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目的:测定三七片中人参皂甙Rg1的含量。方法:双波长薄层扫描法。结果:6个药厂生产的三七片中人参皂甙Rg1的含量为14.64~20.01mg/g。结论:本法简便、灵敏、准确、可供本品质量控制用。 相似文献
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三七皂甙成分研究进展 总被引:1,自引:0,他引:1
近来,对于人参属药物三七(Panax noto-ginseng.Sanchi ginseng)的研究特别活跃。据国内外的有关文献报导,仅就三七的主要活性成分皂甙类的研究概况作以简介,并对前不久分离鉴定出的新成分三七人参皂甙R_3、-R_4、-R_6的研究方法作以概述,希望对进一步寻找三七新的有效成分有所帮助。 1 概况有关三七的研究,除我国外,日本学者研究得较多,到目前为止,从著名的中国传统的草药——三七中已经分离鉴定出了二十六种皂甙成分。按其结构中甙元的不同分为三类:20(s)原人参二醇型有人参皂甙-Rb_1、-Rb_2、Rb_3、-Rc、-Rd、-F_2,丝石竹皂甙 相似文献
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薄层扫描法测定三七片中人参皂甙Rg1的含量 总被引:3,自引:0,他引:3
目的:测定三七片中人参皂甙Rg1的含量。方法:双波长薄层扫描法。结果:6个药厂生产的三七片中人参皂甙Rg1的含量为14.64~20.01mg/g。结论:本法简便、灵敏、准确、可供本品质量控制用。 相似文献
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高效液相色谱法测定复方丹参片三七皂甙R1的含量 总被引:18,自引:2,他引:18
高效液相色谱法测定复方丹参片三七皂甙R1的含量邸峰孙毅坤(北京市药品检验所100035)复方丹参片为中国药典收载品种。由丹参、三七和冰片组成。其中三七为名贵中药材,其主要有效成分为皂甙类,三七皂甙R1为其特有化学成分。报道的含量测定方法为:薄层扫描法测定三七中人参皂甙Rg1和Rb1[1];高效液相色谱-紫外分光检测法测三七皂甙R1和Rg1,测定波长203nm,实验条件要求严格[2]。本文采用高效液相-差示检测法测定三七皂甙R1含量。实?... 相似文献
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The African flora contains numerous medicinal plants whose biological and chemical properties are incompletely known. Antioxidant and radical scavenging properties of plants are subject to intensive research. In the work described here, we have investigated the antioxidant activity of the plants Diospyros abyssinica (root bark), Lannea velutina (root bark and stem bark) and Crossopteryx febrifuga (seeds). Extracts of different polarity were assayed for radical scavenging activity, using the stable free radical diphenylpicrylhydrazyl, and for inhibition of enzymatic lipid peroxidation mediated by soybean 15-lipoxygenase. All plants investigated showed activity, but there were large differences between plants and between extracts. In general, Diospyros abyssinica and Lannea velutina were richer in antioxidants than Crossopteryx febrifuga. Lipophilic extracts were not active as radical scavengers, but did inhibit 15-lipoxygenase. Semipolar extracts (80% aqueous ethanol and methanol) of Diospyros abyssinica and Lannea velutina showed the highest activity both as radical scavengers and lipoxygenase inhibitors, and also gave the highest extract yields. These plants therefore appear to be excellent sources of antioxidants. 相似文献
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Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro on fresh clinical isolates of Plasmodium falciparum. The screening showed that Sida acuta has a significant activity (IC50 < 5 microg/ml), and Pterocarpus erinaceus has a moderate activity (5 microg/ml < IC50 < 50 microg/ml). Further chemical screening showed that the activity of the most active plant, Sida acuta, was related to its alkaloid contents. 相似文献
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J N Eloff 《Journal of ethnopharmacology》2001,76(3):305-308
Marula bark is widely used for bacteria-related diseases by indigenous cultures in Africa. This study was undertaken to investigate whether the ethnobotanical use can be validated by laboratory studies. Bark and leaves were extracted with acetone and MIC values were determined using a microplate serial dilution technique with Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterococcus faecalis as test organisms. All extracts were active with MIC values from 0.15 to 3 mg/ml. Based on minimum inhibitory concentration values, inner bark extracts tended to be the most potent followed by outer bark and leaf extracts, but the differences were not statistically significant. There were two major bioactive components visible after bioautography of leaf extracts: one strongly polar and the other highly non-polar. The bioactive components could be separated from 92% of the non-active dry matter by solvent-solvent fractionation into the carbon tetrachloride, chloroform and n-butanol fractions; these fractions, however, still contained many different compounds. Using bark may be detrimental to the plant, but leaf material can also be used for antibacterial application. 相似文献
