg]及SBP[(168±28)mmHg]较非肾损害组[(41±8)mmHg,(151±10)mmHg]明显增高。(2)相关分析显示血β2-MG与PP、SBP呈正相关,尿β2-MG与PP、SBP、DBP、MAP呈正相关。其中与PP、SBP相关性较好。结论PP与SBP、DBP、MAP增高均可导致高血压患者早期肾损害,而PP、SBP增大是导致高血压患者早期肾损害的主要因素。     

Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index

BACKGROUND: Visceral adipose tissue is associated with increased risk for cardiovascular disease risk factors and morbidity from cardiovascular diseases. Waist measurement and waist-to-height ratio (WHtR) have been used as proxy measures of visceral adipose tissue, mainly in adults. OBJECTIVE: To validate body mass index (BMI), waist circumference and WHtR as predictors for the presence of cardiovascular disease risk factors in children of Greek-Cypriot origin. SUBJECTS AND METHODS: A total of 1,037 boys and 950 girls with mean age 11.4+/-0.4 y were evaluated. Dependent variables for the study were total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholestrol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and systolic (SBP) and diastolic (DBP) blood pressure. RESULTS: When children were divided into two groups according to the 75th percentile for BMI, waist circumference and WHtR, all dependent variables had higher mean values in the highest percentile groups in WHtR groups and almost all variables in BMI and waist circumference groups. Adjusted odds ratios for predicting pathological values of cardiovascular disease risk factors were slightly higher for the highest WHtR group for predicting lipid and lipoprotein pathological values and for the highest BMI groups in predicting high blood pressure measurement. Using stepwise multiple regression analysis to explain the variance of the dependent variables, waist circumference was the most significant predictor for all variables both for boys and girls, whereas BMI had the lowest predictive value for the detection of cardiovascular disease risk factors. CONCLUSION: Waist circumference and WHtR are better predictors of cardiovascular disease risk factors in children than BMI. Further studies are necessary to determine the cutoff points for these indices for an accurate prediction of risk factors.     

中心型肥胖人体测量学指标研究现状

腰围、腰臀比(WHR)、腰围/身高比值(WHtR)均为反映中心型肥胖的体表测量指标,与糖尿病、高血压、冠心病等密切相关,均能预测糖尿病、高血压及心血管疾病的发生,但各指标的预测价值具有种族筹异.大量研究显示WHtR为中国人群最佳的中心型肥胖指标,与糖球病及冠心病危险因素的关联强于体重指数(BMI)或腰围、WHR.临床上应重视对WHtR的应用和进一步研究.