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A typesetting error occurred in the caption to Table 2 on page 455. The caption to Table 2 should read: ‘Table 2. Dose response study of antidiuretic effects of Vernonia cinerea methanol leaf extract (VCMLE) in rats’ rather than: ‘Table 2. Dose response study of diuretic effects of Vernonia cinerea chloroform leaf extract (VCMLE) in rats’ Also, in Tables 2 and 3, the heading in column 6 should read: ‘Antidiuretic activity of extract (F/N)’ rather than: ‘Antidiuretic activity of extract (N/F)’. 相似文献
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N. D. Onwukaeme 《Phytotherapy research : PTR》1995,9(4):306-308
Extracts of the stem bark of Daniellia oliveri using hexane, ethyl acetate and methanol were tested for analgesic, antipyretic and antiinflammatory activities. The hexane extract exhibited a dose related analgesic activity whilst the methanolic extract was active in the induced inflammatory condition. The ethyl acetate extract was relatively inactive and none of the extracts showed any antipyretic activity. Metabolic cage studies showed that a 70% ethanolic extract of the bark caused significant decreases in body weight, food intake, urine and stool output of rats. This extract also exhibited a competitive antagonism on histamine-induced contractions of the guinea-pig ileum and a non-competitive inhibition of acetyl choline-induced contraction of the frog rectus abdominis muscle. 相似文献
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Pettit GR Meng Y Gearing RP Herald DL Pettit RK Doubek DL Chapuis JC Tackett LP 《Journal of natural products》2004,67(2):214-220
Bioassay (P388 lymphocytic leukemia cell line and human tumor cell lines)-guided separation of the extracts prepared from the tropical and coastal trees Hernandia peltata (Malaysia) and Hernandianymphaeifolia (Republic of Maldives) led to the isolation of a new lignan designated as hernanol (1) and 12 previously known lignans: (-)-deoxypodophyllotoxin (2), deoxypicropodophyllin (3), (+)-epiaschantin (4), (+)-epieudesmin (5), praderin (6), 5'-methoxyyatein (7), podorhizol (8), deoxypodorhizone (9), bursehernin (10), kusunokinol (11), clusin (12), and (-)-maculatin (13). The oxidative cyclization (with VOF(3)) of lignans 8, 9, and 10 resulted in a new and unusual benzopyran (14), isostegane (15), and a new dibenzocyclooctadiene lactone (16), respectively. The structure and relative stereochemistry of hernanol (1) and lignans 3, 7, 8, 9, 10, 11, and 12 were determined by 1D and 2DNMR and HRMS analyses. The structures and absolute stereochemistry of structures 2, 4, 5, 6, 13, 14, 15, and 16 were unequivocally determined by single-crystal X-ray diffraction analyses. Evaluation against the murine P388 lymphocytic leukemia cell line and human tumor cell lines showed podophyllotoxin derivatives 2 and 3 to be strong cancer cell line growth inhibitors and substances 4, 5, 8, and 15 to have marginal cancer cell line inhibitory activities. Seven of the lignans and one of the synthetic modifications (14) inhibited growth of the pathogenic bacterium Neisseria gonorrhoeae. 相似文献
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Diuretic and antidiuretic diuretic of the leaf extracts of Vernonia cinerea (Less) (Fam. Compositae)
The diuretic and anti-diuretic potency of the leaf extracts of Vernonia cinerea was studied in albino rats. The chloroform extract of the leaf induced significant diuresis, while the methanol and aqueous extracts induced significant antidiuresis in rats. In both cases, the observed effects on urine volume and electrolyte excretion were dose dependent. The trend was a significant increase (in the case of diuresis) in natriuretic and kaliuretic activity and a significant decrease (in the case of antidiuresis) in natriuresis and kaliuresis. © 1997 John Wiley & Sons, Ltd. 相似文献